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Rafaela Costa, Nuno G. Oliveira & Ricardo Jorge Dinis-Oliveira. (2019) Pharmacokinetic and pharmacodynamic of bupropion: integrative overview of relevant clinical and forensic aspects. Drug Metabolism Reviews 51:3, pages 293-313.
Read now
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Francesca Toselli, Peter R. Dodd & Elizabeth M. J. Gillam. (2016) Emerging roles for brain drug-metabolizing cytochrome P450 enzymes in neuropsychiatric conditions and responses to drugs. Drug Metabolism Reviews 48:3, pages 379-404.
Read now
Read now
David C Lamb, Michael R Waterman & Bin Zhao. (2013) Streptomyces cytochromes P450: applications in drug metabolism. Expert Opinion on Drug Metabolism & Toxicology 9:10, pages 1279-1294.
Read now
Read now
Xiaojuan Chai, Su Zeng & Wen Xie. (2013) Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond. Expert Opinion on Drug Metabolism & Toxicology 9:3, pages 253-266.
Read now
Read now
David FV Lewis, Yuko Ito & Brian G Lake. (2010) Quantitative structure-activity relationships (QSARs) for inhibitors and substrates of CYP2B enzymes: importance of compound lipophilicity in explanation of potency differences. Journal of Enzyme Inhibition and Medicinal Chemistry 25:5, pages 679-684.
Read now
Read now
Mark J. Rieder, Robert J. Livingston, Ian B. Stanaway & Deborah A. Nickerson. (2008) The Environmental Genome Project: Reference Polymorphisms for Drug Metabolism Genes and Genome-Wide Association Studies. Drug Metabolism Reviews 40:2, pages 241-261.
Read now
Read now
Caitlin M. Brown, Brad Reisfeld & Arthur N. Mayeno. (2008) Cytochromes P450: A Structure-Based Summary of Biotransformations Using Representative Substrates. Drug Metabolism Reviews 40:1, pages 1-100.
Read now
Read now
Franz Oesch, Eric Fabian, Barbara Oesch-Bartlomowicz, Christoph Werner & Robert Landsiedel. (2007) Drug-Metabolizing Enzymes in the Skin of Man, Rat, and Pig. Drug Metabolism Reviews 39:4, pages 659-698.
Read now
Read now
Nicola J. Hewitt, María José Gómez Lechón, J. Brian Houston, David Hallifax, Hayley S. Brown, Patrick Maurel, J. Gerald Kenna, Lena Gustavsson, Christina Lohmann, Christian Skonberg, Andre Guillouzo, Gregor Tuschl, Albert P. Li, Edward LeCluyse, Geny M. M. Groothuis & Jan G. Hengstler. (2007) Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies. Drug Metabolism Reviews 39:1, pages 159-234.
Read now
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Sean Ekins, Sergey Andreyev, Andy Ryabov, Eugene Kirillov, Eugene A Rakhmatulin, Andrej Bugrim & Tatiana Nikolskaya. (2005) Computational prediction of human drug metabolism. Expert Opinion on Drug Metabolism & Toxicology 1:2, pages 303-324.
Read now
Read now
David F. V. Lewis, Brian G. Lake & M. Dickins. (2004) Quantitative structure-activity relationships within a homologous series of 7-alkoxyresorufins exhibiting activity towards CYP1A and CYP2B enzymes: molecular modelling studies on key members of the resorufin series with CYP2C5-derived models of human CYP1A1, CYP1A2, CYP2B6 and CYP3A4. Xenobiotica 34:6, pages 501-513.
Read now
Read now
Sharon Miksys & Rachel F. Tyndale. (2004) The Unique Regulation of Brain Cytochrome P450 2 (CYP2) Family Enzymes by Drugs and Genetics. Drug Metabolism Reviews 36:2, pages 313-333.
Read now
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David F. V. Lewis & Maruice Dickins. (2003) Baseline Lipophilicity Relationships in Human Cytochromes P450 Associated with Drug Metabolism. Drug Metabolism Reviews 35:1, pages 1-18.
Read now
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Isabelle Dussault, Min Lin, Kevin Hollister, Ming Fan, John Termini, Mark A. Sherman & Barry M. Forman. (2002) A Structural Model of the Constitutive Androstane Receptor Defines Novel Interactions That Mediate Ligand-Independent Activity. Molecular and Cellular Biology 22:15, pages 5270-5280.
Read now
Read now
Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
Read now
Read now
Articles from other publishers (114)
Longqiang Li, Zhou Lu, Guixia Liu, Yun Tang & Weihua Li. (2023) Machine Learning Models to Predict Cytochrome P450 2B6 Inhibitors and Substrates. Chemical Research in Toxicology.
Crossref
Crossref
Ethan D. Angle & Philip M. Cox. (2023) Multidisciplinary Insights into the Structure–Function Relationship of the CYP2B6 Active Site. Drug Metabolism and Disposition 51:3, pages 369-384.
Crossref
Crossref
Yaya Kassogue, Brehima Diakite, Mamoudou Maiga, Oumar Kassogue, Issa Konate, Kadidiatou Tamboura, Fousseyni Diarra, Zoumana Diarra, Mahamadou Karamoko Sawadogo, Yaya Goita, Sidi Boula Sissoko, Adama Seydou Sissoko, Nouhoum Guirou, Hind Dehbi, Sellama Nadifi, Sekou Bah, Cheick Bougadari Traore, Bakarou Kamate, Sounkalo Dao & Guimogo Dolo. (2022) Influence of CYP2B6 and CYP3A4 polymorphisms on the virologic and immunologic responses of patients treated with efavirenz-containing regimen. Pharmacogenetics and Genomics 32:6, pages 219-225.
Crossref
Crossref
Usman Ali Ashfaq, Farah Shahid & Samman Munir. 2022. Biochemistry of Drug Metabolizing Enzymes. Biochemistry of Drug Metabolizing Enzymes
29
72
.
Slobodan P. Rendic & F. Peter Guengerich. (2021) Human Family 1–4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update. Archives of Toxicology 95:2, pages 395-472.
Crossref
Crossref
Rumasha N. T. Kankanamage, Abhisek Brata Ghosh, Di Jiang, Karmel Gkika, Tia Keyes, Laura A. Achola, Steven Suib & James F. Rusling. (2020)
Metabolites of Tobacco- and E-Cigarette-Related Nitrosamines Can Drive Cu
2+
-Mediated DNA Oxidation
. Chemical Research in Toxicology 33:8, pages 2072-2086.
Crossref
Crossref
Wanda Mączka, Katarzyna Wińska & Małgorzata Grabarczyk. (2020) One Hundred Faces of Geraniol. Molecules 25:14, pages 3303.
Crossref
Crossref
Tsukasa Mori, Yoichiro Kitani, Den Hatakeyama, Kazumasa Machida, Naoko Goto-Inoue, Satoshi Hayakawa, Naoyuki Yamamoto, Keiko Kashiwagi & Akihiko Kashiwagi. (2020) Predation threats for a 24-h period activated the extension of axons in the brains of Xenopus tadpoles. Scientific Reports 10:1.
Crossref
Crossref
Harim Kim, Yejin Lee, Vitchan Kim, Rowoon Lee, Soo Kyung Bae, Mi-Kyoung Kwak, Sung Hoon Lee & Donghak Kim. (2019) Inhibition of cytochrome P450 2B6 by Astragalus extract mixture HT042. Toxicological Research 36:3, pages 195-201.
Crossref
Crossref
Mahadi Hasan, Mohammad Tuhin Ali, Rifat Khan, Parag Palit, Aminul Islam, Veronique Seidel, Rabeya Akter & Laizuman Nahar. (2018) Hepatoprotective, antihyperglycemic and antidiabetic effects of Dendrophthoe pentandra leaf extract in rats. Clinical Phytoscience 4:1.
Crossref
Crossref
F. Oesch, E. Fabian & Robert Landsiedel. (2018) Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models. Archives of Toxicology 92:8, pages 2411-2456.
Crossref
Crossref
Hind Hassani Idrissi, Nada El Khorb, Abdelhafid Akoudad, Rachida Habbal & Sellama Nadifi. (2018) Association of CYP2B6 ( G15631T ) polymorphism with Clopidogrel resistance and genetic predisposition to Acute Coronary Syndromes (ACSs) in Morocco. Gene Reports 11, pages 244-249.
Crossref
Crossref
Yejin Lee, Hyoung-Goo Park, Vitchan Kim, Myung-A. Cho, Harim Kim, Thien-Hoang Ho, Kyoung Sang Cho, Im-Soon Lee & Donghak Kim. (2018) Inhibitory effect of α-terpinyl acetate on cytochrome P450 2B6 enzymatic activity. Chemico-Biological Interactions 289, pages 90-97.
Crossref
Crossref
Leabaneng Tawe, Thato Motshoge, Pleasure Ramatlho, Naledi Mutukwa, Charles Waithaka Muthoga, Ghyslaine Bruna Djeunang Dongho, Axel Martinelli, Elias Peloewetse, Gianluca Russo, Isaac Kweku Quaye & Giacomo Maria Paganotti. (2018) Human cytochrome P450 2B6 genetic variability in Botswana: a case of haplotype diversity and convergent phenotypes. Scientific Reports 8:1.
Crossref
Crossref
Meng-Hui Zhang, Qin-Hai Shen, Zhao-Min Qin, Qiao-Ling Wang & Xi Chen. (2016) Systematic tracking of disrupted modules identifies significant genes and pathways in hepatocellular carcinoma. Oncology Letters 12:5, pages 3285-3295.
Crossref
Crossref
Zeruesenay Desta, Ingrid F. Metzger, Nancy Thong, Jessica B. L. Lu, John T. Callaghan, Todd C. Skaar, David A. Flockhart & Raymond E. Galinsky. (2016) Inhibition of Cytochrome P450 2B6 Activity by Voriconazole Profiled Using Efavirenz Disposition in Healthy Volunteers. Antimicrobial Agents and Chemotherapy 60:11, pages 6813-6822.
Crossref
Crossref
William D. Hedrich, Hazem E. Hassan & Hongbing Wang. (2016) Insights into CYP2B6-mediated drug–drug interactions. Acta Pharmaceutica Sinica B 6:5, pages 413-425.
Crossref
Crossref
Jingbao Liu, Manish B. Shah, Qinghai Zhang, C. David Stout, James R. Halpert & P. Ross Wilderman. (2016) Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations. Biochemistry 55:13, pages 1997-2007.
Crossref
Crossref
Doo-Yeoun Cho, Joan H.Q. Shen, Suzanne M. Lemler, Todd C. Skaar, Lang Li, Julia Blievernicht, Ulrich M. Zanger, Kwon-Bok Kim, Jae-Gook Shin, David A. Flockhart & Zeruesenay Desta. (2016) Rifampin enhances cytochrome P450 (CYP) 2B6-mediated efavirenz 8-hydroxylation in healthy volunteers. Drug Metabolism and Pharmacokinetics 31:2, pages 107-116.
Crossref
Crossref
Claudio A. Erratico, Anand K. Deo & Stelvio M. Bandiera. 2015. Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450. Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450
131
149
.
F. Oesch, E. Fabian, K. Guth & R. Landsiedel. (2014) Xenobiotic-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models. Archives of Toxicology 88:12, pages 2135-2190.
Crossref
Crossref
Nazan Yuce-Artun, Gulcin Kose & H. Sinan Suzen. (2014) Allele and genotype frequencies of CYP2B6 in a Turkish population. Molecular Biology Reports 41:6, pages 3891-3896.
Crossref
Crossref
Zhong Hai Yuan, Yi Ju Hou, Chen Zhao & Yan Li. (2014) Association of CYP2B6 c.516G>T Polymorphism with Acute Lymphoblastic Leukemia Susceptibility. Advanced Materials Research 926-930, pages 1073-1076.
Crossref
Crossref
Maria Karakosta, Vassiliki Kalotychou, Alkiviadis Kostakis, Gabriel Pantelias, Ioannis Rombos, Gregory Kouraklis & Kalliopi N. Manola. (2014) UGT1A1*28 Polymorphism in Chronic Lymphocytic Leukemia: The First Investigation of the Polymorphism in Disease Susceptibility and Its Specific Cytogenetic Abnormalities. Acta Haematologica 132:1, pages 59-67.
Crossref
Crossref
Yaya Kassogue, Meryem Quachouh, Hind Dehbi, Asma Quessar, Said Benchekroun & Sellama Nadifi. (2013) Functional polymorphism of CYP2B6 G15631T is associated with hematologic and cytogenetic response in chronic myeloid leukemia patients treated with imatinib. Medical Oncology 31:1.
Crossref
Crossref
Soo Hyeon Bae, Min Jo Kwon, Eu Jin Choi, Yu Fen Zheng, Kee Dong Yoon, Kwang-Hyeon Liu & Soo Kyung Bae. (2013) Potent inhibition of cytochrome P450 2B6 by sibutramine in human liver microsomes. Chemico-Biological Interactions 205:1, pages 11-19.
Crossref
Crossref
Katarina Ilic, Roy L. Hawke, Ranjit K. Thirumaran, Erin G. Schuetz, J. Heyward Hull, Angela D.M. Kashuba, Paul W. Stewart, Celeste M. Lindley & Mei-Ling Chen. (2013)
The Influence of Sex, Ethnicity, and
CYP2B6
Genotype on Bupropion Metabolism as an Index of Hepatic CYP2B6 Activity in Humans
. Drug Metabolism and Disposition 41:3, pages 575-581.
Crossref
Crossref
Fen Jiang, Zeruesenay Desta, Ji-Hong Shon, Chang-Woo Yeo, Ho-Sook Kim, Kwang-Hyeon Liu, Soo-Kyung Bae, Sang-Seop Lee, David A. Flockhart & Jae-Gook Shin. (2013) Effects of clopidogrel and itraconazole on the disposition of efavirenz and its hydroxyl metabolites: exploration of a novel CYP2B6 phenotyping index. British Journal of Clinical Pharmacology 75:1, pages 244-253.
Crossref
Crossref
Chitra Sridar, Jaime D'Agostino & Paul F. Hollenberg. (2012) Bioactivation of the Cancer Chemopreventive Agent Tamoxifen to Quinone Methides by Cytochrome P4502B6 and Identification of the Modified Residue on the Apoprotein. Drug Metabolism and Disposition 40:12, pages 2280-2288.
Crossref
Crossref
Alexander V. LyubimovShalu Jhajra, Ninad Ramesh Varkhede, Deepak Suresh Ahire, Bukke Vidyasagar Naik, Bhagwat Prasad, Jyoti Paliwal & Saranjit Singh. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
99
.
Slobodan Rendic & F. Peter Guengerich. (2012) Contributions of Human Enzymes in Carcinogen Metabolism. Chemical Research in Toxicology 25:7, pages 1316-1383.
Crossref
Crossref
Jillissa C. Molnari, Hazem E. Hassan & Alan L. Myers. (2011) Effects of sertraline on the pharmacokinetics of bupropion and its major metabolite, hydroxybupropion, in mice. European Journal of Drug Metabolism and Pharmacokinetics 37:1, pages 57-63.
Crossref
Crossref
Alexander V. LyubimovUlrich M. Zanger. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
36
.
Zhong-hai Yuan, Qian Liu, Ying Zhang, Hong-xing Liu, Jun Zhao & Ping Zhu. (2010) CYP2B6 gene single nucleotide polymorphisms and leukemia susceptibility. Annals of Hematology 90:3, pages 293-299.
Crossref
Crossref
Evan T. Ogburn, David R. Jones, Andrea R. Masters, Cong Xu, Yingying Guo & Zeruesenay Desta. (2010) Efavirenz Primary and Secondary Metabolism In Vitro and In Vivo: Identification of Novel Metabolic Pathways and Cytochrome P450 2A6 as the Principal Catalyst of Efavirenz 7-Hydroxylation. Drug Metabolism and Disposition 38:7, pages 1218-1229.
Crossref
Crossref
Izaskun Arenaz, Jorge Vicente, Ana Fanlo, Patricia Vásquez, Juan Carlos Medina, Blanca Conde, Fabricio González‐Andrade & Blanca Sinués. (2010)
Haplotype structure and allele frequencies of
CYP2B6
in Spaniards and Central Americans
. Fundamental & Clinical Pharmacology 24:2, pages 247-253.
Crossref
Crossref
Michael ZientekChad StonerRobyn AyscueJacquelyn Klug-McLeodYing JiangMichael WestClaire CollinsSean Ekins. (2010) Integrated in Silico−in Vitro Strategy for Addressing Cytochrome P450 3A4 Time-Dependent Inhibition. Chemical Research in Toxicology 23:3, pages 664-676.
Crossref
Crossref
Shayne Cox GadEugene G. Hrycay & Stelvio M. Bandiera. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
Ilia G. Denisov, Daniel J. Frank & Stephen G. Sligar. (2009) Cooperative properties of cytochromes P450. Pharmacology & Therapeutics 124:2, pages 151-167.
Crossref
Crossref
Max K. Leong, Yen-Ming Chen & Tzu-Hsien Chen. (2009) Prediction of human cytochrome P450 2B6-substrate interactions using hierarchical support vector regression approach. Journal of Computational Chemistry 30:12, pages 1899-1909.
Crossref
Crossref
Mehmet Berköz & Serap Yalin. (2009) Association of CYP2B6 G15631T polymorphism with acute leukemia susceptibility. Leukemia Research 33:7, pages 919-923.
Crossref
Crossref
Daisuke Itokawa, Aiko Yamauchi & Hiroshi Chuman. (2009) Quantitative Structure-Activity Relationship for Inhibition of CYP2B6 and CYP3A4 by Azole Compounds - Comparison with Their Binding Affinity. QSAR & Combinatorial Science 28:6-7, pages 629-636.
Crossref
Crossref
Lan Fan, Jin-Chao Wang, Feng Jiang, Zhi-Rong Tan, Yao Chen, Qing Li, Wei Zhang, Guo Wang, He-Ping Lei, Dong-Li Hu, Dan Wang & Hong-Hao Zhou. (2008) Induction of cytochrome P450 2B6 activity by the herbal medicine baicalin as measured by bupropion hydroxylation. European Journal of Clinical Pharmacology 65:4, pages 403-409.
Crossref
Crossref
Yumi Nishiya, Katsunobu Hagihara, Takashi Ito, Masami Tajima, Shin-ichi Miura, Atsushi Kurihara, Nagy A. Farid & Toshihiko Ikeda. (2009) Mechanism-Based Inhibition of Human Cytochrome P450 2B6 by Ticlopidine, Clopidogrel, and the Thiolactone Metabolite of Prasugrel. Drug Metabolism and Disposition 37:3, pages 589-593.
Crossref
Crossref
Sharon Miksys & Rachel F Tyndale. (2008) Brain Drug-Metabolizing Cytochrome P450 Enzymes are Active In Vivo, Demonstrated by Mechanism-Based Enzyme Inhibition. Neuropsychopharmacology 34:3, pages 634-640.
Crossref
Crossref
Steven Karch. 2008. Karch's Pathology of Drug Abuse, Fourth Edition. Karch's Pathology of Drug Abuse, Fourth Edition
367
374
.
J. Andrew Williams, Tommy Andersson, Tommy B. Andersson, Rebecca Blanchard, Martin Otto Behm, Nadine Cohen, Timi Edeki, Monique Franc, Kathleen M. Hillgren, Keith J. Johnson, David A. Katz, Mark N. Milton, Bernard P. Murray, Joseph W. Polli, Deb Ricci, Lisa A. Shipley, Subrahmanyam Vangala & Steven A. Wrighton. (2008) PhRMA White Paper on ADME Pharmacogenomics. The Journal of Clinical Pharmacology 48:7, pages 849-889.
Crossref
Crossref
Rebecka Coles & Evan D. Kharasch. (2008) Stereoselective Metabolism of Bupropion by Cytochrome P4502B6 (CYP2B6) and Human Liver Microsomes. Pharmaceutical Research 25:6, pages 1405-1411.
Crossref
Crossref
Evan D. Kharasch, Darain Mitchell, Rebecka Coles & Roberto Blanco. (2008) Rapid Clinical Induction of Hepatic Cytochrome P4502B6 Activity by Ritonavir. Antimicrobial Agents and Chemotherapy 52:5, pages 1663-1669.
Crossref
Crossref
Evan D. Kharasch, Darain Mitchell & Rebecka Coles. (2008) Stereoselective Bupropion Hydroxylation as an In Vivo Phenotypic Probe for Cytochrome P4502B6 (CYP2B6) Activity. The Journal of Clinical Pharmacology 48:4, pages 464-474.
Crossref
Crossref
Rheem A. Totah, Pamela Sheffels, Toni Roberts, Dale Whittington, Kenneth Thummel & Evan D. Kharasch. (2008) Role of CYP2B6 in Stereoselective Human Methadone Metabolism. Anesthesiology 108:3, pages 363-374.
Crossref
Crossref
Suk-whan ChoiSe Hun LimSang-Eun LeeYoung Hwan KimJeong Han LeeKun Moo LeeSoon Ho CheongYoung-Kyun ChoeYoung Jae KimChee-Mahn Shin. (2008) The correlation between actual blood concentration of propofol and the difference of estimated lean body mass with actual lean body mass in target controlled infusion. Korean Journal of Anesthesiology 55:6, pages 666.
Crossref
Crossref
Margalida Rotger, Maria Saumoy, Kunlin Zhang, Markus Flepp, Roland Sahli, Laurent Decosterd & Amalio Telenti. (2007) Partial deletion of CYP2B6 owing to unequal crossover with CYP2B7. Pharmacogenetics and Genomics 17:10, pages 885-890.
Crossref
Crossref
Leslie M. Tompkins & Andrew D. Wallace. (2007) Mechanisms of cytochrome P450 induction. Journal of Biochemical and Molecular Toxicology 21:4, pages 176-181.
Crossref
Crossref
Ulrich M Zanger, Kathrin Klein, Tanja Saussele, Julia Blievernicht, Marco H Hofmann & Matthias Schwab. (2007)
Polymorphic
CYP2B6
: molecular mechanisms and emerging clinical significance
. Pharmacogenomics 8:7, pages 743-759.
Crossref
Crossref
Amal Al Omari & Daryl J. Murry. (2016) Pharmacogenetics of the Cytochrome P450 Enzyme System: Review of Current Knowledge and Clinical Significance. Journal of Pharmacy Practice 20:3, pages 206-218.
Crossref
Crossref
Ernest Hodgson & Randy L. Rose. (2007) The importance of cytochrome P450 2B6 in the human metabolism of environmental chemicals. Pharmacology & Therapeutics 113:2, pages 420-428.
Crossref
Crossref
Julia K Blievernicht, Elke Schaeffeler, Kathrin Klein, Michel Eichelbaum, Matthias Schwab & Ulrich M Zanger. (2007) MALDI-TOF Mass Spectrometry for Multiplex Genotyping of CYP2B6 Single-Nucleotide Polymorphisms. Clinical Chemistry 53:1, pages 24-33.
Crossref
Crossref
Benjamin J. Davies, Janet K. Coller, Andrew A. Somogyi, Robert W. Milne & Benedetta C. Sallustio. (2007) CYP2B6, CYP2D6, and CYP3A4 Catalyze the Primary Oxidative Metabolism of Perhexiline Enantiomers by Human Liver Microsomes. Drug Metabolism and Disposition 35:1, pages 128-138.
Crossref
Crossref
Larry J. Jolivette & Sean Ekins. 2007.
131
176
.
Manuel Baader & Urs A. Meyer. 2007. xPharm: The Comprehensive Pharmacology Reference. xPharm: The Comprehensive Pharmacology Reference
1
3
.
Robert L. Walsky, Angela V. Astuccio & R. Scott Obach. (2006) Evaluation of 227 Drugs for In Vitro Inhibition of Cytochrome P450 2B6. The Journal of Clinical Pharmacology 46:12, pages 1426-1438.
Crossref
Crossref
David J. Waxman & Caitlin O’Connor. (2006) Growth Hormone Regulation of Sex-Dependent Liver Gene Expression. Molecular Endocrinology 20:11, pages 2613-2629.
Crossref
Crossref
Joseph Meletiadis, Stephen Chanock & Thomas J. Walsh. (2006) Human Pharmacogenomic Variations and Their Implications for Antifungal Efficacy. Clinical Microbiology Reviews 19:4, pages 763-787.
Crossref
Crossref
Miia Turpeinen, Laura E. Korhonen, Ari Tolonen, Jouko Uusitalo, Risto Juvonen, Hannu Raunio & Olavi Pelkonen. (2006) Cytochrome P450 (CYP) inhibition screening: Comparison of three tests. European Journal of Pharmaceutical Sciences 29:2, pages 130-138.
Crossref
Crossref
Sean Ekins, Sergey Andreyev, Andy Ryabov, Eugene Kirillov, Eugene A. Rakhmatulin, Svetlana Sorokina, Andrej Bugrim & Tatiana Nikolskaya. (2006) A COMBINED APPROACH TO DRUG METABOLISM AND TOXICITY ASSESSMENT. Drug Metabolism and Disposition 34:3, pages 495-503.
Crossref
Crossref
Mohamad Shebley, Monica I. Jushchyshyn & Paul F. Hollenberg. (2006)
SELECTIVE PATHWAYS FOR THE METABOLISM OF PHENCYCLIDINE BY CYTOCHROME P450 2B ENZYMES: IDENTIFICATION OF ELECTROPHILIC METABOLITES, GLUTATHIONE, AND
N
-ACETYL CYSTEINE ADDUCTS
. Drug Metabolism and Disposition 34:3, pages 375-383.
Crossref
Crossref
Jue Wang, Anders Sönnerborg, Anders Rane, Filip Josephson, Stefan Lundgren, Lars Ståhle & Magnus Ingelman-Sundberg. (2006) Identification of a novel specific CYP2B6 allele in Africans causing impaired metabolism of the HIV drug efavirenz. Pharmacogenetics and Genomics 16:3, pages 191-198.
Crossref
Crossref
David F.V. Lewis, Brian G. Lake, Yuko Ito & Pavel Anzenbacher. (2006) QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS (QSARs) WITHIN CYTOCHROMES P450 2B (CYP2B) SUBFAMILY ENZYMES: THE IMPORTANCE OF LIPOPHILICITY FOR BINDING AND METABOLISM. Drug Metabolism and Drug Interactions 21:3-4.
Crossref
Crossref
Kathrin Klein, Thomas Lang, Tanja Saussele, Eduardo Barbosa-Sicard, Wolf-Hagen Schunck, Michel Eichelbaum, Matthias Schwab & Ulrich M. Zanger. (2005) Genetic variability of CYP2B6 in populations of African and Asian origin: allele frequencies, novel functional variants, and possible implications for anti-HIV therapy with efavirenz. Pharmacogenetics and Genomics 15:12, pages 861-873.
Crossref
Crossref
Kari L. Stone, Rachel K. Behan & Michael T. Green. (2005) X-ray absorption spectroscopy of chloroperoxidase compound I: Insight into the reactive intermediate of P450 chemistry. Proceedings of the National Academy of Sciences 102:46, pages 16563-16565.
Crossref
Crossref
Parvaneh Afsharian, Lars Mollgard, Zuzana Hassan, Hanjing Xie, Eva Kimby & Moustapha Hassan. (2005) The effect of ciprofloxacin on cyclophosphamide pharmacokinetics in patients with non-Hodgkin lymphoma. European Journal of Haematology 75:3, pages 206-211.
Crossref
Crossref
F. Peter Guengerich. 2005. Cytochrome P450. Cytochrome P450
377
530
.
Géraldine Lemaire, Georges de Sousa & Roger Rahmani. (2004) A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides. Biochemical Pharmacology 68:12, pages 2347-2358.
Crossref
Crossref
Thomas Lang, Kathrin Klein, Tanja Richter, Arne Zibat, Reinhold Kerb, Michel Eichelbaum, Matthias Schwab & Ulrich M. Zanger. (2004)
Multiple Novel Nonsynonymous
CYP2B6
Gene Polymorphisms in Caucasians: Demonstration of Phenotypic Null Alleles
. Journal of Pharmacology and Experimental Therapeutics 311:1, pages 34-43.
Crossref
Crossref
Stanislav Micuda, Lucie Mundlova, Eva Anzenbacherova, Pavel Anzenbacher, Jaroslav Chladek, Leos Fuksa & Jirina Martinkova. (2004) Inhibitory effects of memantine on human cytochrome P450 activities: prediction of in vivo drug interactions. European Journal of Clinical Pharmacology 60:8, pages 583-589.
Crossref
Crossref
Robyn M Jacob, Elaine C Johnstone, Matt J Neville & Robert T Walton. (2004) Identification of CYP2B6 Sequence Variants by Use of Multiplex PCR with Allele-Specific Genotyping. Clinical Chemistry 50:8, pages 1372-1377.
Crossref
Crossref
David F.V. Lewis, Miriam N. Jacobs & Maurice Dickins. (2004) Compound lipophilicity for substrate binding to human P450s in drug metabolism. Drug Discovery Today 9:12, pages 530-537.
Crossref
Crossref
E. Harleton. (2004) Metabolism of N,N',N''-Triethylenethiophosphoramide by CYP2B1 and CYP2B6 Results in the Inactivation of Both Isoforms by Two Distinct Mechanisms. Journal of Pharmacology and Experimental Therapeutics 310:3, pages 1011-1019.
Crossref
Crossref
John F. Rawls, Buck S. Samuel & Jeffrey I. Gordon. (2004) Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota. Proceedings of the National Academy of Sciences 101:13, pages 4596-4601.
Crossref
Crossref
Liping Du, Susan M.G Hoffman & Diane S Keeney. (2004) Epidermal CYP2 family cytochromes P450. Toxicology and Applied Pharmacology 195:3, pages 278-287.
Crossref
Crossref
David F.V. Lewis. (2004) Quantitative structure–activity relationships (QSARs) for substrates of human cytochromes P450 CYP2 family enzymes. Toxicology in Vitro 18:1, pages 89-97.
Crossref
Crossref
D.F V. Lewis, B.G. Lake & M. Dickins. (2004) Substrates of Human Cytochromes P4S0 from Families CYP1 and CYP2: Analysis of Enzyme Selectivity and Metabolism. Drug Metabolism and Drug Interactions 20:3.
Crossref
Crossref
Tanja Richter, Thomas E. Mürdter, Georg Heinkele, Jürgen Pleiss, Stephan Tatzel, Matthias Schwab, Michel Eichelbaum & Ulrich M. Zanger. (2004) Potent Mechanism-Based Inhibition of Human CYP2B6 by Clopidogrel and Ticlopidine. Journal of Pharmacology and Experimental Therapeutics 308:1, pages 189-197.
Crossref
Crossref
John G. Gerber, Robert J. Rhodes & Joseph Gal. (2003) Stereoselective metabolism of methadone N‐demethylation by cytochrome P4502B6 and 2C19. Chirality 16:1, pages 36-44.
Crossref
Crossref
Aiming Yu & Robert Haining. 2003. Drug Metabolizing Enzymes. Drug Metabolizing Enzymes
375
419
.
Jarmo S. Salonen, Leena Nyman, Alan R. Boobis, Robert J. Edwards, Patricia Watts, Brian G. Lake, Roger J. Price, Anthony B. Renwick, Maria-José Gómez-Lechón, José V. Castell, Magnus Ingelman-Sundberg, Mats Hidestrand, Andre Guillouzo, Laurent Corcos, Peter S. Goldfarb, David F.V. Lewis, Päivi Taavitsainen & Olavi Pelkonen. (2003) COMPARATIVE STUDIES ON THE CYTOCHROME P450-ASSOCIATED METABOLISM AND INTERACTION POTENTIAL OF SELEGILINE BETWEEN HUMAN LIVER-DERIVED IN VITRO SYSTEMS. Drug Metabolism and Disposition 31:9, pages 1093-1102.
Crossref
Crossref
Bryan A. Ward, J. Christopher Gorski, David R. Jones, Stephen D. Hall, David A. Flockhart & Zeruesenay Desta. (2003) The Cytochrome P450 2B6 (CYP2B6) Is the Main Catalyst of Efavirenz Primary and Secondary Metabolism: Implication for HIV/AIDS Therapy and Utility of Efavirenz as a Substrate Marker of CYP2B6 Catalytic Activity. Journal of Pharmacology and Experimental Therapeutics 306:1, pages 287-300.
Crossref
Crossref
Britt Jansson, Ulrika S.H. Simonsson & Michael Ashton. (2003) Simultaneous enantiospecific separation and quantitation of mephenytoin and its metabolites nirvanol and 4?-hydroxymephenytoin in human plasma by liquid chromatography. Journal of Chromatography B 791:1-2, pages 179-191.
Crossref
Crossref
Hongbing Wang, Stephanie R. Faucette, Darryl Gilbert, Summer L. Jolley, Tatsuya Sueyoshi, Masahiko Negishi & Edward L. LeCluyse. (2003) Glucocorticoid Receptor Enhancement of Pregnane X Receptor-Mediated CYP2B6 Regulation in Primary Human Hepatocytes. Drug Metabolism and Disposition 31:5, pages 620-630.
Crossref
Crossref
Susumu Saito, Aritoshi Iida, Akihiro Sekine, Saori Kawauchi, Shoko Higuchi, Chie Ogawa & Yusuke Nakamura. (2003) Catalog of 680 variations among eight cytochrome P450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population. Journal of Human Genetics 48:5, pages 249-270.
Crossref
Crossref
Hideto Jinno, Toshiko Tanaka-Kagawa, Akiko Ohno, Yuko Makino, Erika Matsushima, Nobumitsu Hanioka & Masanori Ando. (2003) Functional Characterization of Cytochrome P450 2B6 Allelic Variants. Drug Metabolism and Disposition 31:4, pages 398-403.
Crossref
Crossref
Gordon A. FrancisElisabeth FayardFrédéric PicardJohan Auwerx. (2003) Nuclear Receptors and the Control of Metabolism. Annual Review of Physiology 65:1, pages 261-311.
Crossref
Crossref
A. K. Daly. (2003) Pharmacogenetics of the major polymorphic metabolizing enzymes. Fundamental and Clinical Pharmacology 17:1, pages 27-41.
Crossref
Crossref
J.M. Pascussi, S. Gerbal-Chaloin, L. Drocourt, P. Maurel & M.J. Vilarem. (2003) The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors. Biochimica et Biophysica Acta (BBA) - General Subjects 1619:3, pages 243-253.
Crossref
Crossref
Anthony R Tricker. (2003) Nicotine metabolism, human drug metabolism polymorphisms, and smoking behaviour. Toxicology 183:1-3, pages 151-173.
Crossref
Crossref
Thomas K. H. Chang, Stelvio M. Bandiera & Jie Chen. (2003) Constitutive Androstane Receptor and Pregnane X Receptor Gene Expression in Human Liver: Interindividual Variability and Correlation with CYP2B6 mRNA Levels. Drug Metabolism and Disposition 31:1, pages 7-10.
Crossref
Crossref
H-J Xie, Ü Yasar, S Lundgren, L Griskevicius, Y Terelius, M Hassan & A Rane. (2003) Role of polymorphic human CYP2B6 in cyclophosphamide bioactivation. The Pharmacogenomics Journal 3:1, pages 53-61.
Crossref
Crossref
Tong Li-Masters & Edward T Morgan. (2002) Down-regulation of phenobarbital-induced cytochrome P4502B mRNAs and proteins by endotoxin in mice: independence from nitric oxide production by inducible nitric oxide synthase. Biochemical Pharmacology 64:12, pages 1703-1711.
Crossref
Crossref
Elmar Richter & Birgit Branner. (2002) Biomonitoring of exposure to aromatic amines: haemoglobin adducts in humans. Journal of Chromatography B 778:1-2, pages 49-62.
Crossref
Crossref
Marie Stiborová, Lucie Bořek-Dohalská, Petr Hodek, Jaroslav Mráz & Eva Frei. (2002) New selective inhibitors of cytochromes P450 2B and their application to antimutagenesis of tamoxifen. Archives of Biochemistry and Biophysics 403:1, pages 41-49.
Crossref
Crossref
Karthik Venkatakrishnan, Lisa L. von Moltke & David J. Greenblatt. (2002)
Evaluation of Supermix
TM
as an
in vitro
model of human liver microsomal drug metabolism
. Biopharmaceutics & Drug Disposition 23:5, pages 183-190.
Crossref
Crossref
Chitra Sridar, Ute M. Kent, Lisa M. Notley, Elizabeth M. J. Gillam & Paul F. Hollenberg. (2002) Effect of Tamoxifen on the Enzymatic Activity of Human Cytochrome CYP2B6. Journal of Pharmacology and Experimental Therapeutics 301:3, pages 945-952.
Crossref
Crossref
Cüneyt Güzey, Åke Norström & Olav Spigset. (2002) Change From the CYP2D6 Extensive Metabolizer to the Poor Metabolizer Phenotype During Treatment With Bupropion. Therapeutic Drug Monitoring 24:3, pages 436-437.
Crossref
Crossref
Marcel J. de Groot & Sean Ekins. (2002) Pharmacophore modeling of cytochromes P450. Advanced Drug Delivery Reviews 54:3, pages 367-383.
Crossref
Crossref
D.F.V. Lewis, B.G. Lake, M. Dickins & P.S. Goldfarb. (2002) Molecular Modelling of CYP2B6 Based on Homology with the CYP2C5 Crystal Structure: Analysis of Enzyme-Substrate Interactions. Drug Metabolism and Drug Interactions 19:2.
Crossref
Crossref
Susanne Bremer, Cristian Pellizzer, Sandra Coecke, Martin Paparella & Paolo Catalani. (2019) Detection of the Embryotoxic Potential of Cyclophosphamide by Using a Combined System of Metabolic Competent Cells and Embryonic Stem Cells. Alternatives to Laboratory Animals 30:1, pages 77-85.
Crossref
Crossref
Ulrich M. Zanger, Joachim Fischer, Kathrin Klein & Thomas Lang. 2002. Cytochrome P450 Part C. Cytochrome P450 Part C
45
53
.
P. Baumann, D. Zullino & C. B. Eap. 2002. Depression 2000. Depression 2000
37
50
.
Susan M. G. Hoffman, David R. Nelson & Diane S. Keeney. (2001) Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19. Pharmacogenetics 11:8, pages 687-698.
Crossref
Crossref
David Lewis. 2001. Guide to Cytochromes P450. Guide to Cytochromes P450
164
210
.
Thomas Lang, Kathrin Klein, Joachim Fischer, Andreas Nussler, Peter Neuhaus, Ute Hofmann, Michel Eichelbaum, Matthias Schwab & Ulrich Zanger. (2001) Pharmacogenetics 11:5, pages 399-415.
Crossref
Crossref
Michael H. Court, Su X. Duan, Leah M. Hesse, Karthik Venkatakrishnan & David J. Greenblatt. (2001) Cytochrome P-450 2B6 Is Responsible for Interindividual Variability of Propofol Hydroxylation by Human Liver Microsomes. Anesthesiology 94:1, pages 110-119.
Crossref
Crossref
Sean Ekins, Barbara J. Ring, James Grace, Donna J. McRobie-Belle & Steven A. Wrighton. (2000) Present and future in vitro approaches for drug metabolism. Journal of Pharmacological and Toxicological Methods 44:1, pages 313-324.
Crossref
Crossref