502
Views
60
CrossRef citations to date
0
Altmetric
Research Article

An Interethnic Comparison of Polymorphisms of the Genes Encoding Drug-Metabolizing Enzymes and Drug Transporters: Experience in Singapore

, Ph.D., , Ph.D. & , Ph.D.
Pages 327-378 | Published online: 09 Oct 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (13)

Tingting Zhang, Qiuyan Li, Bonan Dong, Xiao Liang, Mansha Jia, Jing Bai, Jingcui Yu & Songbin Fu. (2021) Genetic Polymorphism of Drug Metabolic Gene CYPs, VKORC1, NAT2, DPYD and CHST3 of Five Ethnic Minorities in Heilongjiang Province, Northeast China. Pharmacogenomics and Personalized Medicine 14, pages 1537-1547.
Read now
Yujing Cheng, Qi Li, Xin Yang, Heng Ding, Wanlu Chen, Run Dai & Chan Zhang. (2021) Analysis of Very Important Pharmacogenomics Variants in the Chinese Lahu Population. Pharmacogenomics and Personalized Medicine 14, pages 1275-1289.
Read now
Rashmi R. Shah. (2015) Inter-ethnic differences in drug response: Implications for drug development and complying with drug regulation. Clinical Research and Regulatory Affairs 32:3, pages 88-98.
Read now
Hassan R. Dhaini & Loulou Kobeissi. (2014) Toxicogenetic Profile and Cancer Risk in Lebanese. Journal of Toxicology and Environmental Health, Part B 17:2, pages 95-125.
Read now
Miao Hu & Brian Tomlinson. (2013) Lipid-lowing pharmacogenomics in Chinese patients. Expert Review of Cardiovascular Therapy 11:8, pages 985-997.
Read now
Viet Hong Phan, Cindy Tan, Anneliese Rittau, Hongmei Xu, Andrew J McLachlan & Stephen J Clarke. (2011) An update on ethnic differences in drug metabolism and toxicity from anti-cancer drugs. Expert Opinion on Drug Metabolism & Toxicology 7:11, pages 1395-1410.
Read now
Shu-Feng Zhou, Jun-Ping Liu & Balram Chowbay. (2009) Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metabolism Reviews 41:2, pages 89-295.
Read now
Viet Hong Phan, Melissa M Moore, Andrew J McLachlan, Micheline Piquette-Miller, Hongmei Xu & Stephen J Clarke. (2009) Ethnic differences in drug metabolism and toxicity from chemotherapy. Expert Opinion on Drug Metabolism & Toxicology 5:3, pages 243-257.
Read now
Mark J. Rieder, Robert J. Livingston, Ian B. Stanaway & Deborah A. Nickerson. (2008) The Environmental Genome Project: Reference Polymorphisms for Drug Metabolism Genes and Genome-Wide Association Studies. Drug Metabolism Reviews 40:2, pages 241-261.
Read now
Struan FA Grant & Hakon Hakonarson. (2007) Recent development in pharmacogenomics: from candidate genes to genome-wide association studies. Expert Review of Molecular Diagnostics 7:4, pages 371-393.
Read now
S. Quaranta, D. Chevalier, D. Allorge, J. M. Lo-Guidice, F. Migot-Nabias, A. Kenani, M. Imbenotte, F. Broly, B. Lacarelle & M. Lhermitte. (2006) Ethnic differences in the distribution of CYP3A5 gene polymorphisms. Xenobiotica 36:12, pages 1191-1200.
Read now
Uwe Christians, Volker Schmitz & Manuel Haschke. (2005) Functional interactions between P-glycoprotein and CYP3A in drug metabolism. Expert Opinion on Drug Metabolism & Toxicology 1:4, pages 641-654.
Read now

Articles from other publishers (47)

Elise Miller, Chinwuwanuju Ugo‐Obi Sampson, Ankit A. Desai & Jason H. Karnes. (2023) Differential drug response in pulmonary arterial hypertension: The potential for precision medicine. Pulmonary Circulation 13:4.
Crossref
Aashiq Hussain Bhat, Umer Majeed Khaja, Maroof Ahmed, Waseem Younis Khan & Showkat Ahmad Ganie. 2023. Pharmacogenomics. Pharmacogenomics 195 221 .
Ammara Siddique, Samra Bashir & Mateen Abbas. 2023. Therapeutic Approaches in Cancer Treatment. Therapeutic Approaches in Cancer Treatment 141 175 .
Matthew Ng, Sylvia Chen, Whee Sze Ong, Akhila Balachander, Amanda Seet, Joe Yeong, Natalia Sutiman, Tony Kiat Hon Lim, Bernett Lee, Yu Amanda Guo, Wai Fook Leong, Sze Sing Lee, Justina Lam, Su Pin Choo, Anders Jacobsen Skanderup, Subhra Kumar Biswas, David Tai & Balram Chowbay. (2022) A phase 1b study of OXIRI in pancreatic adenocarcinoma patients and its immunomodulatory effects . International Journal of Cancer 151:3, pages 435-449.
Crossref
Kai Kou, Xiaodong Sun, Mingqian Li, Ting Li, Yuelei Hu, Shuxuan Li & Guoyue Lv. (2021) Beneficial effects of Wuzhi Capsule on tacrolimus blood concentrations in liver transplant patients with different donor‐recipient CYP3A5 genotypes. Journal of Clinical Pharmacy and Therapeutics 47:2, pages 200-210.
Crossref
Paula Ferreira Salles, Daiana Souza Perce-da-Silva, Atila Duque Rossi, Luisa Riehl Raposo, Aina Danaisa Ramirez Ramirez, Otílio Machado Pereira Bastos, Lilian Rose Pratt-Riccio, Gustavo Capatti Cassiano, Andrea Regina Souza Baptista, Cynthia Chester Cardoso, Dalma Maria Banic & Ricardo Luiz Dantas Machado. (2021) CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region. Frontiers in Pharmacology 12.
Crossref
Nur Salwani Bakar. (2021) Pharmacogenetics of common SNP affecting drug metabolizing enzymes: comparison of allele frequencies between European and Malaysian/Singaporean. Drug Metabolism and Personalized Therapy 0:0.
Crossref
Basu Dev Banerjee, Ranjeet Kumar, Krishna Latha Thamineni, Harendra Shah, Gaurav Kumar Thakur & Tusha Sharma. (2020) Effect of Environmental Exposure and Pharmacogenomics on Drug Metabolism. Current Drug Metabolism 20:14, pages 1103-1113.
Crossref
Narayan Prasad, Akhilesh Jaiswal, Manas Ranjan Behera, Vikas Agarwal, Ravi Kushwaha, Dharmendra Bhadauria, Anupama Kaul & Amit Gupta. (2020) Melding Pharmacogenomic Effect of MDR1 and CYP3A5 Gene Polymorphism on Tacrolimus Dosing in Renal Transplant Recipients in Northern India. Kidney International Reports 5:1, pages 28-38.
Crossref
Palden Wangyel Dorji, Sonam Wangchuk, Kanyarat Boonprasert, Mayuri Tarasuk & Kesara Na-Bangchang. (2019) Pharmacogenetic relevant polymorphisms of CYP2C9, CYP2C19, CYP2D6, and CYP3A5 in Bhutanese population. Drug Metabolism and Personalized Therapy 34:4.
Crossref
Palden Wangyel Dorji, Gyem Tshering & Kesara Na‐Bangchang. (2019) CYP2C9, CYP2C19, CYP2D6 and CYP3A5 polymorphisms in South‐East and East Asian populations: A systematic review. Journal of Clinical Pharmacy and Therapeutics.
Crossref
Nada Ezzeldin, Dalia El-Lebedy, Amira Darwish, Ahmed El-Bastawisy, Mirhane Hassan, Shereen Abd El-Aziz, Mohamed Abdel-Hamid & Amal Saad-Hussein. (2017) Genetic polymorphisms of human cytochrome P450 CYP1A1 in an Egyptian population and tobacco-induced lung cancer. Genes and Environment 39:1.
Crossref
Huma Mehboob, Imtiaz Mahmood Tahir, Tahir Iqbal, Naheed Akhter, Naveed Munir & Muhammad Riaz. 2017. Genetic Polymorphisms. Genetic Polymorphisms.
Tomohiro Kaneko, Momoko Arai, Atsushi Watanabe & Shuichi Tsuruoka. (2017) Effectiveness of Measuring Genetic Polymorphisms in Metabolizing Enzymes of Tacrolimus within One Medical Facility. Journal of Nippon Medical School 84:6, pages 274-279.
Crossref
Edward Chia-Cheng Lai, Cheng-Yang Hsieh, Chien-Chou Su, Yea-Huei Kao Yang, Chin-Wei Huang, Swu-Jane Lin & Soko Setoguchi. (2016) Comparative persistence of antiepileptic drugs in patients with epilepsy. Medicine 95:35, pages e4481.
Crossref
Annette S. Gross, Caroline Goldfrad, Soichiro Hozawa, Mark H. James, Christine S. Clifton, Yutaro Sugiyama & Loretta Jacques. (2015) Ethnic sensitivity assessment of fluticasone furoate/vilanterol in East Asian asthma patients from randomized double-blind multicentre Phase IIb/III trials. BMC Pulmonary Medicine 15:1.
Crossref
Z. R. Tan, Y. X. Zhou, J. Liu, W. H. Huang, Y. Chen, Y. C. Wang & L. S. Wang. (2015) The influence of ABCB1 polymorphism C3435T on the pharmacokinetics of silibinin. Journal of Clinical Pharmacy and Therapeutics 40:6, pages 685-688.
Crossref
G Sivolapenko. (2015) A Pharmacokinetic Analysis and Pharmacogenomic Study of 6-mercaptopurine. International Journal of Pharmaceutical Sciences and Developmental Research, pages 002-007.
Crossref
Yang Mei, Sai-Ying Wang, Yang Li, Shuang-Qiang Yi, Chun-Yan Wang, Mi Yang & Kai-Ming Duan. (2015) Role of SLCO1B1, ABCB1, and CHRNA1 gene polymorphisms on the efficacy of rocuronium in Chinese patients. The Journal of Clinical Pharmacology 55:3, pages 261-268.
Crossref
I. Cavaco, R. Piedade, M. I. Msellem, A. Bjorkman & J. P. Gil. (2012) Cytochrome 1A1 and 1B1 gene diversity in the Zanzibar islands . Tropical Medicine & International Health 17:7, pages 854-857.
Crossref
H R Ashbee & M H Gilleece. (2011) Has the era of individualised medicine arrived for antifungals? A review of antifungal pharmacogenomics. Bone Marrow Transplantation 47:7, pages 881-894.
Crossref
Elizabeth Perry. (2011) Clopidogrel hyporesponsiveness: Are we all the same?. American Journal of Health-System Pharmacy 68:17, pages 1580-1580.
Crossref
Qing Zhou, Xiaomin Yu, Chang Shu, Yimei Cai, Wei Gong, Xumin Wang, Duen-mei Wang & Songnian Hu. (2011) Analysis of CYP3A4 genetic polymorphisms in Han Chinese. Journal of Human Genetics 56:6, pages 415-422.
Crossref
Kathleen A. Neville, Mara L. Becker, Jennifer L. Goldman & Gregory L. Kearns. (2011) Developmental pharmacogenomics. Pediatric Anesthesia 21:3, pages 255-265.
Crossref
Michael Man, Mark Farmen, Carmen Dumaual, Choo Hua Teng, Brian Moser, Shin Irie, Gyu Jeong Noh, Reuben Njau, Sandra Close, Stephen Wise & Richard Hockett. (2013) Genetic Variation in Metabolizing Enzyme and Transporter Genes: Comprehensive Assessment in 3 Major East Asian Subpopulations With Comparison to Caucasians and Africans. The Journal of Clinical Pharmacology 50:8, pages 929-940.
Crossref
L Zhang, K Miyaki, W Wang & M Muramatsu. (2009) CYP3A5 polymorphism and sensitivity of blood pressure to dietary salt in Japanese men. Journal of Human Hypertension 24:5, pages 345-350.
Crossref
Izaskun Arenaz, Jorge Vicente, Ana Fanlo, Patricia Vásquez, Juan Carlos Medina, Blanca Conde, Fabricio González‐Andrade & Blanca Sinués. (2010) Haplotype structure and allele frequencies of CYP2B6 in Spaniards and Central Americans . Fundamental & Clinical Pharmacology 24:2, pages 247-253.
Crossref
Michael Oettel. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 28 .
C Kiyohara, M Washio, T Horiuchi, Y Tada, T Asami, S Ide, H Takahashi & G Kobashi. (2009) Cigarette smoking, N-acetyltransferase 2 polymorphisms and systemic lupus erythematosus in a Japanese population. Lupus 18:7, pages 630-638.
Crossref
Murielle BochudPascal BovetMichel Burnier & Chin B Eap. (2009) CYP3A5 and ABCB1 genes and hypertension . Pharmacogenomics 10:3, pages 477-487.
Crossref
Kyoung-Ah Kim, Pil-Whan Park & Ji-Young Park. (2008) Effect of CYP3A5*3 genotype on the pharmacokinetics and antiplatelet effect of clopidogrel in healthy subjects. European Journal of Clinical Pharmacology 64:6, pages 589-597.
Crossref
M Gratacòs, V Soria, M Urretavizcaya, J R González, J M Crespo, M Bayés, R de Cid, J M Menchón, J Vallejo & X Estivill. (2007) A brain-derived neurotrophic factor (BDNF) haplotype is associated with antidepressant treatment outcome in mood disorders. The Pharmacogenomics Journal 8:2, pages 101-112.
Crossref
Qi-Biao Su, Fan He, Xue-Ding Wang, Su Guan, Zhi-Yong Xie, Lai-You Wang, Yu-Jing Lu, Lian-Quan Gu, Zhi-Shu Huang, Xiao Chen, Min Huang & Shu-Feng Zhou. (2007) Biotransformation and pharmacokinetics of the novel anticancer drug, SYUIQ-5, in the rat. Investigational New Drugs 26:2, pages 119-137.
Crossref
Min Seong ShimJoo Duk KimHyung Kyu ChoiSoo Bong YooSie Jeong RyuKyung Han KimSe Hwan KimTae Ho Chang. (2008) Optimal Dose of Remifentanil and Propofol TCI for Minimizing Cardiovascular Changes to Tracheal Intubation during Total Intravenous Anesthesia. Korean Journal of Anesthesiology 54:4, pages 389.
Crossref
Madhuri Kakarala & Max S. Wicha. (2007) Cancer Stem Cells: Implications for Cancer Treatment and Prevention. The Cancer Journal 13:5, pages 271-275.
Crossref
Blanca Sinues, Jorge Vicente, Ana Fanlo, Patricia Vasquez, Juan Carlos Medina, Esteban Mayayo, Blanca Conde, Izaskun Arenaz & Begoña Martinez-Jarreta. (2007) CYP3A5*3 and CYP3A4*1B Allele Distribution and Genotype Combinations: Differences Between Spaniards and Central Americans. Therapeutic Drug Monitoring 29:4, pages 412-416.
Crossref
Jackie Yao Liu, Kevin Qu, Anthony D. Sferruzza & Richard A. Bender. (2007) Distribution of the UGT1A1*28 polymorphism in Caucasian and Asian populations in the US: a genomic analysis of 138 healthy individuals. Anti-Cancer Drugs 18:6, pages 693-696.
Crossref
Chin B. EapMurielle BochudRobert C. ElstonPascal BovetMarc P. MaillardJuerg NussbergerLaurent SchildConrad ShamlayeMichel Burnier. (2007) CYP3A5 and ABCB1 Genes Influence Blood Pressure and Response to Treatment, and Their Effect Is Modified by Salt . Hypertension 49:5, pages 1007-1014.
Crossref
Kyoung-Ah Kim, Pil-Whan Park & Ji-Young Park. (2007) Effect of ABCB1 (MDR1) haplotypes derived from G2677T/C3435T on the pharmacokinetics of amlodipine in healthy subjects. British Journal of Clinical Pharmacology 63:1, pages 53-58.
Crossref
Yi Lu, Shirley Kow-Yin Kham, Toon-Chai Foo, Ariffin Hany, Thuan-Chong Quah & Allen Eng-Juh Yeoh. (2007) Genotyping of eight polymorphic genes encoding drug-metabolizing enzymes and transporters using a customized oligonucleotide array. Analytical Biochemistry 360:1, pages 105-113.
Crossref
Satohiro Masuda & Ken-ichi Inui. (2006) An up-date review on individualized dosage adjustment of calcineurin inhibitors in organ transplant patients. Pharmacology & Therapeutics 112:1, pages 184-198.
Crossref
Su Guan, Min Huang, Xin Li, Xiao Chen, Eli Chan & Shu-Feng Zhou. (2006) Intra- and Inter-ethnic Differences in the Allele Frequencies of Cytochrome P450 2B6 Gene in Chinese. Pharmaceutical Research 23:9, pages 1983-1990.
Crossref
Seok Hwee Koo & Edmund Jon Deoon Lee. (2006) PHARMACOGENETICS APPROACH TO THERAPEUTICS. Clinical and Experimental Pharmacology and Physiology 33:5-6, pages 525-532.
Crossref
Mei-Ling Chen. (2006) Ethnic or Racial Differences Revisited. Clinical Pharmacokinetics 45:10, pages 957-964.
Crossref
Toshiro Niwa, Toshifumi Shiraga, Minoru Omura, Toshihiko Kondo, Masatoshi Kuroda & Akira Takagi. (2006) . Folia Pharmacologica Japonica 128:6, pages 395-404.
Crossref
B S Shastry. (2005) Pharmacogenetics and the concept of individualized medicine. The Pharmacogenomics Journal 6:1, pages 16-21.
Crossref
Chin-Hung Liu, Konan Peck, Jin-ding Huang, Min-Shung Lin, Chin-Hsiung Wang, Wen-Pin Hsu, Hong-Wen Wang, Hui-Ling Lee & Ming-Liang Lai. (2005) Screening CYP3A single nucleotide polymorphisms in a Han Chinese population with a genotyping chip. Pharmacogenomics 6:7, pages 731-747.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.