Advanced search
Publication Cover
Renal Failure Volume 25, 2003 - Issue 3
Submit an article Journal homepage
544
Views
42
CrossRef citations to date
0
Altmetric
CLINICAL STUDY

Combination of Pentoxifylline with Angiotensin Converting Enzyme Inhibitors Produces an Additional Reduction in Microalbuminuria in Hypertensive Type 2 Diabetic Patients

Özlem Harmankaya Department of Nephrology, Sisli Etfal Training and Research Hospital, Istanbul, TurkeyCorrespondence[email protected]
, M.D.,
Selcuk Seber Department of Medicine, Sisli Etfal Training and Research Hospital, Istanbul, Turkey
&
Mürvet Yılmaz Department of Nephrology, Sisli Etfal Training and Research Hospital, Istanbul, Turkey
Pages 465-470 | Published online: 26 Aug 2009

Citations (42)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (6)

Mark B. Plotnikov, Oleg I. Aliev, Alexander Y. Shamanaev, Anastasia V. Sidekhmenova, Yana Anfinogenova, Anna M. Anishchenko, Tatiana I. Fomina & Alexander M. Arkhipov. (2017) Effects of pentoxifylline on hemodynamic, hemorheological, and microcirculatory parameters in young SHRs during arterial hypertension development. Clinical and Experimental Hypertension 39:6, pages 570-578.
Read now
Giorgio Gentile, Daniela Mastroluca, Piero Ruggenenti & Giuseppe Remuzzi. (2014) Novel effective drugs for diabetic kidney disease? or not?. Expert Opinion on Emerging Drugs 19:4, pages 571-601.
Read now
Samuel S. Blumenthal. (2011) Evolution of Treatment for Diabetic Nephropathy: Historical Progression from RAAS Inhibition and Onward. Postgraduate Medicine 123:6, pages 166-179.
Read now
Jamshid Roozbeh, Mohammad Amin Banihashemi, Mohammad Ghezlou, Raha Afshariani, Soheila Salari, Maryam Moini & Mohammad Mahdi Sagheb. (2010) Captopril and Combination Therapy of Captopril and Pentoxifylline in Reducing Proteinuria in Diabetic Nephropathy. Renal Failure 32:2, pages 172-178.
Read now
J. Basic, E. Golubovic, P. Miljkovic, G. Bjelakovic, T. Cvetkovic & V. Milosevic. (2008) Microalbuminuria in Children with Vesicoureteral Reflux. Renal Failure 30:6, pages 639-643.
Read now
M. E. Dávila-Esqueda, A. A. Vertiz-Hernández & F. Martínez-Morales. (2005) Comparative Analysis of the Renoprotective Effects of Pentoxifylline and Vitamin E on Streptozotocin-Induced Diabetes Mellitus. Renal Failure 27:1, pages 115-122.
Read now

Articles from other publishers (36)

Julia MT Colombijn, Lotty Hooft, Min Jun, Angela C Webster, Michiel L Bots, Marianne C Verhaar & Robin WM Vernooij. (2023) Antioxidants for adults with chronic kidney disease. Cochrane Database of Systematic Reviews 2023:11.
Crossref
Hui Yu, Yi-Yun Song & Xian-Hua Li. (2023) Early diabetic kidney disease: Focus on the glycocalyx. World Journal of Diabetes 14:5, pages 460-480.
Crossref
João Faria, Karin G.F. Gerritsen, Tri Q. Nguyen, Silvia M. Mihaila & Rosalinde Masereeuw. (2021) Diabetic proximal tubulopathy: Can we mimic the disease for in vitro screening of SGLT inhibitors?. European Journal of Pharmacology 908, pages 174378.
Crossref
B.R. Mattos, G.F. Bonacio, T.R. Vitorino, V.T. Garcia, J.H. Amaral, R. Dellalibera-Joviliano, S.C. Franca, J.E. Tanus-Santos & E. Rizzi. (2020) TNF-α inhibition decreases MMP-2 activity, reactive oxygen species formation and improves hypertensive vascular hypertrophy independent of its effects on blood pressure. Biochemical Pharmacology 180, pages 114121.
Crossref
David J. Leehey. (2020) Targeting Inflammation in Diabetic Kidney Disease: Is There a Role for Pentoxifylline?. Kidney360 1:4, pages 292-299.
Crossref
Mark B. Plotnikov, Alexander Y. Shamanaev, Oleg I. Aliev, Anastasia V. Sidekhmenova, Anna M. Anishchenko & Alexander M. Arkhipov. (2017) Pentoxifylline treatment enhances antihypertensive activity of captopril through hemorheological improvement in spontaneously hypertensive rats during development of arterial hypertension. Journal of the American Society of Hypertension 11:11, pages 769-778.
Crossref
Dong Liu, Li-na Wang, Hong-xia Li, Ping Huang, Liang-bo Qu & Fei-yan Chen. (2017) Pentoxifylline plus ACEIs/ARBs for proteinuria and kidney function in chronic kidney disease: a meta-analysis. Journal of International Medical Research 45:2, pages 383-398.
Crossref
Mark B. Plotnikov, Oleg I. Aliev, Alexey V. Nosarev, Alexander Y. Shamanaev, Anastasia V. Sidekhmenova, Yana Anfinogenova, Anna M. Anishchenko & Ekaterina V. Pushkina. (2016) Relationship between arterial blood pressure and blood viscosity in spontaneously hypertensive rats treated with pentoxifylline. Biorheology 53:2, pages 93-107.
Crossref
LuAnn Sabounjian, Philip Graham, Lijun Wu, Virginia Braman, Changfu Cheng, Julie Liu, James Shipley, Joel Neutel & Michael Dao. (2016) A First-in-Patient, Multicenter, Double-Blind, 2-Arm, Placebo-Controlled, Randomized Safety and Tolerability Study of a Novel Oral Drug Candidate, CTP-499, in Chronic Kidney Disease. Clinical Pharmacology in Drug Development 5:4, pages 314-325.
Crossref
Christian Leporini, Anna Pisano, Emilio Russo, Graziella D⿿Arrigo, Giovambattista de Sarro, Giuseppe Coppolino & Davide Bolignano. (2016) Effect of pentoxifylline on renal outcomes in chronic kidney disease patients: A systematic review and meta-analysis. Pharmacological Research 107, pages 315-332.
Crossref
P-C Wu, C-J Wu, C-J Lin, C-F Pan, C-Y Chen, T-M Huang, C-H Wu, S-L Lin, Y-M Chen, L Chen & V-C Wu. (2015) Pentoxifylline Decreases Dialysis Risk in Patients With Advanced Chronic Kidney Disease. Clinical Pharmacology & Therapeutics 98:4, pages 442-449.
Crossref
Mao-Lu Tian, Yan Shen, Zhao-Lin Sun & Yan Zha. (2015) Efficacy and safety of combining pentoxifylline with angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker in diabetic nephropathy: a meta-analysis. International Urology and Nephrology 47:5, pages 815-822.
Crossref
Shahrzad Shahidi, Marziyeh Hoseinbalam, Bijan Iraj & Mojtaba Akbari. (2015) Effect of Pentoxifylline on Microalbuminuria in Diabetic Patients: A Randomized Controlled Trial. International Journal of Nephrology 2015, pages 1-7.
Crossref
Carmen Mora-Fernández, Virginia Domínguez-Pimentel, Mercedes Muros de Fuentes, José L. Górriz, Alberto Martínez-Castelao & Juan F. Navarro-González. (2014) Diabetic kidney disease: from physiology to therapeutics. The Journal of Physiology 592:18, pages 3997-4012.
Crossref
Xiaonan Tang, Gary Bridson, Jing Ke, Lijun Wu, Halil Erol, Phillip Graham, Chih Hsien Lin, Virginia Braman, Harry Zhao, Julie F. Liu, Zhongping (John) Lin & Changfu Cheng. (2014) Quantitative analyses of CTP-499 and five major metabolites by core-structure analysis. Journal of Chromatography B 963, pages 1-9.
Crossref
Ping-Min Chen, Tai-Shuan Lai, Ping-Yu Chen, Chun-Fu Lai, VinCent Wu, Wen-Chih Chiang, Yung-Ming Chen, Kwan-Dun Wu & Tun-Jun Tsai. (2014) Renoprotective effect of combining pentoxifylline with angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker in advanced chronic kidney disease. Journal of the Formosan Medical Association 113:4, pages 219-226.
Crossref
Amin T. Hamed, Mohammed M. Taha & Luay M. Nasser. (2013) Renoprotective effect of aliskiren monotherapy and aliskiren−pentoxifylline combination in hypertensive-diabetic type 2 patients with diabetic nephropathy. Bulletin of Faculty of Pharmacy, Cairo University 51:2, pages 221-227.
Crossref
Akira Mima. (2013) Inflammation and Oxidative Stress in Diabetic Nephropathy: New Insights on Its Inhibition as New Therapeutic Targets. Journal of Diabetes Research 2013, pages 1-8.
Crossref
Virginia Braman, Philip Graham, Changfu Cheng, David Turnquist, Mark Harnett, LuAnn Sabounjian & James Shipley. (2013) A Randomized Phase I Evaluation of CTP‐499, a Novel Deuterium‐Containing Drug Candidate for Diabetic Nephropathy. Clinical Pharmacology in Drug Development 2:1, pages 53-66.
Crossref
Akira Mima, Weier Qi & George L. King. (2012) Implications of Treatment That Target Protective Mechanisms Against Diabetic Nephropathy. Seminars in Nephrology 32:5, pages 471-478.
Crossref
Dan Shan, Hong Mei Wu, Qi Yuan Yuan, Jun Li, Rong Le Zhou & Guan J Liu. (2012) Pentoxifylline for diabetic kidney disease. Cochrane Database of Systematic Reviews.
Crossref
Desirée Luis-Rodríguez. (2012) Pathophysiological role and therapeutic implications of inflammation in diabetic nephropathy. World Journal of Diabetes 3:1, pages 7.
Crossref
Dhruv K. Singh, Peter Winocour & Ken Farrington. (2010) Oxidative stress in early diabetic nephropathy: fueling the fire. Nature Reviews Endocrinology 7:3, pages 176-184.
Crossref
Faruk Turgut & Warren Kline Bolton. (2010) Potential New Therapeutic Agents for Diabetic Kidney Disease. American Journal of Kidney Diseases 55:5, pages 928-940.
Crossref
Boglárka Laczy, Judit Cseh, Márton Mohás, Lajos Markó, Mónika Tamaskó, Tamás Kőszegi, Gergő A. Molnár, Zoltán Wagner, László Wagner & István Wittmann. (2008) Effects of pentoxifylline and pentosan polysulphate combination therapy on diabetic neuropathy in type 2 diabetes mellitus. Acta Diabetologica 46:2, pages 105-111.
Crossref
Robert M. Perkins, Matthew C. Aboudara, Alice L. Uy, Stephen W. Olson, Howard M. Cushner & Christina M. Yuan. (2009) Effect of Pentoxifylline on GFR Decline in CKD: A Pilot, Double-Blind, Randomized, Placebo-Controlled Trial. American Journal of Kidney Diseases 53:4, pages 606-616.
Crossref
Antonio Rivero, Carmen Mora, Mercedes Muros, Javier García, Havidian Herrera & Juan F. Navarro-González. (2009) Pathogenic perspectives for the role of inflammation in diabetic nephropathy. Clinical Science 116:6, pages 479-492.
Crossref
Brendan B. McCormick, Amy Sydor, Ayub Akbari, Dean Fergusson, Steve Doucette & Greg Knoll. (2008) The Effect of Pentoxifylline on Proteinuria in Diabetic Kidney Disease: A Meta-analysis. American Journal of Kidney Diseases 52:3, pages 454-463.
Crossref
Juan F. Navarro-González & Carmen Mora-Fernández. (2008) The Role of Inflammatory Cytokines in Diabetic Nephropathy. Journal of the American Society of Nephrology 19:3, pages 433-442.
Crossref
Carmen Mora & Juan F. Navarro. (2006) Inflammation and diabetic nephropathy. Current Diabetes Reports 6:6, pages 463-468.
Crossref
Y.-M. Chen, S.-L. Lin, W.-C. Chiang, K.-D. Wu & T.-J. Tsai. (2006) Pentoxifylline ameliorates proteinuria through suppression of renal monocyte chemoattractant protein-1 in patients with proteinuric primary glomerular diseases. Kidney International 69:8, pages 1410-1415.
Crossref
Juan F. Navarro & Carmen Mora. (2005) Role of inflammation in diabetic complications. Nephrology Dialysis Transplantation 20:12, pages 2601-2604.
Crossref
Carmen Mora & Juan F. Navarro. (2005) The role of inflammation as a pathogenic factor in the development of renal disease in diabetes. Current Diabetes Reports 5:6, pages 399-401.
Crossref
Juan F. Navarro, Carmen Mora, Mercedes Muros & Javier García. (2005) Additive Antiproteinuric Effect of Pentoxifylline in Patients with Type 2 Diabetes under Angiotensin II Receptor Blockade: A Short-Term, Randomized, Controlled Trial. Journal of the American Society of Nephrology 16:7, pages 2119-2126.
Crossref
M. Radfar, B. Larijani, M. Hadjibabaie, B. Rajabipour, A. Mojtahedi & M. Abdollahi. (2005) Effects of pentoxifylline on oxidative stress and levels of EGF and NO in blood of diabetic type-2 patients; a randomized, double-blind placebo-controlled clinical trial. Biomedicine & Pharmacotherapy 59:6, pages 302-306.
Crossref
. (2003) Current literature in diabetes. Diabetes/Metabolism Research and Reviews 19:6, pages 494-501.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.