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Research Article

Engineering Lipid Vesicles of Enhanced Intratumoral Transport Capabilities: Correlating Liposome Characteristics with Penetration into Human Prostate Tumor Spheroids

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Pages 15-27 | Published online: 09 Dec 2008

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Jing Yu, Ryan Lu, Jessie R. Nedrow & George Sgouros. (2020) Response of breast cancer carcinoma spheroids to combination therapy with radiation and DNA-PK inhibitor: growth arrest without a change in α/β ratio. International Journal of Radiation Biology 96:12, pages 1534-1540.
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Srujan Kumar Gandham, Meghna Talekar, Amit Singh & Mansoor M Amiji. (2015) Inhibition of hexokinase-2 with targeted liposomal 3-bromopyruvate in an ovarian tumor spheroid model of aerobic glycolysis. International Journal of Nanomedicine 10, pages 4405-4423.
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Ângelo M.L. Denadai, André M. de Oliveira, Izabela M.P. Daniel, Luan A. Carneiro, Kherolayne C. Ribeiro, Heloísa de O. Beraldo, Kelen J.R. da Costa, Vivianne C. da Cunha, Maria E. Cortés & Rubén D. Sinisterra. (2012) Chlorhexidine/losartan ionic pair binding and its nanoprecipitation: physico-chemical characterisation and antimicrobial activity. Supramolecular Chemistry 24:3, pages 204-212.
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Stavroula Sofou & George Sgouros. (2008) Antibody-targeted liposomes in cancer therapy and imaging. Expert Opinion on Drug Delivery 5:2, pages 189-204.
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Uttom Nandi, Ichioma Onyesom & Dennis Douroumis. (2021) Anti-cancer activity of sirolimus loaded liposomes in prostate cancer cell lines. Journal of Drug Delivery Science and Technology 61, pages 102200.
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Guowei Wang, Bihan Wu, Qunying Li, Siqin Chen, Xiaoqin Jin, Yajing Liu, Zhuxian Zhou, Youqing Shen & Pintong Huang. (2020) Active Transportation of Liposome Enhances Tumor Accumulation, Penetration, and Therapeutic Efficacy. Small 16:44, pages 2004172.
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Aziz Ur Rahman, Shahzeb Khan & Munasib Khan. (2020) Transport of trans-activator of transcription (TAT) peptide in tumour tissue model: evaluation of factors affecting the transport of TAT evidenced by flow cytometry. Journal of Pharmacy and Pharmacology 72:4, pages 519-530.
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R.M. de Kruijff, A.J.G.M. van der Meer, C.A.A. Windmeijer, J.J.M. Kouwenberg, A. Morgenstern, F. Bruchertseifer, P. Sminia & A.G. Denkova. (2018) The therapeutic potential of polymersomes loaded with 225Ac evaluated in 2D and 3D in vitro glioma models. European Journal of Pharmaceutics and Biopharmaceutics 127, pages 85-91.
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Bu-Wei Huang & Jian-Qing Gao. (2018) Application of 3D cultured multicellular spheroid tumor models in tumor-targeted drug delivery system research. Journal of Controlled Release 270, pages 246-259.
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Guanqing Yang, Xin Wang, Shengxiang Fu, Rupei Tang & Jun Wang. (2017) pH-triggered chitosan nanogels via an ortho ester-based linkage for efficient chemotherapy. Acta Biomaterialia 60, pages 232-243.
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Yuki Takechi-Haraya, Yukihiro Goda & Kumiko Sakai-Kato. (2017) Control of Liposomal Penetration into Three-Dimensional Multicellular Tumor Spheroids by Modulating Liposomal Membrane Rigidity. Molecular Pharmaceutics 14:6, pages 2158-2165.
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Zhuxian Zhou, Xiangrui Liu, Dingcheng Zhu, Yue Wang, Zhen Zhang, Xuefei Zhou, Nasha Qiu, Xuesi Chen & Youqing Shen. (2017) Nonviral cancer gene therapy: Delivery cascade and vector nanoproperty integration. Advanced Drug Delivery Reviews 115, pages 115-154.
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Muhammad Raza Shah, Muhammad Imran & Shafi Ullah. 2017. Lipid-Based Nanocarriers for Drug Delivery and Diagnosis. Lipid-Based Nanocarriers for Drug Delivery and Diagnosis 219 238 .
Blanca Millán-Chiu, Giselle Camacho, Alfredo Varela-Echavarría, Elisa Tamariz, Francisco Fernández, Luz M. López-Marín & Achim M. Loske. (2014) Shock Waves and DNA-Cationic Lipid Assemblies: A Synergistic Approach to Express Exogenous Genes in Human Cells. Ultrasound in Medicine & Biology 40:7, pages 1599-1608.
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Caoyun Ju, Ran Mo, Jingwei Xue, Lei Zhang, Zekai Zhao, Lingjing Xue, Qineng Ping & Can Zhang. (2014) Sequential Intra‐Intercellular Nanoparticle Delivery System for Deep Tumor Penetration. Angewandte Chemie International Edition 53:24, pages 6253-6258.
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Caoyun Ju, Ran Mo, Jingwei Xue, Lei Zhang, Zekai Zhao, Lingjing Xue, Qineng Ping & Can Zhang. (2014) Sequential Intra‐Intercellular Nanoparticle Delivery System for Deep Tumor Penetration. Angewandte Chemie 126:24, pages 6367-6372.
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Ângelo M.L. Denadai, Jeferson G. Da Silva, Pedro P.G. Guimarães, Leonardo Bertolini S. Gomes, Antonio S. Mangrich, Edivaltrys I.P. de Rezende, Izabela M.P. Daniel, Heloísa Beraldo & Rubén D. Sinisterra. (2013) Control of size in losartan/copper(II) coordination complex hydrophobic precipitate. Materials Science and Engineering: C 33:7, pages 3916-3922.
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Geeta Mehta, Amy Y. Hsiao, Marylou Ingram, Gary D. Luker & Shuichi Takayama. (2012) Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy. Journal of Controlled Release 164:2, pages 192-204.
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Carolyn L. Waite & Charles M. Roth. (2011) Binding and transport of PAMAM-RGD in a tumor spheroid model: The effect of RGD targeting ligand density. Biotechnology and Bioengineering 108:12, pages 2999-3008.
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Cecilie B. Rygh, Shengping Qin, Jai W. Seo, Lisa M. Mahakian, Hua Zhang, Roger Adamson, Jane Q. Chen, Alexander D. Borowsky, Robert D. Cardiff, Rolf K. Reed, Fitz-Roy E. Curry & Katherine W. Ferrara. (2011) Longitudinal Investigation of Permeability and Distribution of Macromolecules in Mouse Malignant Transformation Using PET. Clinical Cancer Research 17:3, pages 550-559.
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Dan Niculescu-Duvaz, Gabriel Negoita-Giras, Ion Niculescu-Duvaz, Douglas Hedley & Caroline J. Springer. 2010. Prodrugs and Targeted Delivery. Prodrugs and Targeted Delivery 271 344 .
Shrirang Karve, Amey Bandekar, Md. R. Ali & Stavroula Sofou. (2010) The pH-dependent association with cancer cells of tunable functionalized lipid vesicles with encapsulated doxorubicin for high cell-kill selectivity. Biomaterials 31:15, pages 4409-4416.
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Amer F. Saleh, Harmesh Aojula, Yamini Arthanari, Shaun Offerman, Myasar Alkotaji & Alain Pluen. (2010) Improved Tat-mediated plasmid DNA transfer by fusion to LK15 peptide. Journal of Controlled Release 143:2, pages 233-242.
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Cestmir Altaner. (2008) Prodrug cancer gene therapy. Cancer Letters 270:2, pages 191-201.
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Min-Yuan Chang, Jonathan Seideman & Stavroula Sofou. (2008) Enhanced Loading Efficiency and Retention of 225 Ac in Rigid Liposomes for Potential Targeted Therapy of Micrometastases . Bioconjugate Chemistry 19:6, pages 1274-1282.
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Renu Singh Dhanikula, Anteneh Argaw, Jean-Francois Bouchard & Patrice Hildgen. (2008) Methotrexate Loaded Polyether-Copolyester Dendrimers for the Treatment of Gliomas: Enhanced Efficacy and Intratumoral Transport Capability. Molecular Pharmaceutics 5:1, pages 105-116.
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Stavroula Sofou, Barry J. Kappel, Jaspreet S. Jaggi, Michael R. McDevitt, David A. Scheinberg & George Sgouros. (2007) Enhanced Retention of the α-Particle-Emitting Daughters of Actinium-225 by Liposome Carriers. Bioconjugate Chemistry 18:6, pages 2061-2067.
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Stavroula Sofou. (2007) Surface-active liposomes for targeted cancer therapy. Nanomedicine 2:5, pages 711-724.
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