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Pharmaceutical Development and Technology Volume 5, 2000 - Issue 2
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Research Article

Comparison of Various Injectable Protein-Loaded Biodegradable Poly(Lactide-co-glycolide) (PLGA) Devices: In-Situ-Formed Implant Versus In-Situ-Formed Microspheres Versus Isolated Microspheres

Rajeev A. Jain
,
Christopher T. Rhodes Department of Applied Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, 02881, Rhode Island
,
Aruna M. Railkar
,
A. Waseem Malick
&
Navnit H. Shah
Pages 201-207 | Received 02 Feb 1999, Accepted 01 Sep 1999, Published online: 19 Apr 2000

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Lu Li, Zhiguo Li, Yongxin Guo, Kai Zhang, Weidong Mi & Jing Liu. (2022) Preparation of uniform-sized GeXIVA[1,2]-loaded PLGA microspheres as long-effective release system with high encapsulation efficiency. Drug Delivery 29:1, pages 2283-2295.
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Ravi Vaishya, Varun Khurana, Sulabh Patel & Ashim K Mitra. (2015) Long-term delivery of protein therapeutics. Expert Opinion on Drug Delivery 12:3, pages 415-440.
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Agata A Exner & Gerald M Saidel. (2008) Drug-eluting polymer implants in cancer therapy. Expert Opinion on Drug Delivery 5:7, pages 775-788.
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David Li, Poh Yee Chow, Tzu Ping Lin, Celine Cheow, Zhuoxuan Li & Matthias G. Wacker. (2023) Simulate SubQ: The Methods and the Media. Journal of Pharmaceutical Sciences 112:6, pages 1492-1508.
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Muge Kilicarslan & Ayse Nur Buke. (2021) An Overview: The Evaluation of Formation Mechanisms, Preparation Techniques and Chemical and Analytical Characterization Methods of the In Situ Forming Implants. Current Pharmaceutical Analysis 17:3, pages 375-408.
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Aurélie Schoubben, Maurizio Ricci & Stefano Giovagnoli. (2019) Meeting the unmet: from traditional to cutting-edge techniques for poly lactide and poly lactide-co-glycolide microparticle manufacturing. Journal of Pharmaceutical Investigation 49:4, pages 381-404.
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Anjali Jain, Wahid Khan & Agnieszka Kyzioł. 2019. Materials for Biomedical Engineering. Materials for Biomedical Engineering 349 380 .
Byung Kook Lee, Yeonhee Yun & Kinam Park. (2016) PLA micro- and nano-particles. Advanced Drug Delivery Reviews 107, pages 176-191.
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Oren Levy, W. Nathaniel Brennen, Edward Han, David Marc Rosen, Juliet Musabeyezu, Helia Safaee, Sudhir Ranganath, Jessica Ngai, Martina Heinelt, Yuka Milton, Hao Wang, Sachin H. Bhagchandani, Nitin Joshi, Neil Bhowmick, Samuel R. Denmeade, John T. Isaacs & Jeffrey M. Karp. (2016) A prodrug-doped cellular Trojan Horse for the potential treatment of prostate cancer. Biomaterials 91, pages 140-150.
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Oren Levy, Edward Han, Jessica Ngai, Priya Anandakumaran, Zhixiang Tong, Kelvin S. Ng & Jeffrey M. Karp. 2014. Micro- and Nanoengineering of the Cell Surface. Micro- and Nanoengineering of the Cell Surface 253 279 .
C. Wischke & S. P. Schwendeman. 2012. Fundamentals and Applications of Controlled Release Drug Delivery. Fundamentals and Applications of Controlled Release Drug Delivery 171 228 .
Christian Wischke & Steven P. Schwendeman. (2008) Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles. International Journal of Pharmaceutics 364:2, pages 298-327.
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Guohua Chen & Gunjan Junnarkar. 2008. Modified-Release Drug Delivery Technology, Second Edition. Modified-Release Drug Delivery Technology, Second Edition 215 225 .
Liwei Wang, Subbu Venkatraman & Lothar Kleiner. (2004) Drug release from injectable depots: two different in vitro mechanisms. Journal of Controlled Release 99:2, pages 207-216.
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Liwei Wang, Lothar Kleiner & Subbu Venkatraman. (2003) Structure formation in injectable poly(lactide–co-glycolide) depots. Journal of Controlled Release 90:3, pages 345-354.
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