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Pharmaceutical Development and Technology Volume 7, 2002 - Issue 1
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Research Article

Mechanism for Further Enhancement in Drug Dissolution from Solid-Dispersion Granules upon Storage

Manish K. Gupta School of Pharmacy, University of Connecticut, Storrs, Connecticut, U.S.A.
,
Robin H. Bogner School of Pharmacy, University of Connecticut, Storrs, Connecticut, U.S.A.; Institute of Materials Science, University of Connecticut, Storrs, Connecticut, U.S.A.
,
David Goldman Pharmaceutical Technology, Pharmaceutical Division, Bayer Corporation, West Haven, Connecticut, U.S.A.
&
Yin-Chao Tseng Pharmaceutical Technology, Pharmaceutical Division, Bayer Corporation, West Haven, Connecticut, U.S.A.
Pages 103-112 | Received 23 Apr 2001, Accepted 09 Jun 2001, Published online: 22 Apr 2002

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Shambhavi Borde, Sagar Kumar Paul & Harsh Chauhan. (2021) Ternary solid dispersions: classification and formulation considerations. Drug Development and Industrial Pharmacy 47:7, pages 1011-1028.
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Benchawan Chamsai, Sontaya Limmatvapirat, Srisagul Sungthongjeen & Pornsak Sriamornsak. (2017) Enhancement of solubility and oral bioavailability of manidipine by formation of ternary solid dispersion with d-α-tocopherol polyethylene glycol 1000 succinate and copovidone. Drug Development and Industrial Pharmacy 43:12, pages 2064-2075.
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C.M. Hentzschel, M. Alnaief, I. Smirnova, A. Sakmann & C.S. Leopold. (2012) Tableting properties of silica aerogel and other silicates. Drug Development and Industrial Pharmacy 38:4, pages 462-467.
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Riikka Laitinen, Eero Suihko, Mikko Bjorkqvist, Joakim Riikonen, Vesa-Pekka Lehto, Kristiina Jarvinen & Jarkko Ketolainen. (2010) Perphenazine solid dispersions for orally fast-disintegrating tablets: physical stability and formulation. Drug Development and Industrial Pharmacy 36:5, pages 601-613.
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Articles from other publishers (15)

Shaveta Sharma. (2022) The Role of Excipients in Liquisolid Technology. CGC International Journal of Contemporary Technology and Research 4:2, pages 296-299.
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Ashok Neelkanth MahajanNaazneen SurtiPriyal PatelAshwini PatelDimal ShahVandana Patel. (2020) Melt Dispersion Adsorbed onto Porous Carriers: An Effective Method to Enhance the Dissolution and Flow Properties of Raloxifene Hydrochloride. ASSAY and Drug Development Technologies 18:6, pages 282-294.
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Roberta Censi, Maria Rosa Gigliobianco, Alessandra Dubbini, Ladjan Malaj & Piera Di Martino. (2015) New Nanometric Solid Dispersions of Glibenclamide in Neusilin® UFL2. AAPS PharmSciTech 17:5, pages 1204-1212.
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C. C. C. Teixeira, L. M. Mendonça, M. M. Bergamaschi, R. H. C. Queiroz, G. E. P. Souza, L. M. G. Antunes & L. A. P. Freitas. (2015) Microparticles Containing Curcumin Solid Dispersion: Stability, Bioavailability and Anti-Inflammatory Activity. AAPS PharmSciTech 17:2, pages 252-261.
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Riccardo Rascioni, Roberta Censi, Ledjan Malaj & Piera Di Martino. (2015) Effect of particle size reduction and crystalline form on dissolution behaviour of nimesulide. Journal of Thermal Analysis and Calorimetry 123:3, pages 2213-2223.
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Tarique Meer, Ritesh Fule, Deepak Khanna & Purnima Amin. (2013) Solubility modulation of bicalutamide using porous silica. Journal of Pharmaceutical Investigation 43:4, pages 279-285.
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Amrit Paudel, Erik Nies & Guy Van den Mooter. (2012) Relating Hydrogen-Bonding Interactions with the Phase Behavior of Naproxen/PVP K 25 Solid Dispersions: Evaluation of Solution-Cast and Quench-Cooled Films. Molecular Pharmaceutics 9:11, pages 3301-3317.
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Korbinian Löbmann, Riikka Laitinen, Holger Grohganz, Keith C. Gordon, Clare Strachan & Thomas Rades. (2011) Coamorphous Drug Systems: Enhanced Physical Stability and Dissolution Rate of Indomethacin and Naproxen. Molecular Pharmaceutics 8:5, pages 1919-1928.
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Phuong Ha-Lien Tran, Thao Truong-Dinh Tran, Jun Bom Park & Beom-Jin Lee. (2011) Controlled Release Systems Containing Solid Dispersions: Strategies and Mechanisms. Pharmaceutical Research 28:10, pages 2353-2378.
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R. Tripathi, Shailesh V. Biradar, B. Mishra & Anant R. Paradkar. (2010) Study of Polymorphs of Progesterone by Novel Melt Sonocrystallization Technique: A Technical Note. AAPS PharmSciTech 11:3, pages 1493-1498.
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Bernard Van Eerdenbrugh, Michiel Van Speybroeck, Raf Mols, Kristof Houthoofd, Johan A. Martens, Ludo Froyen, Jan Van Humbeeck, Patrick Augustijns & Guy Van den Mooter. (2009) Itraconazole/TPGS/Aerosil®200 solid dispersions. European Journal of Pharmaceutical Sciences 38:3, pages 270-278.
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Ambarish H. Vadher, Jolly R. Parikh, Rajesh H. Parikh & Ajay B. Solanki. (2009) Preparation and Characterization of Co-Grinded Mixtures of Aceclofenac and Neusilin US2 for Dissolution Enhancement of Aceclofenac. AAPS PharmSciTech 10:2, pages 606-614.
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Subrata Mallick, Satyanarayan Pattnaik, Kalpana Swain, Pintu K. De, Arindam Saha, Gaurisankar Ghoshal & Arijit Mondal. (2008) Formation of physically stable amorphous phase of ibuprofen by solid state milling with kaolin. European Journal of Pharmaceutics and Biopharmaceutics 68:2, pages 346-351.
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Deepak Bahl & Robin H. Bogner. (2006) Amorphization of Indomethacin by Co-Grinding with Neusilin US2: Amorphization Kinetics, Physical Stability and Mechanism. Pharmaceutical Research 23:10, pages 2317-2325.
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Manish K. Gupta, Adam Vanwert & Robin H. Bogner. (2003) Formation of Physically Stable Amorphous Drugs by Milling with Neusilin. Journal of Pharmaceutical Sciences 92:3, pages 536-551.
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