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Molecular and Cellular Biology Volume 36, 2016 - Issue 9
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Article

NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration

Erik Hedricka Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas, USAView further author information
,
Syng-Ook Leeb Department of Food Science and Technology, Keimyung University, Daegu, Republic of KoreaView further author information
,
Ravi Doddapanenic Department of Pharmaceutics, College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, Florida, USAView further author information
,
Mandip Singhc Department of Pharmaceutics, College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, Florida, USAView further author information
&
Stephen Safea Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas, USACorrespondence[email protected]
View further author information
Pages 1383-1394 | Received 30 Sep 2015, Accepted 24 Feb 2016, Published online: 17 Mar 2023

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Erik Hedrick & Stephen Safe. (2017) Transforming Growth Factor β/NR4A1-Inducible Breast Cancer Cell Migration and Epithelial-to-Mesenchymal Transition Is p38α (Mitogen-Activated Protein Kinase 14) Dependent. Molecular and Cellular Biology 37:18.
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Ricardo Rodríguez-Calvo, Marta Tajes & Manuel Vázquez-Carrera. (2017) The NR4A subfamily of nuclear receptors: potential new therapeutic targets for the treatment of inflammatory diseases. Expert Opinion on Therapeutic Targets 21:3, pages 291-304.
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Articles from other publishers (39)

Anil Kumar Kalvala, Ramesh Nimma, Arvind Bagde, Sunil Kumar Surapaneni, Nilkumar Patel, Peggy Arthur, Li Sun, Rakesh Singh, Nagavendra Kommineni, Aakash Nathani, Yan Li & Mandip Singh. (2023) The role of Cannabidiol and tetrahydrocannabivarin to overcome doxorubicin resistance in MDA-MB-231 xenografts in athymic nude mice. Biochimie 208, pages 19-30.
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Anil Kumar Kalvala, Arvind Bagde, Peggy Arthur, Tanmay Kulkarni, Santanu Bhattacharya, Sunil Surapaneni, Nil Kumar Patel, Ramesh Nimma, Aragaw Gebeyehu, Nagavendra Kommineni, David G. Meckes, Jr.Li Sun, Bipika Banjara, Keb Mosley-Kellum, Thanh Cong Dinh & Mandip Singh. (2023) Cannabidiol-Loaded Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Paclitaxel-Induced Peripheral Neuropathy. Pharmaceutics 15:2, pages 554.
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Sunil Kumar Surapaneni, Nilkumar Patel, Li Sun, Nagavendra Kommineni, Anil Kumar Kalvala, Aragaw Gebeyehu, Peggy Arthur, Leanne C. Duke, Ramesh Nimma, David G MeckesJrJr & Mandip Singh. (2022) Anticancer and chemosensitization effects of cannabidiol in 2D and 3D cultures of TNBC: involvement of GADD45α, integrin-α5, -β5, -β1, and autophagy. Drug Delivery and Translational Research 12:11, pages 2762-2777.
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Lei Zhang, Greg Martin, Kumaravel Mohankumar, Joshua Trae Hampton, Wenshe Ray Liu & Stephen Safe. (2022) Resveratrol Binds Nuclear Receptor 4A1 (NR4A1) and Acts as an NR4A1 Antagonist in Lung Cancer Cells. Molecular Pharmacology 102:2, pages 80-91.
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Disraeli Vasconcelos, Beatriz Chaves, Aline Albuquerque, Luca Andrade, Andrielly Henriques, Geraldo Sartori, Wilson Savino, Ernesto Caffarena & João Herminio Martins-Da-Silva. (2022) Development of New Potential Inhibitors of β1 Integrins through In Silico Methods—Screening and Computational Validation. Life 12:7, pages 932.
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Kumaravel Mohankumar, Rupesh Shrestha & Stephen Safe. (2021) Nuclear receptor 4A1 (NR4A1) antagonists target paraspeckle component 1 (PSPC1) in cancer cells. Molecular Carcinogenesis 61:1, pages 73-84.
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Ebony Nottingham, Elizabeth Mazzio, Sunil Kumar Surapaneni, Shallu Kutlehria, Arindam Mondal, Ramesh Badisa, Stephen Safe, Arun K. Rishi & Mandip Singh. (2021) Synergistic effects of methyl 2-cyano-3,11-dioxo-18beta-olean-1,-12-dien-30-oate and erlotinib on erlotinib-resistant non-small cell lung cancer cells. Journal of Pharmaceutical Analysis 11:6, pages 799-807.
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Nikolaos Vlachos, Marios Lampros, Spyridon Voulgaris & George A. Alexiou. (2021) Repurposing Antipsychotics for Cancer Treatment. Biomedicines 9:12, pages 1785.
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Nilkumar Patel, Nagavendra Kommineni, Sunil Kumar Surapaneni, Anil Kalvala, Xuegang Yaun, Aragaw Gebeyehu, Peggy Arthur, Leanne C. Duke, Sara B. York, Arvind Bagde, David G. MeckesJrJr & Mandip Singh. (2021) Cannabidiol loaded extracellular vesicles sensitize triple-negative breast cancer to doxorubicin in both in-vitro and in vivo models. International Journal of Pharmaceutics 607, pages 120943.
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Keshav Karki, Kumaravel Mohankumar, Abigail Schoeller, Gregory Martin, Rupesh Shrestha & Stephen Safe. (2021) NR4A1 Ligands as Potent Inhibitors of Breast Cancer Cell and Tumor Growth. Cancers 13:11, pages 2682.
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Hyo-Seon Lee, Soo-Hyun Kim, Bo-Mi Kim, Stephen Safe & Syng-Ook Lee. (2021) Broussochalcone A Is a Novel Inhibitor of the Orphan Nuclear Receptor NR4A1 and Induces Apoptosis in Pancreatic Cancer Cells. Molecules 26:8, pages 2316.
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Rupesh Shrestha, Kumaravel Mohankumar, Un-ho Jin, Gregory Martin & Stephen Safe. (2021) The Histone Methyltransferase Gene G9A Is Regulated by Nuclear Receptor 4A1 in Alveolar Rhabdomyosarcoma Cells. Molecular Cancer Therapeutics 20:3, pages 612-622.
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Daniel Crean & Evelyn P. Murphy. (2021) Targeting NR4A Nuclear Receptors to Control Stromal Cell Inflammation, Metabolism, Angiogenesis, and Tumorigenesis. Frontiers in Cell and Developmental Biology 9.
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Lejla Medzikovic, Hylja Heese, Pieter B. van Loenen, Cindy P. A. A. van Roomen, Ingeborg B. Hooijkaas, Vincent M. Christoffels, Esther E. Creemers, Carlie J. M. de Vries & Vivian de Waard. (2021) Nuclear Receptor Nur77 Controls Cardiac Fibrosis through Distinct Actions on Fibroblasts and Cardiomyocytes. International Journal of Molecular Sciences 22:4, pages 1600.
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Peng-bo Yang, Pei-pei Hou, Fu-yuan Liu, Wen-bin Hong, Hang-zi Chen, Xiao-yu Sun, Peng Li, Yi Zhang, Cui-yu Ju, Li-juan Luo, Sheng-fu Wu, Jia-xin Zhou, Zhi-jing Wang, Jian-ping He, Li Li, Tong-Jin Zhao, Xianming Deng, Tianwei Lin & Qiao Wu. (2020) Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression. Proceedings of the National Academy of Sciences 117:44, pages 27412-27422.
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Samah EL-Ghlban, Elsayed Saber AbouElnour, Abd El-Monem Abd El- Kader EL- Torgoman & Saeed Mohamed Saeed Abu Elabas. (2020) Gene expression of Epithelial Membrane Protein 2 gene and β1-Integrin gene in patients with breast cancer. Biochemistry and Biophysics Reports 22, pages 100708.
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Kumaravel Mohankumar, Xi Li, Nuri Sung, Yeon Jean Cho, Sang Jun Han & Stephen Safe. (2020) Bis-Indole–Derived Nuclear Receptor 4A1 (NR4A1, Nur77) Ligands as Inhibitors of Endometriosis. Endocrinology 161:4.
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Subhashree Kumaravel, Sumeet Singh, Sukanya Roy, Lavanya Venkatasamy, Tori K. White, Samiran Sinha, Shannon S. Glaser, Stephen H. Safe & Sanjukta Chakraborty. (2020) CXCL11-CXCR3 Axis Mediates Tumor Lymphatic Cross Talk and Inflammation-Induced Tumor, Promoting Pathways in Head and Neck Cancers. The American Journal of Pathology 190:4, pages 900-915.
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Keshav Karki, Gus A. Wright, Kumaravel Mohankumar, Un-Ho Jin, Xing-Han Zhang & Stephen Safe. (2020) A Bis-Indole–Derived NR4A1 Antagonist Induces PD-L1 Degradation and Enhances Antitumor Immunity. Cancer Research 80:5, pages 1011-1023.
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Vellingiri, Iyer, Devi Subramaniam, Jayaramayya, Siama, Giridharan, Narayanasamy, Abdal Dayem & Cho. (2020) Understanding the Role of the Transcription Factor Sp1 in Ovarian Cancer: from Theory to Practice. International Journal of Molecular Sciences 21:3, pages 1153.
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Linjie Zhao, Hongbo Hu, Jan-Åke Gustafsson & Shengtao Zhou. (2020) Nuclear Receptors in Cancer Inflammation and Immunity. Trends in Immunology 41:2, pages 172-185.
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Fu Ou-Yang, Mei-Ren Pan, Shu-Jyuan Chang, Chun-Chieh Wu, Shao-Yu Fang, Chung-Liang Li, Ming-Feng Hou & Chi-Wen Luo. (2019) Identification of CHD4-β1 integrin axis as a prognostic marker in triple-negative breast cancer using next-generation sequencing and bioinformatics. Life Sciences 238, pages 116963.
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Erik Hedrick, Kumaravel Mohankumar, Alexandra Lacey & Stephen Safe. (2019) Inhibition of NR4A1 Promotes ROS Accumulation and IL24-Dependent Growth Arrest in Rhabdomyosarcoma. Molecular Cancer Research 17:11, pages 2221-2232.
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Erik Hedrick, Xi Li, Yating Cheng, Alexandra Lacey, Kumaravel Mohankumar, Mahsa Zarei & Stephen Safe. (2019) Potent inhibition of breast cancer by bis-indole-derived nuclear receptor 4A1 (NR4A1) antagonists. Breast Cancer Research and Treatment 177:1, pages 29-40.
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Erik Hedrick, Kumaravel Mohankumar & Stephen Safe. (2018) TGFβ-Induced Lung Cancer Cell Migration Is NR4A1-Dependent. Molecular Cancer Research 16:12, pages 1991-2002.
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Alexandra Lacey, Erik Hedrick, Yating Cheng, Kumaravel Mohankumar, Melanie Warren & Stephen Safe. (2018) Interleukin-24 (IL24) Is Suppressed by PAX3-FOXO1 and Is a Novel Therapy for Rhabdomyosarcoma. Molecular Cancer Therapeutics 17:12, pages 2756-2766.
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Lingjuan Wu & Liqun Chen. (2018) Characteristics of Nur77 and its ligands as potential anticancer compounds (Review). Molecular Medicine Reports.
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Dimakatso Senthebane, Tina Jonker, Arielle Rowe, Nicholas Thomford, Daniella Munro, Collet Dandara, Ambroise Wonkam, Dhirendra Govender, Bridget Calder, Nelson Soares, Jonathan Blackburn, M. Parker & Kevin Dzobo. (2018) The Role of Tumor Microenvironment in Chemoresistance: 3D Extracellular Matrices as Accomplices. International Journal of Molecular Sciences 19:10, pages 2861.
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Lei Zhang, Qun Wang, Wen Liu, Fangyan Liu, Ailing Ji & Yanzhang Li. (2018) The Orphan Nuclear Receptor 4A1: A Potential New Therapeutic Target for Metabolic Diseases. Journal of Diabetes Research 2018, pages 1-10.
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Kumaravel Mohankumar, Jehoon Lee, Chia Shan Wu, Yuxiang Sun & Stephen Safe. (2018) Bis-Indole–Derived NR4A1 Ligands and Metformin Exhibit NR4A1-Dependent Glucose Metabolism and Uptake in C2C12 Cells. Endocrinology 159:5, pages 1950-1963.
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Nahla Gueder, Ghada Allan, Marie-Sophie Telliez, Frédéric Hague, José M. Fernandez, Elena M. Sanchez-Fernandez, Carmen Ortiz-Mellet, Ahmed Ahidouch & Halima Ouadid-Ahidouch. (2017) sp 2 -Iminosugar α-glucosidase inhibitor 1- C -octyl-2-oxa-3-oxocastanospermine specifically affected breast cancer cell migration through Stim1, β1-integrin, and FAK signaling pathways . Journal of Cellular Physiology 232:12, pages 3631-3640.
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Jonghwan Choi, Sanghyun Park, Youngmi Yoon & Jaegyoon Ahn. (2017) Improved prediction of breast cancer outcome by identifying heterogeneous biomarkers. Bioinformatics 33:22, pages 3619-3626.
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Geum-A Lee, Kyung-A Hwang & Kyung-Chul Choi. (2017) Inhibitory effects of 3,3′-diindolylmethane on epithelial-mesenchymal transition induced by endocrine disrupting chemicals in cellular and xenograft mouse models of breast cancer. Food and Chemical Toxicology 109, pages 284-295.
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Hyo-Seon Lee, Stephen Safe & Syng-Ook Lee. (2017) Inactivation of the orphan nuclear receptor NR4A1 contributes to apoptosis induction by fangchinoline in pancreatic cancer cells. Toxicology and Applied Pharmacology 332, pages 32-39.
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Erik Hedrick, Syng-ook Lee & Stephen Safe. (2017) The nuclear orphan receptor NR4A1 regulates β1-integrin expression in pancreatic and colon cancer cells and can be targeted by NR4A1 antagonists. Molecular Carcinogenesis 56:9, pages 2066-2075.
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Alexandra Lacey, Aline Rodrigues-Hoffman & Stephen Safe. (2017) PAX3-FOXO1A Expression in Rhabdomyosarcoma Is Driven by the Targetable Nuclear Receptor NR4A1. Cancer Research 77:3, pages 732-741.
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Erik Hedrick, Xi Li & Stephen Safe. (2017) Penfluridol Represses Integrin Expression in Breast Cancer through Induction of Reactive Oxygen Species and Downregulation of Sp Transcription Factors. Molecular Cancer Therapeutics 16:1, pages 205-216.
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Zhixiong Wang, Zhao Wang, Guanghua Li, Hui Wu, Kaiyu Sun, Jianhui Chen, Yun Feng, Chuangqi Chen, Shirong Cai, Jianbo Xu & Yulong He. (2017) CXCL1 from tumor-associated lymphatic endothelial cells drives gastric cancer cell into lymphatic system via activating integrin β1/FAK/AKT signaling. Cancer Letters 385, pages 28-38.
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Dinglan Wu, Alyson Cheung, Yuliang Wang, Shan Yu & Franky L. Chan. (2016) The emerging roles of orphan nuclear receptors in prostate cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1866:1, pages 23-36.
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