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Current Medical Research and Opinion Volume 19, 2003 - Issue 6
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Research Article

Effects of pioglitazone on metabolic control and blood pressure: a randomised study in patients with type 2 diabetes mellitus

Pietro Gerber Clinica al Parco, Lugano, SwitzerlandCorrespondence[email protected]
,
Georg Lübben Takeda Pharma, Aachen, Germany
,
Sabine Heusler Takeda Pharma, Aachen, Germany; Takeda Pharma, Lachen, Switzerland
&
Ayako Dodo Takeda Pharma, Lachen, Switzerland
Pages 532-539 | Accepted 24 Jul 2003, Published online: 22 Sep 2008

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Hui Wang, Yaqiang Tian, Yanyan Chen, Xiaoxia Shen, Lin Pan & Guangwei Li. (2020) Hyperinsulinemia rather than insulin resistance itself induces blood pressure elevation in high fat diet-fed rats. Clinical and Experimental Hypertension 42:7, pages 614-621.
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CV Rizos, EN Liberopoulos, DP Mikhailidis & MS Elisaf. (2008) Pleiotropic effects of thiazolidinediones. Expert Opinion on Pharmacotherapy 9:7, pages 1087-1108.
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Sheila A Doggrell. (2008) Clinical trials with thiazolidinediones in subjects with Type 2 diabetes – is pioglitazone any different from rosiglitazone?. Expert Opinion on Pharmacotherapy 9:3, pages 405-420.
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Mozhgan Dorkhan & Anders Frid. (2007) A review of pioglitazone HCL and glimepiride in the treatment of type 2 diabetes. Vascular Health and Risk Management 3:5, pages 721-731.
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Pantelis A. Sarafidis & Peter M. Nilsson. (2006) The effects of thiazolidinediones on blood pressure levels – A systematic review. Blood Pressure 15:3, pages 135-150.
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Juan F Viles-Gonzalez, Brian G Choi, Valentin Fuster & Juan J Badimon. (2004) Peroxisome proliferator-activated receptor ligands in atherosclerosis. Expert Opinion on Investigational Drugs 13:11, pages 1393-1403.
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David S. H. Bell & Terri Jerkins. (2023) In praise of pioglitazone: An economically efficacious therapy for type 2 diabetes and other manifestations of the metabolic syndrome. Diabetes, Obesity and Metabolism 25:11, pages 3093-3102.
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Renata Libianto, Duygu Batu, Richard J. MacIsaac, Mark E. Cooper & Elif I. Ekinci. (2018) Pathophysiological Links Between Diabetes and Blood Pressure. Canadian Journal of Cardiology 34:5, pages 585-594.
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Elena Filipova, Katya Uzunova, Krassimir Kalinov & Toni Vekov. (2017) Effects of pioglitazone therapy on blood parameters, weight and BMI: a meta-analysis. Diabetology & Metabolic Syndrome 9:1.
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Paresh Dandona, Husam Ghanim, Ajay Chaudhuri & Priya Mohanty. (2008) Thiazolidinediones—improving endothelial function and potential long-term benefits on cardiovascular disease in subjects with type 2 diabetes. Journal of Diabetes and its Complications 22:1, pages 62-75.
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Beatriz de Rivas, Manuel Luque, Nieves Martell, Cristina Fernández & Arturo Fernández-Cruz. (2007) Pioglitazone Decreases Ambulatory Blood Pressure in Type 2 Diabetics With Difficult-to-Control Hypertension. The Journal of Clinical Hypertension 9:7, pages 530-537.
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Charles W Bolten, Maria A Payne, William G McDonald, Patrick M Blanner, Robert C Chott, Sarbani Ghosh, Graciela B Arhancet, Nicholas R Staten, Eric A Gulve, Patrick M Sullivan, Alexander E Hromockyj & Jerry R Colca. (2016) Thiazolidinediones inhibit the progression of established hypertension in the Dahl salt-sensitive rat. Diabetes and Vascular Disease Research 4:2, pages 117-123.
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Ozlem Tarcin, Mandeep Bajaj & Sema Akalin. (2007) Insulin Resistance, Adipocyte Biology, and Thiazolidinediones: A Review. Metabolic Syndrome and Related Disorders 5:2, pages 103-115.
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Janaka Karalliedde & Robin E Buckingham. (2007) Thiazolidinediones and their Fluid-Related Adverse Effects. Drug Safety 30:9, pages 741-753.
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Florian Blaschke, Evren Caglayan & Willa A. Hsueh. (2006) Peroxisome Proliferator-Activated Receptor Gamma Agonists: Their Role as Vasoprotective Agents in Diabetes. Endocrinology and Metabolism Clinics of North America 35:3, pages 561-574.
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H. Shimizu, S. Oh-I, T. Tsuchiya, K.-I. Ohtani, S. Okada & M. Mori. (2006) Pioglitazone increases circulating adiponectin levels and subsequently reduces TNF-alpha levels in Type 2 diabetic patients: a randomized study. Diabetic Medicine 23:3, pages 253-257.
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Florian BlaschkeYasunori TakataEvren CaglayanRonald E. LawWilla A. Hsueh. (2006) Obesity, Peroxisome Proliferator-Activated Receptor, and Atherosclerosis in Type 2 Diabetes. Arteriosclerosis, Thrombosis, and Vascular Biology 26:1, pages 28-40.
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Rehan Qayyum & Jurga Adomaityte. (2007) A Meta‐Analysis of the Effect of Thiazolidinediones on Blood Pressure. The Journal of Clinical Hypertension 8:1, pages 19-28.
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Panteleimon A. Sarafidis, Anastasios N. Lasaridis, Peter M. Nilsson, Tzant F. Mouslech, Areti D. Hitoglou-Makedou, Panagiotis C. Stafylas, Kiriakos A. Kazakos, John G. Yovos & Achilleas A. Tourkantonis. (2005) The effect of rosiglitazone on novel atherosclerotic risk factors in patients with type 2 diabetes mellitus and hypertension. Metabolism 54:9, pages 1236-1242.
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Ian W Campbell. (2016) Pioglitazone — an oral antidiabetic agent and metabolic syndrome modulator. Can theory translate into practice?. The British Journal of Diabetes & Vascular Disease 5:4, pages 209-216.
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R. Mukhtar & J. P. D. Reckless. (2005) Dyslipidaemia in Type 2 diabetes: effects of the thiazolidinediones pioglitazone and rosiglitazone. Diabetic Medicine 22:s3, pages 6-10.
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Andrew J. DrexlerRichard W. NestoMartin J. AbrahamsonGeorge BakrisDavid BellJohn BrunzellParesh DandonaJaime DavidsonVivian FonsecaMichael FowlerRobert FryeThomas GilesSteven HaffnerNorman HollenbergWilla HsuehRonald LawJorge PlutzkyRobert RatnerJane ReuschAndrew SelwynJames SowersKathleen WyneLawrence H. Young. (2005) Evaluating the Cardiovascular Effects of the Thiazolidinediones and Their Place in the Management of Type 2 Diabetes in Relation to the Metabolic Syndrome. Metabolic Syndrome and Related Disorders 3:2, pages 147-173.
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Graham T. McMahon, Jorge Plutzky, Edouard Daher, Tammy Bhattacharyya, George Grunberger & Marcelo F. DiCarli. (2005) Effect of a Peroxisome Proliferator–Activated Receptor-γ Agonist on Myocardial Blood Flow in Type 2 Diabetes. Diabetes Care 28:5, pages 1145-1150.
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Maria H. Clough, David J. Schneider, Burton E. Sobel, Morris F. White, Marilyn P. Wadsworth & Douglas J. Taatjes. (2016) Attenuation of Accumulation of Neointimal Lipid by Pioglitazone in Mice Genetically Deficient in Insulin Receptor Substrate-2 and Apolipoprotein E. Journal of Histochemistry & Cytochemistry 53:5, pages 603-610.
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Thomas Konrad, Georg L??bben & Christine Franzen. (2005) Pioglitazone Lowers Blood Pressure in??Hypertensive Patients with Type 2 Diabetes Mellitus. Clinical Drug Investigation 25:5, pages 337-340.
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Panteleimon A Sarafidis, Anastasios N Lasaridis, Peter M Nilsson, Emmanuil M Pagkalos, Areti D Hitoglou-Makedou, Christodoulos I Pliakos, Kiriakos A Kazakos, John G Yovos, Pantelis E Zebekakis, Ioannis M Tziolas & Achilleas N Tourkantonis. (2004) Ambulatory blood pressure reduction after rosiglitazone treatment in patients with type 2 diabetes and hypertension correlates with insulin sensitivity increase. Journal of Hypertension 22:9, pages 1769-1777.
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Florian Blaschke, Dennis Bruemmer & Ronald E. Law. (2004) Will the potential of peroxisome proliferator-activated receptor agonists be realized in the clinical setting?. Clinical Cardiology 27:S4, pages 3-10.
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Jochen Seufert, Georg L?bben, Karin Dietrich & Peter C. Bates. (2004) A comparison of the effects of thiazolidinediones and metformin on metabolic control in patients with type 2 diabetes mellitus. Clinical Therapeutics 26:6, pages 805-818.
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Mandeep Bajaj & Ralph A. DeFronzo. 2003. International Textbook of Diabetes Mellitus. International Textbook of Diabetes Mellitus.
Richard A. Guthrie & Diana W. Guthrie. (2004) Pathophysiology of Diabetes Mellitus. Critical Care Nursing Quarterly 27:2, pages 113-125.
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