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Research Article

Adjustable maintenance dosing with budesonide/formoterol compared with fixed-dose salmeterol/fluticasone in moderate to severe asthma

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Pages 225-240 | Accepted 19 Nov 2004, Published online: 12 Dec 2004

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Jiangtao Lin, Xin Zhou, Changzheng Wang, Chuntao Liu, Shaoxi Cai & Mao Huang. (2018) Symbicort® Maintenance and Reliever Therapy (SMART) and the evolution of asthma management within the GINA guidelines. Expert Review of Respiratory Medicine 12:3, pages 191-202.
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Hiroshi Chantaphakul & Kiat Ruxrungtham. (2016) Fixed-Dose combination of the inhaled corticosteroid and long-acting beta2-agonist therapy in adults with persistent asthma. Expert Opinion on Pharmacotherapy 17:5, pages 631-642.
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Heather E Hoch & Stanley J Szefler. (2016) Intermittent steroid inhalation for the treatment of childhood asthma. Expert Review of Clinical Immunology 12:2, pages 183-194.
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David Hodgson, Kevin Mortimer & Tim Harrison. (2010) Budesonide/formoterol in the treatment of asthma. Expert Review of Respiratory Medicine 4:5, pages 557-566.
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Shu Zhang, Xiaoning Zeng, Jifu Wei, Shan Li & Shaoheng He. (2010) Analysis of patents on anti-allergic therapies issued in China from 1988 to 2008. Expert Opinion on Therapeutic Patents 20:6, pages 727-737.
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Christina Lee & Jonathan Corren. (2008) Budesonide/formoterol in the treatment of asthma. Expert Review of Respiratory Medicine 2:5, pages 551-564.
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David MG Halpin. (2008) Symbicort: a pharmacoeconomic review. Journal of Medical Economics 11:2, pages 345-362.
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Olof Selroos. (2007) A smarter way to manage asthma with a combination of a long-acting β2-agonist and inhaled corticosteroid. Therapeutics and Clinical Risk Management 3:2, pages 349-359.
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R Buhl & C Vogelmeier. (2007) Budesonide/formoterol maintenance and reliever therapy: a new treatment approach for adult patients with asthma. Current Medical Research and Opinion 23:8, pages 1867-1878.
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Steven J. Edwards, Kevin Gruffydd-Jones & Dermot P. Ryan. (2007) Systematic review and meta-analysis of budesonide/formoterol in a single inhaler. Current Medical Research and Opinion 23:8, pages 1809-1820.
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Iolo Doull, David Price, Mike Thomas, Neil Hawkins, Eugena Stamuli, Maggie Tabberer, Toby Gosden & Helen Rudge. (2007) Cost-effectiveness of salmeterol xinafoate/fluticasone propionate combination inhaler in chronic asthma. Current Medical Research and Opinion 23:5, pages 1147-1159.
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Mirjam Mensing & René Aalbers. (2007) Comparison and optimal use of fixed combinations in the management of COPD. International Journal of Chronic Obstructive Pulmonary Disease 2:2, pages 107-116.
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Mikael Lundborg, Sören Wille, Leif Bjermer, Björn Tilling, Michael Lundgren, Gunilla Telg, Tommy Ekström & Olof Selroos. (2006) Maintenance plus reliever budesonide/formoterol compared with a higher maintenance dose of budesonide/formoterol plus formoterol as reliever in asthma:an efficacy and cost-effectiveness study. Current Medical Research and Opinion 22:5, pages 809-821.
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Mario Cazzola, Maria Gabriella Matera & Jan Lötvall. (2005) Ultra long-acting β2-agonists in development for asthma and chronic obstructive pulmonary disease. Expert Opinion on Investigational Drugs 14:7, pages 775-783.
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Jan Lötvall. (2004) Combination therapy in asthma -fixed or variable dosing in different patients?. Current Medical Research and Opinion 20:11, pages 1711-1727.
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David Price, John Haughney, Adam Lloyd, Julia Hutchinson & Jonathan Plumb. (2004) An economic evaluation of adjustable and fixed dosing with budesonide/formoterol via a single inhaler in asthma patients: the ASSURE study. Current Medical Research and Opinion 20:10, pages 1671-1679.
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R. Scicchitano, R. Aalbers, D. Ukena, A. Manjra, L. Fouquert, S. Centanni, L.-P. Boulet, I. P. Naya & C. Hultquist. (2004) Efficacy and safety of budesonide/formoterol single inhaler therapy versus a higher dose of budesonide in moderate to severe asthma. Current Medical Research and Opinion 20:9, pages 1403-1418.
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Yuji Oba, Sumayya Anwer, Tinashe Maduke, Tarang Patel & Sofia Dias. (2022) Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and varying doses of inhaled corticosteroids in adolescents and adults with asthma: a systematic review and network meta-analysis. Cochrane Database of Systematic Reviews 2022:12.
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Ralph Brattsand & Olof Selroos. (2022) May a different kinetic mode explain the high efficacy/safety profile of inhaled budesonide?. Pulmonary Pharmacology & Therapeutics 77, pages 102167.
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Orlagh O'Shea, Elizabeth Stovold & Christopher J Cates. (2021) Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and an inhaled corticosteroid for chronic asthma: serious adverse events. Cochrane Database of Systematic Reviews 2021:4.
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Simon Wan Yau Ming, John Haughney, Iain Small, Stephanie Wolfe, John Hamill, Kevin Gruffydd-Jones, Cathal Daly, Joan B. Soriano, Elizabeth Gardener, Derek Skinner, Martina Stagno d'Alcontres & David B. Price. (2017) Initiating or changing to a fixed-dose combination of Fluticasone propionate/Formoterol over Fluticasone propionate/Salmeterol: A real-life effectiveness and cost impact evaluation. Respiratory Medicine 129, pages 199-206.
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Iain Crossingham, David JW Evans, Nathan R Halcovitch & Paul A Marsden. (2017) Stepping down the dose of inhaled corticosteroids for adults with asthma. Cochrane Database of Systematic Reviews 2017:2.
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Alberto PapiAdel H. MansurTetyana PertsevaKirsten KaiserTammy McIverBirgit GrotheSanjeeva Dissanayake. (2016) Long-Term Fluticasone Propionate/Formoterol Fumarate Combination Therapy Is Associated with a Low Incidence of Severe Asthma Exacerbations. Journal of Aerosol Medicine and Pulmonary Drug Delivery 29:4, pages 346-361.
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Eileen Wang & Flavia C.L. Hoyte. (2016) Traditional Therapies for Severe Asthma. Immunology and Allergy Clinics of North America 36:3, pages 581-608.
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Tari Haahtela, Olof Selroos & Paul M. O'Byrne. (2015) Revisiting early intervention in adult asthma. ERJ Open Research 1:1, pages 00022-2015.
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Masayuki Hojo, Motoyasu Iikura, Junko Hirashima, Manabu Suzuki & Haruhito Sugiyama. (2014) A Comparison of Long-Term Anti-Inflammatory Effect of Two ICS/LABA Combination Inhalers; Fix-Dosed Maintenance Therapy with Budesonide/Formoterol and Salmeterol/Fluticasone. Allergology International 63:1, pages 103-111.
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Ren? Aalbers. (2013) Single inhaler as maintenance and reliever therapy?is it SMART?. The Lancet Respiratory Medicine 1:1, pages 2-3.
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Roland Buhl, Piotr Kuna, Matthew J Peters, Tomas LG Andersson, Ian P Naya, Stefan Peterson & Klaus F Rabe. (2012) The effect of budesonide/formoterol maintenance and reliever therapy on the risk of severe asthma exacerbations following episodes of high reliever use: an exploratory analysis of two randomised, controlled studies with comparisons to standard therapy. Respiratory Research 13:1, pages 59.
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Stephanie Korn & Roland Buhl. (2012) Efficacy of a fixed combination of ciclesonide and formoterol: The EXCITED-study. Respiratory Medicine 106:1, pages 57-67.
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Toby J Lasserson, Giovanni Ferrara & Lucio Casali. (2011) Combination fluticasone and salmeterol versus fixed dose combination budesonide and formoterol for chronic asthma in adults and children. Cochrane Database of Systematic Reviews.
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Alex Thomas, Robert F. LemanskeJr.Jr. & Daniel J. Jackson. (2011) Approaches to stepping up and stepping down care in asthmatic patients. Journal of Allergy and Clinical Immunology 128:5, pages 915-924.
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Geoff K. Frampton & Jonathan Shepherd. (2010) Patient-reported outcomes in clinical trials of inhaled asthma medications: systematic review and research needs. Quality of Life Research 20:3, pages 343-357.
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René Aalbers. (2010) Fixed or Adjustable Maintenance-Dose Budesonide/Formoterol Compared with Fixed Maintenance-Dose Salmeterol/Fluticasone Propionate in Asthma Patients Aged ≥16 Years. Clinical Drug Investigation 30:7, pages 439-451.
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Francine M Ducharme, Muireann Ni Chroinin, Ilana Greenstone & Toby J Lasserson. (2010) Addition of long-acting beta2-agonists to inhaled corticosteroids versus same dose inhaled corticosteroids for chronic asthma in adults and children. Cochrane Database of Systematic Reviews.
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Alan Kaplan & Dermot Ryan. (2010) The role of budesonide/formoterol for maintenance and relief in the management of asthma. Pulmonary Pharmacology & Therapeutics 23:2, pages 88-96.
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Christopher J Cates & Toby J Lasserson. (2010) Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and an inhaled corticosteroid for chronic asthma: serious adverse events. Cochrane Database of Systematic Reviews.
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Mohammad Hamzavi. (2010) Combination Therapy with Budesonide and Formoterol in Single Inhaler of Asthma. Clinical Medicine Insights: Therapeutics 2, pages 1179559X1000200.
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Muireann Ni Chroinin, Ilana Greenstone, Toby J Lasserson & Francine M Ducharme. (2009) Addition of long-acting beta2-agonists to inhaled steroids as first line therapy for persistent asthma in steroid-naive adults and children. Cochrane Database of Systematic Reviews.
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