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Research Article

Evaluation of the efficacy of polydeoxyribonucleotides in the healing process of autologous skin graft donor sites: a pilot study

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Pages 403-408 | Accepted 08 Dec 2004, Published online: 22 Jan 2004

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Hyun-Kyung Do, Joong-Hoon Lee & Jae-Young Lim. (2018) Polydeoxyribonucleotide injection in the patients with partial-thickness tear of supraspinatus tendon: a prospective and pilot study using ultrasound. The Physician and Sportsmedicine 46:2, pages 213-220.
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Kwang Ho Yoon, Wan Jong Kim, Sang Kyeun Han, Kook-Il Han, Kung-Woo Nam & Man-Deuk Han. (2015) Polydeoxyribonucleotide administration promotes the expression of proliferating cell nuclear antigen during liver regeneration in rats. Animal Cells and Systems 19:1, pages 54-60.
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Articles from other publishers (29)

Kwang-Soo Lee, Soyeon Lee, Hyesoo Wang, Geonhee Lee, Seolyeong Kim, Yang-Hwan Ryu, Nicole Hyesoo Chang & Yong-Won Kang. (2023) Analysis of Skin Regeneration and Barrier-Improvement Efficacy of Polydeoxyribonucleotide Isolated from Panax Ginseng (C.A. Mey.) Adventitious Root. Molecules 28:21, pages 7240.
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Bo Ri Kim, Soon Hyo KwonJee Woo KimWoo-Jin Jeong, Wonjae ChaYoung Ho JungJung-Im NaChang-Hun HuhJung-Won Shin. (2023) Early Postoperative Injections of Polydeoxyribonucleotide Prevent Hypertrophic Scarring After Thyroidectomy: A Randomized Controlled Trial. Advances in Wound Care 12:7, pages 361-370.
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Sun Mee Shin, Eun Joo Baek, Kwang Ho Kim, Kwang Joong Kim & Eun Joo Park. (2023) Polydeoxyribonucleotide exerts opposing effects on ERK activity in human skin keratinocytes and fibroblasts. Molecular Medicine Reports 28:2.
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Aawrish Khan, Guobao Wang, Feng Zhou, Lunli Gong, Jun Zhang, Lili Qi & Haiyan Cui. (2022) Polydeoxyribonucleotide: A promising skin anti-aging agent. Chinese Journal of Plastic and Reconstructive Surgery 4:4, pages 187-193.
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Mariarosaria Galeano, Giovanni Pallio, Natasha Irrera, Federica Mannino, Alessandra Bitto, Domenica Altavilla, Mario Vaccaro, Giovanni Squadrito, Vincenzo Arcoraci, Michele Rosario Colonna, Rita Lauro & Francesco Squadrito. (2021) Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing. Pharmaceuticals 14:11, pages 1103.
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Ho-Kyung Lim, Yeh-Jin Kwon, Seok-Jin Hong, Hyo-Geun Choi, Sung-Min Chung, Byoung-Eun Yang, Jong-Ho Lee & Soo-Hwan Byun. (2021) Bone regeneration in ceramic scaffolds with variable concentrations of PDRN and rhBMP-2. Scientific Reports 11:1.
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Ji Yeong Kim, Yoo Na Kim, Yu Jung Lee, Sung Eun Sim, Yu Ri Ko, Jin Woo Shim, Ku Sang Lee, Mina Joo & Hue Jung Park. (2021) Pilot Study to Evaluate the Efficacy of Polynucleotide Sodium Compared to Sodium Hyaluronate and Crosslinked Sodium Hyaluronate in Patients with Knee Osteoarthritis. Journal of Clinical Medicine 10:5, pages 1138.
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Magda Belmontesi. (2020) Polydeoxyribonucleotide for the improvement of a hypertrophic retracting scar—An interesting case report. Journal of Cosmetic Dermatology 19:11, pages 2982-2986.
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Maria T Colangelo, Carlo Galli & Stefano Guizzardi. (2020) The effects of polydeoxyribonucleotide on wound healing and tissue regeneration: a systematic review of the literature. Regenerative Medicine 15:6, pages 1801-1821.
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Yeon-Ji Kim, Min-Jung Kim, Dong-Keon Kweon, Seung-Taik Lim & Sung-Joon Lee. (2019) Polydeoxyribonucleotide Activates Mitochondrial Biogenesis but Reduces MMP-1 Activity and Melanin Biosynthesis in Cultured Skin Cells. Applied Biochemistry and Biotechnology 191:2, pages 540-554.
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Tien-Lin Chang, Shang-Fang Wu, Der-Yuan Wang & Chih-Hung Huang. (2020) A unified method for different placental products species identification. Pharmacognosy Magazine 16:68, pages 8.
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Sung Hyun Lee, Sie Hyeon Yoo, Hae-Jin Lee, Donggyu Han, Jiyoung Lee, Seung Hwan Jeon, Eun-Ah Cho & Hue Jung Park. (2020) Anti-Allodynic Effects of Polydeoxyribonucleotide in an Animal Model of Neuropathic Pain and Complex Regional Pain Syndrome. Journal of Korean Medical Science 35:26.
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Ahreum Baek, Yoon Kim, Jin Woo Lee, Sang Chul Lee & Sung-Rae Cho. (2018) Effect of Polydeoxyribonucleotide on Angiogenesis and Wound Healing in an In Vitro Model of Osteoarthritis . Cell Transplantation 27:11, pages 1623-1633.
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Kyu‑Hee Hwang, Ji‑Hee Kim, Eun Park & Seung‑Kuy Cha. (2018) An effective range of polydeoxyribonucleotides is critical for wound healing quality. Molecular Medicine Reports.
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Shin Hyuk Kang, Min Seok Choi, Han Koo Kim, Woo Seob Kim, Tae Hui Bae, Mi Kyung Kim & Seung Hwan Chang. (2017) Polydeoxyribonucleotide improves tendon healing following achilles tendon injury in rats. Journal of Orthopaedic Research 36:6, pages 1767-1776.
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Francesca Veronesi, Dante Dallari, Giacomo Sabbioni, Chiara Carubbi, Lucia Martini & Milena Fini. (2017) Polydeoxyribonucleotides (PDRNs) From Skin to Musculoskeletal Tissue Regeneration via Adenosine A 2A Receptor Involvement . Journal of Cellular Physiology 232:9, pages 2299-2307.
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Francesco Squadrito, Alessandra Bitto, Natasha Irrera, Gabriele Pizzino, Giovanni Pallio, Letteria Minutoli & Domenica Altavilla. (2017) Pharmacological Activity and Clinical Use of PDRN. Frontiers in Pharmacology 8.
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Chiara Castellini, Silvana Belletti, Paolo Govoni & Stefano Guizzardi. (2017) Anti Inflammatory Property of PDRN—An <i>in Vitro</i> Study on Cultured Macrophages. Advances in Bioscience and Biotechnology 08:01, pages 13-26.
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Barbara Buffoli, Gaia Favero, Elisa Borsani, Ramon Boninsegna, Guido Sancassani, Mauro Labanca, Rita Rezzani, Pier Francesco Nocini, Massimo Albanese & Luigi Fabrizio Rodella. (2017) Sodium-DNA for Bone Tissue Regeneration: An Experimental Study in Rat Calvaria. BioMed Research International 2017, pages 1-9.
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Seok-Kon Kim, Chang-Kyu Huh, Jae-Hoon Lee, Kyung-Wook Kim & Moon-Young Kim. (2016) Histologic study of bone-forming capacity on polydeoxyribonucleotide combined with demineralized dentin matrix. Maxillofacial Plastic and Reconstructive Surgery 38:1.
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Dong Won Lee, Hyun Joon Hong, Huyn Roh & Won Jai Lee. (2015) The Effect of Polydeoxyribonucleotide on Ischemic Rat Skin Flap Survival. Annals of Plastic Surgery 75:1, pages 84-90.
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이지영, 윤필영, 안교진, 김수연, 김영균 & 박주철. (2014) Evaluation of bone healing capacity of xenogenic tooth bone graft material with polydeoxyribonucleotide in bone defect surrounding an implant. Oral Biology Research 38:1, pages 9-16.
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Piyali Datta Chakraborty, Sutapa Goswami, Sudipta Bera & Indranil Mukhopadhyay. (2014) Quantitation of Polydeoxyribonucletides (PDRNs) in Human Placental Extract by Fluorescence Spectroscopy Using Ethidium Bromide. American Journal of Analytical Chemistry 05:12, pages 784-795.
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Luisa Gennero, Tetyana Denysenko, Gian Franco Calisti, Andrea Vercelli, Carlo Maria Vercelli, Stefano Amedeo, Silvia Mioletti, Enrico Parino, Manuela Montanaro, Antonio Melcarne, Carola Juenemann, Enrico De Vivo, Alessandro Longo, Giovanni Cavallo & Rocco De Siena. (2012) Protective effects of polydeoxyribonucleotides on cartilage degradation in experimental cultures. Cell Biochemistry and Function 31:3, pages 214-227.
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Francesca Polito, Alessandra Bitto, Mariarosaria Galeano, Natasha Irrera, Herbert Marini, Margherita Calò, Francesco Squadrito & Domenica Altavilla. (2012) Polydeoxyribonucleotide restores blood flow in an experimental model of ischemic skin flaps. Journal of Vascular Surgery 55:2, pages 479-488.
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Jieun Jung, Hyun-Jung Lee, Jung Min Lee, Kyu-Hwan Na, Seong-Gyu Hwang & Gi Jin Kim. (2011) Placenta extract promote liver regeneration in CCl4-injured liver rat model. International Immunopharmacology 11:8, pages 976-984.
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Roberto Vanelli, Pietro Costa, Stefano Marco Paolo Rossi & Francesco Benazzo. (2010) Efficacy of intra-articular polynucleotides in the treatment of knee osteoarthritis: a randomized, double-blind clinical trial. Knee Surgery, Sports Traumatology, Arthroscopy 18:7, pages 901-907.
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Mariarosaria Galeano, Alessandra Bitto, Domenica Altavilla, Letteria Minutoli, Francesca Polito, Margherita Calò, Patrizia Lo Cascio, Francesco Stagno d'Alcontres & Francesco Squadrito. (2008) Polydeoxyribonucleotide stimulates angiogenesis and wound healing in the genetically diabetic mouse. Wound Repair and Regeneration 16:2, pages 208-217.
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S. Guizzardi, D. Martini, B. Bacchelli, L. Valdatta, A. Thione, S. Scamoni, J. Uggeri & A. Ruggeri. (2007) Effects of heat deproteinate bone and polynucleotides on bone regeneration: An experimental study on rat. Micron 38:7, pages 722-728.
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