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Brief Report

Preliminary observations on the use of propionyl-L-carnitine in combination with sildenafil in patients with erectile dysfunction and diabetes

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Pages 1377-1384 | Accepted 05 Jul 2004, Published online: 16 Jul 2004

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Fatih Kılıçlı, Sebila Dökmetaş, Ferhan Candan, Sefa Özşahin, Serdal Korkmaz, Elvan Amasyalı, Koray Fakıoğlu, Kürşat Dal, Fettah Acıbucu & İlkay Çakır. (2010) Inspiratory Muscle Strength is Correlated with Carnitine Levels in Type 2 Diabetes. Endocrine Research 35:2, pages 51-58.
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Yun Chen, Yutian Dai & Run Wang. (2008) Treatment strategies for diabetic patients suffering from erectile dysfunction. Expert Opinion on Pharmacotherapy 9:2, pages 257-266.
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Articles from other publishers (29)

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Axel Alberto Cayetano‐Alcaraz, Tharu Tharakan, Runzhi Chen, Nikolaos Sofikitis & Suks Minhas. (2022) The management of erectile dysfunction in men with diabetes mellitus unresponsive to phosphodiesterase type 5 inhibitors. Andrology 11:2, pages 257-269.
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Liang Su, Zhao-tian Yang, Hua Qu, Cheng-long Luo, Guo-xing Yuan, Jie Wu & Yong-zheng Jiao. (2022) Effect of Antioxidants Supplementation on Erectile Dysfunction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Sexual Medicine Reviews 10:4, pages 754-763.
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Maija Dambrova, Marina Makrecka-Kuka, Janis Kuka, Reinis Vilskersts, Didi Nordberg, Misty M. Attwood, Stefan Smesny, Zumrut Duygu Sen, An Chi Guo, Eponine Oler, Siyang Tian, Jiamin Zheng, David S. Wishart, Edgars Liepinsh & Helgi B. Schiöth. (2022) Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials. Pharmacological Reviews 74:3, pages 506-551.
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Pablo Garrido-Abad, Isabel Senra-Bravo, Celeste Manfredi, Esaú Fernández-Pascual, Estefanía Linares-Espinós, Manuel Fernández-Arjona, David Varillas-Delgado & Juan Ignacio Martínez-Salamanca. (2021) Combination therapy with topical alprostadil and phosphodiesterase-5 inhibitors after failure of oral therapy in patients with erectile dysfunction: a prospective, two-arm, open-label, non-randomized study. International Journal of Impotence Research 34:2, pages 164-171.
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D. Menafra, C. de Angelis, F. Garifalos, M. Mazzella, G. Galdiero, M. Piscopo, M. Castoro, N. Verde, C. Pivonello, C. Simeoli, R. S. Auriemma, A. Colao & R. Pivonello. (2022) Long-term high-dose l-arginine supplementation in patients with vasculogenic erectile dysfunction: a multicentre, double-blind, randomized, placebo-controlled clinical trial. Journal of Endocrinological Investigation 45:5, pages 941-961.
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Ioannis Mykoniatis, Nikolaos Pyrgidis, Ioannis Sokolakis, Andreas Ouranidis, Petros Sountoulides, Anna-Bettina Haidich, Koenraad van Renterghem, Georgios Hatzichristodoulou & Dimitrios Hatzichristou. (2021) Assessment of Combination Therapies vs Monotherapy for Erectile Dysfunction. JAMA Network Open 4:2, pages e2036337.
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Taymour Mostafa, Laila A. Rashed, Dina A. Sabry, Ihab Osman, Nashaat Nabil, Firas Kareem & Ingi A. Mostafa. (2018) Serum l-carnitine and vitamin D levels may be low among oral sildenafil citrate non-responders. International Journal of Impotence Research 31:2, pages 85-91.
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Luke Fortney. 2018. Integrative Medicine. Integrative Medicine 623 629.e2 .
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Carmen Brás Silva & Delminda Neves. 2015. Anti-ageing nutrients. Anti-ageing nutrients 203 245 .
Thomas E Ichim, Timothy Warbington, Octav Cristea, Joseph L Chin & Amit N Patel. (2013) Intracavernous administration of bone marrow mononuclear cells: a new method of treating erectile dysfunction?. Journal of Translational Medicine 11:1.
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Kazuko SakaiKei FukamiSho-ichi YamagishiYusuke KaidaTakeki AdachiRyotaro AndoRie ManabeAki OtsukaKenzo SugiSeiji UedaSeiya Okuda. (2013) Evidence for a Positive Association Between Serum Carnitine and Free Testosterone Levels in Uremic Men with Hemodialysis. Rejuvenation Research 16:3, pages 200-205.
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D. Gianfrilli, R. Lauretta, C. Di Dato, C. Graziadio, C. Pozza, J. De Larichaudy, E. Giannetta, A. M. Isidori & A. Lenzi. (2012) Propionyl-L-carnitine, L-arginine and niacin in sexual medicine: a nutraceutical approach to erectile dysfunction. Andrologia 44, pages 600-604.
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Mariano Malaguarnera. (2012) Carnitine derivatives. Current Opinion in Gastroenterology 28:2, pages 166-176.
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Luke Fortney. 2012. Integrative Medicine. Integrative Medicine 560 566.e2 .
Carmen Mingorance, Rosalia Rodriguez-Rodriguez, Maria Luisa Justo, Maria Dolores Herrera & Maria Alvarez de Sotomayor. (2011) Pharmacological effects and clinical applications of propionyl-L-carnitine. Nutrition Reviews 69:5, pages 279-290.
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Rohit R Dhir, Hao-Cheng Lin, Steven E Canfield & Run Wang. (2011) Combination therapy for erectile dysfunction: an update review. Asian Journal of Andrology 13:3, pages 382-390.
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Enzo Vicari, Sandro La Vignera, Rosita Condorelli & Aldo Eugenio Calogero. (2010) Endothelial Antioxidant Administration Ameliorates the Erectile Response to PDE5 Regardless of the Extension of the Atherosclerotic Process. The Journal of Sexual Medicine 7:3, pages 1247-1253.
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Jyoti Shah. 2009. Herbal Drugs: Ethnomedicine to Modern Medicine. Herbal Drugs: Ethnomedicine to Modern Medicine 67 80 .
Robert Pickard. (2007) Editorial Comment on: Antioxidant Treatment Associated with Sildenafil Reduces Monocyte Activation and Markers of Endothelial Damage in Patients with Diabetic Erectile Dysfunction: A Double-Blind, Placebo-Controlled Study. European Urology 52:6, pages 1774-1775.
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Susanna Morano, Elisabetta Mandosi, Mara Fallarino, Alessandra Gatti, Claudio Tiberti, Maurizio Sensi, Loredana Gandini, Barbara Buchetti, Luisa Lenti, Emmanuele Angelo Jannini & Andrea Lenzi. (2007) Antioxidant Treatment Associated with Sildenafil Reduces Monocyte Activation and Markers of Endothelial Damage in Patients with Diabetic Erectile Dysfunction: A Double-Blind, Placebo-Controlled Study. European Urology 52:6, pages 1768-1776.
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Ronald Tamler & Jeffrey I. Mechanick. (2007) Dietary Supplements and Nutraceuticals in the Management of Andrologic Disorders. Endocrinology and Metabolism Clinics of North America 36:2, pages 533-552.
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Ba X. Hoang, D. Graeme Shaw, Phuong Pham & Stephen Levine. (2007) Restoration of cellular energetic balance with l-carnitine in the neuro-bioenergetic approach for cancer prevention and treatment. Medical Hypotheses 69:2, pages 262-272.
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Ronald Tamler & Jeffrey I Mechanick. (2006) Dietary supplements and nutraceuticals in the management of endocrine disorders. Current Opinion in Endocrinology and Diabetes 13:5, pages 425-430.
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Giorgio Cavallini. (2006) Carnitines for Men?s Health. Seminars in Preventive and Alternative Medicine 2:2, pages 91-95.
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Giorgio Cavallini, Fabio Modenini, Giovanni Vitali & Aleardo Koverech. (2005) Acetyl-l-carnitine plus propionyl-l-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy. Urology 66:5, pages 1080-1085.
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Puneet Masson, Sarah M. Lambert, Melissa Brown & Ridwan Shabsigh. (2005) PDE-5 Inhibitors: Current Status and Future Trends. Urologic Clinics of North America 32:4, pages 511-525.
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