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Brief Report

Renal protection by radical scavenging in cardiac surgery patients

, &
Pages 1161-1164 | Accepted 27 May 2005, Published online: 22 Jun 2005

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Mei Mei, Hong-Wen Zhao, Qian-Guang Pan, You-Min Pu, Mao-Zhi Tang & Bing-Bing Shen. (2018) Efficacy of N-Acetylcysteine in Preventing Acute Kidney Injury After Cardiac Surgery: A Meta-Analysis Study. Journal of Investigative Surgery 31:1, pages 14-23.
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Articles from other publishers (36)

Fatemeh Javaherforooshzadeh, Zahra Shaker, Mahboobeh Rashidi, Reza Akhondzadeh & Fatemeh Hayati. (2021) The effect of N-acetyl cysteine injection on renal function after coronary artery bypass graft surgery: a randomized double blind clinical trial. Journal of Cardiothoracic Surgery 16:1.
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Ali Mirza Onder, David Rosen, Charles Mullett, Lesley Cottrell, Sherry Kanosky, Oulimata Kane Grossman, Hafiz Imran Iqbal, Eric Seachrist, Lennie Samsell, Kelly Gustafson, Larry Rhodes & Robert Gustafson. (2016) Comparison of Intraoperative Aminophylline Versus Furosemide in Treatment of Oliguria During Pediatric Cardiac Surgery*. Pediatric Critical Care Medicine 17:8, pages 753-763.
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Jong Wook Song, Jae Kwang Shim, Sarah Soh, Jaewon Jang & Young Lan Kwak. (2015) Double-blinded, randomized controlled trial of N-acetylcysteine for prevention of acute kidney injury in high risk patients undergoing off-pump coronary artery bypass. Nephrology 20:2, pages 96-102.
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Miki Ueda, Kohei Uchimura, Yuki Narita, Yoshikazu Miyasato, Teruhiko Mizumoto, Jun Morinaga, Manabu Hayata, Yutaka Kakizoe, Masataka Adachi, Taku Miyoshi, Naoki Shiraishi, Daisuke Kadowaki, Yoshiki Sakai, Masashi Mukoyama & Kenichiro Kitamura. (2015) The Serine Protease Inhibitor Camostat Mesilate Attenuates the Progression of Chronic Kidney Disease through its Antioxidant Effects. Nephron 129:3, pages 223-232.
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Eduesley Santana-Santos, Luis Henrique W. Gowdak, Fabio A. Gaiotto, Luiz B. Puig, Ludhmila A. Hajjar, Suely P. Zeferino, Luciano F. Drager, Maria Heloisa M. Shimizu, Luiz A. Bortolotto & Jose J.G. De Lima. (2014) High Dose of N-Acetylcystein Prevents Acute Kidney Injury in Chronic Kidney Disease Patients Undergoing Myocardial Revascularization. The Annals of Thoracic Surgery 97:5, pages 1617-1623.
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Mehmet Ozaydin, Tulay Peker, Selahaddin Akcay, Bayram A. Uysal, Habil Yucel, Atilla Icli, Dogan Erdogan, Ercan Varol, Abdullah Dogan & Huseyin Okutan. (2014) Addition of N-Acetyl Cysteine to Carvedilol Decreases the Incidence of Acute Renal Injury After Cardiac Surgery. Clinical Cardiology 37:2, pages 108-114.
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Mathew Zacharias, Mohan Mugawar, G Peter Herbison, Robert J Walker, Karen Hovhannisyan, Pal Sivalingam & Niamh P Conlon. (2013) Interventions for protecting renal function in the perioperative period. Cochrane Database of Systematic Reviews.
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Tamas Szakmany, Balázs Hauser & Peter Radermacher. (2012) N-acetylcysteine for sepsis and systemic inflammatory response in adults. Cochrane Database of Systematic Reviews 2018:12.
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L. David Hillis, Peter K. Smith, Jeffrey L. Anderson, John A. Bittl, Charles R. Bridges, John G. Byrne, Joaquin E. Cigarroa, Verdi J. DiSesa, Loren F. Hiratzka, Adolph M. HutterJrJr, Michael E. Jessen, Ellen C. Keeley, Stephen J. Lahey, Richard A. Lange, Martin J. London, Michael J. Mack, Manesh R. Patel, John D. Puskas, Joseph F. Sabik, Ola Selnes, David M. Shahian, Jeffrey C. Trost & Michael D. Winniford. (2012) 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery. Anesthesia & Analgesia 114:1, pages 11-45.
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L. David Hillis, Peter K. Smith, Jeffrey L. Anderson, John A. Bittl, Charles R. Bridges, John G. Byrne, Joaquin E. Cigarroa, Verdi J. DiSesa, Loren F. Hiratzka, Adolph M. HutterJrJr, Michael E. Jessen, Ellen C. Keeley, Stephen J. Lahey, Richard A. Lange, Martin J. London, Michael J. Mack, Manesh R. Patel, John D. Puskas, Joseph F. Sabik, Ola Selnes, David M. Shahian, Jeffrey C. Trost, Michael D. Winniford, Alice K. Jacobs, Jeffrey L. Anderson, Nancy Albert, Mark A. Creager, Steven M. Ettinger, Robert A. Guyton, Jonathan L. Halperin, Judith S. Hochman, Frederick G. Kushner, E. Magnus Ohman, William Stevenson & Clyde W. Yancy. (2012) 2011 ACCF/AHA guideline for coronary artery bypass graft surgery: Executive summary. The Journal of Thoracic and Cardiovascular Surgery 143:1, pages 4-34.
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L. David HillisPeter K. SmithJeffrey L. AndersonJohn A. BittlCharles R. BridgesJohn G. ByrneJoaquin E. CigarroaVerdi J. DiSesaLoren F. HiratzkaAdolph M. HutterJrJrMichael E. JessenEllen C. KeeleyStephen J. LaheyRichard A. LangeMartin J. LondonMichael J. MackManesh R. PatelJohn D. PuskasJoseph F. SabikOla SelnesDavid M. ShahianJeffrey C. TrostMichael D. Winniford. (2011) 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery. Circulation 124:23.
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L. David HillisPeter K. SmithJeffrey L. AndersonJohn A. BittlCharles R. BridgesJohn G. ByrneJoaquin E. CigarroaVerdi J. DiSesaLoren F. HiratzkaAdolph M. HutterJrJrMichael E. JessenEllen C. KeeleyStephen J. LaheyRichard A. LangeMartin J. LondonMichael J. MackManesh R. PatelJohn D. PuskasJoseph F. SabikOla SelnesDavid M. ShahianJeffrey C. TrostMichael D. Winniford. (2011) 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery: Executive Summary. Circulation 124:23, pages 2610-2642.
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L. David Hillis, Peter K. Smith, Jeffrey L. Anderson, John A. Bittl, Charles R. Bridges, John G. Byrne, Joaquin E. Cigarroa, Verdi J. DiSesa, Loren F. Hiratzka, Adolph M. HutterJrJr, Michael E. Jessen, Ellen C. Keeley, Stephen J. Lahey, Richard A. Lange, Martin J. London, Michael J. Mack, Manesh R. Patel, John D. Puskas, Joseph F. Sabik, Ola Selnes, David M. Shahian, Jeffrey C. Trost & Michael D. Winniford. (2011) 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery. Journal of the American College of Cardiology 58:24, pages e123-e210.
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L. David Hillis, Peter K. Smith, Jeffrey L. Anderson, John A. Bittl, Charles R. Bridges, John G. Byrne, Joaquin E. Cigarroa, Verdi J. DiSesa, Loren F. Hiratzka, Adolph M. HutterJrJr, Michael E. Jessen, Ellen C. Keeley, Stephen J. Lahey, Richard A. Lange, Martin J. London, Michael J. Mack, Manesh R. Patel, John D. Puskas, Joseph F. Sabik, Ola Selnes, David M. Shahian, Jeffrey C. Trost & Michael D. Winniford. (2011) 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery: Executive Summary. Journal of the American College of Cardiology 58:24, pages 2584-2614.
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Erminio Sisillo & Giancarlo Marenzi. (2011) N-Acetylcysteine for the Prevention of Acute Kidney Injury After Cardiac Surgery. The Journal of Clinical Pharmacology 51:11, pages 1603-1610.
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Guyan Wang, Daniel Bainbridge, Janet Martin & Davy Cheng. (2011) N-acetylcysteine in Cardiac Surgery: Do the Benefits Outweigh the Risks? A Meta-Analytic Reappraisal. Journal of Cardiothoracic and Vascular Anesthesia 25:2, pages 268-275.
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Giancarlo Marenzi, Erminio Sisillo & Antonio L. Bartorelli. 2011. Studies on Renal Disorders. Studies on Renal Disorders 367 388 .
Apoorva Prasad, Sanjaykumar Banakal & Kanchi Muralidhar. (2010) N-Acetylcysteine does not prevent renal dysfunction after off-pump coronary artery bypass surgery. European Journal of Anaesthesiology 27:11, pages 973-977.
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Alan Ashworth & Stephen T. Webb. (2010) Does the prophylactic administration of N-acetylcysteine prevent acute kidney injury following cardiac surgery?. Interactive CardioVascular and Thoracic Surgery 11:3, pages 303-308.
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I. A. Hilmi, Z. Peng, R. M. Planinsic, D. Damian, F. Dai, Y. Y. Tyurina, V. E. Kagan & J. A. Kellum. (2010) N-acetylcysteine does not prevent hepatorenal ischaemia-reperfusion injury in patients undergoing orthotopic liver transplantation. Nephrology Dialysis Transplantation 25:7, pages 2328-2333.
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Yun‐Hui Teng, Chih‐Wei Wang, Yun‐Tsan Liao, Min‐Wen Yang & Tsung‐Yun Liu. (2010) Quantification of urinary 8‐iso‐prostaglandin F 2α using liquid chromatography–tandem mass spectrometry during cardiac valve surgery . Journal of Clinical Laboratory Analysis 24:4, pages 237-245.
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A. S. Adabag, A. Ishani, H. E. Bloomfield, A. K. Ngo & T. J. Wilt. (2009) Efficacy of N-acetylcysteine in preventing renal injury after heart surgery: a systematic review of randomized trials. European Heart Journal 30:15, pages 1910-1917.
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Sagar U. Nigwekar & Praveen Kandula. (2009) N-Acetylcysteine in Cardiovascular-Surgery–Associated Renal Failure: A Meta-Analysis. The Annals of Thoracic Surgery 87:1, pages 139-147.
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Mathew Zacharias, Niamh P Conlon, G Peter Herbison, Pal Sivalingam, Robert J Walker & Karen Hovhannisyan. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
A. Selcuk Adabag, Areef Ishani, Suresh Koneswaran, Deborah J. Johnson, Rosemary F. Kelly, Herbert B. Ward, Edward O. McFalls, Hanna E. Bloomfield & Yellaprada Chandrashekhar. (2008) Utility of N-acetylcysteine to prevent acute kidney injury after cardiac surgery: A randomized controlled trial. American Heart Journal 155:6, pages 1143-1149.
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Linda F. Barr & Kenneth Kolodner. (2008) N-acetylcysteine and fenoldopam protect the renal function of patients with chronic renal insufficiency undergoing cardiac surgery. Critical Care Medicine 36:5, pages 1427-1435.
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M. Schetz, T. Bove, A. MorelliS. Mankad, C. Ronco & J.A. Kellum. (2018) Prevention of Cardiac Surgery-Associated Acute Kidney Injury. The International Journal of Artificial Organs 31:2, pages 179-189.
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Catherine C. S. Bouman & Marcus J. Schultz. (2008) N-acetylcysteine: Multiple organ saver during cardiac surgery?*. Critical Care Medicine 36:1, pages 338-340.
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Erminio Sisillo, Roberto Ceriani, Franco Bortone, Glauco Juliano, Luca Salvi, Fabrizio Veglia, Cesare Fiorentini & Giancarlo Marenzi. (2008) N-acetylcysteine for prevention of acute renal failure in patients with chronic renal insufficiency undergoing cardiac surgery: A prospective, randomized, clinical trial*. Critical Care Medicine 36:1, pages 81-86.
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Danny Del Duca, Sameena Iqbal, Elham Rahme, Peter Goldberg & Benoit de Varennes. (2007) Renal Failure After Cardiac Surgery: Timing of Cardiac Catheterization and Other Perioperative Risk Factors. The Annals of Thoracic Surgery 84:4, pages 1264-1271.
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János G. Filep. (2007) N-Acetylcysteine for the prevention of renal dysfunction in high-risk patients undergoing coronary bypass graft surgery: An unfulfilled promise?*. Critical Care Medicine 35:5, pages 1431-1433.
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Michael Haase, Anja Haase-Fielitz, Sean M. Bagshaw, Michael C. Reade, Stanislao Morgera, Siven Seevenayagam, George Matalanis, Brian Buxton, Laurie Doolan & Rinaldo Bellomo. (2007) Phase II, randomized, controlled trial of high-dose N-acetylcysteine in high-risk cardiac surgery patients*. Critical Care Medicine 35:5, pages 1324-1331.
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Karien Fokkelman, Erika Haase, Johnathan Stevens, Halliday Idikio, Gregory Korbutt, David Bigam & Po-Yin Cheung. (2007) Tissue-specific changes in glutathione content of hypoxic newborn pigs reoxygenated with 21% or 100% oxygen. European Journal of Pharmacology 562:1-2, pages 132-137.
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Jiaquan Zhu, Rong Yin, Hongtao Shao, Guohua Dong, Liguo Luo & Hua Jing. (2007) N-acetylcysteine to ameliorate acute renal injury in a rat cardiopulmonary bypass model. The Journal of Thoracic and Cardiovascular Surgery 133:3, pages 696-703.e1.
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U. M. Fischer & U. Mehlhorn. (2007) Radical scavenging for renal protection in cardiac surgeryEinsatz von Antioxidantien zur Nierenprotektion während herzchirurgischer Eingriffe. Clinical Research in Cardiology Supplements 2:S1, pages S81-S84.
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A. Ristikankare, T. Kuitunen, A. Kuitunen, L. Uotila, A. Vento, R. Suojaranta-Ylinen, M. Salmenpera & R. Poyhia. (2006) Lack of renoprotective effect of i.v. N-acetylcysteine in patients with chronic renal failure undergoing cardiac surgery. British Journal of Anaesthesia 97:5, pages 611-616.
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