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Original Article

Glimepiride versus pioglitazone combination therapy in subjects with type 2 diabetes inadequately controlled on metformin monotherapy: results of a randomized clinical trial

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Pages 751-759 | Accepted 02 Feb 2006, Published online: 21 Mar 2006

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Read on this site (11)

Awadhesh Kumar Singh. (2015) Polemics of pioglitazone: an appraisal in 2015. Expert Review of Endocrinology & Metabolism 10:4, pages 447-458.
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Ye-Fong Du, Horng-Yih Ou, Elizabeth A Beverly & Ching-Ju Chiu. (2014) Achieving glycemic control in elderly patients with type 2 diabetes: a critical comparison of current options. Clinical Interventions in Aging 9, pages 1963-1980.
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Vanessa J Briscoe, Michelle L Griffith & Stephen N Davis. (2010) The role of glimepiride in the treatment of type 2 diabetes mellitus. Expert Opinion on Drug Metabolism & Toxicology 6:2, pages 225-235.
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Giuseppe Derosa & Sibilla AT Salvadeo. (2009) Risk management in the treatment of type 2 diabetes with pioglitazone. Diabetes, Metabolic Syndrome and Obesity 2, pages 51-60.
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Bo Ahrén. (2008) Novel combination treatment of type 2 diabetes DPP-4 inhibition + metformin. Vascular Health and Risk Management 4:2, pages 383-394.
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John M Stafford & Tom Elasy. (2007) Treatment update: thiazolidinediones in combination with metformin for the treatment of type 2 diabetes. Vascular Health and Risk Management 3:4, pages 503-510.
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Yan Peng, Shu‐Hong Chen, Xiao‐Nan Liu & Qing‐Yun Sun. (2018) Efficacy of different antidiabetic drugs based on metformin in the treatment of type 2 diabetes mellitus: A network meta‐analysis involving eight eligible randomized‐controlled trials. Journal of Cellular Physiology 234:3, pages 2795-2806.
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L. M. Neff, M. S. Broder, D. Beenhouwer, E. Chang, E. Papoyan & Z. W. Wang. (2017) Network meta-analysis of lorcaserin and oral hypoglycaemics for patients with type 2 diabetes mellitus and obesity. Clinical Obesity 7:6, pages 337-346.
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Niki Katsiki, Nikolaos Tentolouris & Dimitri P. Mikhailidis. (2017) Dyslipidaemia in type 2 diabetes mellitus. Current Opinion in Cardiology 32:4, pages 422-429.
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Yean Yean Soong, Joseph Lim, Lijuan Sun & Christiani Jeyakumar Henry. (2015) Effect of co-ingestion of amino acids with rice on glycaemic and insulinaemic response. British Journal of Nutrition 114:11, pages 1845-1851.
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James H. Flory & Alvin I. Mushlin. (2015) Observational and clinical trial findings on the comparative effectiveness of diabetes drugs showed agreement. Journal of Clinical Epidemiology 68:2, pages 200-210.
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M. Monami, S. Genovese & E. Mannucci. (2013) Cardiovascular safety of sulfonylureas: a meta-analysis of randomized clinical trials. Diabetes, Obesity and Metabolism 15:10, pages 938-953.
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S.‐C. Liu, Y.‐K. Tu, M.‐N. Chien & K.‐L. Chien. (2012) Effect of antidiabetic agents added to metformin on glycaemic control, hypoglycaemia and weight change in patients with type 2 diabetes: a network meta‐analysis. Diabetes, Obesity and Metabolism 14:9, pages 810-820.
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Lyudmila Alexandrovna Ruyatkina & Maksim Yur'evich Sorokin. (2012) Modern antihyperglycemic therapy: safety and efficacy of glimepiride. Diabetes mellitus 15:2, pages 89-97.
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Dae Young Yoo, Woosuk Kim, Sung Min Nam, Ki-Yeon Yoo, Choong Hyun Lee, Jung Hoon Choi, Moo-Ho Won, In Koo Hwang & Yeo Sung Yoon. (2011) Reduced Cell Proliferation and Neuroblast Differentiation in the Dentate Gyrus of High Fat Diet-Fed Mice are Ameliorated by Metformin and Glimepiride Treatment. Neurochemical Research 36:12, pages 2401-2408.
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A. Avogaro, M. Federici, J. Betteridge, R. Bonadonna, I. W. Campbell, G. H. Schernthaner, B. Staels, E. Farinaro & G. Crepaldi. (2014) Which is the eligible patient to be treated with pioglitazone? The expert view. Journal of Endocrinological Investigation 34:10, pages 781-787.
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Nobuyuki Shihara, Masafumi Kitaoka, Nobuya Inagaki, Takashi Kadowaki, Seisuke Koumoto, Jo Satoh, Yasuo Terauchi, Kiyohide Nunoi, Yuichiro Yamada, Hiroyuki Sakamaki & Yutaka Seino. (2011) Randomized controlled trial of single-agent glimepiride and pioglitazone in Japanese patients with type 2 diabetes: A comparative study. Journal of Diabetes Investigation 2:5, pages 391-398.
Crossref
Giuseppe Derosa. (2010) Efficacy and Tolerability of Pioglitazone in Patients with Type 2 Diabetes Mellitus. Drugs 70:15, pages 1945-1961.
Crossref
Namyi Gu, Bo-Hyung Kim, HyouYoung Rhim, Jae-Yong Chung, Jung-Ryul Kim, Hyun-Suk Shin, Seo-Hyun Yoon, Joo-Youn Cho, Sang-Goo Shin, In-Jin Jang & Kyung-Sang Yu. (2010) Comparison of the bioavailability and tolerability of fixed-dose combination glimepiride/metformin 2/500-mg tablets versus separate tablets: A single-dose, randomized-sequence, open-label, two-period crossover study in healthy Korean volunteers. Clinical Therapeutics 32:7, pages 1408-1418.
Crossref
Dan-yan Xu, Shui-Ping Zhao, Qiu-xia Huang, Wei Du, Yu-hua Liu, Ling Liu & Xiao-mei Xie. (2010) Effects of Glimepiride on metabolic parameters and cardiovascular risk factors in patients with newly diagnosed type 2 diabetes mellitus. Diabetes Research and Clinical Practice 88:1, pages 71-75.
Crossref
R. A. DeFronzo, A. H. Stonehouse, J. Han & M. E. Wintle. (2010) Relationship of baseline HbA 1c and efficacy of current glucose-lowering therapies: a meta-analysis of randomized clinical trials . Diabetic Medicine 27:3, pages 309-317.
Crossref
Michael A Nauck & Irfan Vardarli. (2010) Comparative evaluation of incretin‐based antidiabetic medications and alternative therapies to be added to metformin in the case of monotherapy failure†. Journal of Diabetes Investigation 1:1-2, pages 24-36.
Crossref
Shelley R Salpeter, Elizabeth Greyber, Gary A Pasternak & Edwin E Salpeter (posthumous). 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Jochen Seufert. (2009) The backbone of oral glucose-lowering therapy: time for a paradigm shift?. Fundamental & Clinical Pharmacology 23:6, pages 651-667.
Crossref
Stephen C. Bain. (2009) Treatment of Type 2 Diabetes Mellitus With Orally Administered Agents: Advances in Combination Therapy. Endocrine Practice 15:7, pages 750-762.
Crossref
G. Bolli, F. Dotta, L. Colin, B. Minic & M. Goodman. (2009) Comparison of vildagliptin and pioglitazone in patients with type 2 diabetes inadequately controlled with metformin. Diabetes, Obesity and Metabolism 11:6, pages 589-595.
Crossref
Mark Stolar. (2009) Safety and Efficacy of Pioglitazone/Metformin Combination Therapy in Treatment of Type 2 Diabetes: A Rationale for Earlier Use. Clinical Medicine. Therapeutics 1, pages CMT.S2370.
Crossref
N. PapanasE. Maltezos. (2009) Metformin: A Review of Its Use in the Treatment of Type 2 Diabetes. Clinical Medicine. Therapeutics 1, pages CMT.S1085.
Crossref
Nicole R Pinelli, Raymond Cha, Morton B Brown & Linda A Jaber. (2008) Addition of Thiazolidinedione or Exenatide to Oral Agents in Type 2 Diabetes: A Meta-Analysis. Annals of Pharmacotherapy 42:11, pages 1541-1551.
Crossref
John HB Scarpello & Harry CS Howlett. (2008) Metformin therapy and clinical uses. Diabetes and Vascular Disease Research 5:3, pages 157-167.
Crossref
E. Mannucci, M. Monami, C. Lamanna, G. F. Gensini & N. Marchionni. (2008) Pioglitazone and cardiovascular risk. A comprehensive meta-analysis of randomized clinical trials. Diabetes, Obesity and Metabolism 0:0, pages 080526191604039-???.
Crossref
Matteo Monami, Caterina Lamanna, Niccolò Marchionni & Edoardo Mannucci. (2008) Comparison of different drugs as add-on treatments to metformin in type 2 diabetes: A meta-analysis. Diabetes Research and Clinical Practice 79:2, pages 196-203.
Crossref
A. Macías Batista, I. Peiró Martínez & P.L. de Pablos Velasco. (2008) Terapia combinada. Endocrinología y Nutrición 55, pages 58-65.
Crossref
G. Bolli, F. Dotta, E. Rochotte & S. E. Cohen. (2007) Efficacy and tolerability of vildagliptin vs. pioglitazone when added to metformin: a 24-week, randomized, double-blind study. Diabetes, Obesity and Metabolism 0:0, pages 071127144208007-???.
Crossref
G. Derosa. (2007) Pioglitazone plus glimepiride: a promising alternative in metabolic control. International Journal of Clinical Practice 61, pages 28-36.
Crossref
Emanuele Bosi, Riccardo Paolo Camisasca, Carole Collober, Erika Rochotte & Alan J. Garber. (2007) Effects of Vildagliptin on Glucose Control Over 24 Weeks in Patients With Type 2 Diabetes Inadequately Controlled With Metformin. Diabetes Care 30:4, pages 890-895.
Crossref
Shelley R Salpeter, Elizabeth Greyber, Gary A Pasternak & Edwin E Salpeter. 1996. The Cochrane Database of Systematic Reviews (Complete Reviews). The Cochrane Database of Systematic Reviews (Complete Reviews).
Emma D Deeks & Lesley J Scott. (2006) Pioglitazone/Metformin. Drugs 66:14, pages 1863-1877.
Crossref

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