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Review

Mycophenolic acid trough level monitoring in solid organ transplant recipients treated with mycophenolate mofetil: association with clinical outcome

Pages 2355-2364 | Accepted 22 Sep 2006, Published online: 23 Oct 2006

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H. S. Ciftci, E. Demir, M. S. Karadeniz, T. Tefik, I. Nane, F. S. Oguz, F. Aydin & A. Turkmen. (2018) Influence of uridine diphosphate-glucuronosyltransferases (1A9) polymorphisms on mycophenolic acid pharmacokinetics in patients with renal transplant. Renal Failure 40:1, pages 395-402.
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Moro O Salifu & Rahul M Jindal. (2009) Mycophenolate mofetil dosage modifications following gastrointestinal complications in renal transplant patients. Expert Review of Pharmacoeconomics & Outcomes Research 9:1, pages 29-32.
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Irmgard Neumann, Heinz Fuhrmann, Marina Kanzler, I-Fei Fang, Adelheid Jaeger, Helmut Graf, Peter Bayer & Josef Kovarik. (2008) Pharmacokinetics of enteric-coated mycophenolate sodium: comparative study in patients with autoimmune disease and renal allograft. Expert Opinion on Pharmacotherapy 9:6, pages 879-886.
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Articles from other publishers (30)

Ole Martin Drevland, Ida Robertsen, Marte Theie Gustavsen, Hanne Kamilla Kveim, Markus Herberg Hovd, Karsten Midtvedt & Anders Åsberg. (2023) Impact of Fasting Status and Circadian Variation on the Pharmacokinetics of Mycophenolate Mofetil and the Glucuronide Metabolite in Renal Transplant Recipients. Transplantation Direct 9:3, pages e1448.
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Álvaro Luque-Uría, Riikka Peltomaa, Tarja K. Nevanen, Henri O. Arola, Kristiina Iljin, Elena Benito-Peña & María C. Moreno-Bondi. (2021) Recombinant Peptide Mimetic NanoLuc Tracer for Sensitive Immunodetection of Mycophenolic Acid. Analytical Chemistry 93:29, pages 10358-10364.
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Agnieszka Siebert, Milena Deptuła, Mirosława Cichorek, Anna Ronowska, Grzegorz Cholewiński & Janusz Rachon. (2021) Anticancer Properties of Amino Acid and Peptide Derivatives of Mycophenolic Acid. Anti-Cancer Agents in Medicinal Chemistry 21:4, pages 462-467.
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Kimberly S. Collins, Ying‐Hua Cheng, Ricardo M. Ferreira, Hongyu Gao, Matthew D. Dollins, Danielle Janosevic, Nida A. Khan, Chloe White, Pierre C. Dagher & Michael T. Eadon. (2020) Interindividual Variability in Lymphocyte Stimulation and Transcriptomic Response Predicts Mycophenolic Acid Sensitivity in Healthy Volunteers. Clinical and Translational Science 13:6, pages 1137-1149.
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Yajun Song, Wengang Hu, Ya Xiao, Yang Li, Xu Wang, Weifeng He, Jingming Hou, Yun Liu, Guangping Liang & Chibing Huang. (2020) Keratinocyte growth factor ameliorates mycophenolate mofetil-induced intestinal barrier disruption in mice. Molecular Immunology 124, pages 61-69.
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Martin Bleasel & Gregory Peterson. (2020) Emetine, Ipecac, Ipecac Alkaloids and Analogues as Potential Antiviral Agents for Coronaviruses. Pharmaceuticals 13:3, pages 51.
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Aurelija Radzevičienė, Edgaras Stankevičius, Franck Saint-Marcoux, Pierre Marquet, Rima Maslauskienë & Edmundas Kaduševičius. (2020) Pharmacokinetic evaluation of MFF in combinations with tacrolimus and cyclosporine. Findings of C0 and AUC. Medicine 99:12, pages e19441.
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David K. Metz, Nick Holford, Joshua Y. Kausman, Amanda Walker, Noel Cranswick, Christine E. Staatz, Katherine A. Barraclough & Francesco Ierino. (2019) Optimizing Mycophenolic Acid Exposure in Kidney Transplant Recipients: Time for Target Concentration Intervention. Transplantation 103:10, pages 2012-2030.
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Negiin Pourafshar, Ashkan Karimi, Xuerong Wen, Eric Sobel, Shirin Pourafshar, Nikhil Agrawal, Emma Segal, Rajesh Mohandas & Mark S Segal. (2019) The utility of trough mycophenolic acid levels for the management of lupus nephritis. Nephrology Dialysis Transplantation 34:1, pages 83-89.
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Agnieszka Siebert, Magdalena Wysocka, Beata Krawczyk, Grzegorz Cholewiński & Janusz Rachoń. (2018) Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid. European Journal of Medicinal Chemistry 143, pages 646-655.
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Nada A Yazigi. (2017) Adherence and the pediatric transplant patient. Seminars in Pediatric Surgery 26:4, pages 267-271.
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Ekaterina K. Todorova, Shih‐Han S. Huang, Marta C. Kobrzynski & Guido Filler. (2015) What is the intrapatient variability of mycophenolic acid trough levels?. Pediatric Transplantation 19:7, pages 669-674.
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Pieter Langers, Rogier R. Press, Akin Inderson, Serge C. L. M. Cremers, Jan den Hartigh, Andrzej G. Baranski & Bart van Hoek. (2014) Limited Sampling Model for Advanced Mycophenolic Acid Therapeutic Drug Monitoring After Liver Transplantation. Therapeutic Drug Monitoring 36:2, pages 141-147.
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Hyeyoung KimNam-Joon YiJuyeun LeeJoohyun KimMi-Ra MoonJaehong JeongJeong-Moo LeeTae Suk YouSuk-Won SuhMin-Su ParkYoungRok ChoiGeun HongHae Won LeeKwang-Woong LeeKyung-Suk Suh. (2014) Safety of reduced dose of mycophenolate mofetil combined with tacrolimus in living-donor liver transplantation. Clinical and Molecular Hepatology 20:3, pages 291.
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Laurence Chan, Amado Andres, Suphamai Bunnapradist, Kristene Gugliuzza, Ravi Parasuraman, V. Ram Peddi, Elisabeth Cassuto & Marquis Hart. (2012) Renal Function and NODM in De Novo Renal Transplant Recipients Treated with Standard and Reduced Levels of Tacrolimus in Combination with EC-MPS . Journal of Transplantation 2012, pages 1-9.
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Catherine M.T. Sherwin, Tsuyoshi Fukuda, Hermine I. Brunner, Jens Goebel & Alexander A. Vinks. (2011) The Evolution of Population Pharmacokinetic Models to Describe the Enterohepatic Recycling of Mycophenolic Acid in Solid Organ Transplantation and Autoimmune Disease. Clinical Pharmacokinetics 50:1, pages 1-24.
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A. Kornberg, B. Küpper, K. Thrum, B. Krause, P. Büchler, J. Kornberg, A. Sappler, A. Altendorf-Hofmann, J. Wilberg & H. Friess. (2010) Sustained Renal Response to Mycophenolate Mofetil and CNI Taper Promotes Survival in Liver Transplant Patients with CNI-Related Renal Dysfunction. Digestive Diseases and Sciences 56:1, pages 244-251.
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Katherine A Barraclough, Nicole M Isbel, Michael E Franklin, Katie J Lee, Paul J Taylor, Scott B Campbell, William G Petchey & Christine E Staatz. (2010) Evaluation of Limited Sampling Strategies for Mycophenolic Acid After Mycophenolate Mofetil Intake in Adult Kidney Transplant Recipients. Therapeutic Drug Monitoring 32:6, pages 723-733.
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Wai-Johnn Sam & Melanie S Joy. (2010) Population Pharmacokinetics of Mycophenolic Acid and Metabolites in Patients With Glomerulonephritis. Therapeutic Drug Monitoring 32:5, pages 594-605.
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Nigel W Brown, Michael E Franklin, Eyrun N Einarsdottir, Christopher E Gonde, Maria Pires, Paul J Taylor & J Michael Tredger. (2010) An Investigation Into the Bias Between Liquid Chromatography–Tandem Mass Spectrometry and an Enzyme Multiplied Immunoassay Technique for the Measurement of Mycophenolic Acid. Therapeutic Drug Monitoring 32:4, pages 420-426.
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Katherine A. Barraclough, Nicole M. Isbel & Christine E. Staatz. (2010) Evaluation of the Mycophenolic Acid Exposure Estimation Methods Used in the APOMYGERE, FDCC, and Opticept Trials. Transplantation 90:1, pages 44-51.
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Helio Tedesco‐Silva, Claudia R. Felipe, Sung I. Park, Paula G. Pinheiro‐Machado, Riberto Garcia, Alan Slade, Robert Schmouder & Jose O. Medina‐Pestana. (2010) Randomized crossover study to assess the inter‐ and intrasubject variability of morning mycophenolic acid concentrations from enteric‐coated mycophenolate sodium and mycophenolate mofetil in stable renal transplant recipients. Clinical Transplantation 24:4.
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Sibylle von Vietinghoff, Hui Ouyang & Klaus Ley. (2010) Mycophenolic acid suppresses granulopoiesis by inhibition of interleukin-17 production. Kidney International 78:1, pages 79-88.
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Christoph Seger & Michael Vogeser. (2010) Immunosuppressant drug monitoring – a routine undertaking? 1. LaboratoriumsMedizin 34:3, pages -.
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Christoph Seger & Michael Vogeser. (2010) Immunsuppressiva-Medikamentenspiegelmessung – reine Routine? / Immunosuppressant drug monitoring: a routine undertaking?. LaboratoriumsMedizin 34:3, pages 117-128.
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Leora M. Birnbaum, Mark Lipman, Steven Paraskevas, Prosanto Chaudhury, Jean Tchervenkov, Dana Baran, Andrea Herrera-Gayol & Marcelo Cantarovich. (2009) Management of Chronic Allograft Nephropathy: A Systematic Review: Table 1.. Clinical Journal of the American Society of Nephrology 4:4, pages 860-865.
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I. Neumann, H. Fuhrmann, I-F. Fang, A. Jaeger, P. Bayer & J. Kovarik. (2008) Association between mycophenolic acid 12-h trough levels and clinical endpoints in patients with autoimmune disease on mycophenolate mofetil. Nephrology Dialysis Transplantation 23:11, pages 3514-3520.
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Lillian S L Ting, Nilufar Partovi, Robert D Levy, K Wayne Riggs & Mary H H Ensom. (2008) Pharmacokinetics of Mycophenolic Acid and its Phenolic-Glucuronide and Acyl Glucuronide Metabolites in Stable Thoracic Transplant Recipients. Therapeutic Drug Monitoring 30:3, pages 282-291.
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Dustin R. Bunch & Sihe Wang. (2008) Measurement of mycophenolic acid in plasma or serum by a commercial enzyme inhibition technique in comparison with a high performance liquid chromatography method. Clinical Chemistry and Laboratory Medicine 46:9.
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Takafumi Naito, Yasuaki Mino, Atsushi Otsuka, Tomomi Ushiyama, Seiichiro Ozono, Yoshiyuki Kagawa & Junichi Kawakami. (2008) Influence of Metal Cations on Plasma Trough Concentration of Mycophenolic Acid and Its Glucuronide in Tacrolimus-Treated and Cyclosporine-Treated Kidney Transplant Recipients. Biological & Pharmaceutical Bulletin 31:6, pages 1292-1296.
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