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Original Article

Effect of tesaglitazar, a dual PPARα/γ agonist, on glucose and lipid abnormalities in patients with type 2 diabetes: a 12‐week dose-ranging trial

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Pages 2575-2590 | Accepted 16 Oct 2006, Published online: 22 Nov 2006

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Kristina Wallenius, Ann Kjellstedt, Pia Thalén, Lars Löfgren & Nicholas D. Oakes. (2013) The PPAR α / γ Agonist, Tesaglitazar, Improves Insulin Mediated Switching of Tissue Glucose and Free Fatty Acid Utilization In Vivo in the Obese Zucker Rat . PPAR Research 2013, pages 1-14.
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Longxin Qiu, Hong Ye, Limei Chen, Yamin Hong, Fojin Zhong & Tingting Zhang. (2012) Red Clover Extract Ameliorates Dyslipidemia in Streptozotocin-induced Diabetic C57BL/6 Mice by Activating Hepatic PPARα. Phytotherapy Research 26:6, pages 860-864.
Crossref
Kim Henriksen, Claus Christiansen & Morten Asser Karsdal. (2011) Serological biochemical markers of surrogate efficacy and safety as a novel approach to drug repositioning. Drug Discovery Today 16:21-22, pages 967-975.
Crossref
Adrian V. Hernandez, Ali Usmani, Anitha Rajamanickam & A. Moheet. (2011) Thiazolidinediones and Risk of Heart Failure in Patients with or at High Risk of Type 2 Diabetes Mellitus. American Journal Cardiovascular Drugs 11:2, pages 115-128.
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Suzanne M. de la Monte, Maoyin Pang, Rajeev Chaudhry, Kevin Duan, Lisa Longato, Jade Carter, Jiyun Ouh & Jack R. Wands. (2011) Peroxisome proliferator-activated receptor agonist treatment of alcohol-induced hepatic insulin resistance. Hepatology Research 41:4, pages 386-398.
Crossref
Zafar H Israili. (2011) Advances in the Treatment of Type 2 Diabetes Mellitus. American Journal of Therapeutics 18:2, pages 117-152.
Crossref
Monique Heald & Michael A. Cawthorne. 2011. Diabetes - Perspectives in Drug Therapy. Diabetes - Perspectives in Drug Therapy 35 51 .
Hyun Woo Jeong, Joo-Won Lee, Woo Sik Kim, Sung Sik Choe, Hyun Jung Shin, Gha Young Lee, Dongkyu Shin, Jun Hee Lee, Eun Bok Choi, Hyun Kyu Lee, Gyu Hwan Yon, Bongjun Cho, Hye Ryung Kim, Sung Hee Choi, Young Sun Chung, Seung Bum Park, Heekyoung Chung, Seonggu Ro & Jae Bum Kim. (2010) A Nonthiazolidinedione Peroxisome Proliferator-Activated Receptor α/γ Dual Agonist CG301360 Alleviates Insulin Resistance and Lipid Dysregulation in db/db Mice . Molecular Pharmacology 78:5, pages 877-885.
Crossref
Jakob Ribbing, Bengt Hamrén, Maria K. Svensson & Mats O. Karlsson. (2013) A Model for Glucose, Insulin, and Beta‐Cell Dynamics in Subjects With Insulin Resistance and Patients With Type 2 Diabetes. The Journal of Clinical Pharmacology 50:8, pages 861-872.
Crossref
P Sanwald-Ducray, X Liogier D'ardhuy, C Jamois & L Banken. (2010) Pharmacokinetics, Pharmacodynamics, and Tolerability of Aleglitazar in Patients With Type 2 Diabetes: Results From a Randomized, Placebo-Controlled Clinical Study. Clinical Pharmacology & Therapeutics 88:2, pages 197-203.
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Hong Chen, Beatriz Dardik, Ling Qiu, Xianglin Ren, Shari L. Caplan, Bryan Burkey, Brian R. Boettcher & Jesper Gromada. (2010) Cevoglitazar, a Novel Peroxisome Proliferator-Activated Receptor-α/γ Dual Agonist, Potently Reduces Food Intake and Body Weight in Obese Mice and Cynomolgus Monkeys. Endocrinology 151:7, pages 3115-3124.
Crossref
Michael J. Haas & Arshag D. Mooradian. (2010) Therapeutic Interventions to Enhance Apolipoprotein A-I-Mediated Cardioprotection. Drugs 70:7, pages 805-821.
Crossref
Pradeep Natarajan, Kausik K. Ray & Christopher P. Cannon. (2010) High-Density Lipoprotein and Coronary Heart Disease. Journal of the American College of Cardiology 55:13, pages 1283-1299.
Crossref
Derek J Hausenloy & Derek M Yellon. (2009) Enhancing cardiovascular disease risk reduction: raising high-density lipoprotein levels. Current Opinion in Cardiology 24:5, pages 473-482.
Crossref
S. Skalli, M. Baudrant & S. Halimi. (2009) Traitement du diab?te de type 2?: pourquoi les glitazars n?ont-ils pas ?t? introduits sur le march???. M?decine des Maladies M?taboliques 3:4, pages 406-411.
Crossref
Uwe Grether, Agnes Bénardeau, Jörg Benz, Alfred Binggeli, Denise Blum, Hans Hilpert, Bernd Kuhn, Hans Peter Märki, Markus Meyer, Peter Mohr, Kurt Püntener, Susanne Raab, Armin Ruf & Daniel Schlatter. (2009) Design and Biological Evaluation of Novel, Balanced Dual PPARα/γ Agonists. ChemMedChem 4:6, pages 951-956.
Crossref
Agnes Bénardeau, Jörg Benz, Alfred Binggeli, Denise Blum, Markus Boehringer, Uwe Grether, Hans Hilpert, Bernd Kuhn, Hans Peter Märki, Markus Meyer, Kurt Püntener, Susanne Raab, Armin Ruf, Daniel Schlatter & Peter Mohr. (2009) Aleglitazar, a new, potent, and balanced dual PPARα/γ agonist for the treatment of type II diabetes. Bioorganic & Medicinal Chemistry Letters 19:9, pages 2468-2473.
Crossref
JWA Van Der Hoorn, JW Jukema, LM Havekes, E Lundholm, G Camejo, PCN Rensen & HMG Princen. (2009) The dual PPARα/γ agonist tesaglitazar blocks progression of pre-existing atherosclerosis in APOE*3Leiden.CETP transgenic mice. British Journal of Pharmacology 156:7, pages 1067-1075.
Crossref
Karin AM Jandeleit-Dahm, Anna Calkin, Chris Tikellis & Merlin Thomas. (2009) Direct antiatherosclerotic effects of PPAR agonists. Current Opinion in Lipidology 20:1, pages 24-29.
Crossref
R.C.L. Page. 2009. 689 702 .
B Hamrén, E Björk, M Sunzel & MO Karlsson. (2008) Models for Plasma Glucose, HbA1c, and Hemoglobin Interrelationships in Patients with Type 2 Diabetes Following Tesaglitazar Treatment. Clinical Pharmacology & Therapeutics 84:2, pages 228-235.
Crossref
E. Mannucci, M. Monami, C. Lamanna, G. F. Gensini & N. Marchionni. (2008) Pioglitazone and cardiovascular risk. A comprehensive meta-analysis of randomized clinical trials. Diabetes, Obesity and Metabolism 0:0, pages 080526191604039-???.
Crossref
Herbert Schuster, Björn Fagerberg, Siôn Edwards, Tamas Halmos, Jerzy Lopatynski, Steen Stender, Grethe Stoa Birketvedt, Serena Tonstad, Ingrid Gause-Nilsson, Sigrún Halldórsdóttir & K. Peter Öhman. (2008) Tesaglitazar, a dual peroxisome proliferator-activated receptor α/γ agonist, improves apolipoprotein levels in non-diabetic subjects with insulin resistance. Atherosclerosis 197:1, pages 355-362.
Crossref
Anna C. Calkin & Merlin C. Thomas. (2008) PPAR Agonists and Cardiovascular Disease in Diabetes. PPAR Research 2008, pages 1-12.
Crossref
Barbara Caleen Hansen. 2008. The Metabolic Syndrome. The Metabolic Syndrome 373 386 .
Shi-Ying Ding, Xenia T. Tigno, Gheorghe T. Braileanu, Katsuhiko Ito & Barbara C. Hansen. (2007) A novel peroxisome proliferator–activated receptor α/γ dual agonist ameliorates dyslipidemia and insulin resistance in prediabetic rhesus monkeys. Metabolism 56:10, pages 1334-1339.
Crossref
Robert E RatnerShamik ParikhConrad Tou. (2016) Efficacy, safety and tolerability of tesaglitazar when added to the therapeutic regimen of poorly controlled insulin-treated patients with type 2 diabetes. Diabetes and Vascular Disease Research 4:3, pages 214-221.
Crossref
Burkhard GökeIngrid Gause-NilssonAnders Persson. (2016) The effects of tesaglitazar as add-on treatment to metformin in patients with poorly controlled type 2 diabetes. Diabetes and Vascular Disease Research 4:3, pages 204-213.
Crossref
John PH WildingIngrid Gause-NilssonAnders Persson. (2016) Tesaglitazar, as add-on therapy to sulphonylurea, dose-dependently improves glucose and lipid abnormalities in patients with type 2 diabetes. Diabetes and Vascular Disease Research 4:3, pages 194-203.
Crossref
Harold BaysJennifer McElhattanBrian S Bryzinski. (2016) A double-blind, randomised trial of tesaglitazar versus pioglitazone in patients with type 2 diabetes mellitus. Diabetes and Vascular Disease Research 4:3, pages 181-193.
Crossref
Bjorn FagerbergHerbert SchusterGrethe Støa BirketvedtSerena TonstadKarl Peter ÖhmanIngrid Gause-Nilsson. (2016) Improvement of postprandial lipid handling and glucose tolerance in a non-diabetic population by the dual PPARα/γ agonist, tesaglitazar. Diabetes and Vascular Disease Research 4:3, pages 174-180.
Crossref
Serena Tonstad, Kjetil Retterstøl, Leiv Ose, K. Peter Öhman, Magnus B. Lindberg & Maria Svensson. (2007) The dual peroxisome proliferator–activated receptor α/γ agonist tesaglitazar further improves the lipid profile in dyslipidemic subjects treated with atorvastatin. Metabolism 56:9, pages 1285-1292.
Crossref
Heike Hellmold, Hui Zhang, Ulf Andersson, Bo Blomgren, Tom Holland, Anna-Lena Berg, Marie Elebring, Niclas Sjögren, Krister Bamberg, Björn Dahl, Rolf Westerberg, Birgitta Dillner, Jonathan Tugwood, Jonathan Tugwood, Ruth Roberts, Erik Lundholm, German Camejo, Inger Skånberg & John Evans. (2007) Tesaglitazar, a PPARα/γ Agonist, Induces Interstitial Mesenchymal Cell DNA Synthesis and Fibrosarcomas in Subcutaneous Tissues in Rats. Toxicological Sciences 98:1, pages 63-74.
Crossref
Feng Chang, Linda A Jaber, Helen D Berlie & Mary Beth O'Connell. (2007) Evolution of Peroxisome Proliferator-Activated Receptor Agonists. Annals of Pharmacotherapy 41:6, pages 973-983.
Crossref
Young-Ran KangChoong-Hwan KwakJin-Yong Hwang. (2007) Safety and Efficacy of Peroxisome Proliferator-Activated Receptor-α Agonist for Treating Cardiovascular Disease. Korean Circulation Journal 37:12, pages 599.
Crossref

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