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Review

Reaching goal in hypercholesterolaemia: dual inhibition of cholesterol synthesis and absorption with simvastatin plus ezetimibe

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Pages 511-528 | Accepted 17 Jan 2006, Published online: 01 Feb 2006

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Matilda Florentin, Evangelos N Liberopoulos, Dimitri P Mikhailidis & Moses S Elisaf. (2011) Emerging options in the treatment of dyslipidemias: a bright future?. Expert Opinion on Emerging Drugs 16:2, pages 247-270.
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Dimitri P. Mikhailidis, Richard W. Lawson, Anna-Louise McCormick, Gillian C. Sibbring, Andrew M. Tershakovec, Glenn M. Davies & Kaan Tunceli. (2011) Comparative efficacy of the addition of ezetimibe to statin vs statin titration in patients with hypercholesterolaemia: systematic review and meta-analysis. Current Medical Research and Opinion 27:6, pages 1191-1210.
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Germán Gómez Briseño & Dolores Mino-León. (2010) Cost-effectiveness of rosuvastatin versus ezetimibe/simvastatin in managing dyslipidemic patients in Mexico. Current Medical Research and Opinion 26:5, pages 1075-1081.
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I. Migdalis, A. Efthimiadis, St. Pappas, D. Alexopoulos, F. Vlasserou & D. P. Mikhailidis. (2009) Clinical experience with ezetimibe/simvastatin in a Mediterranean population. Current Medical Research and Opinion 25:10, pages 2571-2576.
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Steven K. Hildemann, Christian Barho, Barbara Karmann, Harald Darius & Christoph Bode. (2008) Sustained effects in hypercholesterolaemic patients on combined simvastatin/ezetimibe treatment: observational cohort study in clinical practice. Current Medical Research and Opinion 24:10, pages 2777-2784.
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CS Derdemezis, TD Filippatos, AD Tselepis, DP Mikhailidis & MS Elisaf. (2008) Effects of ezetimibe, either alone or in combination with atorvastatin, on serum visfatin levels: a pilot study. Expert Opinion on Pharmacotherapy 9:11, pages 1829-1837.
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E. S. Nakou, T. D. Filippatos, M. Georgoula, D. N. Kiortsis, A. D. Tselepis, D. P. Mikhailidis & M. S. Elisaf. (2008) The effect of orlistat and ezetimibe, alone or in combination, on serum LDL and small dense LDL cholesterol levels in overweight and obese patients with hypercholesterolaemia. Current Medical Research and Opinion 24:7, pages 1919-1929.
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Minna T Jänis, Reijo Laaksonen & Matej Oresic. (2008) Metabolomic strategies to identify tissue-specific effects of cardiovascular drugs. Expert Opinion on Drug Metabolism & Toxicology 4:6, pages 665-680.
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Vasilios G Athyros, Konstantinos Tziomalos, Dimitri P Mikhailidis, Efstathios D Pagourelias, Anna I Kakafika, Athanasios Skaperdas, Apostolos Hatzitolios & Asterios Karagiannis. (2007) Do we need a statin-nicotinic acid-aspirin mini-polypill to treat combined hyperlipidaemia?. Expert Opinion on Pharmacotherapy 8:14, pages 2267-2277.
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Konstantinos Tziomalos, Vasilios G Athyros, Asterios Karagiannis & Dimitri P Mikhailidis. (2007) Endothelial function, arterial stiffness and lipid lowering drugs. Expert Opinion on Therapeutic Targets 11:9, pages 1143-1160.
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Irene F. Gazi, Stella S. Daskalopoulou, Devaki R. Nair & Dimitri P. Mikhailidis. (2007) Effect of ezetimibe in patients who cannot tolerate statins or cannot get to the low density lipoprotein cholesterol target despite taking a statin. Current Medical Research and Opinion 23:9, pages 2183-2192.
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D. P. Mikhailidis, G. C. Sibbring, C. M. Ballantyne, G. M. Davies & A. L. Catapano. (2007) Meta-analysis of the cholesterol-lowering effect of ezetimibe added to ongoing statin therapy. Current Medical Research and Opinion 23:8, pages 2009-2026.
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Mihalis Kalogirou, Vasilis Tsimihodimos, Irene Gazi, Theodosios Filippatos, Vasilis Saougos, Alexandros D. Tselepis, Dimitri P. Mikhailidis & Moses Elisaf. (2007) Effect of ezetimibe monotherapy on the concentration of lipoprotein subfractions in patients with primary dyslipidaemia. Current Medical Research and Opinion 23:5, pages 1169-1176.
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Irene F Gazi & Dimitri P Mikhailidis. (2006) Non-low-density lipoprotein cholesterol-associated actions of ezetimibe: an overview. Expert Opinion on Therapeutic Targets 10:6, pages 851-866.
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Stella S. Daskalopoulou & Dimitri P. Mikhailidis. (2006) Ezetimibe/simvastatin single tablet versus rosuvastatin in patients with hypercholesterolemia. Current Medical Research and Opinion 22:10, pages 2037-2039.
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Lieske Kuitert. (2006) Introduction: inhaled insulins:potential therapies for diabetes mellitus. Current Medical Research and Opinion 22:sup3, pages S1-S4.
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Patrick Wainwright, Aidan Ryan, Rasaq Olufadi & Christopher D Byrne. 2005. Encyclopedia of Life Sciences. Encyclopedia of Life Sciences 1 12 .
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Harold E. Bays, Scott E. Conard, Lawrence A. Leiter, Steven R. Bird, Robert S. Lowe & Andrew M. Tershakovec. (2011) Influence of age, gender, and race on the efficacy of adding ezetimibe to atorvastatin vs. atorvastatin up-titration in patients at moderately high or high risk for coronary heart disease. International Journal of Cardiology 153:2, pages 141-147.
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Scott E. Conard, Harold E. Bays, Lawrence A. Leiter, Steven R. Bird, Joseph Rubino, Robert S. Lowe, Joanne E. Tomassini & Andrew M. Tershakovec. (2008) Efficacy and Safety of Ezetimibe Added on to Atorvastatin (20 mg) Versus Uptitration of Atorvastatin (to 40 mg) in Hypercholesterolemic Patients at Moderately High Risk for Coronary Heart Disease††Conflicts of interest: Dr. Conard served as a consultant and advisor for Merck & Company and Merck/Schering-Plough. Dr. Bays received research grants from Amylin, San Diego, California, Amgen, Thousand Oaks, California, J&J, Langhorne, Pennsylvania, Aegerion, Bridgewater, New Jersey, Abbott, Chicago, Illinois, Arena Pharmaceuticals, San Diego, California, GlaxoSmithKline (Glaxo), London, UK, Hoffmann LaRoche, Nutley, New Jersey, Merck, Whitehouse Station, New Jersey, MSP, Kenilworth, New Jersey, Metabolex, San Jose, California, Schering-Plough, Kenilworth, New Jersey, Orexigen, San Diego, California, Reliant, Liberty Corner, New Jersey, Sciele, Atlanta, Georgia, Takeda, Osaka, Japan, TAP, Lake Forest, Illinois, and Vivus, Mountain View, California; received speakers' honoraria from Abbott, Daiichi Sankyo, Tokyo, Japan, GlaxoSmithKline, Reliant, Merck & Company, Merck/Schering-Plough, and Schering-Plough; received honoraria from Abbott, AstraZeneca, London, UK (Wilmington, Delaware, US Headquarters), Daiichi Sankyo, GlaxoSmithKline, Reliant, Merck & Company, Merck/Schering-Plough, and Schering-Plough; and served as a consultant and advisor for Abbott, GlaxoSmithKline, Metabolex, San Jose, California, Reliant, Takeda, AstraZeneca, and Essentialis, Carlsbad, California. Dr. Leiter received grants and speakers' honoraria from and served as a consultant and advisor for AstraZeneca, Merck & Company, Merck/Schering-Plough, and Pfizer, New York, New York. Mr. Bird, Mr. Rubino, and Drs. Lowe, Tomassini, and Tershakovec are employees of Merck & Company and may own stock and/or hold stock options in the company.. The American Journal of Cardiology 102:11, pages 1489-1494.
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Dimitri P. Mikhailidis. 2008. Vascular Complications in Human Disease. Vascular Complications in Human Disease 179 186 .
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Anthony S. Wierzbicki. (2007) Targets - who needs them? Success with statin therapies. International Journal of Clinical Practice 61:8, pages 1239-1242.
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Anthony S Wierzbicki. (2007) How aggressively should cholesterol targets be pursued?. British Journal of Hospital Medicine 68:5, pages 232-233.
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Anna I. Kakafika, Dimitri P. Mikhailidis, Asterios Karagiannis & Vasilios G. Athyros. (2007) The Role of Endocannabinoid System Blockade in the Treatment of the Metabolic Syndrome. The Journal of Clinical Pharmacology 47:5, pages 642-652.
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Irina A. Pikuleva. (2006) Cytochrome P450s and cholesterol homeostasis. Pharmacology & Therapeutics 112:3, pages 761-773.
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