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Current Medical Research and Opinion Volume 23, 2007 - Issue 3
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Brief Review

Verteporfin photodynamic therapy and anti-angiogenic drugs: potential for combination therapy in exudative age-related macular degeneration

P. K. Kaiser Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USACorrespondence[email protected]
Pages 477-487 | Accepted 09 Jan 2007, Published online: 25 Jan 2007

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Martina Santarelli, Laura Diplotti, Francesco Samassa, Daniele Veritti, Baruch D Kuppermann & Paolo Lanzetta. (2015) Advances in pharmacotherapy for wet age-related macular degeneration. Expert Opinion on Pharmacotherapy 16:12, pages 1769-1781.
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Nathan Steinle, Mark Barakat, Darius Moshfeghi & Peter K Kaiser. (2011) Radiation therapy in the treatment of exudative age-related macular degeneration. Expert Review of Ophthalmology 6:3, pages 323-337.
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Jean Pierre Hubschman, Shantan Reddy & Steven D Schwartz. (2009) Age-related macular degeneration: current treatments. Clinical Ophthalmology 3, pages 155-166.
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Peter K. Kaiser. (2009) Verteporfin PDT for subfoveal occult CNV in AMD: two-year results of a randomized trial. Current Medical Research and Opinion 25:8, pages 1853-1860.
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M Vaughn Emerson & Andreas K Lauer. (2008) Current and emerging therapies for the treatment of age-related macular degeneration. Clinical Ophthalmology 2:2, pages 377-388.
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Irene A Barbazetto & Beatriz S Takahashi. (2008) Verteporfin photodynamic therapy in the age of antiangiogenic therapy. Expert Review of Ophthalmology 3:4, pages 365-383.
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Articles from other publishers (35)

Xue-Wei Wang, Rong Zhao, Zi-Yi Yang, Ting Li, Jia-Cheng Yang, Xiu-Li Wang, Xin-Ting Li, Xin-Ran Zhao, Xiao-Zhong Li & Xiao-Xia Wang. (2023) YAP inhibitor verteporfin suppresses tumor angiogenesis and overcomes chemoresistance in esophageal squamous cell carcinoma. Journal of Cancer Research and Clinical Oncology 149:10, pages 7703-7716.
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Ming Yang, Kwok-Fai So, Wai Ching Lam & Amy Cheuk Yin Lo. (2020) Novel Programmed Cell Death as Therapeutic Targets in Age-Related Macular Degeneration?. International Journal of Molecular Sciences 21:19, pages 7279.
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Gloria Cimaglia, Marcela Votruba, James E. Morgan, Helder André & Pete A. Williams. (2020) Potential Therapeutic Benefit of NAD+ Supplementation for Glaucoma and Age-Related Macular Degeneration. Nutrients 12:9, pages 2871.
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Katja Hatz, Ulrike Schneider, P. Bernhard Henrich, Beatrice Braun, Stefan Sacu & Christian Prünte. (2015) Ranibizumab plus Verteporfin Photodynamic Therapy in Neovascular Age-Related Macular Degeneration: 12 Months of Retreatment and Vision Outcomes from a Randomized Study. Ophthalmologica 233:2, pages 66-73.
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Naoto Shirasu, Hiromi Yamada, Hirotomo Shibaguchi, Motomu Kuroki & Masahide Kuroki. (2014) Potent and specific antitumor effect of CEA-targeted photoimmunotherapy. International Journal of Cancer 135:11, pages 2697-2710.
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M. Barakat, N. Steinle & P. K. Kaiser. 2013. Age-related Macular Degeneration. Age-related Macular Degeneration 247 261 .
Fumi Gomi, Miki Sawa, Motokazu Tsujikawa & Kohji Nishida. (2012) TOPICAL BROMFENAC AS AN ADJUNCTIVE TREATMENT WITH INTRAVITREAL RANIBIZUMAB FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION. Retina 32:9, pages 1804-1810.
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Patrycja Nowak‐Sliwinska, Andrea Weiss, Judy R. van Beijnum, Tse J. Wong, Jean‐Pierre Ballini, Blaise Lovisa, Hubert van den Bergh & Arjan W. Griffioen. (2012) Angiostatic kinase inhibitors to sustain photodynamic angio‐occlusion. Journal of Cellular and Molecular Medicine 16:7, pages 1553-1562.
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Peter K. Kaiser, David S. Boyer, Alan F. Cruess, Jason S. Slakter, Stefan Pilz & Annemarie Weisberger. (2012) Verteporfin plus Ranibizumab for Choroidal Neovascularization in Age-Related Macular Degeneration. Ophthalmology 119:5, pages 1001-1010.
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Michael Larsen, Ursula Schmidt-Erfurth, Paolo Lanzetta, Sebastian Wolf, Christian Simader, Erika Tokaji, Stefan Pilz & Annemarie Weisberger. (2012) Verteporfin plus Ranibizumab for Choroidal Neovascularization in Age-related Macular Degeneration. Ophthalmology 119:5, pages 992-1000.
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Chongzhao Ran, Zhaoda Zhang, Jacob Hooker & Anna Moore. (2011) In Vivo Photoactivation Without “Light”: Use of Cherenkov Radiation to Overcome the Penetration Limit of Light. Molecular Imaging and Biology 14:2, pages 156-162.
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Je-Ok Yoo & Kwon-Soo Ha. 2012. 139 174 .
Stefan Scholl & Albert J. Augustin. 2012. Studies on Retinal and Choroidal Disorders. Studies on Retinal and Choroidal Disorders 501 515 .
Rosalia Giustolisi, Nicoletta Fantozzi, Mariateresa Staltari, Jessica Marchiori, Olga Mastrangelo, Roberta Marcucci, Federica Mirra, Paola Mazzotta, Corrado Balacco Gabrieli & The Luce Study Group. (2011) Combined intravitreal ranibizumab and verteporfin photodynamic therapy versus ranibizumab alone for the treatment of age-related macular degeneration. Digital Journal of Ophthalmology 17:3, pages 23-30.
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Ute E. K. Wolf-Schnurrbusch, Christian K. Brinkmann, Lisa Berger & Sebastian Wolf. (2011) Effects of combination therapy with verteporfin photodynamic therapy and ranibizumab in patients with age-related macular degeneration. Acta Ophthalmologica 89:6, pages 585-590.
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Ziad F Bashshur, Alex R Schakal, Georges M El-Mollayess, Samer Arafat, Dalida Jaafar & Haytham I Salti. (2011) RANIBIZUMAB MONOTHERAPY VERSUS SINGLE-SESSION VERTEPORFIN PHOTODYNAMIC THERAPY COMBINED WITH AS-NEEDED RANIBIZUMAB TREATMENT FOR THE MANAGEMENT OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION. Retina 31:4, pages 636-644.
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Hyun Woong KimJung Lim KimMi Hyun LeeHyung Gon YooIn Young ChungJi Eun Lee. (2011) Combined Treatment of Photodynamic Therapy and Bevacizumab for Choroidal Neovascularization Secondary to Age-Related Macular Degeneration. Korean Journal of Ophthalmology 25:4, pages 231.
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Frank G. Holz, Daniel Pauleikhoff, Richard F. Spaide & Alan C. BirdMark R. Barakat, Nathan Steinle & Peter K. Kaiser. 2011. Altersabhängige Makuladegeneration. Altersabhängige Makuladegeneration 253 268 .
Nathan Steinle & Peter K. Kaiser. 2011. Age-related Macular Degeneration Diagnosis and Treatment. Age-related Macular Degeneration Diagnosis and Treatment 99 118 .
Jorn-Hon LiuHsiung WannMi-Mi ChenWynn H.T. PanYei-Ching ChenChi-Ming LiuMing-Yang YehShen-Kou TsaiMason Shing YoungHui-Yen ChuangFang-Ping ChaoHsiao-Ming Chao. (2010) Baicalein Significantly Protects Human Retinal Pigment Epithelium Cells Against H 2 O 2 -Induced Oxidative Stress by Scavenging Reactive Oxygen Species and Downregulating the Expression of Matrix Metalloproteinase-9 and Vascular Endothelial Growth Factor . Journal of Ocular Pharmacology and Therapeutics 26:5, pages 421-429.
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Michael J. Wan, Phil L. Hooper & Tom G. Sheidow. (2010) Combination therapy in exudative age-related macular degeneration: visual outcomes following combined treatment with photodynamic therapy and intravitreal bevacizumab. Canadian Journal of Ophthalmology 45:4, pages 375-380.
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M. Wakui, Yoshihito Yokoyama, H. Wang, T. Shigeto, M. Futagami & H. Mizunuma. (2010) Efficacy of a methyl ester of 5-aminolevulinic acid in photodynamic therapy for ovarian cancers. Journal of Cancer Research and Clinical Oncology 136:8, pages 1143-1150.
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Fumi Gomi, Miki Sawa, Taku Wakabayashi, Yuzuru Sasamoto, Mihoko Suzuki & Motokazu Tsujikawa. (2010) Efficacy of Intravitreal Bevacizumab Combined With Photodynamic Therapy for Polypoidal Choroidal Vasculopathy. American Journal of Ophthalmology 150:1, pages 48-54.e1.
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Jorn-Hon LiuMi-Mi ChenJhao-Wei HuangHsiung WannLi-Kang HoWynn H.T. PanYei-Ching ChenChi-Ming LiuMing-Yang YehShen-Kou TsaiMason Shing YoungLow-Tone HoCheng-Deng KuoHui-Yen ChuangFang-Ping ChaoHsiao-Ming Chao. (2010) Therapeutic Effects and Mechanisms of Action of Mannitol During H 2 O 2 -Induced Oxidative Stress in Human Retinal Pigment Epithelium Cells . Journal of Ocular Pharmacology and Therapeutics 26:3, pages 249-257.
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Yong TaoJost B. Jonas. (2010) Intravitreal Bevacizumab Combined With Intravitreal Triamcinolone for Therapy-Resistant Exudative Age-Related Macular Degeneration. Journal of Ocular Pharmacology and Therapeutics 26:2, pages 207-212.
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Elodie Debefve, Bernadette Pegaz, Jean-Pierre Ballini & Hubert van den Bergh. (2009) Combination Therapy Using Verteporfin and Ranibizumab; Optimizing the Timing in the CAM Model. Photochemistry and Photobiology 85:6, pages 1400-1408.
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Peter K. Kaiser. (2009) Verteporfin Photodynamic Therapy Combined With Intravitreal Bevacizumab for Neovascular Age-Related Macular Degeneration. Ophthalmology 116:4, pages 747-755.e1.
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Gregg T. Kokame & John H. Drouilhet. (2009) SUCCESSFUL COMBINED PHOTODYNAMIC AND INTRAVITREAL AVASTIN THERAPY FOR SUBFOVEAL CHOROIDAL NEOVASCULARIZATION IN A CHILD. RETINAL Cases & Brief Reports 3:1, pages 89-92.
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Zheng Rong Lu & Anagha Vaidya. 2009. Pharmaceutical Perspectives of Cancer Therapeutics. Pharmaceutical Perspectives of Cancer Therapeutics 581 599 .
ATUL KUMAR, KIRAN GOPALAKRISHNAN & SUBIJOY SINHA. (2008) COMBINATION PHOTODYNAMIC THERAPY AND INTRAVITREAL RANIBIZUMAB IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION IN A NORTH INDIAN POPULATION. Retina 28:9, pages 1296-1301.
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ATUL KUMAR, KIRAN GOPALAKRISHNAN & SUBIJOY SINHA. (2008) COMBINATION PHOTODYNAMIC THERAPY AND INTRAVITREAL RANIBIZUMAB IN NEOVASCULAR AMD IN A NORTH INDIAN POPULATION. Retina 28:8, pages 1132-1137.
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Gary D. Novack. (2008) Pharmacotherapy for the Treatment of Choroidal Neovascularization Due to Age-Related Macular Degeneration. Annual Review of Pharmacology and Toxicology 48:1, pages 61-78.
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Asta Juzeniene, Qian Peng & Johan Moan. (2007) Milestones in the development of photodynamic therapy and fluorescence diagnosis. Photochemical & Photobiological Sciences 6:12, pages 1234-1245.
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Alfredo Adán & Ricardo P. Casaroli-Marano. (2007) Nuevos aspectos terapéuticos en la degeneración macular asociada a la edad. Medicina Clínica 129:17, pages 658-659.
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Albert J Augustin & Indre Offermann. (2007) Combination Therapy for Choroidal Neovascularisation. Drugs & Aging 24:12, pages 979-990.
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