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Current Medical Research and Opinion Volume 23, 2007 - Issue 8
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Original Article

Preoperative statins and infectious complications following cardiac surgery

Craig I. Coleman Division of Cardiology, Hartford Hospital, Hartford, CT, USA; University of Connecticut School of Pharmacy, Storrs, CT, USA
,
Diana M. Lucek Division of Cardiology, Hartford Hospital, Hartford, CT, USA; University of Connecticut School of Pharmacy, Storrs, CT, USA
,
Jonathan Hammond Division of Cardiology, Hartford Hospital, Hartford, CT, USA; Division of Cardiothoracic Surgery, Hartford Hospital, Hartford, CT, USA
&
C. Michael White Division of Cardiology, Hartford Hospital, Hartford, CT, USA; University of Connecticut School of Pharmacy, Storrs, CT, USACorrespondence[email protected]
Pages 1783-1790 | Accepted 18 May 2007, Published online: 26 Jun 2007

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Alexander Kulik & Marc Ruel. (2009) Statins and coronary artery bypass graft surgery: preoperative and postoperative efficacy and safety. Expert Opinion on Drug Safety 8:5, pages 559-571.
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Articles from other publishers (53)

Pradeep Narayan, Abhyuday Kumara Swamy, Paramita Auddya Ghorai, Prateek Singh Rautela, Santhosh Rathnam Palani & Vivek Rajagopal. (2022) Effect of preoperative statins on respiratory complications after coronary artery bypass grafting. Journal of Cardiac Surgery 37:12, pages 4639-4645.
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Kaitlin A. Nguyen, George A. Taylor, Theresa K. Webster, Rachel A. Jenkins, Nicklaus S. Houston, Dylan L. Kahler, Andrew A. Gassman & Christine M. Jones. (2022) Incisional Negative Pressure Wound Therapy Is Protective Against Postoperative Cardiothoracic Wound Infection. Annals of Plastic Surgery 88:3, pages S197-S200.
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Heidi E. Steiner, Kevin Gee, Jason Giles, Hayley Knight, Bonnie L Hurwitz & Jason H. Karnes. (2021) Role of the gut microbiome in cardiovascular drug response: The potential for clinical application. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 42:2, pages 165-176.
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S. Scott Sutton, Joseph C. Magagnoli, Tammy H. Cummings & James W. Hardin. (2021) Statin Exposure and Risk of Prosthetic Joint Infection After Total Knee or Hip Arthroplasty Among U.S. Veterans. The Journal of Arthroplasty 36:10, pages 3584-3588.e1.
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Ryu Komatsu, Huseyin Oguz Yilmaz, Natalya Makarova, Alparslan Turan, Daniel I. Sessler, Shobana Rajan & Maged Argalious. (2020) Association Between Preoperative Statin Use and Respiratory Complications After Noncardiac Surgery: A Retrospective Cohort Analysis. Anesthesia & Analgesia 133:1, pages 123-132.
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L Salm, W R Marti, D J Stekhoven, C Kindler, M Von Strauss, E Mujagic & W P Weber. (2021) Impact of bodyweight-adjusted antimicrobial prophylaxis on surgical-site infection rates. BJS Open 5:2.
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Harold L. Lazar. 2021. Technical Aspects of Modern Coronary Artery Bypass Surgery. Technical Aspects of Modern Coronary Artery Bypass Surgery 313 336 .
Umar Ali, Liam Bibo, Madison Pierre, Nicholas Bayfield, Lior Raichel, Chris Merry & Robert Larbalestier. (2020) Deep Sternal Wound Infections After Cardiac Surgery: A New Australian Tertiary Centre Experience. Heart, Lung and Circulation 29:10, pages 1571-1578.
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P Lüthje, S Walker, W Kamolvit, S Mohanty, K Pütsep & A Brauner. (2019) Statins influence epithelial expression of the anti-microbial peptide LL-37/hCAP-18 independently of the mevalonate pathway. Clinical and Experimental Immunology 195:2, pages 265-276.
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Jesper Smit, Luis Eduardo López-Cortés, Reimar W. Thomsen, Henrik C. Schønheyder, Henrik Nielsen, Trine Frøslev, Jesús Rodríguez-Bãno & Mette Søgaard. (2017) Statin Use and Risk of Community-Acquired Staphylococcus aureus Bacteremia: A Population-Based Case-Control Study. Mayo Clinic Proceedings 92:10, pages 1469-1478.
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Kuan-Fu Liao, Kao-Chi Cheng, Cheng-Li Lin & Shih-Wei Lai. (2017) Statin Use Correlates with Reduced Risk of Pyogenic Liver Abscess: A Population-Based Case-Control Study. Basic & Clinical Pharmacology & Toxicology 121:2, pages 144-149.
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Ryu KomatsuHuseyin Oguz YilmazJing YouC. Allen BashourShobana RajanEdward G. SolteszDaniel I. SesslerAlparslan Turan. (2017) Lack of Association between Preoperative Statin Use and Respiratory and Neurologic Complications after Cardiac Surgery. Anesthesiology 126:5, pages 799-809.
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Tomonobu Beika & Dai Une. (2017) Optimal medical therapy to improve saphenous vein graft patency. Journal of the Japanese Coronary Association 23:3, pages 196-203.
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Alessandro Putzu, Bruno Capelli, Alessandro Belletti, Tiziano Cassina, Enrico Ferrari, Michele Gallo, Gabriele Casso & Giovanni Landoni. (2016) Perioperative statin therapy in cardiac surgery: a meta-analysis of randomized controlled trials. Critical Care 20:1.
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Abdulrahman F. AlruwailyBrian H. EisnerMaggie J. BierleinKhurshid R. GhaniJ. Stuart WolfJr.Jr., Brent K. HollenbeckJohn M. Hollingsworth. (2015) Statin Use and Risk of Sepsis After Percutaneous Nephrolithotomy. Journal of Endourology 29:10, pages 1126-1130.
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Elmar W Kuhn, Ingo Slottosch, Thorsten Wahlers & Oliver J Liakopoulos. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
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Kotaro Nochioka, Yasuhiko Sakata, Satoshi Miyata, Masanobu Miura, Tsuyoshi Takada, Soichiro Tadaki, Ryoichi Ushigome, Takeshi Yamauchi, Jun Takahashi & Hiroaki Shimokawa. (2015) Prognostic Impact of Statin Use in Patients With Heart Failure and Preserved Ejection Fraction. Circulation Journal 79:3, pages 574-582.
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Gerwin Erik Engels & Willem van Oeveren. (2015) Biomarkers of Lung Injury in Cardiothoracic Surgery. Disease Markers 2015, pages 1-10.
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S. C. A. M. Bekkers. (2014) The reduction of post-cardiac surgery infections by statins: solid evidence?. Netherlands Heart Journal 22:11, pages 501-502.
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N. L. Hartholt, T. C. D. Rettig, M. Schijffelen, W. J. Morshuis, E. M. W. van de Garde & P. G. Noordzij. (2014) Preoperative statin therapy and infectious complications in cardiac surgery. Netherlands Heart Journal 22:11, pages 503-509.
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Laurent Lagrost, Claude Girard, Sandrine Grosjean, David Masson, Valérie Deckert, Thomas Gautier, Frédérique Debomy, Sandrine Vinault, Aline Jeannin, Jérôme Labbé & Claire Bonithon-Kopp. (2014) Low Preoperative Cholesterol Level Is a Risk Factor of Sepsis and Poor Clinical Outcome in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass*. Critical Care Medicine 42:5, pages 1065-1073.
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Shervin Shokuhi, Ilad Alavi Darazam, Giv Sharifi, Latif Gachkar, Anahita Amirsardari & Mohammad Samadian. (2014) Statins and Postoperative Infections: A Randomized Clinical Trial. Jundishapur Journal of Microbiology 7:4.
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Elmar W. Kuhn, Oliver J. Liakopoulos, Sebastian Stange, Antje-Christin Deppe, Ingo Slottosch, Yeong-Hoon Choi & Thorsten Wahlers. (2014) Preoperative statin therapy in cardiac surgery: a meta-analysis of 90 000 patients†. European Journal of Cardio-Thoracic Surgery 45:1, pages 17-26.
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Waleed T. Kayani, Salman J. Bandeali, Vei-Vei Lee, MacArthur Elayda, Anam Khan, Vijay Nambi, Hani Jneid, Mahboob Alam, James M. Wilson, Henry D. Huang, Yochai Birnbaum, Christie M. Ballantyne & Salim S. Virani. (2013) Association between statins and infections after coronary artery bypass grafting. International Journal of Cardiology 168:1, pages 117-120.
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Inderjeet Singh, Sujit Rajagopalan, Anand Srinivasan, Shyambalaji Achuthan, Puneet Dhamija, Debasish Hota & Amitava Chakrabarti. (2013) Preoperative statin therapy is associated with lower requirement of renal replacement therapy in patients undergoing cardiac surgery: a meta-analysis of observational studies. Interactive CardioVascular and Thoracic Surgery 17:2, pages 345-352.
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Matteo Trezzi, Eugene H. Blackstone, Zhiyuan Sun, Liang Li, Joseph F. SabikIIIIII, Bruce W. Lytle, Steven M. Gordon & Colleen G. Koch. (2013) Statin Therapy Is Associated With Fewer Infections After Cardiac Operations. The Annals of Thoracic Surgery 95:3, pages 892-900.
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Imad M. Tleyjeh, Faisal A. Alasmari, Aref A. Bin Abdulhak, Muhammad Riaz, Musa A. Garbati, Patricia J. Erwin, Tarek Kashour, Mouaz H. Al-Mallah & Larry M. Baddour. (2015) Association between Preoperative Statin Therapy and Postoperative Infectious Complications in Patients Undergoing Cardiac Surgery: A Systematic Review and Meta-analysis. Infection Control & Hospital Epidemiology 33:11, pages 1143-1151.
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L. David HillisPeter K. SmithJeffrey L. AndersonJohn A. BittlCharles R. BridgesJohn G. ByrneJoaquin E. CigarroaVerdi J. DiSesaLoren F. HiratzkaAdolph M. HutterJrJrMichael E. JessenEllen C. KeeleyStephen J. LaheyRichard A. LangeMartin J. LondonMichael J. MackManesh R. PatelJohn D. PuskasJoseph F. SabikOla SelnesDavid M. ShahianJeffrey C. TrostMichael D. Winniford. (2011) 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery. Circulation 124:23.
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L. David Hillis, Peter K. Smith, Jeffrey L. Anderson, John A. Bittl, Charles R. Bridges, John G. Byrne, Joaquin E. Cigarroa, Verdi J. DiSesa, Loren F. Hiratzka, Adolph M. HutterJrJr, Michael E. Jessen, Ellen C. Keeley, Stephen J. Lahey, Richard A. Lange, Martin J. London, Michael J. Mack, Manesh R. Patel, John D. Puskas, Joseph F. Sabik, Ola Selnes, David M. Shahian, Jeffrey C. Trost & Michael D. Winniford. (2011) 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery. Journal of the American College of Cardiology 58:24, pages e123-e210.
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Elmar W. Kuhn, Oliver J. Liakopoulos, Yeong H. Choi & Thorsten Wahlers. (2011) Current Evidence for Perioperative Statins in Cardiac Surgery. The Annals of Thoracic Surgery 92:1, pages 372-379.
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Christos G. Mihos, Maria J. Salas & Orlando Santana. (2010) The Pleiotropic Effects of the Hydroxy-Methyl-Glutaryl-CoA Reductase Inhibitors in Cardiovascular Disease. Cardiology in Review 18:6, pages 298-304.
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Kosmas I. Paraskevas & Dimitri P. Mikhailidis. (2010) Statins may not prevent structural valve degeneration of aortic bioprosthetic valves, but should probably be prescribed to patients undergoing heart valve surgery nonetheless. Interactive CardioVascular and Thoracic Surgery 11:3, pages 302-302.
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Linda Björkhem-Bergman, Peter Bergman, Jan Andersson & Jonatan D. Lindh. (2010) Statin Treatment and Mortality in Bacterial Infections – A Systematic Review and Meta-Analysis. PLoS ONE 5:5, pages e10702.
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Luc de Saint Martin, Didier Tandé, David Goetghebeur, Marie Pan-Lamandé, Yann Segalen & Elisabeth Pasquier. (2010) Statin use does not affect the outcome of acute infection: a prospective cohort study. La Presse Médicale 39:3, pages e52-e57.
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Oliver J. Liakopoulos, Yeong-Hoon Choi, Elmar W. Kuhn, Thorsten Wittwer, Michal Borys, Navid Madershahian, Gernot Wassmer & Thorsten Wahlers. (2009) Statins for prevention of atrial fibrillation after cardiac surgery: A systematic literature review. The Journal of Thoracic and Cardiovascular Surgery 138:3, pages 678-686.e1.
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Felix J.V. Schlösser, Marco J.D. Tangelder, Frans L. Moll & Don Poldermans. (2008) Reply. Journal of Vascular Surgery 48:6, pages 1638-1639.
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