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Original Article

Evaluation of the potential for steady-state pharmacokinetic interaction between vildagliptin and simvastatin in healthy subjects*

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Pages 2913-2920 | Accepted 23 Aug 2007, Published online: 09 Oct 2007

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Read on this site (13)

Sri Harsha Tella & Marc S Rendell. (2015) DPP-4 inhibitors: focus on safety. Expert Opinion on Drug Safety 14:1, pages 127-140.
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Theodosios D Filippatos, Vasilios G Athyros & Moses S Elisaf. (2014) The pharmacokinetic considerations and adverse effects of DDP-4 inhibitors. Expert Opinion on Drug Metabolism & Toxicology 10:6, pages 787-812.
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Thomas Forst & Peter Bramlage. (2014) Vildagliptin, a DPP-4 inhibitor for the twice-daily treatment of type 2 diabetes mellitus with or without metformin. Expert Opinion on Pharmacotherapy 15:9, pages 1299-1313.
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Stephanie A Stein, Elizabeth M Lamos & Stephen N Davis. (2014) Vildagliptin, a dipeptidyl peptidase-4 inhibitor, for the treatment of type 2 diabetes. Expert Opinion on Drug Metabolism & Toxicology 10:4, pages 599-608.
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Ibrahim Gueler, Susanne Mueller, Matthias Helmschrott, Christian U Oeing, Christian Erbel, Lutz Frankenstein, Christian Gleißner, Arjang Ruhparwar, Philipp Ehlermann, Thomas J Dengler, Hugo A Katus & Andreas O Doesch. (2013) Effects of vildagliptin (Galvus®) therapy in patients with type 2 diabetes mellitus after heart transplantation. Drug Design, Development and Therapy 7, pages 297-303.
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Ling-Ling Dai, Lan Fan, Hui-Zi Wu, Zhi-Rong Tan, Yao Chen, Xiang-Dong Peng, Min-Xue Shen, Guo-Ping Yang & Hong-Hao Zhou. (2013) Assessment of a pharmacokinetic and pharmacodynamic interaction between simvastatin and Ginkgo biloba extracts in healthy subjects. Xenobiotica 43:10, pages 862-867.
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Matilda Florentin & Moses S Elisaf. (2012) Simvastatin interactions with other drugs. Expert Opinion on Drug Safety 11:3, pages 439-444.
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Mary Elizabeth Cox, Jennifer Rowell, Leonor Corsino & Jennifer B Green. (2010) Dipeptidyl peptidase-4 inhibitors in the management of type 2 diabetes: safety, tolerability, and efficacy. Drug, Healthcare and Patient Safety 2, pages 7-19.
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S. Halimi, D. Raccah, A. Schweizer & S. Dejager. (2010) Role of vildagliptin in managing type 2 diabetes mellitus in the elderly. Current Medical Research and Opinion 26:7, pages 1647-1656.
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Anna I. Palalau, Abd A. Tahrani, Milan K. Piya & Anthony H. Barnett. (2009) DPP-4 Inhibitors in Clinical Practice. Postgraduate Medicine 121:6, pages 70-100.
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Moulinath Banerjee, Naveed Younis & Handrean Soran. (2009) Vildagliptin in clinical practice: a review of literature. Expert Opinion on Pharmacotherapy 10:16, pages 2745-2757.
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Andreas Holstein & Winfried Beil. (2009) Oral antidiabetic drug metabolism: pharmacogenomics and drug interactions. Expert Opinion on Drug Metabolism & Toxicology 5:3, pages 225-241.
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Serge Halimi, Anja Schweizer, Biljana Minic, James Foley & Sylvie Dejager. (2008) Combination treatment in the management of type 2 diabetes: focus on vildagliptin and metformin as a single tablet . Vascular Health and Risk Management 4:3, pages 481-492.
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Kunika Saini, Smriti Sharma & Yousuf Khan. (2023) DPP-4 inhibitors for treating T2DM - hype or hope? an analysis based on the current literature. Frontiers in Molecular Biosciences 10.
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Aikaterini Saiti, Alexandros Giannopoulos-Dimitriou, Ioannis Kazakos, Eleftheria Galatou & Ioannis S. Vizirianakis. (2023) Systems Pharmacology and Network Analysis to Advance Pharmacogenomics and Precision Medicine Decisions in Type-2 Diabetes Therapy. Future Pharmacology 3:1, pages 329-363.
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Donald J. AbrahamAnn E. Weber & Nancy A. Thornberry. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 48 .
Chin-Ying Ray, Victor Chien-Chia Wu, Chun-Li Wang, Hui-Tzu Tu, Yu-Tung Huang, Chang-Fu Kuo & Shang-Hung Chang. (2021) Hypoglycemia Associated With Drug–Drug Interactions in Patients With Type 2 Diabetes Mellitus Using Dipeptidylpeptidase-4 Inhibitors. Frontiers in Pharmacology 12.
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Beena Kumari & Aparna Khansili. (2020) Analytical Method Development and Validation of UV-visible Spectrophotometric Method for the Estimation of Vildagliptin in Gastric Medium. Drug Research 70:09, pages 417-423.
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Lee M. Tatham, Neill J. Liptrott, Steve P. Rannard & Andrew Owen. (2019) Long-Acting Injectable Statins—Is It Time for a Paradigm Shift?. Molecules 24:15, pages 2685.
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Naina Mohamed Pakkir Maideen. (2019) Drug interactions of dipeptidyl peptidase 4 inhibitors involving CYP enzymes and P-gp efflux pump. World Journal of Meta-Analysis 7:4, pages 156-161.
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Aimei Liu, Qinghua Wu, Jingchao Guo, Irma Ares, José-Luis Rodríguez, María-Rosa Martínez-Larrañaga, Zonghui Yuan, Arturo Anadón, Xu Wang & María-Aránzazu Martínez. (2019) Statins: Adverse reactions, oxidative stress and metabolic interactions. Pharmacology & Therapeutics 195, pages 54-84.
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N. A. Petunina, E. V. Goncharova & S. A. Potapova. (2017) CARDIOVASCULAR SAFETY OF GLIPTINS. FOCUS ON ALOGLIPTIN. Medical Council:3, pages 32-37.
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Gillian M. Keating. (2014) Vildagliptin: A Review of Its Use in Type 2 Diabetes Mellitus. Drugs 74:5, pages 587-610.
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Christina L. Aquilante, Michael F. Wempe, Maha S. Sidhom, Lisa A. Kosmiski & Julie A. Predhomme. (2013) Effect of ABCB1 polymorphisms and atorvastatin on sitagliptin pharmacokinetics in healthy volunteers. European Journal of Clinical Pharmacology 69:7, pages 1401-1409.
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A L Vertkin, A Iu Magomedova, V B Mychka, Iu V Prokhorova & A V Nosova. (2012) The efficacy of application of vildagliptin in the patints presenting with co-morbid pathology. Problems of Endocrinology 58:3, pages 41-45.
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Yan-Ling He. (2012) Clinical Pharmacokinetics and Pharmacodynamics of Vildagliptin. Clinical Pharmacokinetics 51:3, pages 147-162.
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Patrizia Gazzerro, Maria Chiara Proto, Giuseppina Gangemi, Anna Maria Malfitano, Elena Ciaglia, Simona Pisanti, Antonietta Santoro, Chiara Laezza & Maurizio Bifulco. (2012) Pharmacological Actions of Statins: A Critical Appraisal in the Management of Cancer. Pharmacological Reviews 64:1, pages 102-146.
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George P Samraj. (2011) Vildagliptin for the treatment of diabetes. Therapy 8:6, pages 703-719.
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Joshua J. Neumiller. (2011) Clinical Pharmacology of Incretin Therapies for Type 2 Diabetes Mellitus: Implications for Treatment. Clinical Therapeutics 33:5, pages 528-576.
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C. F. Deacon. (2011) Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review. Diabetes, Obesity and Metabolism 13:1, pages 7-18.
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Gillian M. Keating. (2010) Vildagliptin. Drugs 70:16, pages 2089-2112.
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André J. Scheen. (2010) Dipeptidylpeptitase-4 Inhibitors (Gliptins). Clinical Pharmacokinetics 49:9, pages 573-588.
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Joshua J Neumiller, Lindy Wood & R. Keith Campbell. (2010) Dipeptidyl Peptidase-4 Inhibitors for the Treatment of Type 2 Diabetes Mellitus. Pharmacotherapy 30:5, pages 463-484.
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Abd A. Tahrani, Milan K. Piya, Amy Kennedy & Anthony H. Barnett. (2010) Glycaemic control in type 2 diabetes: Targets and new therapies. Pharmacology & Therapeutics 125:2, pages 328-361.
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Donald J. AbrahamAnn E. Weber & Nancy A. Thornberry. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 39 76 .
Harunobu Ito, Teruaki Wajima, Masayuki Yamaguchi, Nobuyuki Mimori & Kaneo Sekiguchi. (2010) Preclinical and clinical findings of the dipeptidyl peptidase-4 inhibitor vildagliptin. Folia Pharmacologica Japonica 136:5, pages 299-308.
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C. Mathieu. (2009) The scientific evidence: vildagliptin and the benefits of islet enhancement. Diabetes, Obesity and Metabolism 11, pages 9-17.
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