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Original Article

Barriers to the initiation of, and persistence with, insulin therapy*

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Pages 3105-3112 | Accepted 24 Sep 2007, Published online: 30 Oct 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Samaneh Kalirai, Jasmina I Ivanova, Magaly Perez-Nieves, Judith J Stephenson, Irene Hadjiyianni, Michael Grabner, Roy Daniel Pollom, Caroline Geremakis, Beverly L Reed & Lawrence Fisher. (2020) Basal Insulin Initiation and Maintenance in Adults with Type 2 Diabetes Mellitus in the United States. Diabetes, Metabolic Syndrome and Obesity 13, pages 1023-1033.
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Magaly Perez-Nieves, Jasmina I. Ivanova, Irene Hadjiyianni, Chen Zhao, Dachuang Cao, Luke Schmerold, Samaneh Kalirai, Sarah King, Amy M. DeLozier, Howard G. Birnbaum & Mark Peyrot. (2017) Basal insulin initiation use and experience among people with type 2 diabetes mellitus with different patterns of persistence: results from a multi-national survey. Current Medical Research and Opinion 33:10, pages 1833-1842.
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Dilek Gogas Yavuz, Habip Bilen, Seda Sancak, Tayfun Garip, Zeliha Hekimsoy, Ibrahim Sahin, Murat Yilmaz, Hasan Aydin, Aysegul Atmaca, Murat Sert, Pinar Karakaya, Dilek Arpaci, Aytekin Oguz & Nilgun Guvener. (2016) Impact of telephonic interviews on persistence and daily adherence to insulin treatment in insulin-naïve type 2 diabetes patients: dropout study. Patient Preference and Adherence 10, pages 851-861.
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Dilek Gogas Yavuz, Sevim Ozcan & Oguzhan Deyneli. (2015) Adherence to insulin treatment in insulin-naïve type 2 diabetic patients initiated on different insulin regimens. Patient Preference and Adherence 9, pages 1225-1231.
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Eric Q. Wu, Steve Zhou, Andrew Yu, Mei Lu, Hari Sharma, Jasvinder Gill & Thomas Graf. (2012) Outcomes Associated with Post-Discharge Insulin Continuity in US Patients with Type 2 Diabetes Mellitus Initiating Insulin in the Hospital. Hospital Practice 40:4, pages 40-48.
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Machaon MK Bonafede, Anupama Kalsekar, Manjiri Pawaskar, Kimberly M Ruiz, Amelito M Torres, Karen R Kelly & Suellen M Curkendall. (2010) A retrospective database analysis of insulin use patterns in insulin-naïve patients with type 2 diabetes initiating basal insulin or mixtures. Patient Preference and Adherence 4, pages 147-156.
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Abhijit S. Gadkari & Colleen A. McHorney. (2010) Medication nonfulfillment rates and reasons: narrative systematic review. Current Medical Research and Opinion 26:3, pages 683-705.
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Articles from other publishers (29)

Kansak Boonpattharatthiti, Thitinan Saensook, Nipaporn Neelapaijit, Itsarawan Sakunrag, Ines Krass & Teerapon Dhippayom. (2023) The prevalence of adherence to insulin therapy in patients with diabetes: A systematic review and meta-analysis. Research in Social and Administrative Pharmacy.
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Carla Castillo-Laborde, Macarena Hirmas-Adauy, Isabel Matute, Anita Jasmen, Oscar Urrejola, Xaviera Molina, Camila Awad, Catalina Frey-Moreno, Sofia Pumarino-Lira, Fernando Descalzi-Rojas, Tomás José Ruiz & Barbara Plass. (2022) Barriers and Facilitators in Access to Diabetes, Hypertension, and Dyslipidemia Medicines: A Scoping Review. Public Health Reviews 43.
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Kentaro Okazaki, Noriyuki Takahashi, Tomotaka Shingaki, Magaly Perez-Nieves & Heather Stuckey. (2022) Key factors for overcoming psychological insulin resistance: A qualitative study in Japanese people with type 2 diabetes. Primary Care Diabetes 16:3, pages 411-416.
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Stijn Crutzen, Jamila Abou, Sanne E. Smits, Gert Baas, Jacqueline G. Hugtenburg, Mette Heringa, Petra Denig & Katja Taxis. (2021) Older people’s attitudes towards deprescribing cardiometabolic medication. BMC Geriatrics 21:1.
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Semih KALYON, Perihan ÖZKAN GÜMÜŞKAYA, Neslihan ÖZSOY, Mustafa ÖZCAN, Ayşe PALA, Ayşe BASMAKÇI, Yücel ARMAN & Tufan TÜKEK. (2020) Delay in starting insulin therapy in patients with type 2 Diabetes Mellitus. Journal of Surgery and Medicine 4:8, pages 685-688.
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Heather Stuckey, Lawrence Fisher, William H Polonsky, Danielle Hessler, Frank J Snoek, Tricia S Tang, Norbert Hermanns, Xavier Mundet-Tuduri, Maria Elizabeth Rossi da Silva, Jackie Sturt, Kentaro Okazaki, Dachuang Cao, Irene Hadjiyianni, Jasmina I Ivanova, Urvi Desai & Magaly Perez-Nieves. (2019) Key factors for overcoming psychological insulin resistance: an examination of patient perspectives through content analysis. BMJ Open Diabetes Research & Care 7:1, pages e000723.
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Esther Jacobs, Karel Kostev & Wolfgang Rathmann. (2018) Effektivität der glukosesenkenden Therapie bei Patienten mit Typ-2-Diabetes in primärärztlichen PraxenEffectiveness of glucose-lowering therapy in type 2 diabetes in primary care. Der Diabetologe 15:2, pages 89-95.
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Kathy Ellis, Henrietta Mulnier & Angus Forbes. (2018) Perceptions of insulin use in type 2 diabetes in primary care: a thematic synthesis. BMC Family Practice 19:1.
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Samaneh Kalirai, Judith Stephenson, Magaly Perez-Nieves, Michael Grabner, Irene Hadjiyianni, Caroline Geremakis, Roy Daniel Pollom, Beverly Reed & Lawrence Fisher. (2018) Primary care physician perspectives on basal insulin initiation and maintenance in patients with type 2 diabetes mellitus. Primary Care Diabetes 12:2, pages 155-162.
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Roberto Lagunes Córdoba, Isaac Galindo Guevara, Atalia Castillo Reyes, Citlalli Romero Aparicio & Francisco Javier Rosas Santiago. (2017) ¿Por qué los médicos no utilizan en forma temprana la insulinización en pacientes con diabetes mellitus tipo 2?: Un estudio cualitativo en una ciudad mexicana. Salud Colectiva 13:4, pages 693.
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Holger Fleischmann, Rüdiger Göke & Peter Bramlage. (2017) Addition of once daily prandial lixisenatide to basal insulin therapy in patients with type-2 diabetes results in a reduction of HbA1c as an effect of postprandial glucose lowering. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 11, pages S91-S97.
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Wenhui Wei, Erin Buysman, Michael Grabner, Lin Xie, Lee Brekke, Xuehua Ke, James W. Chu & Philip A. Levin. (2017) A real-world study of treatment patterns and outcomes in US managed-care patients with type 2 Diabetes initiating injectable therapies. Diabetes, Obesity and Metabolism 19:3, pages 375-386.
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Kamlesh Khunti & David Millar-Jones. (2017) Clinical inertia to insulin initiation and intensification in the UK: A focused literature review. Primary Care Diabetes 11:1, pages 3-12.
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Paresh Chaudhari, Carlos Vallarino, Ernest H. Law & Raafat Seifeldin. (2016) Evaluation of patients with type 2 diabetes mellitus receiving treatment during the pre-diabetes period: Is early treatment associated with improved outcomes?. Diabetes Research and Clinical Practice 122, pages 162-169.
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Julio A. Rebolledo & Regina Arellano. (2016) Cultural Differences and Considerations When Initiating Insulin. Diabetes Spectrum 29:3, pages 185-190.
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Peter Bramlage, Tobias Bluhmki, Wolfgang Rathmann, Matthias Kaltheuner, Jan Beyersmann & Thomas Danne. (2016) Identifying patients with type 2 diabetes in which basal supported oral therapy may not be the optimal treatment strategy. Diabetes Research and Clinical Practice 116, pages 127-135.
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C. J. Ng, P. S. M. Lai, Y. K. Lee, S. A. Azmi & C. H. Teo. (2015) Barriers and facilitators to starting insulin in patients with type 2 diabetes: a systematic review. International Journal of Clinical Practice 69:10, pages 1050-1070.
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Airin CR Simon, Wouter T Gude, Frits Holleman, Joost BL Hoekstra & Niels Peek. (2014) Diabetes Patients' Experiences With the Implementation of Insulin Therapy and Their Perceptions of Computer-Assisted Self-Management Systems for Insulin Therapy. Journal of Medical Internet Research 16:10, pages e235.
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Wenhui Wei, Chunshen Pan, Lin Xie & Onur Baser. (2014) Real-World Insulin Treatment Persistence among Patients with Type 2 Diabetes. Endocrine Practice 20:1, pages 52-61.
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Sarah Thayer, Wenhui Wei, Erin Buysman, Lee Brekke, William Crown, Michael Grabner, Swetha Raparla, Ralph Quimbo, Mark J. Cziraky, Wenli Hu & Robert Cuddihy. (2013) The INITIATOR Study: Pilot Data on Real-World Clinical and Economic Outcomes in US Patients with Type 2 Diabetes Initiating Injectable Therapy. Advances in Therapy 30:12, pages 1128-1140.
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Sau Nga Fu, Weng Yee Chin, Carlos King Ho Wong, Vincent Tok Fai Yeung, Ming Pong Yiu, Hoi Yee Tsui & Ka Hung Chan. (2013) Development and Validation of the Chinese Attitudes to Starting Insulin Questionnaire (Ch-ASIQ) for Primary Care Patients with Type 2 Diabetes. PLoS ONE 8:11, pages e78933.
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Robert M. Cuddihy & Sarah K. Borgman. (2013) Considerations for Diabetes. American Journal of Therapeutics 20:6, pages 694-702.
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M. J. Davies, J. J. Gagliardino, L. J. Gray, K. Khunti, V. Mohan & R. Hughes. (2013) Real-world factors affecting adherence to insulin therapy in patients with Type 1 or Type 2 diabetes mellitus: a systematic review. Diabetic Medicine 30:5, pages 512-524.
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Eric Q. Wu, Steve Zhou, Andrew Yu, Mei Lu, Hari Sharma, Jasvinder Gill & Thomas Graf. (2012) Outcomes Associated With Insulin Therapy Disruption After Hospital Discharge Among Patients with Type 2 Diabetes Mellitus who Had Used Insulin Before and During Hospitalization. Endocrine Practice 18:5, pages 651-659.
Crossref
Huey‐Fen Wang & Mei Chang Yeh. (2011) Psychological resistance to insulin therapy in adults with type 2 diabetes: mixed‐method systematic review. Journal of Advanced Nursing 68:4, pages 743-757.
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Chaoyang Li, Earl S. Ford, Guixiang Zhao, James Tsai, Lina S. Balluz & Wayne H. Giles. (2012) Trends of insulin use among US adults with type 2 diabetes: the Behavioral Risk Factor Surveillance System, 1995–2007. Journal of Diabetes and its Complications 26:1, pages 17-22.
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Stephen N. Davis, Wenhui Wei & Satish Garg. (2011) Clinical Impact of Initiating Insulin Glargine Therapy with Disposable Pen Versus Vial in Patients with Type 2 Diabetes Mellitus in a Managed Care Setting. Endocrine Practice 17:6, pages 845-852.
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Kerstin Berntorp, Mattias Haglund, Sara Larsen, Ann Petruckevitch & Mona Landin-Olsson. (2011) Initiation of biphasic insulin aspart 30/70 in subjects with type 2 diabetes mellitus in a largely primary care-based setting in Sweden. Primary Care Diabetes 5:2, pages 89-94.
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A Gherman, IA Veresiu, RA Sassu, JB Schnur, BL Scheckner & GH Montgomery. (2011) Psychological insulin resistance: a critical review of the literature. Practical Diabetes International 28:3, pages 125.
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