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Original Article

A randomised study comparing the efficacy and safety of rosuvastatin with atorvastatin for achieving lipid goals in clinical practice in Asian patients at high risk of cardiovascular disease (DISCOVERY-Asia study)

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Pages 3055-3068 | Accepted 08 Oct 2007, Published online: 26 Oct 2007

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Juan-Osvaldo Talavera, Gustavo Martinez, Jose-Luis Cervantes, Javier-Aguila Marin, Ignacio Rodriguez-Briones, Jose-Gerardo Gonzalez, Rodolfo Ocampo, Hector Sanchez-Mijangos, Laura P. Bernal-Rosales & Ana Polanco. (2013) A double-blind, double-dummy, randomized, placebo-controlled trial to evaluate the effect of statin therapy on triglyceride levels in Mexican hypertriglyceridemic patients. Current Medical Research and Opinion 29:4, pages 379-386.
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Toivo Laks, Ester Keba, Mariann Leiner, Eero Merilind, Mall Petersen, Sirje Reinmets, Sille Väli, Terje Sööt & Karin Otter. (2008) Achieving lipid goals with rosuvastatin compared with simvastatin in high risk patients in real clinical practice: a randomized, open-label, parallel-group, multi-center study: the DISCOVERY-Beta study. Vascular Health and Risk Management 4:6, pages 1407-1416.
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Handrean Soran & Paul Durrington. (2008) Rosuvastatin: efficacy, safety and clinical effectiveness. Expert Opinion on Pharmacotherapy 9:12, pages 2145-2160.
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Hyo-Soo Kim, Yangfeng Wu, Shing-Jong Lin, Chaicharn Deerochanawong, Robaayah Zambahari, Liancheng Zhao, Qiaoyi Zhang & Peter Yan. (2008) Current status of cholesterol goal attainment after statin therapy among patients with hypercholesterolemia in Asian countries and region: the Return on Expenditure Achieved for Lipid Therapy in Asia (REALITY-Asia) study. Current Medical Research and Opinion 24:7, pages 1951-1963.
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Konstantinos Tsioufis, José María Castellano Vázquez, Georgia Sykara, Franco Mondello Malvestiti & Joris van Vugt. (2021) Real-world Evidence for Adherence and Persistence with Atorvastatin Therapy. Cardiology and Therapy 10:2, pages 445-464.
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Lemlem G Gebremichael, Vijayaprakash Suppiah, Michael D Wiese, Lorraine Mackenzie, Craig Phillips, Desmond B Williams & Michael S Roberts. (2021) Efficacy and safety of statins in ethnic differences: a lesson for application in Indigenous Australian patient care. Pharmacogenomics 22:9, pages 553-571.
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L. Zhang, S. Zhang, Y. Yu, H. Jiang & J. Ge. (2018) Efficacy and safety of rosuvastatin vs. atorvastatin in lowering LDL cholesterolWirksamkeit und Sicherheit von Rosuvastatin vs. Atorvastatin zur Senkung des LDL-Cholesterins. Herz 45:6, pages 594-602.
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Debabrata Roy, Tanmay Mahapatra, Kaushik Manna, Ayan Kar, Md Saiyed Rana, Abhishek Roy, Pallab Kumar Bose, Barnali Banerjee, Srutarshi Paul & Sandipta Chakraborty. (2020) Comparing effectiveness of high-dose Atorvastatin and Rosuvastatin among patients undergone Percutaneous Coronary Interventions: A non-concurrent cohort study in India. PLOS ONE 15:5, pages e0233230.
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Yun Wang, Bryan P Yan, Brian Tomlinson & Vivian WY Lee. (2019) Is lipid goal one-size-fits-all: A review of evidence for recommended low-density lipoprotein treatment targets in Asian patients. European Journal of Preventive Cardiology 26:14, pages 1496-1506.
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Qingzan Kong, Qing Zhu & Liqi Wang. (2018) Bayesian Meta-Analysis: The Effect of Statins on the Treatment of Hypercholesterolemia. International Journal of Pharmacology 14:2, pages 151-163.
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Yundai Chen, Dandan Li, Jing Jing, Hongbing Yan, Jinghua Liu, Zhujun Shen, Stefan James & Christoph Varenhorst. (2017) Treatment Trends, Effectiveness, and Safety of Statins on Lipid Goal Attainment in Chinese Percutaneous Coronary Intervention Patients: a Multicenter, Retrospective Cohort Study. Clinical Therapeutics 39:9, pages 1827-1839.e1.
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Meor Fairuz Rizal Meor Anuar Shuhaili, Intan Nureslyna Samsudin, Johnson Stanslas, Shariful Hasan & Subashini C. Thambiah. (2017) Effects of Different Types of Statins on Lipid Profile: A Perspective on Asians. International Journal of Endocrinology and Metabolism In Press:In Press.
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Juliana C. N. Chan, Alice P. S. Kong, Weihang Bao, Rana Fayyad & Rachel Laskey. (2016) Safety of atorvastatin in Asian patients within clinical trials. Cardiovascular Therapeutics 34:6, pages 431-440.
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Sunghwan SuhChang Hee JungSoon-Jun HongJung-Sun KimByung Ju SongHyun Soon SohnSung Hee Choi. (2016) Economic Evaluation of Rosuvastatin and Atorvastatin for the Treatment of Dyslipidemia from a Korean Health System Perspective. Journal of Lipid and Atherosclerosis 5:1, pages 61.
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Chetan P. Shah, Dayanand K. Kumbla, Asha Moorthy, S. Murthy, Pankaj Aneja, Jagdish Gotur, Anil Gupta, Raman Abhi, Rajeev Bansal, Subhash Sonawala, Anil G. Balani, R. Kedarnathan, Pankaj Soni & P. Chinnaiyan. (2015) A post-marketing study evaluating the lipid-altering efficacy and safety of approved dose ranges of rosuvastatin in Indian hyperlipidemia patients in routine clinical practice (ROSUVEES). Journal of Indian College of Cardiology 5:4, pages 282-290.
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Emily Peckham, Sally Brabyn, Liz Cook, Thomas Devlin, Jo Dumville & David J. Torgerson. (2015) The use of unequal randomisation in clinical trials — An update. Contemporary Clinical Trials 45, pages 113-122.
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Bruce K. Birmingham, Sarah R. Bujac, Robert Elsby, Connie T. Azumaya, Cheryl Wei, Yusong Chen, Rogelio Mosqueda-Garcia & Helen J. Ambrose. (2015) Impact of ABCG2 and SLCO1B1 polymorphisms on pharmacokinetics of rosuvastatin, atorvastatin and simvastatin acid in Caucasian and Asian subjects: a class effect?. European Journal of Clinical Pharmacology 71:3, pages 341-355.
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Yi-Cong Ye, Xi-Liang Zhao & Shu-Yang Zhang. (2015) Use of Atorvastatin in Lipid Disorders and Cardiovascular Disease in Chinese Patients. Chinese Medical Journal 128:2, pages 259-266.
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Stephen P Adams, Sarpreet S Sekhon & James M Wright. (2014) Rosuvastatin for lowering lipids. Cochrane Database of Systematic Reviews 2017:1.
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S. Kangwanvanich & S. Permpongkosol. (2014) Efficacy and safety of rosuvastatin in late-onset hypogonadism patients with dyslipidaemia. Andrologia 46:4, pages 430-436.
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Miao Hu, Sandra S.H. Lui, Gary T.C. Ko & Brian Tomlinson. (2013) Do the lipid responses to rosuvastatin and atorvastatin differ between Chinese and Caucasians? Comparison of the DISCOVERY-Hong Kong study with other DISCOVERY studies. International Journal of Cardiology 168:3, pages 3071-3073.
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Yan‐Peng Li, Li‐rong Zhang, Min Jia & Xiang‐Jie Hu. (2013) Author's Response to Comments by Hu et al. The Journal of Clinical Pharmacology 52:11, pages 1770-1771.
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Miao Hu, Valiant W.L. Mak & Brian Tomlinson. (2013) Comments on “CYP3AP1 *3 Allele Is Associated With Lipid‐Lowering Efficacy of Simvastatin and Atorvastatin in Chinese Women” . The Journal of Clinical Pharmacology 52:11, pages 1768-1769.
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Ping Wang. (2011) Statin dose in Asians: is pharmacogenetics relevant?. Pharmacogenomics 12:11, pages 1605-1615.
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Claudio Aparício S Baptista. (2011) Rabdomiólise após exercício físico não intenso. Revista Brasileira de Medicina do Esporte 17:2, pages 142-146.
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Juan Yang, Lu-jin Li, Kun Wang, Ying-chun He, Yu-cheng Sheng, Ling Xu, Xiao-hui Huang, Feng Guo & Qing-shan Zheng. (2010) Race differences: modeling the pharmacodynamics of rosuvastatin in Western and Asian hypercholesterolemia patients. Acta Pharmacologica Sinica 32:1, pages 116-125.
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Junya Pattaraarchachai, Chalapati Rao, Warangkana Polprasert, Yawarat Porapakkham, Wansa Pao-in, Noppcha Singwerathum & Alan D Lopez. (2010) Cause-specific mortality patterns among hospital deaths in Thailand: validating routine death certification. Population Health Metrics 8:1.
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B Tomlinson, M Hu, V W Y Lee, S S H Lui, T T W Chu, E W M Poon, G T C Ko, L Baum, L S Tam & E K Li. (2010) ABCG2 Polymorphism Is Associated With the Low-Density Lipoprotein Cholesterol Response to Rosuvastatin. Clinical Pharmacology & Therapeutics 87:5, pages 558-562.
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Antonio M. GottoJrJr. (2009) Improving Lipid Goal Attainment. Circulation 120:1, pages 3-5.
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. (2009) Current World Literature. Current Opinion in Lipidology 20:1, pages 63-72.
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Arthur TH Tan, Lip-Ping Low, Chin Hock Lim & Chee Eng Tan. (2009) Effects of Rosuvastatin on Low-Density Lipoprotein Cholesterol and Plasma Lipids in Asian Patients with Hypercholesterolemia. Journal of Atherosclerosis and Thrombosis 16:4, pages 509-516.
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John Wlodarczyk, David Sullivan & Michael Smith. (2008) Comparison of Benefits and Risks of Rosuvastatin Versus Atorvastatin from a Meta-Analysis of Head-to-Head Randomized Controlled Trials. The American Journal of Cardiology 102:12, pages 1654-1662.
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Chern-En Chiang, Shao-Sung Huang & Shih-Hsien Sung. (2008) Efficacy and Safety of Rosuvastatin in Taiwanese Patients. Journal of the Chinese Medical Association 71:3, pages 113-118.
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Gillian M. Keating & Dean M. Robinson. (2012) Rosuvastatin. American Journal of Cardiovascular Drugs 8:2, pages 127-146.
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