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Review

Direct renin inhibition: an evaluation of the safety and tolerability of aliskiren

Pages 2627-2637 | Accepted 10 Jul 2008, Published online: 06 Aug 2008

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Fabio Angeli, Gianpaolo Reboldi, Giovanni Mazzotta, Cristina Poltronieri & Paolo Verdecchia. (2012) Safety and efficacy of aliskiren in the treatment of hypertension: a systematic overview. Expert Opinion on Drug Safety 11:4, pages 659-670.
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Roberto Fogari & Annalisa Zoppi. (2010) New class of agents for treatment of hypertension: focus on direct renin inhibition. Vascular Health and Risk Management 6, pages 869-882.
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Kunal Chaudhary, Ravi Nistala & Adam Whaley-Connell. (2010) Is there a future for direct renin inhibitors?. Expert Opinion on Investigational Drugs 19:5, pages 653-661.
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Thomas W. Littlejohn$suffix/text()$suffix/text(), Peter Trenkwalder, Geert Hollanders, Yanxing Zhao & Weichi Liao. (2009) Long-term safety, tolerability and efficacy of combination therapy with aliskiren and amlodipine in patients with hypertension. Current Medical Research and Opinion 25:4, pages 951-959.
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Articles from other publishers (13)

Saeed Alshahrani. (2023) Renin–angiotensin–aldosterone pathway modulators in chronic kidney disease: A comparative review. Frontiers in Pharmacology 14.
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Yuta Tamemoto, Yukihiro Shibata, Natsumi Hashimoto, Hiromi Sato & Akihiro Hisaka. (2023) Involvement of multiple cytochrome P450 isoenzymes in drug interactions between ritonavir and direct oral anticoagulants. Drug Metabolism and Pharmacokinetics, pages 100498.
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Erika D. Feller. 2017. Heart Failure. Heart Failure 85 96 .
Hisakazu Komori & Ikumi Tamai. (2014) Transporter-mediated drug interaction. Folia Pharmacologica Japonica 143:5, pages 243-248.
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Jasper Dingemanse & Laurent Nicolas. (2013) Drug-Drug Interaction Study of ACT-178882, a New Renin Inhibitor, and Diltiazem in Healthy Subjects. Clinical Drug Investigation 33:3, pages 207-213.
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Vicente Bertomeu Martínez, Mariano de la Figuera & Carlos Calvo. (2011) Inhibición directa de la renina y protección de órganos diana. Más allá del descenso de la presión. Revista Española de Cardiología Suplementos 11, pages 18-24.
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Jamie J. Coleman, Anthony R. Cox & Nicholas J. Cowley. 2011. A worldwide yearly survey of new data in adverse drug reactions. A worldwide yearly survey of new data in adverse drug reactions 413 435 .
Zafar H Israili, Manuel Velasco & Valmore Bermúdez. (2010) Direct Renin Inhibitors as Antihypertensive Agents. American Journal of Therapeutics 17:3, pages 237-254.
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Icilma V. Fergus. (2009) Antihypertensive Pharmacotherapy: Adverse Effects of Medications Promote Nonadherence. Journal of the CardioMetabolic Syndrome 4:1, pages E1-E3.
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Hiddo J Lambers Heerspink, Vlado Perkovic & Dick de Zeeuw. (2009) Renal and cardio-protective effects of direct renin inhibition: a systematic literature review. Journal of Hypertension 27:12, pages 2321-2331.
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C Venkata S Ram. (2009) Direct inhibition of renin: a physiological approach to treat hypertension and cardiovascular disease. Future Cardiology 5:5, pages 453-465.
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Fedor Simko & Olga Pechanova. (2009) Potential roles of melatonin and chronotherapy among the new trends in hypertension treatment. Journal of Pineal Research 47:2, pages 127-133.
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Raymond Vanholder, Angel Argilés, Joachim Beige, Philippe Brunet, Tilman B. Drüeke, Danilo Fliser, Stefan Herget-Rosenthal, Walter H. Hörl, Achim Jörres, Alessandra Perna, Mariano Rodriguez-Portillo, Goce Spasovski, Bernd Stegmayr, Peter Stenvinkel, Christoph Wanner, Andrzej Wiecek & Ziad A. Massy. (2009) Conservative Treatment of the Uremic Syndrome. Seminars in Dialysis 22:4, pages 449-453.
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