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Current Medical Research and Opinion Volume 24, 2008 - Issue 9
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Original article

Modulatory effect of farnesyl pyrophosphate synthase (FDPS) rs2297480 polymorphism on the response to long-term amino-bisphosphonate treatment in postmenopausal osteoporosis

Francesca Marini Department of Internal Medicine, University of Florence, Florence, Italy
,
Alberto Falchetti Department of Internal Medicine, University of Florence, Florence, Italy
,
Sandra Silvestri Department of Internal Medicine, University of Florence, Florence, Italy
,
Yu Bagger Department of Internal Medicine, University of Florence, Florence, Italy; DeGene Spin-off, University of Florence, Florence, Italy
,
Ettore Luzi Department of Internal Medicine, University of Florence, Florence, Italy
,
Annalisa Tanini Department of Internal Medicine, University of Florence, Florence, Italy
,
Claus Christiansen Department of Internal Medicine, University of Florence, Florence, Italy; DeGene Spin-off, University of Florence, Florence, Italy
&
Maria Luisa Brandi Department of Internal Medicine, University of Florence, Florence, Italy; Center of Clinical and Basic Research, Ballerup, DenmarkCorrespondence[email protected]
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Pages 2609-2615 | Accepted 17 Jul 2008, Published online: 06 Aug 2008

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Jiao Zhao, Li Liu, Shanshan Lv, Chun Wang, Hua Yue & Zhenlin Zhang. (2021) PFN1 Gene Polymorphisms and the Bone Mineral Density Response to Alendronate Therapy in Postmenopausal Chinese Women with Low Bone Mass. Pharmacogenomics and Personalized Medicine 14, pages 1669-1678.
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Farkhondeh Pouresmaeili, Behnam Kamalidehghan, Maryam Kamarehei & Yong Meng Goh. (2018) A comprehensive overview on osteoporosis and its risk factors. Therapeutics and Clinical Risk Management 14, pages 2029-2049.
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Laura López-Delgado, Leyre Riancho-Zarrabeitia & José A. Riancho. (2016) Genetic and acquired factors influencing the effectiveness and toxicity of drug therapy in osteoporosis. Expert Opinion on Drug Metabolism & Toxicology 12:4, pages 389-398.
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Subhajit Das & Julie C Crockett. (2013) Osteoporosis – a current view of pharmacological prevention and treatment. Drug Design, Development and Therapy 7, pages 435-448.
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Francesca Marini & Maria Luisa Brandi. (2010) Pharmacogenetics of osteoporosis. Expert Review of Endocrinology & Metabolism 5:6, pages 905-910.
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Articles from other publishers (37)

Álvaro del Real, Carmen Valero, José M. Olmos, Jose L. Hernández & José A. Riancho. (2022) Pharmacogenetics of Osteoporosis: A Pathway Analysis of the Genetic Influence on the Effects of Antiresorptive Drugs. Pharmaceutics 14:4, pages 776.
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Natalia Garcia-Giralt, Neus Roca-Ayats, Josep F Abril, Nuria Martinez-Gil, Diana Ovejero, Santos Castañeda, Xavier Nogues, Daniel Grinberg, Susanna Balcells & Raquel Rabionet. (2022) Gene Network of Susceptibility to Atypical Femoral Fractures Related to Bisphosphonate Treatment. Genes 13:1, pages 146.
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Fernando Rivadeneira & André G. Uitterlinden. 2021. Marcus and Feldman's Osteoporosis. Marcus and Feldman's Osteoporosis 405 451 .
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Katerina Trajanoska & Fernando Rivadeneira. (2020) Genomic Medicine: Lessons Learned From Monogenic and Complex Bone Disorders. Frontiers in Endocrinology 11.
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Z. Guo, W. Cui, L. Que, C. Li, X. Tang & J. Liu. (2020) Pharmacogenetics of medication-related osteonecrosis of the jaw: a systematic review and meta-analysis. International Journal of Oral and Maxillofacial Surgery 49:3, pages 298-309.
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Alina Deniza Ciubean, Rodica Ana Ungur, Laszlo Irsay, Viorela Mihaela Ciortea, Ileana Monica Borda, Gabriela Bombonica Dogaru, Adrian Pavel Trifa, Stefan Cristian Vesa & Anca Dana Buzoianu. (2019) Polymorphisms of FDPS, LRP5, SOST and VKORC1 genes and their relation with osteoporosis in postmenopausal Romanian women. PLOS ONE 14:11, pages e0225776.
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Alina Deniza CIUBEAN, Laszlo IRSAY, Rodica Ana UNGUR, Viorela Mihaela CIORTEA, Ileana Monica BORDA, Bombonica Gabriela DOGARU 1,, Adrian Pavel TRIFA & Anca Dana BUZOIANU. (2019) Association between polymorphisms in GGPS1 and RANKL genes and postmenopausal osteoporosis in Romanian women. Balneo Research Journal 10:Vol.10, No.3, pages 252-258.
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Alina Deniza CIUBEAN, Laszlo IRSAY, Rodica Ana UNGUR, Viorela Mihaela CIORTEA, Ileana Monica BORDA, Bombonica Gabriela DOGARU, Adrian Pavel TRIFA & Anca Dana BUZOIANU. (2019) Genetic polymorphisms and their influence on therapeutic response to alendronate-a pilot study. Balneo Research Journal 10:Vol.10, No.3, pages 243-251.
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Pavel Marozik, Vidmantas Alekna, Ema Rudenko, Marija Tamulaitiene, Alena Rudenka, Asta Mastaviciute, Volha Samokhovec, Andrejus Cernovas, Katsiaryna Kobets & Irma Mosse. (2019) Bone metabolism genes variation and response to bisphosphonate treatment in women with postmenopausal osteoporosis. PLOS ONE 14:8, pages e0221511.
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Guang Yang, Sonal Singh, Yiqing Chen, Issam S. Hamadeh, Taimour Langaee, Caitrin W. McDonough, L. Shannon Holliday, Jatinder K. Lamba, Jan S. Moreb, Joseph Katz & Yan Gong. (2019) Pharmacogenomics of osteonecrosis of the jaw. Bone 124, pages 75-82.
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Mohammad Kharazmi, Karl Michaëlsson, Jörg Schilcher, Niclas Eriksson, Håkan Melhus, Mia Wadelius & Pär Hallberg. (2019) A Genome-Wide Association Study of Bisphosphonate-Associated Atypical Femoral Fracture. Calcified Tissue International 105:1, pages 51-67.
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Tuan V. Nguyen & John A. Eisman. 2018. Genetics of Bone Biology and Skeletal Disease. Genetics of Bone Biology and Skeletal Disease 139 157 .
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Hui Zheng, Chun Wang, Jin-Wei He, Wen-Zhen Fu & Zhen-Lin Zhang. (2016) OPG, RANKL, and RANK gene polymorphisms and the bone mineral density response to alendronate therapy in postmenopausal Chinese women with osteoporosis or osteopenia. Pharmacogenetics and Genomics 26:1, pages 12-19.
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Elisa Cairoli & Iacopo Chiodini. 2016. Biomarkers in Bone Disease. Biomarkers in Bone Disease 1 21 .
I. ZOFKOVA, P. NEMCIKOVA & M. KUKLIK. (2015) Polymorphisms Associated With Low Bone Mass and High Risk of Atraumatic Fracture. Physiological Research, pages 621-631.
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C Wang, H Zheng, J-W He, H Zhang, H Yue, W-W Hu, J-M Gu, C Shao, W-Z Fu, Y-Q Hu, M Li, Y-J Liu & Z-L Zhang. (2014) Genetic polymorphisms in the mevalonate pathway affect the therapeutic response to alendronate treatment in postmenopausal Chinese women with low bone mineral density. The Pharmacogenomics Journal 15:2, pages 158-164.
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Nina Bratanic, Bojana Dzodan, Katarina Trebusak Podkrajsek, Sara Bertok, Barbara Ostanek, Janja Marc, Tadej Battelino & Magdalena Avbelj Stefanija. (2015) Childhood Osteoporosis and Presentation of Two Cases with Osteogenesis Imperfecta Type V / Osteoporoza V Otroški Dobi in Predstavitev Dveh Bolnikov Z Osteogenesis Imperfecta Tipa V. Slovenian Journal of Public Health 54:2, pages 119-125.
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Francesca Marini & Maria Luisa Brandi. (2014) Pharmacogenetics of osteoporosis. Best Practice & Research Clinical Endocrinology & Metabolism 28:6, pages 783-793.
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Francesca Marini & Maria Luisa Brandi. (2014) WITHDRAWN: Pharmacogenetics of osteoporosis. Best Practice & Research Clinical Endocrinology & Metabolism.
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José A. Riancho & Flor M. Pérez-Campo. 2014. Pharmacogenomics in Drug Discovery and Development. Pharmacogenomics in Drug Discovery and Development 661 670 .
Francesco Massart, Francesca Marini, Gerolamo Bianchi, Salvatore Minisola, Giovanni Luisetto, Antonella Pirazzoli, Sara Salvi, Dino Micheli, Mario Miccoli, Angelo Baggiani, Francesca Giusti & Maria Luisa Brandi. (2013) Genetic predictors of skeletal outcomes in healthy fertile women: The Bonturno Study. Joint Bone Spine 80:4, pages 414-419.
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Francesca MariniMaria Luisa Brandi. (2013) The future of pharmacogenetics for osteoporosis. Pharmacogenomics 14:6, pages 641-653.
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André G. Uitterlinden, M. Carola Zillikens & Fernando Rivadeneira. 2013. Osteoporosis. Osteoporosis 563 604 .
Karen Rojo Venegas, Margarita Aguilera, Marisa Cañadas Garre & Miguel A. Calleja Hernández. 2013. Omics for Personalized Medicine. Omics for Personalized Medicine 679 706 .
Karen Rojo VenegasMargarita Aguilera GómezMarisa Cañada GarreAntonio García SánchezCarlos Contreras-OrtegaMiguel Angel Calleja Hernández. (2012) Pharmacogenetics of Osteoporosis: Towards Novel Theranostics for Personalized Medicine?. OMICS: A Journal of Integrative Biology 16:12, pages 638-651.
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Francesca Marini & Maria Luisa Brandi. (2012) Pharmacogenetics of Osteoporosis: What is the Evidence?. Current Osteoporosis Reports 10:3, pages 221-227.
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J M Olmos, M T Zarrabeitia, J L Hernández, C Sañudo, J González-Macías & J A Riancho. (2010) Common allelic variants of the farnesyl diphosphate synthase gene influence the response of osteoporotic women to bisphosphonates. The Pharmacogenomics Journal 12:3, pages 227-232.
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José A RianchoJosé L Hernández. (2012) Pharmacogenomics of osteoporosis: a pathway approach. Pharmacogenomics 13:7, pages 815-829.
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Megan M. Weivoda & Raymond J. Hohl. (2011) The effects of direct inhibition of geranylgeranyl pyrophosphate synthase on osteoblast differentiation. Journal of Cellular Biochemistry 112:6, pages 1506-1513.
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Li Gong, Russ B. Altman & Teri E. Klein. (2011) Bisphosphonates pathway. Pharmacogenetics and Genomics 21:1, pages 50-53.
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Karen Rojo Venegas, Margarita Aguilera Gómez, John Allan Eisman, Antonio García Sánchez, María J Faus Dader & Miguel A Calleja Hernández. (2010) Pharmacogenetics of osteoporosis-related bone fractures: moving towards the harmonization and validation of polymorphism diagnostic tools. Pharmacogenomics 11:9, pages 1287-1303.
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Luigi Gennari. (2010) Pharmacogenomics of Osteoporosis. Clinical Reviews in Bone and Mineral Metabolism 8:2, pages 77-94.
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Francesca Marini & Maria Luisa Brandi. (2010) Genetic Determinants of Osteoporosis: Common Bases to Cardiovascular Diseases?. International Journal of Hypertension 2010, pages 1-16.
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Francesca Marini & Maria Luisa Brandi. (2009) Pharmacogenetics of Osteoporosis: Future Perspectives. Calcified Tissue International 84:5, pages 337-347.
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