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Editorial Commentary

Statin discontinuation: an underestimated risk?

, &
Pages 3059-3062 | Accepted 18 Sep 2008, Published online: 02 Oct 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Hye Yun Jeong, So-Young Lee, Sang Hoon Kim & Jinkwon Kim. (2020) Long-Term Benefit and Withdrawal Effect of Statins After Percutaneous Coronary Intervention: A Nationwide Population-Based Cohort Study. Patient Preference and Adherence 14, pages 717-724.
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Niki Katsiki, Genovefa Kolovou, Pablo Perez-Martinez & Dimitri P. Mikhailidis. (2018) Dyslipidaemia in the elderly: to treat or not to treat?. Expert Review of Clinical Pharmacology 11:3, pages 259-278.
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Vana Kolovou, Helen Bilianou & Genovefa Kolovou. (2016) Safe use of statins: focus on muscle toxicity. Clinical Lipidology 11:1, pages 16-22.
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Aris P Agouridis, Devaki R Nair & Dimitri P Mikhailidis. (2015) Strategies to overcome statin intolerance. Expert Opinion on Drug Metabolism & Toxicology 11:6, pages 851-855.
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Maciej Banach, Manfredi Rizzo, Peter P Toth, Michel Farnier, Michael H Davidson, Khalid Al-Rasadi, Wilbert S Aronow, Vasilis Athyros, Dragan M Djuric, Marat V Ezhov, Robert S Greenfield, G Kees Hovingh, Karam Kostner, Corina Serban, Daniel Lighezan, Zlatko Fras, Patrick M Moriarty, Paul Muntner, Assen Goudev, Richard Ceska, Stephen J Nicholls, Marlena Broncel, Dragana Nikolic, Daniel Pella, Raman Puri, Jacek Rysz, Nathan D Wong, Laszlo Bajnok, Steven R Jones, Kausik K Ray & Dimitri P Mikhailidis. (2015) Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel. Expert Opinion on Drug Safety 14:6, pages 935-955.
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Vasilios G. Athyros, Niki Katsiki, Asterios Karagiannis & Dimitri P. Mikhailidis. (2015) Short-, mid-, and long-term benefits of peri-procedural high-intensity statin administration in patients undergoing percutaneous coronary intervention. Current Medical Research and Opinion 31:2, pages 191-195.
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Michael S. Kostapanos, Vasilios G. Athyros, Asterios Karagiannis & Dimitri P. Mikhailidis. (2012) Therapeutic options for statin-intolerant patients. Current Medical Research and Opinion 28:3, pages 345-349.
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N. Katsiki, V.G. Athyros, A. Karagiannis & D.P. Mikhailidis. (2011) Vitamin D deficiency, statin-related myopathy and other links with vascular risk. Current Medical Research and Opinion 27:9, pages 1691-1692.
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Stella S. Daskalopoulou, Robert J. Doonan & Dimitri P. Mikhailidis. (2010) Undertreatment of hypercholesterolemia. Current Medical Research and Opinion 26:2, pages 439-443.
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Articles from other publishers (23)

Kosmas I. Paraskevas, Piotr Musialek, Dimitri P. Mikhailidis & Gregory Y. H. Lip. (2023) Optimal Stroke Risk Management in Carotid Atherosclerotic Disease: A Patient-Centered Multidisciplinary Approach. Angiology 75:1, pages 5-7.
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Mohamed H. Al-Sabri, Neha Behare, Ahmed M. Alsehli, Samuel Berkins, Aadeya Arora, Eirini Antoniou, Eleni I. Moysiadou, Sowmya Anantha-Krishnan, Patricia D. Cosmen, Johanna Vikner, Thiago C. Moulin, Nourhene Ammar, Hadi Boukhatmi, Laura E. Clemensson, Mathias Rask-Andersen, Jessica Mwinyi, Michael J. Williams, Robert Fredriksson & Helgi B. Schiöth. (2022) Statins Induce Locomotion and Muscular Phenotypes in Drosophila melanogaster That Are Reminiscent of Human Myopathy: Evidence for the Role of the Chloride Channel Inhibition in the Muscular Phenotypes. Cells 11:22, pages 3528.
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Kosmas I. Paraskevas, Peter Gloviczki, Pier Luigi Antignani, Anthony J. Comerota, Alan Dardik, Alun H. Davies, Hans-Henning Eckstein, Gianluca Faggioli, Jose Fernandes e Fernandes, Gustav Fraedrich, George Geroulakos, Jonathan Golledge, Ajay Gupta, Victor S. Gurevich, Arkadiusz Jawien, Mateja K. Jezovnik, Stavros K. Kakkos, Michael Knoflach, Gaetano Lanza, Christos D. Liapis, Ian M. Loftus, Armando Mansilha, Andrew N. Nicolaides, Rodolfo Pini, Pavel Poredos, Robert M. Proczka, Jean-Baptiste Ricco, Tatjana Rundek, Luca Saba, Felix Schlachetzki, Mauro Silvestrini, Francesco Spinelli, Francesco Stilo, Jasjit S. Suri, Alexei V. Svetlikov, Clark J. Zeebregts, Seemant Chaturvedi, Frank J. Veith & Dimitri P. Mikhailidis. (2022) Benefits and drawbacks of statins and non-statin lipid lowering agents in carotid artery disease. Progress in Cardiovascular Diseases 73, pages 41-47.
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Xia Wu, Xiao-Bo Liu, Ting Liu, Wen Tian & Yu-Jiao Sun. (2021) Effects of different statins application methods on plaques in patients with coronary atherosclerosis. World Journal of Clinical Cases 9:4, pages 812-821.
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Niki Katsiki, Dimitri P. Mikhailidis, Gani Bajraktari, Andre R. Miserez, Arrigo F.G. Cicero, Eric Bruckert, Maria-Corina Serban, Erkin Mirrakhimov, Fahad Alnouri, Željko Reiner, György Paragh, Amirhossein Sahebkar, Maciej Banach, Fahad Alnouri, Fahma Amar, Atanas G. Atanasov, Gani Bajraktari, Maciej Banach, Marcin A. Bartlomiejczyk, Bojko Bjelakovic, Eric Bruckert, Agata Bielecka-Dabrowa, Alberto Cafferata, Richard Ceska, Arrigo F.G. Cicero, Xavier Collet, Olivier Descamps, Nair Devaki, Dragan Djuric, Ronen Durst, Marat V. Ezhov, Zlatko Fras, Dan Gaita, Stephan von Haehling, Adrian V. Hernandez, Steven R. Jones, Jacek Jozwiak, Nona Kakauridze, Niki Katsiki, Amit Khera, Karam Kostner, Raimondas Kubilius, Gustavs Latkovskis, G.B. John Mancini, A. David Marais, Seth S. Martin, Julio Acosta Martinez, Mohsen Mazidi, Dimitri P. Mikhailidis, Erkin Mirrakhimov, Andre R. Miserez, Olena Mitchenko, Patrick Moriarty, Seyed Mohammad Nabavi, Demosthenes B. Panagiotakos, György Paragh, Daniel Pella, Peter E. Penson, Zaneta Petrulioniene, Matteo Pirro, Arman Postadzhiyan, Raman Puri, Ashraf Reda, Željko Reiner, Jemaa Riadh, Dimitri Richter, Manfredi Rizzo, Massimiliano Ruscica, Amirhossein Sahebkar, Naveed Sattar, Maria-Corina Serban, Abdulla M.A. Shehab, Aleksandr B. Shek, Cesare R. Sirtori, Claudia Stefanutti, Tomasz Tomasik, Peter P. Toth, Margus Viigimaa, Dragos Vinereanu, Branislav Vohnout, Michal Vrablik, Nathan D. Wong, Hung-I Yeh, Jiang Zhisheng & Andreas Zirlik. (2020) Statin therapy in athletes and patients performing regular intense exercise – Position paper from the International Lipid Expert Panel (ILEP). Pharmacological Research 155, pages 104719.
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Bozidarka Zaric, Milan Obradovic, Andreja Trpkovic, Maciej Banach, Dimitri P. Mikhailidis & Esma R. Isenovic. (2020) Endothelial Dysfunction in Dyslipidaemia: Molecular Mechanisms and Clinical Implications. Current Medicinal Chemistry 27:7, pages 1021-1040.
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Jordon Candice Irwin, Andrew Stuart Fenning, Kimberly Rene Ryan & Rebecca Kate Vella. (2018) Validation of a clinically-relevant rodent model of statin-associated muscle symptoms for use in pharmacological studies. Toxicology and Applied Pharmacology 360, pages 78-87.
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Yang Wang, Jinsong Wang & Shenming Wang. (2018) Comparative Effectiveness of Inclisiran 100, 300, and 500 mg in a Population with Hyperlipidemia: A Network Meta-Analysis of Randomized Controlled Trials. American Journal of Cardiovascular Drugs 18:4, pages 271-282.
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Karen Krüger, Niklas Leppkes, Sabine Gehrke-Beck, Wolfram Herrmann, Engi A Algharably, Reinhold Kreutz, Christoph Heintze & Iris Filler. (2018) Improving long-term adherence to statin therapy: a qualitative study of GPs’ experiences in primary care. British Journal of General Practice 68:671, pages e401-e407.
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Charles E. Leonard, Colleen M. Brensinger, Warren B. Bilker, Stephen E. Kimmel, Heather J. Whitaker & Sean Hennessy. (2017) Thromboembolic and neurologic sequelae of discontinuation of an antihyperlipidemic drug during ongoing warfarin therapy. Scientific Reports 7:1.
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Jove H. Graham, Robert J. Sanchez, Joseph J. Saseen, Usha G. Mallya, Mary P. Panaccio & Michael A. Evans. (2017) Clinical and economic consequences of statin intolerance in the United States: Results from an integrated health system. Journal of Clinical Lipidology 11:1, pages 70-79.e1.
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Iris Lin, Jennifer Sung, Robert J. Sanchez, Usha G. Mallya, Mark Friedman, Mary Panaccio, Andrew Koren, Peter Neumann & Joseph Menzin. (2016) Patterns of Statin Use in a Real-World Population of Patients at High Cardiovascular Risk. Journal of Managed Care & Specialty Pharmacy 22:6, pages 685-698.
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Kosmas I. Paraskevas, Dimitri P. Mikhailidis, Frank J. Veith & J. David Spence. (2015) Definition of Best Medical Treatment in Asymptomatic and Symptomatic Carotid Artery Stenosis. Angiology 67:5, pages 411-419.
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Helle Wallach-Kildemoes, Henrik Stovring, Ebba Holme Hansen, Kenneth Howse & Hálfdán Pétursson. (2016) Statin prescribing according to gender, age and indication: what about the benefit-risk balance?. Journal of Evaluation in Clinical Practice 22:2, pages 235-246.
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Kosmas I. Paraskevas & Frank J. Veith. (2014) Thrombolysis May Reduce the Incidence/Extent of Postprocedural Ischemic Strokes Associated With Carotid Artery Stenting. Angiology 66:7, pages 604-606.
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Maciej Banach & Dimitri P. Mikhailidis. (2015) In reply—Coenzyme Q10 and Statin-Induced Myopathy. Mayo Clinic Proceedings 90:3, pages 420-421.
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Marta Michalska-Kasiczak, Amirhossein Sahebkar, Dimitri P. Mikhailidis, Jacek Rysz, Paul Muntner, Peter P. Toth, Steven R. Jones, Manfredi Rizzo, G. Kees Hovingh, Michel Farnier, Patrick M. Moriarty, Vera A. Bittner, Gregory Y.H. Lip & Maciej Banach. (2015) Analysis of vitamin D levels in patients with and without statin-associated myalgia — A systematic review and meta-analysis of 7 studies with 2420 patients. International Journal of Cardiology 178, pages 111-116.
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Kosmas I. Paraskevas, Andrew N. Nicolaides & Dimitri P. Mikhailidis. (2013) Statins and Venous Thromboembolism. Angiology 64:7, pages 489-491.
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Warner M. Mampuya, David Frid, Michael Rocco, Julie Huang, Danielle M. Brennan, Stanley L. Hazen & Leslie Cho. (2013) Treatment strategies in patients with statin intolerance: The Cleveland Clinic experience. American Heart Journal 166:3, pages 597-603.
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Helle Wallach-Kildemoes, Morten Andersen, Finn Diderichsen & Theis Lange. (2013) Adherence to preventive statin therapy according to socioeconomic position. European Journal of Clinical Pharmacology 69:8, pages 1553-1563.
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Rumi J. JaumdallyGregory Y. H. LipChetan VarmaAndrew D. Blann. (2011) Impact of High-Dose Atorvastatin on Endothelial, Platelet, and Angiogenic Indices. Angiology 62:7, pages 571-578.
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Thomas F. WhayneJrJr. (2011) Statin Myopathy: Significant Problem With Minimal Awareness by Clinicians and no Emphasis by Clinical Investigators. Angiology 62:5, pages 415-421.
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Stella S Daskalopoulou. (2009) When statin therapy stops: implications for the patient. Current Opinion in Cardiology 24:5, pages 454-460.
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