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Review

Hyoscine butylbromide – a review on its parenteral use in acute abdominal spasm and as an aid in abdominal diagnostic and therapeutic procedures

Pages 3159-3173 | Accepted 11 Sep 2008, Published online: 10 Oct 2008

Keep up to date with the latest research on this topic with citation updates for this article.

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Rehab Abdelhamid Aboshama, Mohammad Abrar Shareef, Abdulhadi A. AlAmodi, Wesam Kurdi, Mohammed M. Al-Tuhaifi, Marwah Ghazi Bintalib, Sileem Ahmed Sileem, Osama Abdelazem, Ahmed Mohamed Abdelhakim, Ahmed M. A. Sobh & Sahar M. Y. Elbaradie. (2022) The effect of hyoscine-N-butylbromide on pain perception during and after hysterosalpingography in infertile women: a systematic review and meta-analysis of randomised controlled trials. Human Fertility 25:3, pages 422-429.
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Matti Ristikankare & Hannele Karinen-Mantila. (2016) The role of routinely given hyoscine-N-butylbromide in colonoscopy: a double-blind, randomized, placebo-controlled, clinical trial. Scandinavian Journal of Gastroenterology 51:3, pages 368-373.
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Farzad Jalali, Reza Afshari & Ali Babaei. (2014) Smoking Crushed Hyoscine/Scopolamine Tablets as Drug Abuse. Substance Use & Misuse 49:7, pages 793-797.
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Articles from other publishers (55)

Umme Hani, Hani E. Alosaimi, Bader Huwaimel, Tareq Nafea Alharby, Jowaher Alanazi & Muteb Alanazi. (2023) Study of Hyoscine solubility in scCO2: Experimental measurement and thermodynamic modeling. Journal of Molecular Liquids 381, pages 121821.
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Falk Gühne, Ferdinand Ndum, Philipp Seifert, Thomas Winkens, Robert Drescher & Martin Freesmeyer. (2023) The effect of butylscopolamine on [18F]FDG uptake in the gastrointestinal tract is negligible and regionally variable. EJNMMI Research 13:1.
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Anna Taylor, Simon Wilkins, Nicholas Gelber, Wei Chun Wang, Karen Oliva, Raymond Yap, Paul McMurrick & Pravin Ranchod. (2023) The effect of anti‐spasmodic administration on the accuracy of magnetic resonance imaging staging of rectal cancer. ANZ Journal of Surgery 93:6, pages 1613-1619.
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Yue Lin, Enis C. Yilmaz, Mason J. Belue & Baris Turkbey. (2023) Prostate MRI and image Quality: It is time to take stock. European Journal of Radiology 161, pages 110757.
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Hayri Ramadan. (2023) Hyoscine N-butylbromide inhalation: they know, how about you?. World Journal of Emergency Medicine 14:1, pages 81.
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Thomas J. Altree, Atqiya Aishah, Kelly A. Loffler, Ronald R. Grunstein & Danny J. Eckert. (2023) The norepinephrine reuptake inhibitor reboxetine alone reduces obstructive sleep apnea severity: a double-blind, placebo-controlled, randomized crossover trial. Journal of Clinical Sleep Medicine 19:1, pages 85-96.
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Lazhin Ibrahim Hasan & Hijran Sanaan Jabbar. (2022) Silver Nanoparticles Application as a Colorimetric Probe for the Spectrophotometric Determination of Hyoscine Butylbromide in Pharmaceutical Formulations. Journal of AOAC INTERNATIONAL.
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Agnieszka Pałucha-Poniewiera. (2022) The role of mGlu2/3 receptor antagonists in the enhancement of the antidepressant-like effect of ketamine. Pharmacology Biochemistry and Behavior 220, pages 173454.
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Saskia Weltings, K. Tim Buddingh, Daniëlle C. van Diepen, Rob C. M. Pelger, Hein Putter, Mandana Rad, Barbara M. A. Schout & Hossain Roshani. (2022) De BUSCOPAN-studie. Een gerandomiseerde non-inferioriteitsstudie van continue butylscopolamine-infusie versus placebo voor niersteenkoliek onvoldoende reagerend op non-steroïdale anti-inflammatoire medicatieThe BUSCOPAN study: a randomized-controlled non-inferiority trial of a continuous butylscopolamine infusion versus placebo in patients with a renal colic not responding to oral non-steroidal anti-inflammatory drugs. Tijdschrift voor Urologie 12:4, pages 72-78.
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Jacqueline Pui Wah Chung, Tracy Sze Man Law, Jennifer Sze Man Mak, Rebecca Chui Yiu Liu, Daljit Singh Sahota & Tin Chiu Li. (2022) Hyoscine butylbromide in pain reduction associated with ultrasound-guided manual vacuum aspiration: a randomized placebo-controlled trial. Reproductive BioMedicine Online 44:2, pages 295-303.
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Hasan Sultanoğlu, Yılmaz Safi, Mustafa Enes Demirel, Mehmet Cihat Demir, Hasan Baki Altinsoy, Mustafa Boğan & Hasan Gümüşboğa. (2021) Comparison of paracetamol and hyoscine-N-butylbromide in the treatment of abdominal pain and cramps due to acute gastroenteritis. IMC Journal of Medical Science, pages 1-7.
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Nauzer Forbes, Levi Frehlich, Mark Borgaonkar, Grigorios I Leontiadis & Frances Tse. (2021) Canadian Association of Gastroenterology (CAG) Position Statement on the Use of Hyoscine- n -butylbromide (Buscopan) During Gastrointestinal Endoscopy . Journal of the Canadian Association of Gastroenterology 4:6, pages 259-268.
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S. Weltings, K. T. Buddingh, D. C. van Diepen, R. C. M. Pelger, H. Putter, M. Rad, B. M. A. Schout & H. Roshani. (2020) The BUSCOPAN study: a randomized-controlled non-inferiority trial of a continuous butylscopolamine infusion versus placebo in patients with a renal colic not responding to oral non-steroidal anti-inflammatory drugs. World Journal of Urology 39:7, pages 2747-2752.
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Finbar Slevin, Matthew Beasley, Jim Zhong, Eleanor Hudson, Richard Speight, John Lilley, Louise J Murray & Ann M Henry. (2021) A feasibility study of hyoscine butylbromide (buscopan) to improve image quality of cone beam computed tomography during abdominal/pelvic Stereotactic Ablative Radiotherapy. BJR|Open 3:1, pages 20210045.
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Muhammad Aziz, Sachit Sharma, Sami Ghazaleh, Rawish Fatima, Ashu Acharya, Marcel Ghanim, Taha Sheikh, Wade Lee-Smith, Syed U. Hamdani & Ali Nawras. (2020) The anti-spasmodic effect of peppermint oil during colonoscopy: a systematic review and meta-analysis. Minerva Gastroenterologica e Dietologica 66:2.
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Jacob Broder Brodersen & Søren Hess. (2020) FDG-PET/CT in Inflammatory Bowel Disease. PET Clinics 15:2, pages 153-162.
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Mohammed Gamal. (2020) Analytical review: analytical techniques for hyoscine N butyl bromide . The Analyst 145:6, pages 2025-2037.
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Tsunetaka Kijima, Ryoji Hyakudomi, Tatsuya Hashimoto, Akari Kusaka, Toshihiko Nakatani & Yutaka Ishibashi. (2019) Adhesion-induced chronic abdominal pain: a case report on the diagnostic value of Carnett’s test. Journal of Medical Case Reports 13:1.
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I. Caglic & T. Barrett. (2019) Optimising prostate mpMRI: prepare for success. Clinical Radiology 74:11, pages 831-840.
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Ahmed M. Abbas, Ahmed M. Elzargha, Abdel Ghaffar M. Ahmed, Ibrahim I. Mohamed, Ahmed Altraigey & Ahmed Y. Abdelbadee. (2019) Oral Diclofenac Potassium Versus Hyoscine-N-Butyl Bromide in Reducing Pain Perception during Office Hysteroscopy: ARandomized Double-blind Placebo-controlled Trial. Journal of Minimally Invasive Gynecology 26:4, pages 709-716.
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Ahmed M. Abbas, Nahed A. Abo-Elela & Ehab M. Mosa. (2018) Effect of oral hyoscine-N-butyl bromide on pain perception during hysterosalpingography: A randomized, double-blind, placebo controlled trial. Middle East Fertility Society Journal 23:1, pages 57-62.
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R.A. Slough, I. Caglic, N.L. Hansen, A.J. Patterson & T. Barrett. (2018) Effect of hyoscine butylbromide on prostate multiparametric MRI anatomical and functional image quality. Clinical Radiology 73:2, pages 216.e9-216.e14.
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Manzoor Ahmed, Muhammad Asghar, Mohammad Yaqoob, Nusrat Munawar, Farkhanda Shahid, Mida Asad & Abdul Nabi. (2017) Flow Injection-Chemiluminescence Method for Determination of Hyoscine Butylbromide Using Silver(III) as Oxidizing Agent. Analytical Sciences 33:11, pages 1259-1263.
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Golnar Sabetian, Farid Zand, Elham Asadpour, Mohammad Ghorbani, Pourya Adibi, Mohammad Mehdi Hosseini, Shahryar Zeyghami & Farzaneh Masihi. (2017) Evaluation of hyoscine N-butyl bromide efficacy on the prevention of catheter-related bladder discomfort after transurethral resection of prostate: a randomized, double-blind control trial. International Urology and Nephrology 49:11, pages 1907-1913.
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Agnieszka Pałucha-Poniewiera, Karolina Podkowa, Tomasz Lenda & Andrzej Pilc. (2017) The involvement of monoaminergic neurotransmission in the antidepressant-like action of scopolamine in the tail suspension test. Progress in Neuro-Psychopharmacology and Biological Psychiatry 79, pages 155-161.
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Sophie Friederike Ullrich, Hansjörg Hagels & Oliver Kayser. (2016) Scopolamine: a journey from the field to clinics. Phytochemistry Reviews 16:2, pages 333-353.
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Eunice Mayumi Suenaga, Ligia de Cássia Val, Mineko Tominaga, José Homero Souza Filho, Gidel Soares, Monalisa Vioto & Clovis Ryuichi Nakaie. (2017) A fast and sensitive UHPLC-MS/MS method for the determination of N- butylscopolamine in human plasma: application in a bioequivalence study . Biomedical Chromatography 31:3, pages e3823.
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Jiayin Chen, Jürgen Brockmöller, Tina Seitz, Jörg König, Mladen V. Tzvetkov & Xijing Chen. (2017) Tropane alkaloids as substrates and inhibitors of human organic cation transporters of the SLC22 (OCT) and the SLC47 (MATE) families. Biological Chemistry 398:2, pages 237-249.
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Santosh Sanagapalli, Kriti Agnihotri, Rupert Leong & Crispin John Corte. (2016) Antispasmodic drugs in colonoscopy: a review of their pharmacology, safety and efficacy in improving polyp detection and related outcomes. Therapeutic Advances in Gastroenterology 10:1, pages 101-113.
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Karolina Podkowa, Adrian Podkowa, Kinga Sałat, Tomasz Lenda, Andrzej Pilc & Agnieszka Pałucha-Poniewiera. (2016) Antidepressant-like effects of scopolamine in mice are enhanced by the group II mGlu receptor antagonist LY341495. Neuropharmacology 111, pages 169-179.
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Mohammad F. Madhoun, Tauseef Ali, William M. Tierney & John T. Maple. (2014) Effect of hyoscine N ‐butylbromide on adenoma detection rate: M eta‐analysis of randomized clinical trials . Digestive Endoscopy 27:3, pages 354-360.
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Karam Nam, Jeong-Hwa Seo, Jung-Hee Ryu, Ah-Young Oh, Taeseung Lee, Hee-Pyoung Park, Young-Tae Jeon & Jung-Won Hwang. (2015) Randomized, clinical trial on the preventive effects of butylscopolamine on early postoperative catheter-related bladder discomfort. Surgery 157:2, pages 396-401.
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Emanuele Rondonotti, Oliver Zolk, Arnaldo Amato, Silvia Paggi, Alessandra Baccarin, Giancarlo Spinzi & Franco Radaelli. (2014) The impact of hyoscine-N-butylbromide on adenoma detection during colonoscopy: meta-analysis of randomized, controlled studies. Gastrointestinal Endoscopy 80:6, pages 1103-1112.e2.
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George Papadopoulos, Andreas Bourdoumis, Stefanos Kachrilas, Christian Bach, Noor Buchholz & Junaid Masood. (2014) Hyoscine N-Butylbromide (Buscopan®) in the Treatment of Acute Ureteral Colic: What Is the Evidence?. Urologia Internationalis 92:3, pages 253-257.
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