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Original Article

Efficacy and safety of sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes

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Pages 537-550 | Accepted 14 Dec 2007, Published online: 11 Jan 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (28)

Jakub Mesinovic, Ayse Zengin, Barbora De Courten, Peter R Ebeling & David Scott. (2019) Sarcopenia and type 2 diabetes mellitus: a bidirectional relationship. Diabetes, Metabolic Syndrome and Obesity 12, pages 1057-1072.
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Agata Schubert, Anders T. Buchholt, Antoine C. El Khoury, Ahmed Kamal & Vanessa Taieb. (2017) Evaluating the costs of glycemic response with canagliflozin versus dapagliflozin and empagliflozin as add-on to metformin in patients with type 2 diabetes mellitus in the United Arab Emirates. Current Medical Research and Opinion 33:6, pages 1155-1163.
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Jennifer Hayes, Rosie Anderson & Jeffrey W Stephens. (2016) Sitagliptin/metformin fixed-dose combination in type 2 diabetes mellitus: an evidence-based review of its place in therapy. Drug Design, Development and Therapy 10, pages 2263-2270.
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Marc Evans, Stephen C. Bain & Jiten Vora. (2016) A systematic review of the safety of incretin-based therapies in type 2 diabetes. Expert Review of Endocrinology & Metabolism 11:2, pages 217-232.
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Charles Andy Schuetz, Siew Hwa Ong & Matthias Blüher. (2015) Clinical trial simulation methods for estimating the impact of DPP-4 inhibitors on cardiovascular disease. ClinicoEconomics and Outcomes Research 7, pages 313-323.
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H.L. Katzeff, D. Williams-Herman, L. Xu, G.T. Golm, H. Wang, Q. Dong, J.R. Johnson, E.A. O’Neill, K.D. Kaufman, S.S. Engel & B.J. Goldstein. (2015) Long-term efficacy of sitagliptin as either monotherapy or add-on therapy to metformin: improvement in glycemic control over 2 years in patients with type 2 diabetes. Current Medical Research and Opinion 31:6, pages 1071-1077.
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Qingwei Zhao, Dongsheng Hong, Dongsheng Zheng, Yao Xiao & Baohua Wu. (2014) Risk of diarrhea in patients with type 2 diabetes mellitus treated with sitagliptin: a meta-analysis of 30 randomized clinical trials. Drug Design, Development and Therapy 8, pages 2283-2294.
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Antonio Ceriello, Liberata Sportiello, Concetta Rafaniello & Francesco Rossi. (2014) DPP-4 inhibitors: pharmacological differences and their clinical implications. Expert Opinion on Drug Safety 13:sup1, pages 57-68.
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Helmut Steinberg, Matt S Anderson, Thomas Musliner, Mary E Hanson & Samuel S Engel. (2013) Management of dyslipidemia and hyperglycemia with a fixed-dose combination of sitagliptin and simvastatin. Vascular Health and Risk Management 9, pages 273-282.
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Marc Rendell, Andjela Drincic & Radha Andukuri. (2012) Alogliptin benzoate for the treatment of type 2 diabetes. Expert Opinion on Pharmacotherapy 13:4, pages 553-563.
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Baptist Gallwitz. (2011) Sitagliptin and metformin combination therapy for the treatment of Type 2 diabetes. Expert Review of Endocrinology & Metabolism 6:4, pages 543-556.
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Sreevidya Subbarayan & Mark Kipnes. (2011) Sitagliptin: a review. Expert Opinion on Pharmacotherapy 12:10, pages 1613-1622.
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Paul S. Jellinger. (2011) Focus on Incretin-Based Therapies: Targeting the Core Defects of Type 2 Diabetes. Postgraduate Medicine 123:1, pages 53-65.
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Mansur Shomali. (2011) Add-on therapies to metformin for type 2 diabetes. Expert Opinion on Pharmacotherapy 12:1, pages 47-62.
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Mary Elizabeth Cox, Jennifer Rowell, Leonor Corsino & Jennifer B Green. (2010) Dipeptidyl peptidase-4 inhibitors in the management of type 2 diabetes: safety, tolerability, and efficacy. Drug, Healthcare and Patient Safety 2, pages 7-19.
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Karen Barnard, Mary Elizabeth Cox & Jennifer B Green. (2010) Clinical utility of fixed combinations of sitagliptin–metformin in treatment of type 2 diabetes. Diabetes, Metabolic Syndrome and Obesity 3, pages 363-372.
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André J Scheen. (2010) Pharmacokinetic and pharmacodynamic evaluation of sitagliptin plus metformin. Expert Opinion on Drug Metabolism & Toxicology 6:10, pages 1265-1276.
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Radha Andukuri, Andjela Drincic & Marc Rendell. (2009) Alogliptin: a new addition to the class of DPP-4 inhibitors. Diabetes, Metabolic Syndrome and Obesity 2, pages 117-126.
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Anna I. Palalau, Abd A. Tahrani, Milan K. Piya & Anthony H. Barnett. (2009) DPP-4 Inhibitors in Clinical Practice. Postgraduate Medicine 121:6, pages 70-100.
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Kristen M Kulasa & Robert R Henry. (2009) Pharmacotherapy of hyperglycemia. Expert Opinion on Pharmacotherapy 10:15, pages 2415-2432.
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Andreas Holstein & Winfried Beil. (2009) Oral antidiabetic drug metabolism: pharmacogenomics and drug interactions. Expert Opinion on Drug Metabolism & Toxicology 5:3, pages 225-241.
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Debora Williams-Herman, Jeremy Johnson, Rujun Teng, Edmund Luo, Michael J. Davies, Keith D. Kaufman, Barry J. Goldstein & John M. Amatruda. (2009) Efficacy and safety of initial combination therapy with sitagliptin and metformin in patients with type 2 diabetes: a 54-week study. Current Medical Research and Opinion 25:3, pages 569-583.
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Joan K Bardsley & Robert E Ratner. (2008) Sitagliptin: an oral agent for glucose control. Expert Review of Endocrinology & Metabolism 3:6, pages 691-697.
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Jonathan Kent Reynolds, Joshua J Neumiller & R Keith Campbell. (2008) Janumet™: a combination product suitable for use in patients with Type 2 diabetes. Expert Opinion on Investigational Drugs 17:10, pages 1559-1565.
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R. Patel, N. Parmar, S. P. Palit, N. Rathwa & R. Begum. (2023) A novel combination of sitagliptin and melatonin ameliorates T2D manifestations: studies on experimental diabetic models. Journal of Endocrinological Investigation 46:8, pages 1597-1612.
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Rania Khalil, Ahmed Shata, Eman M. Abd El-Kader, Hossam Sharaf, Walied S. Abdo, Noha A. Amin & Sameh Saber. (2020) Vildagliptin, a DPP-4 inhibitor, attenuates carbon tetrachloride-induced liver fibrosis by targeting ERK1/2, p38α, and NF-κB signaling. Toxicology and Applied Pharmacology 407, pages 115246.
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A.J. Scheen. (2020) Reduction in HbA1c with SGLT2 inhibitors vs. DPP-4 inhibitors as add-ons to metformin monotherapy according to baseline HbA1c: A systematic review of randomized controlled trials. Diabetes & Metabolism 46:3, pages 186-196.
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Sanaz Kamalinia, Robert G. Josse, Patrick J. Donio, Lindsay Leduc, Baiju R. Shah & Sheldon W. Tobe. (2019) Risk of any hypoglycaemia with newer antihyperglycaemic agents in patients with type 2 diabetes: A systematic review and meta‐analysis. Endocrinology, Diabetes & Metabolism 3:1.
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De-kang Zeng, Qian Xiao, Fa-qi Li, Yu-zhi Tang, Chao-li Jia & Xue-wen Tang. (2019) Cardiovascular risk of sitagliptin in treating patients with type 2 diabetes mellitus. Bioscience Reports 39:7.
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R. E. van Genugten, D. L. Möller‐Goede, D. H. van Raalte & M. Diamant. (2013) Extra‐pancreatic effects of incretin‐based therapies: potential benefit for cardiovascular‐risk management in type 2 diabetes. Diabetes, Obesity and Metabolism 15:7, pages 593-606.
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