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Original Article

Intrinsic cytotoxic effects of fluoroquinolones on human corneal keratocytes and endothelial cells

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Pages 419-424 | Accepted 28 Nov 2007, Published online: 21 Dec 2007

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Read on this site (4)

Katrina L Schmid. (2021) Fluoroquinolones are a potent form of chemotherapy. Clinical and Experimental Optometry 104:3, pages 412-416.
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Guigang Li, Lingjuan Xu, Menglin Jiang & Xianggen Wu. (2020) Eye drops and eye gels of levofloxacin: comparison of ocular absorption characterizations and therapeutic effects in the treatment of bacterial keratitis in rabbits. Drug Development and Industrial Pharmacy 46:4, pages 673-681.
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Vedat Şekeroğlu, Muhammet Aksoy & Zülal Atlı Şekeroğlu. (2017) Cytogenetic alterations in human lymphocyte cultures following exposure to ofloxacin. Drug and Chemical Toxicology 40:2, pages 140-145.
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Ryou Watanabe, Toru Nakazawa, Shunji Yokokura, Akira Kubota, Hisayo Kubota & Kohji Nishida. (2010) Fluoroquinolone antibacterial eye drops: effects on normal human corneal epithelium, stroma, and endothelium. Clinical Ophthalmology 4, pages 1181-1187.
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Articles from other publishers (29)

Jun Heo, Hui kyung Kim, Yeon Ji Jo & Jong Soo Lee. (2023) A Case of Allergic Reaction to 0.5% Moxifloxacin Eye Drops. Journal of the Korean Ophthalmological Society 64:10, pages 966-970.
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E. A. Drozdova & E. V. Berdnikova. (2023) Prevention and Treatment of Epitheliopathy as a Result of Acute Inflammatory Diseases of the Ocular Surface. Ophthalmology in Russia 20:2, pages 326-331.
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Jia Du, Qinghua Liu, Ying Pan, Shaodan Xu, Huanxuan Li & Junhong Tang. (2023) The Research Status, Potential Hazards and Toxicological Mechanisms of Fluoroquinolone Antibiotics in the Environment. Antibiotics 12:6, pages 1058.
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Niloofar Tavangarrad, N. Mosleh, Tahoora Shomali, Fatemeh Namazi & Maliheh Masoudian. (2022) Evaluation of delaying effects of different short‐term dosage regimens of topical ciprofloxacin on corneal ulcer healing in an avian model. Veterinary Medicine and Science 9:2, pages 999-1007.
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Tommaso Mazzierli, Federica Allegretta, Enrico Maffini & Marco Allinovi. (2023) Drug-induced thrombotic microangiopathy: An updated review of causative drugs, pathophysiology, and management. Frontiers in Pharmacology 13.
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Max Piffoux, Jeanne Volatron, Amanda Silva & Florence Gazeau. (2021) Thinking Quantitatively of RNA-Based Information Transfer via Extracellular Vesicles: Lessons to Learn for the Design of RNA-Loaded EVs. Pharmaceutics 13:11, pages 1931.
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Federica De Gaetano, Andreana Marino, Alessia Marchetta, Corrado Bongiorno, Roberto Zagami, Maria C. Cristiano, Donatella Paolino, Venerando Pistarà & Cinzia A. Ventura. (2021) Development of Chitosan/Cyclodextrin Nanospheres for Levofloxacin Ocular Delivery. Pharmaceutics 13:8, pages 1293.
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Laura Fabre, Marc Puyraveau, Audrey Jeanvoine, Garcin Thibaud, Joëlle Pizzuto, Fabienne Pouthier, Bernard Delbosc & Anne Sophie Gauthier. (2021) Changes of Contamination Rate and Microorganism Evaluation in Organ-Cultured Human Corneas: A 14-Year Review From a French Regional Eye Bank. Cornea 40:6, pages 696-703.
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Diana Silva, Hermínio C. de Sousa, Maria Helena Gil, Luís F. Santos, Renata A. Amaral, Jorge A. Saraiva, Madalena Salema-Oom, Carmen Alvarez-Lorenzo, Ana Paula Serro & Benilde Saramago. (2021) Imprinted hydrogels with LbL coating for dual drug release from soft contact lenses materials. Materials Science and Engineering: C 120, pages 111687.
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Ting Yang, Ting-Jun Fan & Bin Xu. (2020) Norfloxacin induces apoptosis and necroptosis in human corneal epithelial cells. Toxicology in Vitro 66, pages 104868.
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Vladimir V. Brzheskiy. (2020) Modern opportunities for the prevention and treatment of inflammatory eye diseases of an infectious nature in children. Ophthalmology Reports 12:4, pages 57-65.
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Ting-Jun Fan, Shu-Xian Wu & Guo-Jian Jiang. (2019) Apoptotic effects of norfloxacin on corneal endothelial cells. Naunyn-Schmiedeberg's Archives of Pharmacology 393:1, pages 77-88.
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E. A. Kasparova, A. A. Fedorov & O. I. Sobkova. (2019) Influence of frequent instillations of anti-infective solutions on eye tissues (an experimental study). Vestnik oftal'mologii 135:5, pages 160.
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Tobias Röck, Johanna Landenberger, Michael Buhl, Efdal Yoeruek, Karl Ulrich Bartz-Schmidt, Matthias Bramkamp, Gunnar Blumenstock & Daniel Röck. (2018) Factors influencing the contamination rates of the conjunctival swabs and organ culture media of human donor eyes. Medicine 97:38, pages e11879.
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Marina Rusch, Astrid Spielmeyer, Jessica Meißner, Manfred Kietzmann, Holger Zorn & Gerd Hamscher. (2017) Efficient Reduction of Antibacterial Activity and Cytotoxicity of Fluoroquinolones by Fungal-Mediated N -Oxidation . Journal of Agricultural and Food Chemistry 65:15, pages 3118-3126.
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Adel Alrwisan, Patrick J. Antonelli & Almut G. Winterstein. (2017) Quinolone Ear Drops After Tympanostomy Tubes and the Risk of Eardrum Perforation: A Retrospective Cohort Study. Clinical Infectious Diseases 64:8, pages 1052-1058.
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Victor E. ReviglioMatias OsabaGabriela SambuelliIrene C. Kuo. (2017) Phototoxic Effect of Topical Fluoroquinolones Administered Before Corneal Crosslinking in a Murine Model. Journal of Ocular Pharmacology and Therapeutics 33:2, pages 73-78.
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Bailey A. Milne-Davies, Patrick J. Antonelli, Nicklas C. Orobello & Carolyn O. Dirain. (2016) Collagen and α-Tubulin of Mouse Tympanic Membrane Fibroblasts Treated with Quinolones and Aminoglycosides. Otolaryngology–Head and Neck Surgery 156:2, pages 341-349.
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Tsan-Chi Chen, Tzu-Yun Tsai & Shu-Wen Chang. (2016) Molecular mechanism of fluoroquinolones modulation on corneal fibroblast motility. Experimental Eye Research 145, pages 10-16.
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Mohammad Ali SAGHIRI, Armen ASATOURIAN, Franklin GARCIA-GODOY & Nader SHEIBANI. (2016) Effect of biomaterials on angiogenesis during vital pulp therapy. Dental Materials Journal 35:5, pages 701-709.
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Masamichi FukudaHiroshi Sasaki. (2015) Effects of Fluoroquinolone-Based Antibacterial Ophthalmic Solutions on Corneal Wound Healing. Journal of Ocular Pharmacology and Therapeutics 31:9, pages 536-540.
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Olga Igorevna Aleksandrova, Igor Nikolaevich Okolov, Yuri Victorovich Takhtaev, Juliya Igorevna Khorolskaya, Tamara Slavikovna Hintuba & Miralda Ivanovna Blinova. (2015) A comparative evaluation of antimicrobial eye drops cytotoxicity. Ophthalmology Reports 8:1, pages 89-97.
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Evg A. Kasparova. (2015) Purulent corneal ulcers: clinical presentation, diagnosis, and conservative treatment. Vestnik oftal'mologii 131:6, pages 106.
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O. I. Alexandrova, Y. I. Khorolskaya, D. Y. Maychuk, M. I. Blinova, O. I. Alexandrova, Y. I. Khorolskaya, D. Y. Maychuk & M. I. Blinova. (2015) Study of common cytotoxicity of aminoglycoside and fluoroquinolone antibiotics in cell cultures. Vestnik oftal'mologii 131:5, pages 43.
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Irmgard Behlau. 2015. Keratoprostheses and Artificial Corneas. Keratoprostheses and Artificial Corneas 153 167 .
Irmgard Behlau, Kathryn V. Martin, Jacqueline N. Martin, Elena N. Naumova, James J. Cadorette, J. Tammy Sforza, Roberto PinedaIIII & Claes H. Dohlman. (2014) Infectious endophthalmitis in Boston keratoprosthesis: incidence and prevention. Acta Ophthalmologica 92:7.
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MASAHIKO AYAKI, ATSUO IWASAWA & YOSHIMI NIWANO. (2012) In vitro Assessment of the Cytotoxicity of Six Topical Antibiotics to Four Cultured Ocular Surface Cell Lines. Biocontrol Science 17:2, pages 93-99.
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Rita Mencucci, Iacopo Paladini, Domenico E. Pellegrini-Giampietro, Ugo Menchini & Tania Scartabelli. (2011) In vitro comparison of the cytotoxic effects of clinically available ophthalmic solutions of fluoroquinolones on human keratocytes. Canadian Journal of Ophthalmology 46:6, pages 513-520.
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M. Krishnaveni & S. Jayachandran. (2009) Inhibition of MAP kinases and down regulation of TNF-α, IL-β and COX-2 genes by the crude extracts from marine bacteria. Biomedicine & Pharmacotherapy 63:7, pages 469-476.
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