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Brief Report

Long-term safety, tolerability and efficacy of aliskiren in combination with valsartan in patients with hypertension: a 6-month interim analysis

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Pages 1039-1047 | Accepted 05 Feb 2008, Published online: 27 Feb 2008

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Read on this site (12)

Keisuke Okamura, Yosuke Takamiya, Ken Mori, Kazuyuki Shirai & Hidenori Urata. (2020) Add-on aliskiren treatment can decrease blood pressure but requires attention to risks of renal impairment and hyperkalemia Chikushi Anti-Hypertension Trial-Rasilez® (CHAT-Ras). Clinical and Experimental Hypertension 42:6, pages 545-552.
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Fabio Angeli, Gianpaolo Reboldi, Giovanni Mazzotta, Cristina Poltronieri & Paolo Verdecchia. (2012) Safety and efficacy of aliskiren in the treatment of hypertension: a systematic overview. Expert Opinion on Drug Safety 11:4, pages 659-670.
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Hernán Trimarchi. (2011) Role of aliskiren in blood pressure control and renoprotection. International Journal of Nephrology and Renovascular Disease 4, pages 41-48.
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Maurizio Destro, Francesca Cagnoni, Giuseppina Patrizia Dognini, Vincenzo Galimberti, Carlo Taietti, Chiara Cavalleri & Emilio Galli. (2011) Telmisartan: just an antihypertensive agent? A literature review. Expert Opinion on Pharmacotherapy 12:17, pages 2719-2735.
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Benjamin J Epstein. (2010) Aliskiren and valsartan combination therapy for the management of hypertension. Vascular Health and Risk Management 6, pages 711-722.
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Steven G. Chrysant, Alexander V. Murray, Uta C. Hoppe, Dan Dattani, Samir Patel, Shannon Ritter & Jack Zhang. (2010) Long-term safety and efficacy of aliskiren and valsartan combination with or without the addition of HCT in patients with hypertension. Current Medical Research and Opinion 26:12, pages 2841-2849.
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J. Signorovitch, J. Zhang, E.Q. Wu, D. Latremouille-Viau, A.P. Yu, H.B. Dastani & K.H. Kahler. (2010) Economic impact of switching from valsartan to other angiotensin receptor blockers in patients with hypertension. Current Medical Research and Opinion 26:4, pages 849-860.
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Steven A Yarows. (2010) Aliskiren/valsartan combination for the treatment of cardiovascular and renal diseases. Expert Review of Cardiovascular Therapy 8:1, pages 19-33.
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Benjamin J Epstein, Steven M Smith & Rushab Choksi. (2009) Recent changes in the landscape of combination RAS blockade. Expert Review of Cardiovascular Therapy 7:11, pages 1373-1384.
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Rainer Düsing & Felicity Sellers. (2009) ACE inhibitors, angiotensin receptor blockers and direct renin inhibitors in combination: a review of their role after the ONTARGET trial. Current Medical Research and Opinion 25:9, pages 2287-2301.
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Raymond O. Estacio. (2009) Renin-Angiotensin-Aldosterone System Blockade in Diabetes: Role of Direct Renin Inhibitors. Postgraduate Medicine 121:3, pages 33-44.
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Kalathil K Sureshkumar. (2008) Renin inhibition with aliskiren in hypertension: focus on aliskiren/hydrochlorothiazide combination therapy. Vascular Health and Risk Management 4:6, pages 1205-1220.
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Articles from other publishers (24)

Joel M. Neutel, Thomas D. Giles, Henry Punzi, Robert J. Weiss, Huiling Li & Amy Finck. (2014) Long-term safety of nebivolol and valsartan combination therapy in patients with hypertension: an open-label, single-arm, multicenter study. Journal of the American Society of Hypertension 8:12, pages 915-920.
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Gowraganahalli Jagadeesh, Pitchai Balakumar & Norman Stockbridge. (2012) How well do aliskiren's purported mechanisms track its effects on cardiovascular and renal disorders?. Cellular Signalling 24:8, pages 1583-1591.
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Samir G Mallat. (2012) What is a preferred angiotensin II receptor blocker-based combination therapy for blood pressure control in hypertensive patients with diabetic and non-diabetic renal impairment?. Cardiovascular Diabetology 11:1, pages 32.
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Anjay Rastogi, Mohamad Rashid & Richard F. Wright. (2011) Reducing Cardiorenal Risk Through Combination Therapy With a Direct Renin Inhibitor. The Journal of Clinical Hypertension 13:11, pages 848-855.
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William B. White, Robert Bresalier, Allen P. Kaplan, Biff F. Palmer, Robert H. Riddell, Anastasia Lesogor, William Chang & Deborah L. Keefe. (2011) Safety and Tolerability of the Direct Renin Inhibitor Aliskiren in Combination With Angiotensin Receptor Blockers and Thiazide Diuretics: A Pooled Analysis of Clinical Experience of 12,942 Patients. The Journal of Clinical Hypertension 13:7, pages 506-516.
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Natale Daniele BrunettiLuisa De GennaroPier Luigi PellegrinoAndrea CuculoLuigi ZiccardiAntonio GaglioneMatteo Di Biase. (2011) Direct renin inhibition: update on clinical investigations with aliskiren. European Journal of Cardiovascular Prevention & Rehabilitation 18:3, pages 424-437.
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Fadi G Hage, Sulaf J Mansur & Suzanne Oparil. (2011) Rationale for the use of multiple blockers of the renin–angiotensin–aldosterone system in specific patient populations. Therapy 8:3, pages 227-236.
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D. Richter, C. Mickel, S. Acharya, P. Brunel & C. Militaru. (2011) Aliskiren-based stepped-care treatment algorithm provides effective blood pressure control. International Journal of Clinical Practice 65:5, pages 613-623.
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Erin Elizabeth Kelland, Leanne Michelle McAuley & Guido Filler. (2010) Are we ready to use aliskiren in children?. Pediatric Nephrology 26:3, pages 473-477.
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Helmy M. Siragy. (2011) Rationale for Combining a Direct Renin Inhibitor with other Renin- Angiotensin System Blockers. Focus on Aliskiren and Combinations. Cardiovascular Drugs and Therapy 25:1, pages 87-97.
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Sulaf J. Mansur, Fadi G. Hage & Suzanne Oparil. (2010) Have the Renin-Angiotensin-Aldosterone System Perturbations in Cardiovascular Disease Been Exhausted?. Current Cardiology Reports 12:6, pages 450-463.
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Sean T. Duggan, Claudine M. Chwieduk & Monique P. Curran. (2010) Aliskiren. Drugs 70:15, pages 2011-2049.
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William B. White, Robert Bresalier, Allen P. Kaplan, Biff F. Palmer, Robert H. Riddell, Anastasia Lesogor, William Chang & Deborah L. Keefe. (2010) Safety and Tolerability of the Direct Renin Inhibitor Aliskiren: A Pooled Analysis of Clinical Experience in More Than 12,000 Patients With Hypertension. The Journal of Clinical Hypertension 12:10, pages 765-775.
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Christian Werner, Janine Pöss & Michael Böhm. (2010) Optimal Antagonism of the Renin-Angiotensin-Aldosterone System. Drugs 70:10, pages 1215-1230.
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Christian W. Mende. (2010) Application of Direct Renin Inhibition to Chronic Kidney Disease. Cardiovascular Drugs and Therapy 24:2, pages 139-149.
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Steven G. Chrysant. (2010) Current Status of Dual Renin Angiotensin Aldosterone System Blockade for the Treatment of Cardiovascular Diseases. The American Journal of Cardiology 105:6, pages 849-852.
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Carlos M. Ferrario. (2010) Addressing the theoretical and clinical advantages of combination therapy with inhibitors of the renin–angiotensin–aldosterone system: Antihypertensive effects and benefits beyond BP control. Life Sciences 86:9-10, pages 289-299.
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Dimitris P. PapadopoulosVasilios PapademetriouThomas K. Makris. (2009) On Target to Dual Block RAS?. Angiology 60:6, pages 739-749.
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Hiddo J Lambers Heerspink, Vlado Perkovic & Dick de Zeeuw. (2009) Renal and cardio-protective effects of direct renin inhibition: a systematic literature review. Journal of Hypertension 27:12, pages 2321-2331.
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C Venkata S Ram. (2009) Direct inhibition of renin: a physiological approach to treat hypertension and cardiovascular disease. Future Cardiology 5:5, pages 453-465.
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Peter S SeverAlan H Gradman & Michel Azizi. (2009) Managing cardiovascular and renal risk: the potential of direct renin inhibition. Journal of the Renin-Angiotensin-Aldosterone System 10:2, pages 65-76.
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Carlos M. Ferrario, Jewell A. Jessup & Jasmina Varagic. 2009. The Local Cardiac Renin-Angiotensin Aldosterone System. The Local Cardiac Renin-Angiotensin Aldosterone System 7 17 .
Steven A. Yarows, Suzanne Oparil, Samir Patel, Hui Fang & Jack Zhang. (2008) Aliskiren and valsartan in stage 2 hypertension: subgroup analysis of a randomized, double-blind study. Advances in Therapy 25:12, pages 1288-1302.
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