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Brief Report

Efficacy and safety of therapy with metformin plus pioglitazone in the treatment of patients with type 2 diabetes: a double-blind, placebo-controlled, clinical trial

Pages 1111-1119 | Accepted 13 Feb 2009, Published online: 23 Mar 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Melissa A. Davidson, Donald R. Mattison, Laurent Azoulay & Daniel Krewski. (2018) Thiazolidinedione drugs in the treatment of type 2 diabetes mellitus: past, present and future. Critical Reviews in Toxicology 48:1, pages 52-108.
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Bhavik J. Pandya, Morgan Bron, Therese McCall, Andrew P. Yu, Kristina S. Chen, Miles E. Mattson & Eric Q. Wu. (2011) Achieving glycemic goal with initial versus sequential combination therapy using metformin and pioglitazone in type 2 diabetes mellitus. Current Medical Research and Opinion 27:1, pages 189-195.
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Pedro de Pablos-Velasco. (2010) Pioglitazone: beyond glucose control. Expert Review of Cardiovascular Therapy 8:8, pages 1057-1067.
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Articles from other publishers (16)

Chu Lin, Xiaoling Cai, Wenjia Yang, Fang Lv, Lin Nie & Linong Ji. (2020) Age, sex, disease severity, and disease duration difference in placebo response: implications from a meta-analysis of diabetes mellitus. BMC Medicine 18:1.
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Xiao-Ling Cai & Li-Nong Ji. (2019) Treatment response between Asian and non-Asian patients with type 2 diabetes. Chinese Medical Journal 132:1, pages 1-3.
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L. M. Neff, M. S. Broder, D. Beenhouwer, E. Chang, E. Papoyan & Z. W. Wang. (2017) Network meta-analysis of lorcaserin and oral hypoglycaemics for patients with type 2 diabetes mellitus and obesity. Clinical Obesity 7:6, pages 337-346.
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Dennis Schrijnders, Raiza Wever, Nanne Kleefstra, Sebastiaan T. Houweling, Kornelis J. J. van Hateren, Geertruida H. de Bock, Henk J. G. Bilo, Klaas H. Groenier & Gijs W. D. Landman. (2016) Addition of sulphonylurea to metformin does not relevantly change body weight: a prospective observational cohort study ( ZODIAC ‐39) . Diabetes, Obesity and Metabolism 18:10, pages 973-979.
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Oded Stempa. (2015) Pioglitazone: lessons and learnings 15 years since launch and beyond. Diabetes Management 5:6, pages 415-429.
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James H. Flory & Alvin I. Mushlin. (2015) Observational and clinical trial findings on the comparative effectiveness of diabetes drugs showed agreement. Journal of Clinical Epidemiology 68:2, pages 200-210.
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M. Bajaj, R. Gilman, S. Patel, J. Kempthorne‐Rawson, D. Lewis‐D'Agostino & H.‐J. Woerle. (2014) Linagliptin improved glycaemic control without weight gain or hypoglycaemia in patients with Type 2 diabetes inadequately controlled by a combination of metformin and pioglitazone: a 24‐week randomized, double‐blind study. Diabetic Medicine 31:12, pages 1505-1514.
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Young Ki LeeSun Ok SongKwang Joon KimYongin ChoYounjeong ChoiYujung YunByung-Wan LeeEun-Seok KangBong Soo ChaHyun Chul Lee. (2013) Glycemic Effectiveness of Metformin-Based Dual-Combination Therapies with Sulphonylurea, Pioglitazone, or DPP4-Inhibitor in Drug-Naïve Korean Type 2 Diabetic Patients. Diabetes & Metabolism Journal 37:6, pages 465.
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Shinzo Hiroi, Kumi Matsuno, Masashi Hirayama, Takaki Hayakawa, Norihito Yoshioka & Koji Kawakami. (2012) Evaluation of the bioequivalence of a fixed-dose combination tablet of pioglitazone–metformin versus commercial tablets in healthy Japanese male volunteers. Diabetes Management 2:5s, pages 13-20.
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S.‐C. Liu, Y.‐K. Tu, M.‐N. Chien & K.‐L. Chien. (2012) Effect of antidiabetic agents added to metformin on glycaemic control, hypoglycaemia and weight change in patients with type 2 diabetes: a network meta‐analysis. Diabetes, Obesity and Metabolism 14:9, pages 810-820.
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Debora MacisSara GandiniAliana Guerrieri-GonzagaHarriet JohanssonPaolo MagniMassimiliano RuscicaMatteo LazzeroniDavide SerranoMassimiliano CazzanigaSerena MoraIrene FeroceMaria PizzamiglioMaria Teresa SandriMarcella GulisanoBernardo BonanniAndrea DeCensi. (2012) Prognostic Effect of Circulating Adiponectin in a Randomized 2 × 2 Trial of Low-Dose Tamoxifen and Fenretinide in Premenopausal Women at Risk for Breast Cancer. Journal of Clinical Oncology 30:2, pages 151-157.
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A. Avogaro, M. Federici, J. Betteridge, R. Bonadonna, I. W. Campbell, G. H. Schernthaner, B. Staels, E. Farinaro & G. Crepaldi. (2014) Which is the eligible patient to be treated with pioglitazone? The expert view. Journal of Endocrinological Investigation 34:10, pages 781-787.
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Esther Phielix, Julia Szendroedi & Michael Roden. (2011) The role of metformin and thiazolidinediones in the regulation of hepatic glucose metabolism and its clinical impact. Trends in Pharmacological Sciences 32:10, pages 607-616.
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Lucio Vilar, Viviane Canadas, Maria Juliana Arruda, Carla Arahata, Rodrigo Agra, Lisete Pontes, Larissa Montenegro, Clarice Freitas Vilar, Lidiane Moura e Silva, José Luciano Albuquerque & Amaro Gusmão. (2010) Comparison of metformin, gliclazide MR and rosiglitazone in monotherapy and in combination for type 2 diabetes. Arquivos Brasileiros de Endocrinologia & Metabologia 54:3, pages 311-318.
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Shelley R Salpeter, Elizabeth Greyber, Gary A Pasternak & Edwin E Salpeter (posthumous). 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
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