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Current Medical Research and Opinion Volume 25, 2009 - Issue 7
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Original Article

Impact of noncompliance with urate-lowering drug on serum urate and gout-related healthcare costs: administrative claims analysis

Rachel Halpern i3 Innovus, Eden Prairie, MN, USACorrespondence[email protected]
,
Reema R. Mody Takeda Pharmaceuticals North America, Inc., Deerfield, IL, USA
,
Mahesh J. Fuldeore Formerly TAP Pharmaceutical Products, Inc., Lake Forest, IL, USA
,
Pankaj A. Patel Formerly TAP Pharmaceutical Products, Inc., Lake Forest, IL, USA
&
Ted R. Mikuls University of Nebraska Medical Center and Omaha Veterans Administration Medical Center, Omaha, NE, USA
Pages 1711-1719 | Accepted 05 May 2009, Published online: 02 Jun 2009

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June M Tordoff, Charlotte Brenkley, Janet Krska & Alesha Smith. (2019) Exploring Medicines Burden Among Adults in New Zealand: A Cross-Sectional Survey. Patient Preference and Adherence 13, pages 2171-2184.
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Gérard Reach, Gaëlle Chenuc, Pascal Maigret, Isabelle Elias-Billon, Luc Martinez & René-Marc Flipo. (2019) Implication Of Character Traits In Adherence To Treatment In People With Gout: A Reason For Considering Nonadherence As A Syndrome. Patient Preference and Adherence 13, pages 1913-1926.
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Sunggun Lee, Min Wook So & Eunyoung Ahn. (2019) Long-term adherence and persistence with febuxostat among male patients with gout in a routine clinical setting. Modern Rheumatology 29:4, pages 662-668.
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Yi-Yun Lee, Li-Na Kuo, Jin-Hua Chen, Yi-Chun Lin, Lung-Fang Chen & Yu Ko. (2019) Prescribing patterns and healthcare costs of gout. Current Medical Research and Opinion 35:6, pages 1051-1058.
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Sharan K Rai, Alyssa Howren, Elizabeth S Wilcox, Anne F Townsend, Carlo A Marra, J Antonio Aviña-Zubieta & Mary A De Vera. (2018) Exploring strategies to support medication adherence in patients with inflammatory arthritis: a patient-oriented qualitative study using an interactive focus group activity. Patient Preference and Adherence 12, pages 2015-2025.
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Thanda Aung, Gihyun Myung & John D FitzGerald. (2017) Treatment approaches and adherence to urate-lowering therapy for patients with gout. Patient Preference and Adherence 11, pages 795-800.
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CSL Tan, GG Teng, KJ Chong, PP Cheung, AYN Lim, HL Wee & A Santosa. (2016) Utility of the Morisky Medication Adherence Scale in gout: a prospective study. Patient Preference and Adherence 10, pages 2449-2457.
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Sunggun Lee & Min Wook So. (2016) Adherence with urate-lowering therapies among male patients with gout in a routine clinical setting. Modern Rheumatology 26:6, pages 950-955.
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Andrew Whelton, Patricia A. MacDonald, Solomon Chefo & Lhanoo Gunawardhana. (2013) Preservation of Renal Function during Gout Treatment with Febuxostat: A Quantitative Study. Postgraduate Medicine 125:1, pages 106-114.
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Joseph A. Lieberman$suffix/text()$suffix/text(). (2011) Treatment and Prophylaxis of Gout Flare in the Clinic: An Office-Based Approach to Gout Management. Postgraduate Medicine 123:6, pages 151-165.
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Paul P. Doghramji. (2011) Managing Your Patient with Gout: A Review of Treatment Options. Postgraduate Medicine 123:3, pages 56-71.
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Bijan Borah, Patricia Sacco & Victoria Zarotsky. (2010) Predictors of adherence among Alzheimer's disease patients receiving oral therapy. Current Medical Research and Opinion 26:8, pages 1957-1965.
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Articles from other publishers (44)

Joong Kyong Ahn. (2023) Epidemiology and treatment-related concerns of gout and hyperuricemia in Korean. Journal of Rheumatic Diseases 30:2, pages 88-98.
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Shuhui Hu, Robert Terkeltaub, Mingshu Sun, Xiaopeng Ji, Zhiyuan Li, Zijing Ran, Yushuang Li, Hui Zhang, Wenyan Sun, Changgui Li & Jie Lu. (2022) Palpable tophi and more comorbidities associated with adherence to urate-lowering medical therapy in a Chinese gout cohort. Joint Bone Spine 89:6, pages 105435.
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Xiaomei Xue, Xuan Yuan, Lin Han, Xinde Li, Tony R. Merriman, Lingling Cui, Zhen Liu, Wenyan Sun, Can Wang, Fei Yan, Yuwei He, Aichang Ji, Jie Lu & Changgui Li. (2022) Effect of Clinical Typing on Serum Urate Targets of Benzbromarone in Chinese Gout Patients: A Prospective Cohort Study. Frontiers in Medicine 8.
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Esha Dasgupta, Zhan P. Chong, Ming N. Ting, Amirul A. Mohd Tajuddin, Ke X. Voon, Tharsyini Sasitharan, Keen S. Tai & Swan S. Yeap. (2022) Relationship of medication adherence, serum uric acid level and diet to recurrent attacks of gout. The Egyptian Rheumatologist 44:1, pages 69-73.
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Shahrzad Salmasi, Ayano Kelly, Susan J. Bartlett, Maarten de Wit, Lyn March, Allison Tong, Peter Tugwell, Kathleen Tymms, Suzanne Verstappen & Mary A. De Vera. (2021) Researchers’ perspectives on methodological challenges and outcomes selection in interventional studies targeting medication adherence in rheumatic diseases: an OMERACT-adherence study. BMC Rheumatology 5:1.
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Chang-Nam Son, Sarah Stewart, Isabel Su, Borislav Mihov, Gregory Gamble & Nicola Dalbeth. (2021) Global patterns of treat-to-serum urate target care for gout: Systematic review and meta-analysis. Seminars in Arthritis and Rheumatism 51:4, pages 677-684.
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Aran Kim, Yunkyung Kim, Geun-Tae Kim, Eunyoung Ahn, Min Wook So & Seung-Geun Lee. (2020) Comparison of persistence rates between allopurinol and febuxostat as first-line urate-lowering therapy in patients with gout: an 8-year retrospective cohort study. Clinical Rheumatology 39:12, pages 3769-3776.
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Ayano Kelly, Kathleen Tymms, Maarten Wit, Susan J. Bartlett, Marita Cross, Therese Dawson, Mary De Vera, Vicki Evans, Michael Gill, Geraldine Hassett, Irwin Lim, Karine Manera, Gabor Major, Lyn March, Sean O’Neill, Marieke Scholte-Voshaar, Premarani Sinnathurai, Daniel Sumpton, Armando Teixeira‐Pinto, Peter Tugwell, Bart Bemt & Allison Tong. (2020) Patient and Caregiver Priorities for Medication Adherence in Gout, Osteoporosis, and Rheumatoid Arthritis: Nominal Group Technique. Arthritis Care & Research 72:10, pages 1410-1419.
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Jasvinder A. Singh, Shuo Yang & Kenneth G. Saag. (2020) Factors Influencing the Effectiveness of Allopurinol in Achieving and Sustaining Target Serum Urate in a US Veterans Affairs Gout Cohort. The Journal of Rheumatology 47:3, pages 449-460.
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Stéphanie Fabre, Pierre Clerson, Jean-Marie Launay, Jean-François Gautier, Tiphaine Vidal-Trecan, Jean-Pierre Riveline, Adam Platt, Anna Abrahamsson, Jeffrey N. Miner, Glen Hughes, Pascal Richette & Thomas Bardin. (2018) Accuracy of the HumaSensplus point-of-care uric acid meter using capillary blood obtained by fingertip puncture. Arthritis Research & Therapy 20:1.
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Allan H. Morton, Tony Hosey & Brian LaMoreaux. (2018) Retreatment with Pegloticase after a Gap in Therapy in Patients with Gout: A Report of Four Cases. Rheumatology and Therapy 5:2, pages 583-594.
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Lieke E J M Scheepers, Andrea M Burden, Ilja C W Arts, Bart Spaetgens, Patrick Souverein, Frank de Vries & Annelies Boonen. (2018) Medication adherence among gout patients initiated allopurinol: a retrospective cohort study in the Clinical Practice Research Datalink (CPRD). Rheumatology 57:9, pages 1641-1650.
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Philip C. Robinson, Nicola Dalbeth & Peter Donovan. (2018) The Cost-effectiveness of Biannual Serum Urate (SU) Monitoring after Reaching Target in Gout: A Health Economic Analysis Comparing SU Monitoring. The Journal of Rheumatology 45:5, pages 697-704.
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John D. FitzGerald, Ted R. Mikuls, Tuhina Neogi, Jasvinder A. Singh, Mark Robbins, Puja P. Khanna, Amy S. Turner, Rachel Myslinski & Lisa G. Suter. (2018) Development of the American College of Rheumatology Electronic Clinical Quality Measures for Gout. Arthritis Care & Research 70:5, pages 659-671.
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Lieke E.J.M. Scheepers, Marloes van Onna, Coen D.A. Stehouwer, Jasvinder A. Singh, Ilja C.W. Arts & Annelies Boonen. (2018) Medication adherence among patients with gout: A systematic review and meta-analysis. Seminars in Arthritis and Rheumatism 47:5, pages 689-702.
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Xin Hui Jasmine Chua, Siriwan Lim, Fui Ping Lim, Yee Nah Anita Lim, Hong-Gu He & Gim Gee Teng. (2018) Factors influencing medication adherence in patients with gout: A descriptive correlational study. Journal of Clinical Nursing 27:1-2, pages e213-e222.
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Daniel Hill-McManus, Elena Soto, Scott Marshall, Steven Lane & Dyfrig Hughes. (2018) Impact of non-adherence on the safety and efficacy of uric acid-lowering therapies in the treatment of gout. British Journal of Clinical Pharmacology 84:1, pages 142-152.
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Natasha K. J. Campbell, Khalid Saadeldin & Mary A. De Vera. (2017) The Duality of Economic Issues With Medication Non-adherence in Patients With Inflammatory Arthritis. Current Rheumatology Reports 19:10.
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Nicola Dalbeth, Thomas Bardin, Michael Doherty, Frédéric Lioté, Pascal Richette, Kenneth G. Saag, Alexander K. So, Lisa K. Stamp, Hyon K. Choi & Robert Terkeltaub. (2017) Discordant American College of Physicians and international rheumatology guidelines for gout management: consensus statement of the Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN). Nature Reviews Rheumatology 13:9, pages 561-568.
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John D. FitzGerald, Tuhina Neogi & Hyon K. Choi. (2017) Editorial: Do Not Let Gout Apathy Lead to Gouty Arthropathy. Arthritis & Rheumatology 69:3, pages 479-482.
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Abhishek Abhishek, Wendy Jenkins, Jonathan La-Crette, Gwen Fernandes & Michael Doherty. (2017) Long-term persistence and adherence on urate-lowering treatment can be maintained in primary care—5-year follow-up of a proof-of-concept study. Rheumatology, pages kew395.
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BRIAN W. COBURN & TED R. MIKULS. (2016) The Problem with Gout Is That It’s Still Such a Problem. The Journal of Rheumatology 43:8, pages 1453-1455.
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Aylin Altan, Aki Shiozawa, Tim Bancroft & Jasvinder A. Singh. (2015) A Real-World Study of Switching From Allopurinol to Febuxostat in a Health Plan Database. JCR: Journal of Clinical Rheumatology 21:8, pages 411-418.
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Gemma E. Shields & Stephen M. Beard. (2015) A Systematic Review of the Economic and Humanistic Burden of Gout. PharmacoEconomics 33:10, pages 1029-1047.
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Sharan K. Rai, Lindsay C. Burns, Mary A. De Vera, Aliya Haji, Dean Giustini & Hyon K. Choi. (2015) The economic burden of gout: A systematic review. Seminars in Arthritis and Rheumatism 45:1, pages 75-80.
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S. Mantarro, A. Capogrosso-Sansone, M. Tuccori, C. Blandizzi, S. Montagnani, I. Convertino, L. Antonioli, M. Fornai, I. Cricelli, S. Pecchioli, C. Cricelli & F. Lapi. (2015) Allopurinol adherence among patients with gout: an Italian general practice database study. International Journal of Clinical Practice 69:7, pages 757-765.
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Robert Jackson, Aki Shiozawa, Erin K Buysman, Aylin Altan, Stephanie Korrer & Hyon Choi. (2015) Flare frequency, healthcare resource utilisation and costs among patients with gout in a managed care setting: a retrospective medical claims-based analysis. BMJ Open 5:6, pages e007214.
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Seoyoung C. Kim, Sebastian Schneeweiss, Niteesh Choudhry, Jun Liu, Robert J. Glynn & Daniel H. Solomon. (2015) Effects of Xanthine Oxidase Inhibitors on Cardiovascular Disease in Patients with Gout: A Cohort Study. The American Journal of Medicine 128:6, pages 653.e7-653.e16.
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Nazia Rashid, Brian W. Coburn, Yi-Lin Wu, T. Craig Cheetham, Jeffrey R. Curtis, Kenneth G. Saag & Ted R. Mikuls. (2015) Modifiable Factors Associated with Allopurinol Adherence and Outcomes Among Patients with Gout in an Integrated Healthcare System. The Journal of Rheumatology 42:3, pages 504-512.
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Bart Spaetgens, José M.A. Wijnands, Caroline van Durme, Sjef van der Linden & Annelies Boonen. (2015) Cost of Illness and Determinants of Costs Among Patients with Gout. The Journal of Rheumatology 42:2, pages 335-344.
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Mary A. De Vera, Greg Marcotte, Sharan Rai, Jessica S. Galo & Vidula Bhole. (2014) Medication Adherence in Gout: A Systematic Review. Arthritis Care & Research 66:10, pages 1551-1559.
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J. W. Maynard, M. A. McAdams-DeMarco, A. Law, L. Kao, A. C. Gelber, J. Coresh & A. N. Baer. (2013) Racial Differences in Gout Incidence in a Population-Based Cohort: Atherosclerosis Risk in Communities Study. American Journal of Epidemiology 179:5, pages 576-583.
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Wendy LynchWing ChanNathan KleinmanL.M. AndrewsAnthony M. Yadao. (2013) Economic Burden of Gouty Arthritis Attacks for Employees with Frequent and Infrequent Attacks. Population Health Management 16:2, pages 138-145.
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Antoni Sicras-Mainar, Ruth Navarro-Artieda & Jordi Ibáñez-Nolla. (2013) Resource Use and Economic Impact of Patients With Gout: A Multicenter, Population-Wide Study. Reumatología Clínica (English Edition) 9:2, pages 94-100.
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Antoni Sicras-Mainar, Ruth Navarro-Artieda & Jordi Ibáñez-Nolla. (2013) Uso de recursos e impacto económico de los pacientes con gota: estudio multicéntrico de ámbito poblacional. Reumatología Clínica 9:2, pages 94-100.
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Eswar Krishnan & Linjun Chen. (2013) Trends in physician diagnosed gout and gout therapies in the US: results from the national ambulatory health care surveys 1993 to 2009. Arthritis Research & Therapy 15:6, pages R181.
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Ariel Berger, Lisa M. Bloudek, Sepideh F. Varon & Gerry Oster. (2012) Adherence with Migraine Prophylaxis in Clinical Practice. Pain Practice 12:7, pages 541-549.
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Haesuk Park, Karen L. Rascati, Karim Prasla & Tyrone McBayne. (2012) Evaluation of Health Care Costs and Utilization Patterns for Patients With Gout. Clinical Therapeutics 34:3, pages 640-652.
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Gérard Reach. (2011) Treatment adherence in patients with gout. Joint Bone Spine 78:5, pages 456-459.
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Naomi Schlesinger. (2011) Difficult-to-Treat Gouty Arthritis. Drugs 71:11, pages 1413-1439.
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Gérard Reach. (2011) L’observance dans la goutte. Revue du Rhumatisme 78:4, pages 319-323.
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