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Original Article

Generic substitution: additional challenge for adherence in hypertensive patients?

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Pages 2515-2521 | Accepted 20 Jul 2009, Published online: 26 Aug 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Helle Håkonsen, Maria Wängberg, Dina Alani & Tove Hedenrud. (2020) Generic versus brand-name over-the-counter analgesics: knowledge and attitudes among Swedish pharmacy customers. Journal of Pharmaceutical Policy and Practice 13:1.
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Zsolt Hepp, Kathleen Wyne, Shivaji R. Manthena, Siting Wang & Ved Gossain. (2018) Adherence to thyroid hormone replacement therapy: a retrospective, claims database analysis. Current Medical Research and Opinion 34:9, pages 1673-1678.
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Nikhil Khandelwal, Beverly Johns, Zsolt Hepp & Jane Castelli-Haley. (2018) The economic impact of switching from Synthroid for the treatment of hypothyroidism. Journal of Medical Economics 21:5, pages 518-524.
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Da Tao, Tieyan Wang, Tieshan Wang & Xingda Qu. (2018) Influence of drug colour on perceived drug effects and efficacy. Ergonomics 61:2, pages 284-294.
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Antoni Sicras-Mainar, Javier Rejas-Gutiérrez & Ruth Navarro-Artieda. (2015) Comparative effectiveness and costs of generic and brand-name gabapentin and venlafaxine in patients with neuropathic pain or generalized anxiety disorder in Spain. ClinicoEconomics and Outcomes Research 7, pages 299-312.
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Pieter Dylst, Arnold Vulto & Steven Simoens. (2015) Societal value of generic medicines beyond cost-saving through reduced prices. Expert Review of Pharmacoeconomics & Outcomes Research 15:4, pages 701-711.
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Steven Edelman, William H. Polonsky & Christopher G. Parkin. (2014) Biosimilar insulins are coming: what they are, what you need to know. Current Medical Research and Opinion 30:11, pages 2217-2222.
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Brian Godman, Solveig Sakshaug, Christian Berg, Björn Wettermark & Alan Haycox. (2011) Combination of prescribing restrictions and policies to engineer low prices to reduce reimbursement costs. Expert Review of Pharmacoeconomics & Outcomes Research 11:1, pages 121-129.
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Josemir W Sander, Philippe Ryvlin, Hermann Stefan, Daniel R Booth & Jürgen Bauer. (2010) Generic substitution of antiepileptic drugs. Expert Review of Neurotherapeutics 10:12, pages 1887-1898.
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Articles from other publishers (73)

Kevin Wirth, Stefan Boes, Markus Näpflin, Carola Huber & Eva Blozik. (2023) Initial prescriptions and medication switches of biological products: an analysis of prescription pathways and determinants in the Swiss healthcare setting. BMJ Open 13:11, pages e077454.
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Cze Ci Chan, Ying‐Chang Tung, Kuang‐Tso Lee, Yi‐Hsin Chan & Pao‐Hsien Chu. (2023) Clinical outcomes of generic versus brand‐name clopidogrel for secondary prevention in patients with acute myocardial infarction: A nationwide cohort study. Clinical and Translational Science.
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Georges Hatem, Nare Navasardyan, Elsa Lahoud, Sanaa Awada, Rana Itani, Roula Ajrouche & Mathijs Goossens. (2022) Predictors of substitution to generic drugs and physicians’ perceived exclusivity of substitution: A cross sectional survey among physicians. Journal of Generic Medicines: The Business Journal for the Generic Medicines Sector 19:1, pages 23-32.
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Jinyi Tao, Shihong Li, Qiling Xu, Shiwei Gong & Fang Zeng. (2023) Patients' attitudes towards switching to national volume-based procurement (NVBP) Drugs—a qualitative investigation in Wuhan, China. BMC Health Services Research 23:1.
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Johanna Weitzel, Klaus Langer & Olaf Rose. (2022) Effects of Generic Exchange of Levodopa Medication in Patients With Parkinson Disease. Journal of Patient Safety 18:7, pages 704-710.
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Riikka Rainio, Riitta Ahonen, Elina Lämsä & Johanna Timonen. (2022) Factors facilitating and hindering counselling about generic substitution and a reference price system in community pharmacies - a survey among Finnish dispensers. BMC Health Services Research 22:1.
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Riikka Rainio, Riitta Ahonen & Johanna Timonen. (2022) The content of counselling received about interchangeable medicines and generic substitution—a survey of pharmacy customers. Journal of Pharmaceutical Health Services Research 13:2, pages 132-142.
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Jinghan Qu, Wei Zuo, Roxane L. Took, Kenneth W. Schafermeyer, Stephanie Lukas, Shaohong Wang, Liping Du, Xin Liu, Yang Gao, Jiantao Li, Hui Pan, Xiaoli Du, Dan Mei & Bo Zhang. (2022) A nationwide survey exploring physicians’ and pharmacists’ knowledge, awareness and perceptions regarding generic medicines in China. BMC Health Services Research 22:1.
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Saskia E van Grondelle, Sytske van Bruggen, Judith Meijer, Erik van Duin, Michiel L Bots, Guy Rutten, Hedwig M M Vos, Mattijs E Numans & Rimke C Vos. (2022) Opinions on hypertension care and therapy adherence at the healthcare provider and healthcare system level: a qualitative study in the Hague, Netherlands. BMJ Open 12:7, pages e062128.
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Blanca Lumbreras, Javier Sanz-Valero & Elsa López-Pintor. (2022) Impact of Variation in Pill/Package Appearance of Drugs on Patients’ Behavior: A Systematic Review. Journal of Patient Safety 18:4, pages 310-317.
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O. A. Polyakova & O. D. Ostroumova. (2022) The problem of choice: original drug or generic? Emphasis on rosuvastatin. Rational Pharmacotherapy in Cardiology 18:2, pages 225-230.
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Jentora WhiteAfton WagnerHima Patel. (2022) The impact of biosimilar insulins on the diabetes landscape. Journal of Managed Care & Specialty Pharmacy 28:1, pages 91-98.
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Natalia Celedón, Cristián González & Cristóbal Cuadrado. (2021) Perspectives of patients and consumers on the use of generic medicines. Medwave 21:11, pages e8155-e8155.
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Jingwei Gao, Tomotsugu Seki & Koji Kawakami. (2021) Comparison of adherence, persistence, and clinical outcome of generic and brand-name statin users: A retrospective cohort study using the Japanese claims database. Journal of Cardiology 77:5, pages 545-551.
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Tamara L Imfeld-Isenegger, Melanie Bich Tram Pham, Dominik Stämpfli, Valerie Albert, Enas Almanasreh, Rebekah Moles, Timothy F Chen & Kurt E Hersberger. (2020) Medication Discrepancies in Community Pharmacies in Switzerland: Identification, Classification, and Their Potential Clinical and Economic Impact. Pharmacy 8:1, pages 36.
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Jesús Mario Arancón-Monge, Alicia de Castro-Cuenca, Ángel Serrano-Vázquez, Luz Campos-Díaz, Ricardo Rodríguez Barrientos, Isabel del Cura-González, Jesús Mario Arancón-Monge, José María Rubio-Ruiz, Jesús Juan Ortiz-Septien, Eva María Illana-Calero, María Cristina Martín-Muñoz, Paula Silvana González-de-Langarica-Bouza, Alicia de Castro-Cuenca, María Isabel Rouco-Regueira, Ángel Serrano-Vázquez, Cristina García-Benito, Carmen Colomes less, María Dolores Miranda Carrasco, Yolanda Úbeda Sánchez, David García Gutiérrez, Nuria Domínguez Pérez, Luz Campos-Díaz, Mercedes García Culebras, Montserrat Díaz Eraso, Generoso Tejedor Pérez, María Fernanda Venegas Gato, Mar García Viada, Carmen Fuentes Manrique, Asunción García Alonso, Verónica Molina Barcena, Josefina Piñera Támes, Margarita Villar Fidalgo, Ana M. Herranz Torrubiano, Elena Polentinos Castro, Mariel Morey Montalvo, Juan A. López Rodríguez, Ricardo Rodríguez Barrientos & Isabel del Cura González. (2020) Efectos del cambio de apariencia de medicamentos en seguridad y adherencia en pacientes crónicos mayores de 65 años en atención primaria. Estudio CAMBIMED. Atención Primaria 52:2, pages 77-85.
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Riikka Rainio, Riitta Ahonen & Johanna Timonen. (2019) The content of patient counseling about interchangeable medicines and generic substitution in Finnish community pharmacies - a survey of dispensers. BMC Health Services Research 19:1.
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Hanna M Tolonen, Marja SA Airaksinen, Päivi Ruokoniemi, Katri Hämeen-Anttila, Kenneth M Shermock & Pekka Kurki. (2019) Medication safety risks to be managed in national implementation of automatic substitution of biological medicines: a qualitative study. BMJ Open 9:10, pages e032892.
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Cristina Mondelo-García, Elvia Mendoza, María-Jesús Movilla-Fernández & Carmen Coronado. (2018) Perceptions of pharmacists and physicians on generic substitution in a financial crisis context in Northwestern Spain: A qualitative study. Health Policy 122:12, pages 1316-1325.
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Walaa Abuelmagd, Helle Håkonsen, Khadijah Qurrat-ul-Ain Mahmood, Najmeh Taghizadeh & Else-Lydia Toverud. (2017) Living with Diabetes: Personal Interviews with Pakistani Women in Norway. Journal of Immigrant and Minority Health 20:4, pages 848-853.
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R. Navarro-Artieda, J. Rejas-Gutiérrez, M. Pérez-Paramo & A. Sicras-Mainar. (2018) Clinical and economic consequences of treating patients with peripheral neuropathic pain with brand name or generic drugs in routine clinical practice: The effects of age and sex. Neurología (English Edition) 33:3, pages 141-153.
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R. Navarro-Artieda, J. Rejas-Gutiérrez, M. Pérez-Paramo & A. Sicras-Mainar. (2018) Efecto de la edad y el género sobre las consecuencias clínicas y económicas del tratamiento con especialidad farmacéutica de marca o genérica en pacientes con dolor neuropático periférico en práctica clínica habitual. Neurología 33:3, pages 141-153.
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Usama Asif, Zikria Saleem, Mahrukh Yousaf, Hamid Saeed, Furqan Khurshid Hashmi & Mohamed Azmi Hassali. (2017) Exploring the knowledge and attitude of medical and pharmacy students about generic medicine in Lahore, Pakistan. Journal of Generic Medicines: The Business Journal for the Generic Medicines Sector 14:1, pages 22-28.
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Philip J. Domeyer, Vassilis Aletras, Fotios Anagnostopoulos, Vasiliki Katsari & Dimitris Niakas. (2017) Development and validation of a tool to assess knowledge and attitudes towards generic medicines among students in Greece: The ATtitude TOwards GENerics (ATTOGEN) questionnaire. PLOS ONE 12:11, pages e0188484.
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Beate Hennie Garcia, Renate Elenjord, Camilla Bjornstad, Kjell Hermann Halvorsen, Sigurd Hortemo & Steinar Madsen. (2017) Safety and efficiency of a new generic package labelling: a before and after study in a simulated setting. BMJ Quality & Safety 26:10, pages 817-823.
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Sabine Vogler, Margit Gombocz & Nina Zimmermann. (2017) Tendering for off-patent outpatient medicines: lessons learned from experiences in Belgium, Denmark and the Netherlands. Journal of Pharmaceutical Health Services Research 8:3, pages 147-158.
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Amanj I. Kurdi, Li-Chia Chen & Rachel A. Elliott. (2017) Exploring factors associated with patients’ adherence to antihypertensive drugs among people with primary hypertension in the United Kingdom. Journal of Hypertension 35:9, pages 1881-1890.
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Francesco Vittorio Costa. (2017) Improving Adherence to Treatment and Reducing Economic Costs of Hypertension: The Role of Olmesartan-Based Treatment. High Blood Pressure & Cardiovascular Prevention 24:3, pages 265-274.
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Erika Olsson, Helle Wallach-Kildemoes, Ban Ahmed, Pontus Ingman, Susanne Kaae & Sofia Kälvemark Sporrong. (2017) The influence of generic substitution on the content of patient–pharmacist communication in Swedish community pharmacies. International Journal of Pharmacy Practice 25:4, pages 274-281.
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Robert J. Straka, Denis J. Keohane & Larry Z. Liu. (2017) Potential Clinical and Economic Impact of Switching Branded Medications to Generics. American Journal of Therapeutics 24:3, pages e278-e289.
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T. Balasopoulos, A. Charonis, K. Athanasakis, J. Kyriopoulos & E. Pavi. (2017) Why do generic drugs fail to achieve an adequate market share in Greece? Empirical findings and policy suggestions. Health Policy 121:3, pages 265-272.
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Tor Endestad, Laura A. Wortinger, Steinar Madsen & Sigurd Hortemo. (2016) Package Design Affects Accuracy Recognition for Medications. Human Factors: The Journal of the Human Factors and Ergonomics Society 58:8, pages 1206-1216.
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Suzanne S. Dunne. (2016) What Do Users of Generic Medicines Think of Them? A Systematic Review of Consumers’ and Patients’ Perceptions of, and Experiences with, Generic Medicines. The Patient - Patient-Centered Outcomes Research 9:6, pages 499-510.
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Pernilla J. Bjerkeli, Anna K. Jönsson, Eva Lesén, Ann-Charlotte Mårdby & Karolina Andersson Sundell. (2016) Refill Adherence in Relation to Substitution and the Use of Multiple Medications: A Nationwide Population Based Study on New ACE-Inhibitor Users. PLOS ONE 11:5, pages e0155465.
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Elene Paltrinieri Nardi & Marcos Bosi Ferraz. (2016) Perception of the value of generic drugs in São Paulo, Brazil. Cadernos de Saúde Pública 32:2.
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Aleksandra Drozdowska & Tomasz Hermanowski. (2016) Predictors of generic substitution: The role of psychological, sociodemographic, and contextual factors. Research in Social and Administrative Pharmacy 12:1, pages 119-129.
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A. O’Leary, C. Usher, M. Lynch, M. Hall, L. Hemeryk, S. Spillane, P. Gallagher & M. Barry. (2015) Generic medicines and generic substitution: contrasting perspectives of stakeholders in Ireland. BMC Research Notes 8:1.
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Suzanne S. Dunne & Colum P. Dunne. (2015) What do people really think of generic medicines? A systematic review and critical appraisal of literature on stakeholder perceptions of generic drugs. BMC Medicine 13:1.
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Sarah Colgan, Kate Faasse, Leslie R Martin, Melika H Stephens, Andrew Grey & Keith J Petrie. (2015) Perceptions of generic medication in the general population, doctors and pharmacists: a systematic review. BMJ Open 5:12, pages e008915.
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Anette Vik Mamen, Helle Håkonsen, Reidun L S Kjome, Bjørn Gustavsen-Krabbesund & Else-Lydia Toverud. (2015) Norwegian elderly patients’ need for drug information and attitudes towards medication use reviews in community pharmacies. International Journal of Pharmacy Practice 23:6, pages 423-428.
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Valérie Piguet, Stéphanie D’Incau, Marie Besson, Jules Desmeules & Christine Cedraschi. (2015) Prescribing Generic Medication in Chronic Musculoskeletal Pain Patients: An Issue of Representations, Trust, and Experience in a Swiss Cohort. PLOS ONE 10:8, pages e0134661.
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Emily C. O'Brien, Lisa A. McCoy, Laine Thomas, Eric D. Peterson & Tracy Y. Wang. (2015) Patient adherence to generic versus brand statin therapy after acute myocardial infarction: Insights from the Can Rapid Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of the American College of Cardiology/American Heart Association Guidelines Registry. American Heart Journal 170:1, pages 55-61.
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Zoltán Kaló, Anke-Peggy Holtorf, Rafael Alfonso-Cristancho, Jie Shen, Tamás Ágh, András Inotai & Diana Brixner. (2015) Need for Multicriteria Evaluation of Generic Drug Policies. Value in Health 18:2, pages 346-351.
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Christine Jacomet, Clotilde Allavena, Fleur Peyrol, Bruno Pereira, Laurence Morand Joubert, Haleh Bagheri, Laurent Cotte, Rodolphe Garaffo, Laurent Gerbaud & Pierre Dellamonica. (2015) Perception of Antiretroviral Generic Medicines: One-Day Survey of HIV-Infected Patients and Their Physicians in France. PLOS ONE 10:2, pages e0117214.
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Aleksandra Drozdowska & Tomasz Hermanowski. (2014) Exploring the opinions and experiences of patients with generic substitution: a representative study of Polish society. International Journal of Clinical Pharmacy 37:1, pages 68-75.
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Helle Håkonsen & Karolina Andersson Sundell. 2015. Pharmaceutical Prices in the 21st Century. Pharmaceutical Prices in the 21st Century 209 227 .
Henrik Trusell & Karolina Andersson Sundell. (2014) Effects of generic substitution on refill adherence to statin therapy: a nationwide population-based study. BMC Health Services Research 14:1.
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Helle Håkonsen, Karine Lees & Else-Lydia Toverud. (2014) Cultural barriers encountered by Norwegian community pharmacists in providing service to non-Western immigrant patients. International Journal of Clinical Pharmacy 36:6, pages 1144-1151.
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Julie A. Chambers, Ronan E. O’Carroll, Martin Dennis, Cathie Sudlow & Marie Johnston. (2013) “My doctor has changed my pills without telling me”: impact of generic medication switches in stroke survivors. Journal of Behavioral Medicine 37:5, pages 890-901.
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Jette Rathe, Jens Søndergaard, Dorte E. Jarbøl, Jesper Hallas & Morten Andersen. (2014) Patients' concern about their medicine after a generic switch: a combined cross‐sectional questionnaire and register study. Pharmacoepidemiology and Drug Safety 23:9, pages 965-973.
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Lorena San Miguel, Uta Augustin, Reinhard Busse, Cécile Knai, Gloria Rubert, Sinikka Sihvo & Rita Baeten. (2014) Recognition of pharmaceutical prescriptions across the European Union: A comparison of five Member States’ policies and practices. Health Policy 116:2-3, pages 206-213.
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Suzanne Dunne, Bill Shannon, Colum Dunne & Walter Cullen. (2014) Patient Perceptions of Generic Medicines: A Mixed-Methods Study. The Patient - Patient-Centered Outcomes Research 7:2, pages 177-185.
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Anne Leendertse, Ulrich Oron & Fred Schobben. (2014) Generieke geneesmiddelen: regels en realiteit. Huisarts en wetenschap 57:3, pages 138-141.
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Asa Auta, Echuku Tercee Bala & David Shalkur. (2014) Generic Medicine Substitution: A Cross-Sectional Survey of the Perception of Pharmacists in North-Central, Nigeria. Medical Principles and Practice 23:1, pages 53-58.
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Jette Rathe, Pia Larsen, Morten Andersen, Maja Paulsen, Dorte Jarbøl, Janus Thomsen & Jens Soendergaard. (2013) Associations between generic substitution and patients' attitudes, beliefs and experiences. European Journal of Clinical Pharmacology 69:10, pages 1827-1836.
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Charlotte Olesen, Philipp Harbig, Ishay Barat & Else Marie Damsgaard. (2013) Generic substitution does not seem to affect adherence negatively in elderly polypharmacy patients. Pharmacoepidemiology and Drug Safety 22:10, pages 1093-1098.
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Johanna Timonen, Reeta Heikkilä & Riitta Ahonen. (2013) Generic substitution in Finland: lessons learned during 2003-2008. Journal of Pharmaceutical Health Services Research 4:3, pages 165-172.
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Alon Harris, Brent Siesky, Ingrida Januleviciene, Leslie Abrams Tobe, Matt Zore, Annahita Amireskandari, Noa Geffen & Barbara Wirostko. (2013) Authors’ response. British Journal of Ophthalmology 97:6, pages 795.2-796.
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Erika Olsson & Sofia Kälvemark Sporrong. (2012) Pharmacists’ experiences and attitudes regarding generic drugs and generic substitution: two sides of the coin. International Journal of Pharmacy Practice 20:6, pages 377-383.
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Helle Håkonsen & Else-Lydia Toverud. (2011) Cultural influences on medicine use among first-generation Pakistani immigrants in Norway. European Journal of Clinical Pharmacology 68:2, pages 171-178.
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J. A. Kanis, J.-Y. Reginster, J.-M. Kaufman, J.-D. Ringe, J. D. Adachi, M. Hiligsmann, R. Rizzoli & C. Cooper. (2011) A reappraisal of generic bisphosphonates in osteoporosis. Osteoporosis International 23:1, pages 213-221.
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Anne Decollogny, Yves Eggli, Patricia Halfon & Thomas M Lufkin. (2011) Determinants of generic drug substitution in Switzerland. BMC Health Services Research 11:1.
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David J. Muzina, Donald A. Malone, Inderpal Bhandari, Rocco Lulic, Rich Baudisch & Matthew Keene. (2011) Rate of non-adherence prior to upward dose titration in previously stable antidepressant users. Journal of Affective Disorders 130:1-2, pages 46-52.
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Helle Håkonsen & Else-Lydia Toverud. (2010) Special challenges for drug adherence following generic substitution in Pakistani immigrants living in Norway. European Journal of Clinical Pharmacology 67:2, pages 193-201.
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Reeta Heikkilä, Pekka Mäntyselkä & Riitta Ahonen. (2011) Do people regard cheaper medicines effective? Population survey on public opinion of generic substitution in Finland. Pharmacoepidemiology and Drug Safety 20:2, pages 185-191.
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Eriko Kobayashi, Hiroshi Karigome, Tomoya Sakurada, Nobunori Satoh & Shiro Ueda. (2011) Patients’ attitudes towards generic drug substitution in Japan. Health Policy 99:1, pages 60-65.
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Else-Lydia Toverud, Anne Kjersti Røise, Grete Hogstad & Inger Wabø. (2010) Norwegian patients on generic antihypertensive drugs: a qualitative study of their own experiences. European Journal of Clinical Pharmacology 67:1, pages 33-38.
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Antoni Sicras Mainar & Ruth Navarro Artieda. (2010) Influencia de la sustitución de medicamentos de marca por genéricos en el cumplimiento terapéutico de la hipertensión arterial y la dislipidemia. Gaceta Sanitaria 24:6, pages 473-482.
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Helle Håkonsen, Heidi Skjønhaug Hopen, Linda Abelsen, Bjørg Ek & Else-Lydia Toverud. (2010) Generic substitution: a potential risk factor for medication errors in hospitals. Advances in Therapy 27:2, pages 118-126.
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Hannah Brennan. (2015) The Cost of Confusion: The Paradox of Trademarked Pharmaceuticals. SSRN Electronic Journal.
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