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Original Article

Glaucoma medication persistence with a fixed combination versus multiple bottles

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Pages 2543-2547 | Accepted 14 Aug 2009, Published online: 04 Sep 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (14)

Gen Suzuki, Eriko Kunikane, Wakasa Shigemi, Keisuke Shinno, Seiko Kozai, Masaaki Kurata & Akio Kawamura. (2021) Ocular and systemic pharmacokinetics of brimonidine and brinzolamide after topical administration in rabbits: comparison between fixed-combination and single-drug formulations. Current Eye Research 46:3, pages 380-386.
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Wesam Shamseldin Shalaby, Vikram Shankar, Reza Razeghinejad & L. Jay Katz. (2020) Current and new pharmacotherapeutic approaches for glaucoma. Expert Opinion on Pharmacotherapy 21:16, pages 2027-2040.
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Lindsay Machen, Reza Razeghinejad & Jonathan S. Myers. (2020) Fixed-combination topical anti-hypertensive ophthalmic agents. Expert Opinion on Pharmacotherapy 21:10, pages 1269-1282.
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Alan L. Robin & Kelly W. Muir. (2019) Medication adherence in patients with ocular hypertension or glaucoma. Expert Review of Ophthalmology 14:4-5, pages 199-210.
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Lutz E Pillunat, Carl Erb, Auli Ropo, Friedemann Kimmich & Norbert Pfeiffer. (2017) Preservative-free fixed combination of tafluprost 0.0015% and timolol 0.5% in patients with open-angle glaucoma and ocular hypertension: results of an open-label observational study. Clinical Ophthalmology 11, pages 1051-1064.
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Sourabh Sharma, Sameer Trikha, Shamira A Perera & Tin Aung. (2015) Clinical effectiveness of brinzolamide 1%–brimonidine 0.2% fixed combination for primary open-angle glaucoma and ocular hypertension. Clinical Ophthalmology 9, pages 2201-2207.
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Nathan M Radcliffe. (2014) The impact of timolol maleate on the ocular tolerability of fixed-combination glaucoma therapies. Clinical Ophthalmology 8, pages 2541-2549.
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Stefan Pfennigsdorf, Leo de Jong, Stefan Makk, Yvette Fournichot, Alain Bron, Robert J Morgan-Warren & John Maltman. (2013) A combined analysis of five observational studies evaluating the efficacy and tolerability of bimatoprost/timolol fixed combination in patients with primary open-angle glaucoma or ocular hypertension. Clinical Ophthalmology 7, pages 1219-1225.
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Gregory Reardon, Sameer Kotak & Gail F Schwartz. (2011) Objective assessment of compliance and persistence among patients treated for glaucoma and ocular hypertension: a systematic review. Patient Preference and Adherence 5, pages 441-463.
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Anton Hommer. (2011) Role of fixed combinations in the management of open-angle glaucoma. Expert Review of Pharmacoeconomics & Outcomes Research 11:1, pages 91-99.
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Parul Ichhpujani & L Jay Katz. (2010) Efficacy, safety and tolerability of combination therapy with timolol and dorzolamide in glaucoma and ocular hypertension. Drug, Healthcare and Patient Safety 2, pages 73-83.
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Articles from other publishers (22)

Karsten Klabe & Andreas Fricke. 2023. Loss of Vision [Working Title]. Loss of Vision [Working Title].
Daniel C. Terveen, Steven R. SarkisianJrJr, Steven D. Vold, Deepan Selvadurai, Blake K. Williamson, Deborah G. Ristvedt, Adam R. Bleeker, Kavita Dhamdhere & Jaime E. DickersonJrJr. (2022) Canaloplasty and trabeculotomy with the OMNI® surgical system in OAG with prior trabecular microbypass stenting. International Ophthalmology 43:5, pages 1647-1656.
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Oya Tekeli & Helin Ceren Köse. (2022) Evaluation of the Use of Brinzolamide-Brimonidine Fixed Combination in Maximum Medical Therapy. Turkish Journal of Ophthalmology 52:4, pages 262-269.
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Hiromitsu Onoe, Kazuyuki Hirooka, Mikio Nagayama, Atsushi Hirota, Hideki Mochizuki, Takeshi Sagara, Katsuyoshi Suzuki, Hideaki Okumichi & Yoshiaki Kiuchi. (2021) The Efficacy, Safety and Satisfaction Associated with Switching from Brinzolamide 1% and Brimonidine 0.1% to a Fixed Combination of Brinzolamide 1% and Brimonidine 0.1% in Glaucoma Patients. Journal of Clinical Medicine 10:22, pages 5228.
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Fotis Topouzis, Ivan Goldberg, Katharina Bell, Andrew J Tatham, Antonia Ridolfi, Douglas Hubatsch, Marcelo Nicolela, Phillipe Denis & S Fabian Lerner. (2019) Brinzolamide/brimonidine fixed-dose combination bid as an adjunct to a prostaglandin analog for open-angle glaucoma/ocular hypertension. European Journal of Ophthalmology 31:1, pages 103-111.
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Sudeepthi Padala, Ramam Sripada, Srivalli Bhaskari Padmavathi Gundabattula, Krishna Jyothi Tadi, Prabhakar Rao Nallamothula, Farzaneh Raveshi & Dasaratha Dhanaraju Magharla. (2020) A comparative study on the efficacy of brinzolamide/timolol versus brinzolamide/brimonidine fixed drug combinations in primary open-angle glaucoma. Future Journal of Pharmaceutical Sciences 6:1.
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Kenji Kashiwagi, Eriko Chono, Sarah Koesters & Poh Sin Yap. (2020) Persistence and treatment patterns of fixed combination drugs for glaucoma: a retrospective claims database study in Japan. BMC Ophthalmology 20:1.
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S. Bertaud, V. Aragno, C. Baudouin & A. Labbé. (2019) Le glaucome primitif à angle ouvert. La Revue de Médecine Interne 40:7, pages 445-452.
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Reza Moosavi & Ejaz Ansari. (2018) Brinzolamide/Brimonidine Fixed Combination: Simplifying Glaucoma Treatment Regimens. Ophthalmology and Therapy 7:2, pages 397-403.
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Sang Wook JinSae Mi Lee. (2018) The Efficacy and Safety of the Fixed Combination of Brinzolamide 1% and Brimonidine 0.2% in Normal Tension Glaucoma: An 18-Month Retrospective Study. Journal of Ocular Pharmacology and Therapeutics 34:3, pages 274-279.
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S. Yu. Petrov, V. S. Zinina & A. V. Volzhanin. (2018) The role of fixed dose combinations in the treatment of primary open-angle glaucoma. Vestnik oftal'mologii 134:4, pages 100.
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Howard S. Barnebey & Alan L. Robin. (2017) Adherence to Fixed-Combination Versus Unfixed Travoprost 0.004%/Timolol 0.5% for Glaucoma or Ocular Hypertension: A Randomized Trial. American Journal of Ophthalmology 176, pages 61-69.
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Curt Hartleben, Juan Camilo Parra, Amy Batoosingh, Paula Bernstein & Margot Goodkin. (2017) A Masked, Randomized, Phase 3 Comparison of Triple Fixed-Combination Bimatoprost/Brimonidine/Timolol versus Fixed-Combination Brimonidine/Timolol for Lowering Intraocular Pressure. Journal of Ophthalmology 2017, pages 1-9.
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Tetsuya Yamamoto, Toru Ikegami, Yuji Ishikawa & Satoru Kikuchi. (2016) Randomized, Controlled, Phase 3 Trials of Carteolol/Latanoprost Fixed Combination in Primary Open-Angle Glaucoma or Ocular Hypertension. American Journal of Ophthalmology 171, pages 35-46.
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Hyun Uk ShinSang Wook Jin. (2016) The Efficacy of Brinzolamide 1%/Brimonidine 0.2% Fixed Combination in Normal Tension Glaucoma. Journal of the Korean Ophthalmological Society 57:10, pages 1619.
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Alfonso García-López, José A Paczka, Jesús Jiménez-Román & Curt Hartleben. (2014) Efficacy and tolerability of fixed-combination bimatoprost/timolol versus fixed-combination dorzolamide/brimonidine/timolol in patients with primary open-angle glaucoma or ocular hypertension: a multicenter, prospective, crossover study. BMC Ophthalmology 14:1.
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Tin Aung, Guna Laganovska, Tania Josefina Hernandez Paredes, James D. Branch, Alexis Tsorbatzoglou & Ivan Goldberg. (2014) Twice-Daily Brinzolamide/Brimonidine Fixed Combination versus Brinzolamide or Brimonidine in Open-Angle Glaucoma or Ocular Hypertension. Ophthalmology 121:12, pages 2348-2355.
Crossref
F. Aptel, A. Labbé, C. Baudouin, A. Bron, Y. Lachkar, E. Sellem, J.-P. Renard, J.-P. Nordmann, J.-F. Rouland & P. Denis. (2014) Traitement du glaucome, conservateurs et surface oculaire. Journal Français d'Ophtalmologie 37:9, pages 728-736.
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Florent Aptel, Christophe Chiquet & Jean-Paul Romanet. (2012) Intraocular Pressure-Lowering Combination Therapies with Prostaglandin Analogues. Drugs 72:10, pages 1355-1371.
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Jane Loftus, Dina Christopoulou, Betina T. Blak & Michelle Hards. (2011) Topical prostaglandin fixed combinations in UK primary care: observational study using data from the health improvement network. European Journal of Ophthalmology 22:3, pages 376-387.
Crossref
Jia-Liang Zhao, Jian Ge, Xiao-Xin Li, Yu-Min Li, Yao-Hua Sheng, Nai-Xue Sun, Xing-Huai Sun, Ke Yao & Zheng Zhong. (2011) Comparative efficacy and safety of the fixed versus unfixed combination of latanoprost and timolol in Chinese patients with open-angle glaucoma or ocular hypertension. BMC Ophthalmology 11:1.
Crossref
Vicky H. Lu, Ivan Goldberg & Christine Y. Lu. (2010) Use of Glaucoma Medications: State of the Science and Directions for Observational Research. American Journal of Ophthalmology 150:4, pages 569-574.e9.
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