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Current Medical Research and Opinion Volume 25, 2009 - Issue 12
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Original Article

Efficacy and safety of pioglitazone/metformin fixed-dose combination therapy compared with pioglitazone and metformin monotherapy in treating patients with T2DM

Alfonso Perez Takeda Global Research & Development Center, Inc., Lake Forest, IL, USACorrespondence[email protected]
,
Zhen Zhao Takeda Global Research & Development Center, Inc., Lake Forest, IL, USA
,
Randal Jacks Hill Country Medical Associates, New Braunfels, TX, USA
&
Robert Spanheimer Takeda Pharmaceuticals North America, Inc., Deerfield, IL, USA
Pages 2915-2923 | Accepted 21 Sep 2009, Published online: 14 Oct 2009

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Melissa A. Davidson, Donald R. Mattison, Laurent Azoulay & Daniel Krewski. (2018) Thiazolidinedione drugs in the treatment of type 2 diabetes mellitus: past, present and future. Critical Reviews in Toxicology 48:1, pages 52-108.
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A Brett Hauber, Steven Han, Jui-Chen Yang, Ira Gantz, Kaan Tunceli, Juan Marcos Gonzalez, Kimberly Brodovicz, Charles M Alexander, Michael Davies, Kristy Iglay, Qiaoyi Zhang & Larry Radican. (2013) Effect of pill burden on dosing preferences, willingness to pay, and likely adherence among patients with type 2 diabetes. Patient Preference and Adherence 7, pages 937-949.
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Bhavik J. Pandya, Morgan Bron, Therese McCall, Andrew P. Yu, Kristina S. Chen, Miles E. Mattson & Eric Q. Wu. (2011) Achieving glycemic goal with initial versus sequential combination therapy using metformin and pioglitazone in type 2 diabetes mellitus. Current Medical Research and Opinion 27:1, pages 189-195.
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Articles from other publishers (27)

Wei-Tse Hung, Yuan-Jung Chen, Chun-Yu Cheng, Bruce Ovbiagele, Meng Lee & Chia-Yu Hsu. (2022) Metformin plus a low hypoglycemic risk antidiabetic drug vs. metformin monotherapy for untreated type 2 diabetes mellitus: A meta-analysis of randomized controlled trials. Diabetes Research and Clinical Practice 189, pages 109937.
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Tian Li, Rui Providencia, Nan Mu, Yue Yin, Mai Chen, Yishi Wang, Manling Liu, Lu Yu, Chunhu Gu & Heng Ma. (2021) Association of metformin monotherapy or combined therapy with cardiovascular risks in patients with type 2 diabetes mellitus. Cardiovascular Diabetology 20:1.
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Päivi Maria Paldánius. (2020) Evaluating the Evidence behind the Novel Strategy of Early Combination from Vision to Implementation. Diabetes & Metabolism Journal 44:6, pages 785-801.
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莎 雷. (2020) Efficacy and Safety of Pioglitazone/Metformin Fixed-Dose Combination Therapy in Treating Patients with Newly Diagnosed T2DM. Advances in Clinical Medicine 10:09, pages 1869-1873.
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Wei Zhu, Wen Huang, Zhiqiang Xu, Mengda Cao, Qiaoli Hu, Chen Pan, Miao Guo, Ji-Fu Wei & Hongyu Yuan. (2019) Analysis of Patents Issued in China for Antihyperglycemic Therapies for Type 2 Diabetes Mellitus. Frontiers in Pharmacology 10.
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Paola Portillo-Sanchez, Fernando Bril, Romina Lomonaco, Diana Barb, Beverly Orsak, Jan Marie Bruder & Kenneth Cusi. (2019) Effect of pioglitazone on bone mineral density in patients with nonalcoholic steatohepatitis: A 36-month clinical trial. Journal of Diabetes 11:3, pages 223-231.
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Evangelia Kalaitzoglou, John L. Fowlkes, Iuliana Popescu & Kathryn M. Thrailkill. (2019) Diabetes pharmacotherapy and effects on the musculoskeletal system. Diabetes/Metabolism Research and Reviews 35:2, pages e3100.
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Chikara Kikuchi, Mifuyu Ohno, Takafumi Izumo, Satoru Takahashi, Masayuki Aoki, Hitoshi Shimomura, Yohei Kawano, Shuji Shimada & Takao Aoyama. (2019) Investigation of Approval Trends and Benefits of New Fixed-Dose Combination Drugs in Japan. Therapeutic Innovation & Regulatory Science, pages 216847901882191.
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Xiaoling Cai, Xueying Gao, Wenjia Yang, Xueyao Han & Linong Ji. (2018) Efficacy and Safety of Initial Combination Therapy in Treatment-Naïve Type 2 Diabetes Patients: A Systematic Review and Meta-analysis. Diabetes Therapy 9:5, pages 1995-2014.
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Yuanyuan Wu, Pengfen Li, Dan Zhang & Yingpu Sun. (2017) Metformin and pioglitazone combination therapy ameliorate polycystic ovary syndrome through AMPK/PI3K/JNK pathway. Experimental and Therapeutic Medicine.
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Pablo Aschner Montoya, Oscar Mauricio Muñoz Velandía, Diana Marcela Girón Cardozo, Olga Milena García Morales, Daniel Gerardo Fernández Ávila, Luz Ángela Casas, Luisa Fernanda Bohórquez Villamizar, Clara María Arango Toro, Liliana Carvajal Gutiérrez, Doris Amanda Ramírez De Peña, Juan Guillermo Sarmiento Ramón, Cristian Alejandro Colón, Nestor Fabian Correa González, Pilar Alarcón Robles & Álvaro Andrés Bustamante. (2017) Guía de práctica clínica para el tratamiento de la diabetes mellitus tipo 2: manejo inicial. Universitas Médica 58:4.
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Cristina Bianchi, Giuseppe Daniele, Angela Dardano, Roberto Miccoli & Stefano Del Prato. (2017) Early Combination Therapy with Oral Glucose-Lowering Agents in Type 2 Diabetes. Drugs 77:3, pages 247-264.
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Avivit Cahn & William T. Cefalu. (2016) Clinical Considerations for Use of Initial Combination Therapy in Type 2 Diabetes. Diabetes Care 39:Supplement_2, pages S137-S145.
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Jianwen Li & He Lian. (2016) Recent development of single preparations and fixed-dose combination tablets for the treatment of non-insulin-dependent diabetes mellitus. Archives of Pharmacal Research 39:6, pages 731-746.
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H Yokoyama, S Araki, K Kawai, K Hirao, M Oishi, K Sugimoto, H Sone, H Maegawa & A Kashiwagi. (2015) Pioglitazone treatment and cardiovascular event and death in subjects with type 2 diabetes without established cardiovascular disease (JDDM 36). Diabetes Research and Clinical Practice 109:3, pages 485-492.
Crossref
Muhammad Abdul-Ghani, Ralph A. DeFronzo & Roy Eldor. 2015. International Textbook of Diabetes Mellitus. International Textbook of Diabetes Mellitus 686 708 .
Hong Yang, Enling Ye, Guangxin Si, Liangmiao Chen, Lingqiao Cai, Chengfu Ye, Chi Zhang & Xuemian Lu. (2014) Adiponectin Gene Polymorphism rs2241766 T/G Is Associated with Response to Pioglitazone Treatment in Type 2 Diabetic Patients from Southern China. PLoS ONE 9:11, pages e112480.
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Zhong-Ning Zhu, Yun-Fa Jiang & Tao Ding. (2014) Risk of fracture with thiazolidinediones: An updated meta-analysis of randomized clinical trials. Bone 68, pages 115-123.
Crossref
O. J. Phung, D. M. Sobieraj, S. S. Engel & S. N. Rajpathak. (2014) Early combination therapy for the treatment of type 2 diabetes mellitus: systematic review and meta-analysis. Diabetes, Obesity and Metabolism 16:5, pages 410-417.
Crossref
Ralph A. DeFronzo, Roy Eldor & Muhammad Abdul-Ghani. (2013) Pathophysiologic Approach to Therapy in Patients With Newly Diagnosed Type 2 Diabetes. Diabetes Care 36:Supplement_2, pages S127-S138.
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Roy Eldor, Ralph A. DeFronzo & Muhammad Abdul-Ghani. (2013) In Vivo Actions of Peroxisome Proliferator–Activated Receptors. Diabetes Care 36:Supplement_2, pages S162-S174.
Crossref
Shinzo Hiroi, Kumi Matsuno, Masashi Hirayama, Takaki Hayakawa, Norihito Yoshioka & Koji Kawakami. (2012) Evaluation of the bioequivalence of a fixed-dose combination tablet of pioglitazone–metformin versus commercial tablets in healthy Japanese male volunteers. Diabetes Management 2:5s, pages 13-20.
Crossref
Lawrence Blonde & Zinnia T. San Juan. (2012) Fixed-Dose Combinations for Treatment of Type 2 Diabetes Mellitus. Advances in Therapy 29:1, pages 1-13.
Crossref
Jamie C. Barner. (2011) Adherence to Oral Antidiabetic Agents with Pioglitazone and Metformin: Comparison of Fixed-Dose Combination Therapy with Monotherapy and Loose-Dose Combination Therapy. Clinical Therapeutics 33:9, pages 1281-1288.
Crossref
Andreas PfütznerThomas SchöndorfDiethelm TschöpeRalf LobmannJürgen MerkeJürgen MüllerUte LehmannWinfried FuchsThomas Forst. (2011) PIOfix-Study: Effects of Pioglitazone/Metformin Fixed Combination in Comparison with a Combination of Metformin with Glimepiride on Diabetic Dyslipidemia. Diabetes Technology & Therapeutics 13:6, pages 637-643.
Crossref
Alfonso Perez, Randal Jacks, Vipin Arora & Robert Spanheimer. (2010) Effects of Pioglitazone and Metformin Fixed‐Dose Combination Therapy on Cardiovascular Risk Markers of Inflammation and Lipid Profile Compared With Pioglitazone and Metformin Monotherapy in Patients With Type 2 Diabetes. The Journal of Clinical Hypertension 12:12, pages 973-982.
Crossref
. (2010) Current awareness: Pharmacoepidemiology and drug safety. Pharmacoepidemiology and Drug Safety 19:7.
Crossref

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