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Brief Review

Iron supplementation in the non-dialysis chronic kidney disease (ND-CKD) patient: oral or intravenous?

Pages 473-482 | Accepted 26 Nov 2009, Published online: 17 Dec 2009

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David Gozzard. (2011) When is high-dose intravenous iron repletion needed? Assessing new treatment options. Drug Design, Development and Therapy 5, pages 51-60.
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Georgia Doumani, Georgios Spanos, Panagiotis Theofilis, Aikaterini Vordoni & Rigas G. Kalaitzidis. (2023) Cardiorenal syndrome and iron supplementation—more benefits than risks: a narrative review. International Urology and Nephrology.
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Howayda El Shinnawy, AbdelRahman Khedr, Ahmad Alghitany, Marina Ramzy & AberHalim Baki. (2021) Role of intravenous ascorbic acid in the management of anemia in hemodialysis patients. Indian Journal of Nephrology 31:3, pages 230.
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Michał Wiciński, Grzegorz Liczner, Karol Cadelski, Tadeusz Kołnierzak, Magdalena Nowaczewska & Bartosz Malinowski. (2020) Anemia of Chronic Diseases: Wider Diagnostics—Better Treatment?. Nutrients 12:6, pages 1784.
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Carla Rognoni, Vittorio Ortalda, Caterina Biasi & Giovanni Gambaro. (2019) Economic Evaluation of Ferric Carboxymaltose for the Management of Hemodialysis Patients with Iron Deficiency Anemia in Italy. Advances in Therapy 36:11, pages 3253-3264.
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Jesse M. G. Hofman, Michele F. Eisenga, Adry Diepenbroek, Ilja M. Nolte, Bastiaan van Dam, Ralf Westerhuis, Stephan J. L. Bakker, Casper F. M. Franssen & Carlo A. J. M. Gaillard. (2018) Switching iron sucrose to ferric carboxymaltose associates to better control of iron status in hemodialysis patients. BMC Nephrology 19:1.
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Chanel F. Whittaker, Margaret A. Miklich, Roshni S. Patel & Jeffrey C. Fink. (2018) Medication Safety Principles and Practice in CKD. Clinical Journal of the American Society of Nephrology 13:11, pages 1738-1746.
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Joydeep Sarkar, Alka A. Potdar & Gerald M. Saidel. (2018) Whole-body iron transport and metabolism: Mechanistic, multi-scale model to improve treatment of anemia in chronic kidney disease. PLOS Computational Biology 14:4, pages e1006060.
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Min Wu, Dajun Sun, Katherine Tyner, Wenlei Jiang & Rodney Rouse. (2017) Comparative Evaluation of U.S. Brand and Generic Intravenous Sodium Ferric Gluconate Complex in Sucrose Injection: In Vitro Cellular Uptake. Nanomaterials 7:12, pages 451.
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Adam E. Gaweda. (2017) Markers of iron status in chronic kidney disease. Hemodialysis International 21:S1.
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Vincenzo Bellizzi, Giuseppe Conte, Silvio Borrelli, Adamasco Cupisti, Luca De Nicola, Biagio R. Di Iorio, Gianfranca Cabiddu, Marcora Mandreoli, Ernesto Paoletti, Giorgina B. Piccoli, Giuseppe Quintaliani, Maura Ravera, Domenico Santoro, Serena Torraca & Roberto Minutolo. (2016) Controversial issues in CKD clinical practice: position statement of the CKD-treatment working group of the Italian Society of Nephrology. Journal of Nephrology 30:2, pages 159-170.
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Tabasum Mughal. (2016) New Insights into Iron Metabolism and Deficiency. EMJ Nephrology, pages 36-41.
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Iain C. Macdougall, Andreas J. Bircher, Kai-Uwe Eckardt, Gregorio T. Obrador, Carol A. Pollock, Peter Stenvinkel, Dorine W. Swinkels, Christoph Wanner, Günter Weiss, Glenn M. Chertow, John W. Adamson, Tadao Akizawa, Stefan D. Anker, Michael Auerbach, Peter Bárány, Anatole Besarab, Sunil Bhandari, Ioav Cabantchik, Alan J. Collins, Daniel W. Coyne, Ángel L.M. de Francisco, Steven Fishbane, Carlo A.J.M. Gaillard, Tomas Ganz, David J. Goldsmith, Chaim Hershko, Ewa A. Jankowska, Kirsten L. Johansen, Kamyar Kalantar-Zadeh, Philip A. Kalra, Bertram L. Kasiske, Francesco Locatelli, Jolanta Małyszko, Gert Mayer, Lawrence P. McMahon, Ashraf Mikhail, Elizabeta Nemeth, Amy Barton Pai, Patrick S. Parfrey, Roberto Pecoits-Filho, Simon D. Roger, Guy Rostoker, Jacques Rottembourg, Ajay K. Singh, Itzchak Slotki, Bruce S. Spinowitz, Der-Cherng Tarng, Francesca Tentori, Jorge E. Toblli, Yusuke Tsukamoto, Nosratola D. Vaziri, Wolfgang C. Winkelmayer, David C. Wheeler & Elena Zakharova. (2016) Iron management in chronic kidney disease: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference. Kidney International 89:1, pages 28-39.
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Jacques Rottembourg & Guy Rostoker. (2015) Utilisation des dérivés injectables du fer au cours de la maladie rénale chronique : intérêts, limites et conseils pour un bon usage. Néphrologie & Thérapeutique 11:7, pages 531-542.
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Theresa McDonagh & Iain C. Macdougall. (2015) Iron therapy for the treatment of iron deficiency in chronic heart failure: intravenous or oral?. European Journal of Heart Failure 17:3, pages 248-262.
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Gillian M. Keating. (2014) Ferric Carboxymaltose: A Review of Its Use in Iron Deficiency. Drugs 75:1, pages 101-127.
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Ifeanyi R Ezedunukwe, Bappa Adamu, Hilary Enuh & Mukoso N Ozieh. (2014) Oral iron for people with chronic kidney disease. Cochrane Database of Systematic Reviews.
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Takahiro Kuragano, Mana Yahiro, Aritoshi Kida, Minoru Furuta, Yasuyuki Nagasawa, Yukiko Hasuike, Masayoshi Nanami & Takeshi Nakanishi. (2014) Effect of Protoconized Therapy for Renal Anemia on Adverse Events of Patients with Maintenance Hemodialysis. The International Journal of Artificial Organs 37:12, pages 865-874.
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David William Mudge & David Wayne Johnson. (2014) Oral iron therapies in development for iron deficiency in chronic kidney disease. Clinical Investigation 4:7, pages 641-648.
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Charles L. Bennett, Sony Jacob, Jeffrey Hymes, Len A. Usvyat & Franklin W. Maddux. (2014) Anaphylaxis and Hypotension after Administration of Peginesatide. New England Journal of Medicine 370:21, pages 2055-2056.
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Iain C. Macdougall, Andreas Bock, Fernando Carrera, Kai-Uwe Eckardt, Carlo Gaillard, David Van Wyck, Bernard Roubert, Timothy Cushway & Simon D. Roger. (2014) The FIND-CKD study—a randomized controlled trial of intravenous iron versus oral iron in non-dialysis chronic kidney disease patients: background and rationale. Nephrology Dialysis Transplantation 29:4, pages 843-850.
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Brigitte Schiller, Premila Bhat & Amit Sharma. (2014) Safety and Effectiveness of Ferumoxytol in Hemodialysis Patients at 3 Dialysis Chains in the United States Over a 12-Month Period. Clinical Therapeutics 36:1, pages 70-83.
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Merche Prats, Ramon Font, Carmen García, Carmen Cabré, Manel Jariod & Alberto Martinez Vea. (2013) Effect of ferric carboxymaltose on serum phosphate and C-terminal FGF23 levels in non-dialysis chronic kidney disease patients: post-hoc analysis of a prospective study. BMC Nephrology 14:1.
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Roberto Minutolo, Francesco Locatelli, Maurizio Gallieni, Renzo Bonofiglio, Giorgio Fuiano, Lamberto Oldrizzi, Giuseppe Conte, Luca De Nicola, Filippo Mangione, Pasquale Esposito & Antonio Dal Canton. (2013) Anaemia management in non-dialysis chronic kidney disease (CKD) patients: a multicentre prospective study in renal clinics. Nephrology Dialysis Transplantation 28:12, pages 3035-3045.
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Jacques Rottembourg, Yves Sonigo, Aurélie Dansaert, Mirela Diaconita & Alain Guerin. (2013) La prise en charge de l’anémie et de ses conséquences chez les patients débutant l’hémodialyse : importance du fer intraveineux en prédialyse. Néphrologie & Thérapeutique 9:7, pages 486-493.
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Donald S. Silverberg, Doron Schwartz, Idit Schwartz & Eyal Ben Assa. (2013) The missed opportunities to diagnose and treat iron deficiency in patients hospitalized with heart failure. International Journal of Cardiology 168:3, pages 2164-2166.
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Lesley J. Scott, Katherine A. Lyseng-Williamson & Paul L. McCormack. (2013) Ferumoxytol: a guide to its use in iron deficiency anaemia in adults with chronic kidney disease in the EU. Drugs & Therapy Perspectives 29:8, pages 223-227.
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Karen Jenkins. (2013) Treating iron deficiency anaemia in patients with chronic kidney disease. Journal of Renal Nursing 5:4, pages 170-177.
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Lesley Bennett. (2013) PATIENT INDEPENDENCE IN CHRONIC KIDNEY DISEASE AND ANAEMIA: IMPLICATIONS OF THE 2012 KDIGO GUIDELINE. Journal of Renal Care 39:2, pages 108-117.
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Ajay Kumar, Moises Auron & Mark Ereth. (2013) Blood Management. Anesthesiology Clinics 31:2, pages 433-450.
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Stuart L. Goldstein, David Morris & Bradley A. Warady. (2013) Comparison of the Safety and Efficacy of 3 Iron Sucrose Iron Maintenance Regimens in Children, Adolescents, and Young Adults With CKD: A Randomized Controlled Trial. American Journal of Kidney Diseases 61:4, pages 588-597.
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E. A. Jankowska, S. von Haehling, S. D. Anker, I. C. Macdougall & P. Ponikowski. (2012) Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives. European Heart Journal 34:11, pages 816-829.
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SUNIL BHANDARI. (2012) Iron therapy in patients with chronic kidney disease. Transfusion Alternatives in Transfusion Medicine 12:3-4, pages 115-121.
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Paul L. McCormack. (2012) Ferumoxytol. Drugs 72:15, pages 2013-2022.
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Iain C. Macdougall, Bernard Canaud, Angel L.M. de Francisco, Gerasimos Filippatos, Piotr Ponikowski, Donald Silverberg, Dirk J. van Veldhuisen & Stefan D. Anker. (2014) Beyond the cardiorenal anaemia syndrome: recognizing the role of iron deficiency. European Journal of Heart Failure 14:8, pages 882-886.
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Donald S. Silverberg & Doron Schwartz. (2012) The Role of Iron, Omega-3 Fatty Acids, and Vitamins in Heart Failure. Current Treatment Options in Cardiovascular Medicine 14:4, pages 328-341.
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A. Martin-Malo, A. Merino, J. Carracedo, M. A. Alvarez-Lara, R. Ojeda, S. Soriano, R. Crespo, R. Ramirez & P. Aljama. (2011) Effects of intravenous iron on mononuclear cells during the haemodialysis session. Nephrology Dialysis Transplantation 27:6, pages 2465-2471.
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Carlo Brugnara & Kai-Uwe Eckardt. 2012. Brenner and Rector's The Kidney. Brenner and Rector's The Kidney 2081 2121 .
Aryeh Shander, Mazyar Javidroozi, Seth Perelman, Thomas Puzio & Gregg Lobel. (2012) From Bloodless Surgery to Patient Blood Management. Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine 79:1, pages 56-65.
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R Andrew Moore, Helen Gaskell, Peter Rose & Jonathan Allan. (2011) Meta-analysis of efficacy and safety of intravenous ferric carboxymaltose (Ferinject) from clinical trial reports and published trial data. BMC Blood Disorders 11:1.
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J. Rottembourg, A. Kadri, E. Leonard, A. Dansaert & A. Lafuma. (2011) Do two intravenous iron sucrose preparations have the same efficacy?. Nephrology Dialysis Transplantation 26:10, pages 3262-3267.
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Yang‐Sung Sohn, Anna‐Maria Mitterstiller, William Breuer, Guenter Weiss & Z Ioav Cabantchik. (2011) Rescuing iron‐overloaded macrophages by conservative relocation of the accumulated metal. British Journal of Pharmacology 164:2b, pages 406-418.
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Donald S. Silverberg, Dov Wexler, Adrian Iaina & Doron Schwartz. (2011) Correction of Iron Deficiency in the Cardiorenal Syndrome. International Journal of Nephrology 2011, pages 1-8.
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Anatole Besarab & Daniel W. Coyne. (2010) Iron supplementation to treat anemia in patients with chronic kidney disease. Nature Reviews Nephrology 6:12, pages 699-710.
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