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Original Article

Persistence and adherence to disease modifying drugs among patients with multiple sclerosis

, , &
Pages 663-674 | Accepted 14 Dec 2009, Published online: 13 Jan 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (20)

Claude Mékiès, Olivier Heinzlef, Béatrice Jenny, Anne-Laure Ramelli & Pierre Clavelou. (2018) Treatment satisfaction and quality of life in patients treated with fingolimod. Patient Preference and Adherence 12, pages 899-907.
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Diana Ferraro, Valentina Camera, Eleonora Baldi, Veria Vacchiano, Erica Curti, Angelica Guareschi, Susanna Malagù, Sara Montepietra, Silvia Strumia, Mario Santangelo, Luisa Caniatti, Matteo Foschi, Alessandra Lugaresi, Franco Granella, Ilaria Pesci, Luisa Motti, Walter Neri, Paolo Immovilli, Enrico Montanari, Francesca Vitetta, Anna Maria Simone & Patrizia Sola. (2018) First-line disease-modifying drugs in relapsing–remitting multiple sclerosis: an Italian real-life multicenter study on persistence. Current Medical Research and Opinion 34:10, pages 1803-1807.
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Dessalegn Y Melesse, Ruth Ann Marrie, James F Blanchard, Bo Nancy Yu & Charity Evans. (2017) Persistence to disease-modifying therapies for multiple sclerosis in a Canadian cohort. Patient Preference and Adherence 11, pages 1093-1101.
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María Dolores Edo Solsona, Emilio Monte Boquet, Bonaventura Casanova Estruch & José Luis Poveda Andrés. (2017) Impact of adherence on subcutaneous interferon beta-1a effectiveness administered by Rebismart® in patients with multiple sclerosis. Patient Preference and Adherence 11, pages 415-421.
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Michael Munsell, Molly Frean, Joseph Menzin & Amy L Phillips. (2017) An evaluation of adherence in patients with multiple sclerosis newly initiating treatment with a self-injectable or an oral disease-modifying drug. Patient Preference and Adherence 11, pages 55-62.
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Kendra L Furber, Marina Van Agten, Charity Evans, Azita Haddadi, J Ronald Doucette & Adil J Nazarali. (2017) Advances in the treatment of relapsing–remitting multiple sclerosis: the role of pegylated interferon β-1a. Degenerative Neurological and Neuromuscular Disease 7, pages 47-60.
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Thomas R. Einarson, Basil G. Bereza & Márcio Machado. (2017) Comparative effectiveness of interferons in relapsing–remitting multiple sclerosis: a meta-analysis of real-world studies. Current Medical Research and Opinion 33:3, pages 579-593.
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Peter Joseph Jongen, Wim A Lemmens, Raymond Hupperts, Erwin LJ Hoogervorst, Hans M Schrijver, Astrid Slettenaar, Els L de Schryver, Jan Boringa, Esther van Noort & Rogier Donders. (2016) Persistence and adherence in multiple sclerosis patients starting glatiramer acetate treatment: assessment of relationship with care received from multiple disciplines. Patient Preference and Adherence 10, pages 909-917.
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Damiano Paolicelli, Eleonora Cocco, Valentina Di Lecce, Vita Direnzo, Lucia Moiola, Roberta Lanzillo, Paola Perini, Simona Malucchi, Giovanna Borriello, Emilio Portaccio, Valentina Panetta, Giuseppe Fenu, Francesca Sangalli, Laura Cacciaguerra & Maria Trojano. (2016) Exploratory analysis of predictors of patient adherence to subcutaneous interferon beta-1a in multiple sclerosis: TRACER study. Expert Opinion on Drug Delivery 13:6, pages 799-805.
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Antonios Bayas & Mathias Mäurer. (2015) Teriflunomide for the treatment of relapsing–remitting multiple sclerosis: patient preference and adherence. Patient Preference and Adherence 9, pages 265-274.
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Marcello Moccia, Raffaele Palladino, Cinzia Russo, Marco Massarelli, Antonio Nardone, Maria Triassi, Alessandra Lugaresi & Vincenzo Brescia Morra. (2015) How many injections did you miss last month? A simple question to predict interferon β-1a adherence in multiple sclerosis. Expert Opinion on Drug Delivery 12:12, pages 1829-1835.
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Sander Yermakov, Matthew Davis, Michaela Calnan, Monica Fay, Brieana Cox-Buckley, Sujata Sarda, Mei Sheng Duh & Ravi Iyer. (2015) Impact of increasing adherence to disease-modifying therapies on healthcare resource utilization and direct medical and indirect work loss costs for patients with multiple sclerosis. Journal of Medical Economics 18:9, pages 711-720.
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Antonios Bayas, Jean Christophe Ouallet, Boris Kallmann, Raymond Hupperts, Ulrich Fulda & Kurt Marhardt. (2015) Adherence to, and effectiveness of, subcutaneous interferon β-1a administered by RebiSmart® in patients with relapsing multiple sclerosis: results of the 1-year, observational SMART study. Expert Opinion on Drug Delivery 12:8, pages 1239-1250.
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Raymond Hupperts, Veit Becker, Janne Friedrich, Claudio Gobbi, Antonio Vasco Salgado, Bjørn Sperling & Xiaojun You. (2015) Multiple sclerosis patients treated with intramuscular IFN-β-1a autoinjector in a real-world setting: prospective evaluation of treatment persistence, adherence, quality of life and satisfaction. Expert Opinion on Drug Delivery 12:1, pages 15-25.
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Mark Cascione, Daniel Wynn, Luigi M. Barbato, Linda Pestreich, Lesley Schofield & Kevin McCague. (2013) Randomized, open-label study to evaluate patient-reported outcomes with fingolimod after changing from prior disease-modifying therapy for relapsing multiple sclerosis: EPOC study rationale and design. Journal of Medical Economics 16:7, pages 859-865.
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MerriKay Oleen-Burkey, Anissa Cyhaniuk & Eric Swallow. (2013) Treatment patterns in multiple sclerosis: administrative claims analysis over 10 years. Journal of Medical Economics 16:3, pages 397-406.
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J. I. Ivanova, R. E. Bergman, H. G. Birnbaum, A. L. Phillips, M. Stewart & D. M. Meletiche. (2012) Impact of medication adherence to disease-modifying drugs on severe relapse, and direct and indirect costs among employees with multiple sclerosis in the US. Journal of Medical Economics 15:3, pages 601-609.
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Rachel Halpern, Sonalee Agarwal, Carole Dembek, Leigh Borton & Maria Lopez-Bresnahan. (2011) Comparison of adherence and persistence among multiple sclerosis patients treated with disease-modifying therapies: a retrospective administrative claims analysis. Patient Preference and Adherence 5, pages 73-84.
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Krithika Rajagopalan, Richard A. Brook, Ian A. Beren & Nathan L. Kleinman. (2011) Comparing costs and absences for multiple sclerosis among US employees: pre- and post-treatment initiation. Current Medical Research and Opinion 27:1, pages 179-188.
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Nathan L. Kleinman, Ian A. Beren, Krithika Rajagopalan & Richard A. Brook. (2010) Medication adherence with disease modifying treatments for multiple sclerosis among US employees. Journal of Medical Economics 13:4, pages 633-640.
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Articles from other publishers (62)

Aliza Bitton Ben-Zacharia, Bryan Walker, Amy Perrin Ross, Carlo Tornatore, Natalie C. Edwards, Yvette Lipman & Amy L. Phillips. (2023) Factors Associated With Disease-Modifying Therapy Adherence and Persistence in Multiple Sclerosis: A Scoping Literature Review. International Journal of MS Care 25:5, pages 188-195.
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Elizabeth S. Gromisch, Aaron P. Turner, Steven L. Leipertz, John Beauvais & Jodie K. Haselkorn. (2022) Demographic and Clinical Factors Are Associated With Frequent Short-Notice Cancellations in Veterans With Multiple Sclerosis on Disease Modifying Therapies. Archives of Physical Medicine and Rehabilitation 103:5, pages 915-920.e1.
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Francesca Washington & Dawn Langdon. (2021) Factors affecting adherence to disease-modifying therapies in multiple sclerosis: systematic review. Journal of Neurology 269:4, pages 1861-1872.
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Anthony T Reder, Nancy Arndt, Cortnee Roman, Caroline Geremakis, Jason P Mendoza, Ray Su, Charles Makin, Robin L Avila & Megan C Vignos. (2021) Real-world propensity score comparison of treatment effectiveness of peginterferon beta-1a vs. subcutaneous interferon beta-1a, glatiramer acetate, and teriflunomide in patients with relapsing-remitting multiple sclerosis. Multiple Sclerosis and Related Disorders 51, pages 102935.
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Sanni Lahdenperä, Merja Soilu‐Hänninen, Hanna‐Maija Kuusisto, Sari Atula, Jouni Junnila & Anders Berglund. (2020) Medication adherence/persistence among patients with active multiple sclerosis in Finland. Acta Neurologica Scandinavica 142:6, pages 605-612.
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Kathiaja Miranda Souza, Isabela Maia Diniz, Lívia Lovato Pires de Lemos, Nélio Gomes Ribeiro Junior, Isabella de Figueiredo Zuppo, Juliana Alvares Teodoro, Francisco de Assis Acurcio, Álvaro Nagib Atallah & Augusto Afonso Guerra Júnior. (2020) Effectiveness of first-line treatment for relapsing-remitting multiple sclerosis in Brazil: A 16-year non-concurrent cohort study. PLOS ONE 15:9, pages e0238476.
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Elizabeth S. Gromisch, Aaron P. Turner, Steven L. Leipertz, John Beauvais & Jodie K. Haselkorn. (2020) Risk Factors for Suboptimal Medication Adherence in Persons With Multiple Sclerosis: Development of an Electronic Health Record-Based Explanatory Model for Disease-Modifying Therapy Use. Archives of Physical Medicine and Rehabilitation 101:5, pages 807-814.
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Sergio Sauri-Suárez, Sandra Quiñones-Aguilar, Arturo Contreras-Marín, Erik Omar Ramiro-Guerrero, David Zúñiga-García, Leticia Salinas-Vázquez, Leonardo Llamas-López, Carolina León-Jiménez, Adriana García-Martell, Iliana González-Hernández, Erwin Chiquete & Silvia García. (2020) Adherence to self-administering interferon-β1a using RebiSmart® device in Mexican patients with relapsing multiple sclerosis. PLOS ONE 15:4, pages e0230959.
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Pengxiang Li, Vrushabh P. Ladage, Joseph Berger, Salim Chahin, Mehul Jhaveri, Caroline Geremakis & Jalpa A. Doshi. (2020) Disease-Modifying Therapy Adherence and Associated Factors in a National Sample of Medicare Patients With Multiple Sclerosis. Value in Health 23:3, pages 328-334.
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Elizabeth S. Gromisch, Aaron P. Turner, Steven L. Leipertz, John Beauvais & Jodie K. Haselkorn. (2020) Who is not coming to clinic? A predictive model of excessive missed appointments in persons with multiple sclerosis. Multiple Sclerosis and Related Disorders 38, pages 101513.
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Nick Bansback, Judy A. Chiu, Robert Carruthers, Rebecca Metcalfe, Emmanuelle Lapointe, Alice Schabas, Marilyn Lenzen, Larry D. Lynd & Anthony Traboulsee. (2019) Development and usability testing of a patient decision aid for newly diagnosed relapsing multiple sclerosis patients. BMC Neurology 19:1.
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David P. Jarmolowicz, Derek D. Reed, Amanda S. Bruce & Jared M. Bruce. (2019) On the behavioral economics of medication choice: A research story. Behavioural Processes 165, pages 66-77.
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J Nicholas, JJ Ko, Y Park, P Navaratnam, HS Friedman, FR Ernst & V Herrera. (2017) Assessment of treatment patterns associated with injectable disease-modifying therapy among relapsing–remitting multiple sclerosis patients. Multiple Sclerosis Journal - Experimental, Translational and Clinical 3:1, pages 205521731769611.
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Matthew Warrender-Sparkes, Tim Spelman, Guillermo Izquierdo, Maria Trojano, Alessandra Lugaresi, François Grand’Maison, Eva Havrdova, Dana Horakova, Cavit Boz, Celia Oreja-Guevara, Raed Alroughani, Gerardo Iuliano, Pierre Duquette, Marc Girard, Murat Terzi, Raymond Hupperts, Pierre Grammond, Thor Petersen, Ricardo Fernandez-Bolaños, Marcela Fiol, Eugenio Pucci, Jeannette Lechner-Scott, Freek Verheul, Edgardo Cristiano, Vincent Van Pesch, Tatjana Petkovska-Boskova, Fraser Moore, Ilya Kister, Roberto Bergamaschi, Maria Laura Saladino, Mark Slee, Michael Barnett, Maria Pia Amato, Cameron Shaw, Neil Shuey, Carolyn Young, Orla Gray, Ludwig Kappos, Helmut Butzkueven, Tomas Kalincik & Vilija Jokubaitis. (2015) The effect of oral immunomodulatory therapy on treatment uptake and persistence in multiple sclerosis. Multiple Sclerosis Journal 22:4, pages 520-532.
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Kerstin Hansen, Katrin Schüssel, Marita Kieble, Johanna Werning, Martin Schulz, Robert Friis, Dieter Pöhlau, Norbert Schmitz & Joachim Kugler. (2015) Adherence to Disease Modifying Drugs among Patients with Multiple Sclerosis in Germany: A Retrospective Cohort Study. PLOS ONE 10:7, pages e0133279.
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A. Saiz, S. Mora & J. Blanco. (2015) Treatment compliance with first line disease-modifying therapies in patients with multiple sclerosis. COMPLIANCE Study. Neurología (English Edition) 30:4, pages 214-222.
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A. Saiz, S. Mora & J. Blanco. (2015) Cumplimiento terapéutico con terapias modificadoras de la enfermedad de primera línea en pacientes con esclerosis múltiple. Estudio COMPLIANCE. Neurología 30:4, pages 214-222.
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Simon Zhornitsky, Jamie Greenfield, Marcus W. Koch, Scott B. Patten, Colleen Harris, Winona Wall, Katayoun Alikhani, Jodie Burton, Kevin Busche, Fiona Costello, Jeptha W. Davenport, Scott E. Jarvis, Dina Lavarato, Helene Parpal, David G. Patry, Michael Yeung & Luanne M. Metz. (2015) Long-Term Persistence with Injectable Therapy in Relapsing-Remitting Multiple Sclerosis: An 18-Year Observational Cohort Study. PLOS ONE 10:4, pages e0123824.
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