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Original Article

Post-herpetic neuralgia: 5% lidocaine medicated plaster, pregabalin, or a combination of both? A randomized, open, clinical effectiveness study

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Pages 1607-1619 | Accepted 05 Apr 2010, Published online: 30 Apr 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (21)

Marion Voute, Véronique Morel & Gisèle Pickering. (2021) Topical Lidocaine for Chronic Pain Treatment. Drug Design, Development and Therapy 15, pages 4091-4103.
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Gisèle Pickering, Elodie Martin, Florence Tiberghien, Claire Delorme & Gérard Mick. (2017) Localized neuropathic pain: an expert consensus on local treatments. Drug Design, Development and Therapy 11, pages 2709-2718.
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John Schutzer-Weissmann & Paul Farquhar-Smith. (2017) Post-herpetic neuralgia – a review of current management and future directions. Expert Opinion on Pharmacotherapy 18:16, pages 1739-1750.
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Rainer Sabatowski, Irmgard Bösl, Simone König, Bettina Buchheister, Torsten Meier & Ralf Baron. (2017) Treatment of postherpetic neuralgia with 5% lidocaine medicated plaster in elderly patients – subgroup analyses from three European clinical trials. Current Medical Research and Opinion 33:3, pages 595-603.
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Oscar A de León-Casasola & Victor Mayoral. (2016) The topical 5% lidocaine medicated plaster in localized neuropathic pain: a reappraisal of the clinical evidence. Journal of Pain Research 9, pages 67-79.
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Roberto Casale & Consalvo Mattia. (2014) Building a diagnostic algorithm on localized neuropathic pain (LNP) and targeted topical treatment: focus on 5% lidocaine-medicated plaster. Therapeutics and Clinical Risk Management 10, pages 259-268.
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Roberto Casale, Yuriy Romanenko & Massimo Allegri. (2014) 5% lidocaine medicated plaster double effect in a case of orofacial localized neuropathic pain. Journal of Pain Research 7, pages 639-643.
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Roberto Casale, Maria Di Matteo, Cristina E Minella, Guido Fanelli & Massimo Allegri. (2014) Reduction of painful area as new possible therapeutic target in post-herpetic neuropathic pain treated with 5% lidocaine medicated plaster: a case series. Journal of Pain Research 7, pages 353-357.
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Patricia Bruckenthal & Robert L Barkin. (2013) Options for treating postherpetic neuralgia in the medically complicated patient. Therapeutics and Clinical Risk Management 9, pages 329-340.
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Kai-Uwe Kern, Srinivas Nalamachu, Louis Brasseur & Joanna M Zakrzewska. (2013) Can treatment success with 5% lidocaine medicated plaster be predicted in cancer pain with neuropathic components or trigeminal neuropathic pain?. Journal of Pain Research 6, pages 261-280.
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Daniele R de Araújo, Deyse C da Silva, Raquel M Barbosa, Michelle Franz-Montan, Cíntia MS Cereda, Cristina Padula, Patrizia Santi & Eneida de Paula. (2013) Strategies for delivering local anesthetics to the skin: focus on liposomes, solid lipid nanoparticles, hydrogels and patches. Expert Opinion on Drug Delivery 10:11, pages 1551-1563.
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Tina Khadem & Vanessa Stevens. (2013) Therapeutic Options for the Treatment of Postherpetic Neuralgia: A Systematic Review. Journal of Pain & Palliative Care Pharmacotherapy 27:3, pages 268-283.
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R. Norman Harden, Alan David Kaye, Thomas Kintanar & Charles E. Argoff. (2013) Evidence-based Guidance for the Management of Postherpetic Neuralgia in Primary Care. Postgraduate Medicine 125:4, pages 191-202.
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Gerardo Correa-Illanes, Ricardo Roa, José Luis Piñeros & Wilfredo Calderón. (2012) Use of 5% lidocaine medicated plaster to treat localized neuropathic pain secondary to traumatic injury of peripheral nerves. Local and Regional Anesthesia 5, pages 47-53.
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Rainer Sabatowski, Guy Hans, Ingrid Tacken, Sofia Kapanadze, Bettina Buchheister & Ralf Baron. (2012) Safety and efficacy outcomes of long-term treatment up to 4 years with 5% lidocaine medicated plaster in patients with post-herpetic neuralgia. Current Medical Research and Opinion 28:8, pages 1337-1346.
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Gérard Mick & Gerardo Correa-Illanes. (2012) Topical pain management with the 5% lidocaine medicated plaster – a review. Current Medical Research and Opinion 28:6, pages 937-951.
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Michael A. Überall & Gerhard H.H. Müller-Schwefe. (2012) Patient perceptions associated with the 5% lidocaine medicated plaster in daily practice. Current Medical Research and Opinion 28:6, pages 901-909.
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Cory Toth. (2012) Drug safety evaluation of pregabalin . Expert Opinion on Drug Safety 11:3, pages 487-502.
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Charles E. Argoff. (2011) Review of Current Guidelines on the Care of Postherpetic Neuralgia. Postgraduate Medicine 123:5, pages 134-142.
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Gerardo Correa-Illanes, Wilfredo Calderón, Ricardo Roa, José Luis Piñeros, Jacqueline Dote & David Medina. (2010) Treatment of localized post-traumatic neuropathic pain in scars with 5% lidocaine medicated plaster. Local and Regional Anesthesia 3, pages 77-83.
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Articles from other publishers (37)

Michael A Überall, Mariëlle Eerdekens, Els Hollanders, Irmgard Bösl & Ingo Sabatschus. (2022) Lidocaine 700 mg medicated plaster for postherpetic neuralgia: real-world data from the German Pain e-Registry. Pain Management 12:2, pages 195-209.
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Chunmei Zhao, Niti Shrestha, Hongbing Liu, Ying Shen, Lan Meng, Bifa Fan & Fang Luo. (2021) The PATCH trial: efficacy and safety of 5% lidocaine-medicated plaster for the treatment of patients with trigeminal neuralgia: a study protocol for a multicentric, double-blind, enriched enrolment randomised withdrawal, vehicle-controlled study. BMJ Open 11:8, pages e045493.
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Shin-nosuke Watanabe, Kazuhiro Imai, Tetsu Kimura, Yoshitaro Saito, Shinogu Takashima, Ikuo Matsuzaki, Nobuyasu Kurihara, Maiko Atari, Tsubasa Matsuo, Hidenobu Iwai, Yusuke Sato, Satoru Motoyama, Kyoko Nomura, Toshiaki Nishikawa & Yoshihiro Minamiya. (2020) Effect of lidocaine cream analgesia for chest drain tube removal after video-assisted thoracoscopic surgery for lung cancer: a randomized clinical trial. Regional Anesthesia & Pain Medicine 45:1, pages 16-21.
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Calista M. Harbaugh & Pasithorn A. Suwanabol. (2019) Optimizing Pain Control During the Opioid Epidemic. Surgical Clinics of North America 99:5, pages 867-883.
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Gisèle Pickering, Véronique Morel, Elodie Martin, Claire Delorme & Gérard Mick. (2019) Traitements topiques et douleur neuropathique localisée. Douleurs : Évaluation - Diagnostic - Traitement 20:1, pages 4-11.
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Steve McGaraughty, Katharine L. Chu & Jun Xu. (2018) Characterization and pharmacological modulation of noci-responsive deep dorsal horn neurons across diverse rat models of pathological pain. Journal of Neurophysiology 120:4, pages 1893-1905.
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Lei Wang, Erik A. M. Verschuuren, Coretta C. van Leer-Buter, Stephan J. L. Bakker, Anoek A. E. de Joode, Johanna Westra & Nicolaas A. Bos. (2018) Herpes Zoster and Immunogenicity and Safety of Zoster Vaccines in Transplant Patients: A Narrative Review of the Literature. Frontiers in Immunology 9.
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Masahiko Sumitani, Tetsuya Sakai, Yoichi Matsuda, Hiroaki Abe, Shigeki Yamaguchi, Toyoshi Hosokawa & Sei Fukui. (2018) Executive summary of the Clinical Guidelines of Pharmacotherapy for Neuropathic Pain: second edition by the Japanese Society of Pain Clinicians. Journal of Anesthesia 32:3, pages 463-478.
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Roberto Casale, Z. Symeonidou & M. Bartolo. (2017) Topical Treatments for Localized Neuropathic Pain. Current Pain and Headache Reports 21:3.
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Peter Keogh & Vivek Mehta. (2016) Recent Advances in the Pharmacological Management of Neuropathic Pain. Current Anesthesiology Reports 6:4, pages 327-333.
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Ralf Baron, Massimo Allegri, Gerardo Correa-Illanes, Guy Hans, Michael Serpell, Gerard Mick & Victor Mayoral. (2016) The 5% Lidocaine-Medicated Plaster: Its Inclusion in International Treatment Guidelines for Treating Localized Neuropathic Pain, and Clinical Evidence Supporting its Use. Pain and Therapy 5:2, pages 149-169.
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Carolyn Middleton. (2016) Pharmacological management of post-herpetic neuralgia. Nurse Prescribing 14:3, pages 140-146.
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Adam Gater, Mathieu Uhart, Rachael McCool & Emmanuelle Préaud. (2015) The humanistic, economic and societal burden of Herpes Zoster in Europe: a critical review. BMC Public Health 15:1.
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Marie Louise Navez, Christopher Monella, Irmgard Bösl, Daniela Sommer & Claire Delorme. (2015) 5% Lidocaine Medicated Plaster for the Treatment of Postherpetic Neuralgia: A Review of the Clinical Safety and Tolerability. Pain and Therapy 4:1, pages 1-15.
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John F. Peppin, Phillip J. Albrecht, Charles Argoff, Burkhard Gustorff, Marco Pappagallo, Frank L. Rice & Mark S. Wallace. (2015) Skin Matters: A Review of Topical Treatments for Chronic Pain. Part Two: Treatments and Applications. Pain and Therapy 4:1, pages 33-50.
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Charles E. Argoff, Manpreet Kaur & Kelly Donnelly. 2015. Treatment of Chronic Pain by Medical Approaches. Treatment of Chronic Pain by Medical Approaches 77 87 .
José-Luis de la Calle, José De Andres, María Pérez & Vanessa López. (2014) Add-On Treatment with Pregabalin for Patients with Uncontrolled Neuropathic Pain Who Have Been Referred to Pain Clinics. Clinical Drug Investigation 34:12, pages 833-844.
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Florentin Clère, Claire Delorme-Morin, Brigitte George, Malou Navez, Bruno Rioult, Florence Tiberghien-Chatelain & Hervé Ganry. (2011) 5% Lidocaine Medicated Plaster in Elderly Patients with Postherpetic Neuralgia. Drugs & Aging 28:9, pages 693-702.
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