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Original Article

A randomized, double-blind, placebo-controlled, dose ranging study to assess the efficacy and safety of eltrombopag in patients receiving carboplatin/paclitaxel for advanced solid tumors

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Pages 2339-2346 | Accepted 19 Jul 2010, Published online: 25 Aug 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Andrew B. Song & Hanny Al-Samkari. (2023) Emerging data on thrombopoietin receptor agonists for management of chemotherapy-induced thrombocytopenia. Expert Review of Hematology 16:5, pages 365-375.
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Hanny Al‐Samkari & Gerald A. Soff. (2021) Clinical challenges and promising therapies for chemotherapy-induced thrombocytopenia. Expert Review of Hematology 14:5, pages 437-448.
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Stephen A. Strickland, Xin Victoria Wang, Jan Cerny, Jacob M. Rowe, Witold Rybka, Martin S. Tallman, Mark Litzow & Hillard M. Lazarus. (2020) A novel PrECOG (PrE0901) dose-escalation trial using eltrombopag: enhanced platelet recovery during consolidation therapy in acute myeloid leukemia. Leukemia & Lymphoma 61:9, pages 2191-2199.
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Sif Gudbrandsdottir, Henrik Frederiksen & Hans Hasselbalch. (2012) Thrombopoietin-receptor agonists in haematological disorders: The Danish experience. Platelets 23:6, pages 423-429.
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Articles from other publishers (43)

Wen Chen, Yubingxue Liu, Luchun Li & Xianghua Zeng. (2023) Efficacy and safety of thrombopoietin receptor agonists in solid tumors with chemotherapy-induced thrombocytopenia: a meta-analysis. BMC Pharmacology and Toxicology 24:1.
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Gerald Soff, Avi Leader, Hanny Al-Samkari, Anna Falanga, Anthony Maraveyas, Kristen Sanfilippo, Tzu-Fei Wang & Jeffrey Zwicker. (2023) Management of chemotherapy-induced thrombocytopenia: guidance from the ISTH Subcommittee on Hemostasis and Malignancy. Journal of Thrombosis and Haemostasis.
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Hanny Al-Samkari. (2023) Optimal management of chemotherapy-induced thrombocytopenia with thrombopoietin receptor agonists. Blood Reviews, pages 101139.
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Ai Gao, Linlin Zhang & Diansheng Zhong. (2023) Chemotherapy-induced thrombocytopenia: literature review. Discover Oncology 14:1.
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Hanny Al-Samkari. (2022) Thrombopoietin receptor agonists for chemotherapy-induced thrombocytopenia: a new solution for an old problem. Hematology 2022:1, pages 286-295.
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Abdulkadir Erçalışkan, Fatma Zehra Avcı & Ahmet Emre Eşkazan. (2022) Successful Management of Ibrutinib-Induced Thrombocytopenia with Eltrombopag in a Patient with Waldenström Macroglobulinemia. Turkish Journal of Hematology 39:4, pages 275-276.
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Yayun Cui, Yifu He, Changlu Hu, Congyin Tu, Jin Huang, Xiaofeng Zhu, Chunbao Zang, Kaiyang Ding, Bihong Zhan, Yufei Zhao & Liting Qian. (2022) Avatrombopag for the treatment of thrombocytopenia induced by chemotherapy in patients with solid tumors: A multicenter, open-label, single-arm trial. Frontiers in Pharmacology 13.
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Gerald A. Soff, Isabelle Ray-Coquard, Luis J. Marfil Rivera, Jon Fryzek, Megan Mullins, Lauren C. Bylsma & Joseph K. Park. (2022) Systematic literature review and meta-analysis on use of Thrombopoietic agents for chemotherapy-induced thrombocytopenia. PLOS ONE 17:6, pages e0257673.
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David J. Kuter. (2022) Treatment of chemotherapy-induced thrombocytopenia in patients with non-hematologic malignancies. Haematologica 107:6, pages 1243-1263.
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Irene Marini, Gunalp Uzun, Kinan Jamal & Tamam Bakchoul. (2022) Treatment of drug-induced immune thrombocytopenias. Haematologica 107:6, pages 1264-1277.
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Hanny Al-Samkari, Jaroslaw Kolb-Sielecki, Sufiia Z Safina, Xiaoqiang Xue & Brian D Jamieson. (2022) Avatrombopag for chemotherapy-induced thrombocytopenia in patients with non-haematological malignancies: an international, randomised, double-blind, placebo-controlled, phase 3 trial. The Lancet Haematology 9:3, pages e179-e189.
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Hyerim Ha & Joo Han Lim. (2022) Managing Side Effects of Cytotoxic Chemotherapy in Patients With High Grade Gliomas. Brain Tumor Research and Treatment 10:3, pages 158.
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Qiuhua Zhu, Shimei Yang, Wenbin Zeng, Mingjie Li, Zebing Guan, Lanlan Zhou, Hong Wang, Yanan Liu, Yanmin Gao, Shiqiu Qiu, Chaolun Chen, Huan Li, Shanshan Zheng, Yuemei Yuan, Hanling Zhang & Xueyi Pan. (2021) A Real-World Observation of Eltrombopag and Recombinant Human Thrombopoietin (rhTPO) in Lymphoma Patients With Chemotherapy Induced Thrombocytopenia. Frontiers in Oncology 11.
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Francesco Paciullo, Loredana Bury & Paolo Gresele. (2020) Eltrombopag to allow chemotherapy in a patient with MYH9-related inherited thrombocytopenia and pancreatic cancer. International Journal of Hematology 112:5, pages 725-727.
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Sara Singer & Basem M. William. (2020) Use of thrombopoietin receptor agonists after hematopoietic progenitor cell transplantation. ADVANCES IN CELL AND GENE THERAPY 3:4.
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Axel Matzdorff. 2020. Kompendium Internistische Onkologie. Kompendium Internistische Onkologie 1 4 .
Jodi V. Mones & Gerald Soff. 2019. Thrombosis and Hemostasis in Cancer. Thrombosis and Hemostasis in Cancer 139 150 .
Taisuke KanajiMy-Nuong VoSachiko KanajiAlessandro ZarpellonRyan ShapiroYosuke MorodomiAkinori YuzurihaKoji EtoRajesh BelaniMinh-Ha DoXiang-Lei YangZaverio M. Ruggeri & Paul Schimmel. (2018) Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia. Proceedings of the National Academy of Sciences 115:35.
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Yi-Hong Wu, Hsing-Yu Chen, Chyong-Huey Lai, Chein-Shuo Yeh, Jong-Hwei S. Pang, Jian-Tai Qiu, Hung-Hsueh Chou, Lan-Yan Yang & Yu-Bin Pan. (2018) Use of Chinese Herbal Medicine Improves Chemotherapy-Induced Thrombocytopenia among Gynecological Cancer Patients: An Observational Study. Evidence-Based Complementary and Alternative Medicine 2018, pages 1-8.
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Jenny Despotovic & Amanda Grimes. 2018. Antibody Therapy. Antibody Therapy 261 276 .
Eric S. Winer, Howard Safran, Boguslawa Karaszewska, Sebastian Bauer, Dilawar Khan, Steffen Doerfel, Paul Burgess, Stacey Kalambakas, Yasser Mostafa Kamel & Frederic Forget. (2017) Eltrombopag for thrombocytopenia in patients with advanced solid tumors receiving gemcitabine-based chemotherapy: a randomized, placebo-controlled phase 2 study. International Journal of Hematology 106:6, pages 765-776.
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Xia Zhang, Yunhai Chuai, Wei Nie, Aiming Wang & Guanghai Dai. (2017) Thrombopoietin receptor agonists for prevention and treatment of chemotherapy-induced thrombocytopenia in patients with solid tumours. Cochrane Database of Systematic Reviews 2017:11.
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Harinder Gill, Raymond S. M. Wong & Yok-Lam Kwong. (2017) From chronic immune thrombocytopenia to severe aplastic anemia: recent insights into the evolution of eltrombopag. Therapeutic Advances in Hematology 8:5, pages 159-174.
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Michael D. Tarantino & Sarah Chalmers. 2017. Platelets in Thrombotic and Non-Thrombotic Disorders. Platelets in Thrombotic and Non-Thrombotic Disorders 1417 1429 .
Caroline I. Piatek & Howard A. Liebman. 2017. Platelets in Thrombotic and Non-Thrombotic Disorders. Platelets in Thrombotic and Non-Thrombotic Disorders 841 850 .
Michael Desborough, Lise J Estcourt, Carolyn Doree, Marialena Trivella, Sally Hopewell, Simon J Stanworth & Michael F Murphy. (2016) Alternatives, and adjuncts, to prophylactic platelet transfusion for people with haematological malignancies undergoing intensive chemotherapy or stem cell transplantation. Cochrane Database of Systematic Reviews 2016:8.
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Takashi Tanaka, Yoshihiro Inamoto, Takuya Yamashita, Shigeo Fuji, Keiji Okinaka, Saiko Kurosawa, Sung-Won Kim, Ryuji Tanosaki & Takahiro Fukuda. (2016) Eltrombopag for Treatment of Thrombocytopenia after Allogeneic Hematopoietic Cell Transplantation. Biology of Blood and Marrow Transplantation 22:5, pages 919-924.
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Xia Zhang, Yunhai Chuai, Wei Nie, Aiming Wang & Guanghai Dai. (2016) Thrombopoietin receptor agonists for prevention and treatment of chemotherapy-induced thrombocytopenia in patients with solid tumours. Cochrane Database of Systematic Reviews.
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Ferrán Catalá-López, Inmaculada Corrales, César de la Fuente-Honrubia, Diana González-Bermejo, Gloria Martín-Serrano, Dolores Montero & Diego Macías Saint-Gerons. (2015) Risk of thromboembolism with thrombopoietin receptor agonists in adult patients with thrombocytopenia: Systematic review and meta-analysis of randomized controlled trials. Medicina Clínica 145:12, pages 511-519.
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Ferrán Catalá-López, Inmaculada Corrales, César de la Fuente-Honrubia, Diana González-Bermejo, Gloria Martín-Serrano, Dolores Montero & Diego Macías Saint-Gerons. (2015) Risk of thromboembolism with thrombopoietin receptor agonists in adult patients with thrombocytopenia: Systematic review and meta-analysis of randomized controlled trials. Medicina Clínica (English Edition) 145:12, pages 511-519.
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Patricia L. McElroy, Ping Wei, Keri Buck, Angus M. Sinclair, Michael Eschenberg, Barbra Sasu & Graham Molineux. (2015) Romiplostim promotes platelet recovery in a mouse model of multicycle chemotherapy-induced thrombocytopenia. Experimental Hematology 43:6, pages 479-487.
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Eric S. Winer, Howard Safran, Boguslawa Karaszewska, Donald A. Richards, Lee Hartner, Frederic Forget, Rodryg Ramlau, Kirushna Kumar, Bhabita Mayer, Brendan M. Johnson, Conrad A. Messam & Yasser Mostafa Kamel. (2014) Eltrombopag with gemcitabine‐based chemotherapy in patients with advanced solid tumors: a randomized phase I study. Cancer Medicine 4:1, pages 16-26.
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Caizheng Li & Li Zheng. (2014) The pharmacology and clinical application of thrombopoietin receptor agonists. International Journal of Hematology 100:6, pages 529-539.
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Howard A. Liebman. (2014) Thrombocytopenia in cancer patients. Thrombosis Research 133, pages S63-S69.
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Sant P Chawla, Arthur Staddon, Andrew Hendifar, Conrad A Messam, Rita Patwardhan & Yasser Yasser Mostafa Kamel. (2013) Results of a phase I dose escalation study of eltrombopag in patients with advanced soft tissue sarcoma receiving doxorubicin and ifosfamide. BMC Cancer 13:1.
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Jane L. Liesveld, Gordon L. PhillipsIIII, Michael Becker, Louis S. Constine, Jonathan Friedberg, Jeffrey R. Andolina, Laurie A. Milner, Jessica DeBolt, Therese Smudzin, Ollivier Hyrien, Connie L. Erickson-Miller, Brendan M. Johnson, Katie-Louise Dawson & Yuhchyau Chen. (2013) A Phase 1 Trial of Eltrombopag in Patients Undergoing Stem Cell Transplantation after Total Body Irradiation. Biology of Blood and Marrow Transplantation 19:12, pages 1745-1752.
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Siobhan Hayes, Paul N. MuddJr.Jr., Daniele Ouellet, Brendan M. Johnson, Daphne Williams & Ekaterina Gibiansky. (2013) Population PK/PD modeling of eltrombopag in subjects with advanced solid tumors with chemotherapy-induced thrombocytopenia. Cancer Chemotherapy and Pharmacology 71:6, pages 1507-1520.
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Bernhard Wörmann. (2013) Clinical Indications for Thrombopoietin and Thrombopoietin-Receptor Agonists. Transfusion Medicine and Hemotherapy 40:5, pages 319-325.
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Ferrán Catalá-López, Inmaculada Corrales, Gloria Martín-Serrano, Aurelio Tobías & Gonzalo Calvo. (2012) Risk of thromboembolism with thrombopoietin receptor agonists in adult patients with thrombocytopenia: systematic review and meta-analysis of randomized controlled trials. Medicina Clínica 139:10, pages 421-429.
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Michael RothBritta WillGuillermo SimkinSwathi NarayanagariLaura BarreyroBoris BartholdyRoni TamariConstantine S. MitsiadesAmit Verma & Ulrich Steidl. (2012) Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation. Blood 120:2, pages 386-394.
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Mary B. Wire, Heidi B. McLean, Carolyn Pendry, Dickens Theodore, Jung W. Park & Bin Peng. (2012) Assessment of the Pharmacokinetic Interaction between Eltrombopag and Lopinavir-Ritonavir in Healthy Adult Subjects. Antimicrobial Agents and Chemotherapy 56:6, pages 2846-2851.
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J. Paul Duic, Jai Grewal, Kerry McConie, Harry Staszewski, Jonathan Haas & Santosh Kesari. (2011) Eltrombopag for radiation-induced thrombocytopenia in a glioblastoma patient. Journal of Neuro-Oncology 106:2, pages 427-429.
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Yang Zhang & Jill M. Kolesar. (2011) Eltrombopag: An Oral Thrombopoietin Receptor Agonist for the Treatment of Idiopathic Thrombocytopenic Purpura. Clinical Therapeutics 33:11, pages 1560-1576.
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