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Original Article

Effect of ustekinumab on physical function and health-related quality of life in patients with psoriatic arthritis: a randomized, placebo-controlled, phase II trial

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Pages 2385-2392 | Accepted 11 Aug 2010, Published online: 13 Sep 2010

Keep up to date with the latest research on this topic with citation updates for this article.

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Flavia Sunzini, Arianna D’Antonio, Mauro Fatica, Paola Triggianese, Paola Conigliaro, Elisabetta Greco, Alberto Bergamini & Maria Sole Chimenti. (2022) What’s new and what’s next for biological and targeted synthetic treatments in psoriatic arthritis?. Expert Opinion on Biological Therapy 22:12, pages 1545-1559.
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Amy C. Foulkes, Christopher E. M. Griffiths, Hector Chinoy & Richard B. Warren. (2014) Unmasking of axial spondyloarthritis and oligoarthritis following discontinuation of tumour necrosis factor inhibitor therapy for psoriasis. Journal of Dermatological Treatment 25:1, pages 61-62.
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Philip M Laws & Richard B Warren. (2011) Ustekinumab for the treatment of psoriasis. Expert Review of Clinical Immunology 7:2, pages 155-164.
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Articles from other publishers (41)

Ahmed Safi Vahidy, Faizan Niaz, Samiuddin Tariq, Irtebaat Fatima, Yusra Afzal & Abdulqadir J. Nashwan. (2023) IL-23 Inhibitors to treat psoriatic arthritis: A systematic review & meta-analysis of randomized controlled trials. Clinical Immunology Communications 4, pages 7-22.
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Danpeng Shen, Zhiqiang Wang, Hongwei Wang, Hongyan Zhu, Cuibao Jiang, Fan Xie, Hongpeng Zhang, Qian Lv, Qi Liu, Nianmin Qi & Hao Wang. (2023) Evaluation of preclinical efficacy of human umbilical cord mesenchymal stem cells in ankylosing spondylitis. Frontiers in Immunology 14.
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Vipawee S. Chat, Shelley K. Uppal, Donovan G. Kearns & Jashin J. Wu. (2021) Comparison of guidelines for the use of Ustekinumab for psoriasis in the United States, Europe, and the United Kingdom: A critical appraisal and comprehensive review. Dermatologic Therapy 34:4.
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Louisa Nitsch, Linda Schneider, Julian Zimmermann & Marcus Müller. (2021) Microglia-Derived Interleukin 23: A Crucial Cytokine in Alzheimer's Disease?. Frontiers in Neurology 12.
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Dennis McGonagle, Abdulla Watad, Kassem Sharif & Charlie Bridgewood. (2021) Why Inhibition of IL-23 Lacked Efficacy in Ankylosing Spondylitis. Frontiers in Immunology 12.
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Dennis McGonagle, Abdulla Watad, Kassem Sharif & Charlie Bridgewood. (2021) Warum die Hemmung von IL-23 bei ankylosierender Spondylitis nicht wirksam war. Kompass Autoimmun 3:3, pages 100-107.
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Wei Zhu, Xuxia He, Kaiyuan Cheng, Linjie Zhang, Di Chen, Xiao Wang, Guixing Qiu, Xu Cao & Xisheng Weng. (2019) Ankylosing spondylitis: etiology, pathogenesis, and treatments. Bone Research 7:1.
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Alan Menter, Bruce E. Strober, Daniel H. Kaplan, Dario Kivelevitch, Elizabeth Farley Prater, Benjamin Stoff, April W. Armstrong, Cody Connor, Kelly M. Cordoro, Dawn M.R. Davis, Boni E. Elewski, Joel M. Gelfand, Kenneth B. Gordon, Alice B. Gottlieb, Arthur Kavanaugh, Matthew Kiselica, Neil J. Korman, Daniela Kroshinsky, Mark Lebwohl, Craig L. Leonardi, Jason Lichten, Henry W. Lim, Nehal N. Mehta, Amy S. Paller, Sylvia L. Parra, Arun L. Pathy, Reena N. Rupani, Michael Siegel, Emily B. Wong, Jashin J. Wu, Vidhya Hariharan & Craig A. Elmets. (2019) Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics. Journal of the American Academy of Dermatology 80:4, pages 1029-1072.
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Phuong Anh Pham, Corinna Dressler, Lisa Eisert, Alexander Nast & Ricardo Niklas Werner. (2019) Time until onset of action when treating psoriatic arthritis: meta-analysis and novel approach of generating confidence intervals. Rheumatology International 39:4, pages 605-618.
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Vibeke Strand, Kurt de Vlam, Jose A Covarrubias-Cobos, Philip J Mease, Dafna D Gladman, Linda Chen, Elizabeth Kudlacz, Joseph Wu, Joseph C Cappelleri, Thijs Hendrikx & Ming-Ann Hsu. (2019) Effect of tofacitinib on patient-reported outcomes in patients with active psoriatic arthritis and an inadequate response to tumour necrosis factor inhibitors in the phase III, randomised controlled trial: OPAL Beyond. RMD Open 5:1, pages e000808.
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Philip Mease, Vibeke Strand & Dafna Gladman. (2018) Functional impairment measurement in psoriatic arthritis: Importance and challenges. Seminars in Arthritis and Rheumatism 48:3, pages 436-448.
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Tim Pickles, Robin Christensen, Lai-Shan Tam, Lee S Simon & Ernest H Choy. (2018) Early phase and adaptive design clinical trials in rheumatoid arthritis: a systematic review of early phase trials. Rheumatology Advances in Practice 2:2.
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Janet Roberts, Darren D O'Rielly & Proton Rahman. (2018) A review of ustekinumab in the treatment of psoriatic arthritis. Immunotherapy 10:5, pages 361-372.
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Jiří Štolfa. (2018) Biological treatment of psoriatic arthritis. Vnitřní lékařství 64:2, pages 127-135.
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Sibel Bakirci Ureyen, Catherine Ivory, Umut Kalyoncu, Jacob Karsh & Sibel Zehra Aydin. (2018) What does evidence-based medicine tell us about treatments for different subtypes of psoriatic arthritis? A systematic literature review on randomized controlled trials. Rheumatology Advances in Practice 2:1.
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F.M. Ali, A.C. Cueva, J. Vyas, A.A. Atwan, M.S. Salek, A.Y. Finlay & V. Piguet. (2017) A systematic review of the use of quality-of-life instruments in randomized controlled trials for psoriasis. British Journal of Dermatology 176:3, pages 577-593.
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Sarah Elyoussfi, Benjamin J. Thomas & Coziana Ciurtin. (2016) Tailored treatment options for patients with psoriatic arthritis and psoriasis: review of established and new biologic and small molecule therapies. Rheumatology International 36:5, pages 603-612.
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L Gossec, J S Smolen, S Ramiro, M de Wit, M Cutolo, M Dougados, P Emery, R Landewé, S Oliver, D Aletaha, N Betteridge, J Braun, G Burmester, J D Cañete, N Damjanov, O FitzGerald, E Haglund, P Helliwell, T K Kvien, R Lories, T Luger, M Maccarone, H Marzo-Ortega, D McGonagle, I B McInnes, I Olivieri, K Pavelka, G Schett, J Sieper, F van den Bosch, D J Veale, J Wollenhaupt, A Zink & D van der Heijde. (2016) European League Against Rheumatism (EULAR) recommendations for the management of psoriatic arthritis with pharmacological therapies: 2015 update. Annals of the Rheumatic Diseases 75:3, pages 499-510.
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Mahta Mortezavi & Christopher Ritchlin. (2015) IL12/IL23 Inhibition in the Treatment of Psoriatic Arthritis. Current Treatment Options in Rheumatology 1:2, pages 197-209.
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Sherry Rohekar, Jon Chan, Shirley M.L. Tse, Nigil Haroon, Vinod Chandran, Louis Bessette, Dianne Mosher, Cathy Flanagan, Kevin J. Keen, Karen Adams, Michael Mallinson, Carter Thorne, Proton Rahman, Dafna D. Gladman & Robert D. Inman. (2015) 2014 Update of the Canadian Rheumatology Association/Spondyloarthritis Research Consortium of Canada Treatment Recommendations for the Management of Spondyloarthritis. Part II: Specific Management Recommendations. The Journal of Rheumatology 42:4, pages 665-681.
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Maria L. Acosta Felquer & Enrique R. Soriano. (2015) New treatment paradigms in psoriatic arthritis. Current Opinion in Rheumatology 27:2, pages 99-106.
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Yi Liu, Jian-ping Gong & Wen-fang Li. (2014) Therapeutic Effect and Safety of Ustekinumab for Plaque Psoriasis: A Meta-analysis. Chinese Medical Sciences Journal 29:3, pages 131-138.
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Kate McKeage. (2014) Ustekinumab: A Review of Its Use in Psoriatic Arthritis. Drugs 74:9, pages 1029-1039.
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Ricardo Prado Golmia, Ayk Helena Barbosa Martins & Morton Scheinberg. (2014) When anti-TNF fails, anti-IL12-23 is an alternate option in psoriasis and psoriatic arthritis. Revista Brasileira de Reumatologia (English Edition) 54:3, pages 247-249.
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Ricardo Prado Golmia, Ayk Helena Barbosa Martins & Morton Scheinberg. (2014) Quando anti‐TNF não obtém sucesso, anti‐IL‐12‐23 é opção alternativa na psoríase e na artrite psoriásica. Revista Brasileira de Reumatologia 54:3, pages 247-249.
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Alice Gottlieb & Kirti Narang. (2013) Ustekinumab in the treatment of psoriatic arthritis: latest findings and clinical potential. Therapeutic Advances in Musculoskeletal Disease 5:5, pages 277-285.
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Vibeke Strand, Georg Schett, ChiaChi Hu & Randall M. Stevens. (2013) Patient-reported Health-related Quality of Life with Apremilast for Psoriatic Arthritis: A Phase II, Randomized, Controlled Study. The Journal of Rheumatology 40:7, pages 1158-1165.
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Sueli Carneiro, Valderílio Feijó Azevedo, Rubens Bonfi glioli, Roberto Ranza, Célio Roberto Gonçalves, Mauro Keiserman, Eduardo de Souza Meirelles, Marcelo de Medeiros Pinheiro, Antonio Carlos Ximenes, Wanderley Bernardo & Percival Degrava Sampaio-Barros. (2013) Recomendações sobre diagnóstico e tratamento da artrite psoriásica. Revista Brasileira de Reumatologia 53:3, pages 227-241.
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Sueli Carneiro, Valderílio Feijó Azevedo, Rubens Bonfiglioli, Roberto Ranza, Célio Roberto Gonçalves, Mauro Keiserman, Eduardo de Souza Meirelles, Marcelo de Medeiros Pinheiro, Antonio Carlos Ximenes, Wanderley Bernardo & Percival Degrava Sampaio-Barros. (2013) Recommendations for the management and treatment of psoriatic arthritis. Revista Brasileira de Reumatologia (English Edition) 53:3, pages 227-241.
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Marie-Elise Truchetet, M. Djavad Mossalayi & Katia Boniface. (2013) IL-17 in the Rheumatologist’s Line of Sight. BioMed Research International 2013, pages 1-18.
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Jason J. Emer, Amir Larian & Mark G. Lebwohl. 2013. Comprehensive Dermatologic Drug Therapy. Comprehensive Dermatologic Drug Therapy 319 332.e2 .
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Shimon Sakaguchi, Helen Benham, Andrew P Cope & Ranjeny Thomas. (2012) T‐cell receptor signaling and the pathogenesis of autoimmune arthritis: insights from mouse and man. Immunology & Cell Biology 90:3, pages 277-287.
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Segundo González, Ruben Queiro & Javier Ballina. (2012) Actualización en la patogenia de la artritis psoriásica. Reumatología Clínica 8, pages 1-6.
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E. Daudén, S. Castañeda, C. Suárez, J. García-Campayo, A.J. Blasco, M.D. Aguilar, C. Ferrándiz, L. Puig & J.L. Sánchez-Carazo. (2012) Integrated Approach to Comorbidity in Patients With Psoriasis. Actas Dermo-Sifiliográficas (English Edition) 103, pages 1-64.
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E. Daudén, S. Castañeda, C. Suárez, J. García-Campayo, A.J. Blasco, M.D. Aguilar, C. Ferrándiz, L. Puig & J.L. Sánchez-Carazo. (2012) Abordaje integral de la comorbilidad del paciente con psoriasis. Actas Dermo-Sifiliográficas 103, pages 1-64.
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Mary L. Stevenson & Orit Markowitz. (2018) Selection of Therapies in Patients with Psoriasis and Psoriatic Arthritis. Psoriasis Forum 17a:2, pages 144-147.
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