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Current Medical Research and Opinion Volume 27, 2011 - Issue 3
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Original Article

The effect of simvastatin alone versus simvastatin plus ezetimibe on the concentration of small dense low-density lipoprotein cholesterol in subjects with primary hypercholesterolemia

Matilda Florentin Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina 45110, Greece
,
Evangelos N. Liberopoulos Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina 45110, Greece
,
Elisavet Moutzouri Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina 45110, Greece
,
Christos V. Rizos Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina 45110, Greece
,
Alexandros D. Tselepis Laboratory of Biochemistry, School of Chemistry, University of Ioannina, Ioannina 45110, Greece
&
Moses S. Elisaf Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina 45110, GreeceCorrespondence[email protected] [email protected]
Pages 685-692 | Accepted 06 Dec 2010, Published online: 27 Jan 2011

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Read on this site (4)

T. D. Filippatos, M. Florentin, M. Georgoula & M. S. Elisaf. (2017) Pharmacological management of diabetic dyslipidemia. Expert Review of Clinical Pharmacology 10:2, pages 187-200.
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Anastazia A. Kei, Theodosios D. Filippatos & Moses S. Elisaf. (2016) The safety of ezetimibe and simvastatin combination for the treatment of hypercholesterolemia. Expert Opinion on Drug Safety 15:4, pages 559-569.
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Manfredi Rizzo, Gerald H Tomkin, Maria Patti Angelo, Ilenia Pepe, Rosa Valerio Maria, Salvatore Di Rosa, Battista Rini Giovam & Gaetana D Fede. (2011) Effects of hypolipidemic and hypoglycemic agents on atherogenic small, dense LDL in Type 2 diabetes. Clinical Lipidology 6:5, pages 539-547.
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Theodosios D Filippatos & Moses S Elisaf. (2011) Fenofibrate plus simvastatin (fixed-dose combination) for the treatment of dyslipidaemia. Expert Opinion on Pharmacotherapy 12:12, pages 1945-1958.
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Articles from other publishers (22)

Yanjun Liu, Chongyang Dou, Guihua Wei, Liudai Zhang, Wei Xiong, Lingmiao Wen, Chunxiao Xiang, Chunlan Chen, Tinglan Zhang, Alvin Altamirano, Yunhui Chen, Tian-e Zhang & Zhiyong Yan. (2022) Usnea improves high-fat diet- and vitamin D3-induced atherosclerosis in rats by remodeling intestinal flora homeostasis. Frontiers in Pharmacology 13.
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Dhruva Chauhan, Farzana Memon, Vaibhav Patwardhan, Priya Kotwani, Parth Shah & Vikramaditya Samala Venkata. (2022) Comparing Simvastatin Monotherapy V/S Simvastatin-Ezetimibe Combination Therapy for the Treatment of Hyperlipidemia: A Meta-Analysis and Review. Cureus.
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Seyyed Mostafa Arabi, Mahla Chambari, Mahsa Malek-Ahmadi, Leila Sadat Bahrami, Vahid Hadi, Manfredi Rizzo & Amirhossein Sahebkar. (2022) The effect of statin therapy in combination with ezetimibe on circulating C-reactive protein levels: a systematic review and meta-analysis of randomized controlled trials. Inflammopharmacology 30:5, pages 1597-1615.
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Fang Liu, Zheng Wang, Xia Cao, Yingxia Pan, Erqiang Zhang, Jiahuan Zhou & Lina Zheng. (2021) Relationship between small dense low-density lipoprotein cholesterol with carotid plaque in Chinese individuals with abnormal carotid artery intima-media thickness. BMC Cardiovascular Disorders 21:1.
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Shuling Wan, Yuchuan Ding, Xunming Ji & Ran Meng. (2021) The safety and efficacy of Ezetimibe Plus Statins on ASVD and Related Diseases. Aging and disease 12:8, pages 1857.
Crossref
国霖 李. (2021) Determination of Small and Dense of Low-Density Lipoprotein and Coronary Heart Disease. Advances in Clinical Medicine 11:08, pages 3525-3528.
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Shahin Alizadeh-Fanalou, Ali Nazarizadeh, Fatemeh Alian, Parisa Faraji, Bahareh Sorori & Mohsen Khosravi. (2020) Small dense low-density lipoprotein-lowering agents. Biological Chemistry 401:10, pages 1101-1121.
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Xiaoqin Zhao, Jiali Zhu, Liwen Wang, Yongbiao Li, Tingting Zhao, Xiu Chen, Yong Sun, Yaolan Dai, Guihua Wei, Alvin Altamirano, Tiane Zhang & Zhiyong Yan. (2019) U. diffracta extract mitigates high fat diet and VD3-induced atherosclerosis and biochemical changes in the serum liver and aorta of rats. Biomedicine & Pharmacotherapy 120, pages 109446.
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Xue QiaoZhen, Meng AiGuo, Wang Tong, Li JingJing & Liu HaiYing. (2019) Correlation between of small dense low‐density lipoprotein cholesterol with acute cerebral infarction and carotid atherosclerotic plaque stability. Journal of Clinical Laboratory Analysis 33:6.
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Jiali Zhu, Xuemei Zhang, Xiu Chen, Yong Sun, Yaolan Dai, Chang Chen, Tiane Zhang & Zhiyong Yan. (2017) Studies on the regulation of lipid metabolism and the mechanism of the aqueous and ethanol extracts of Usnea. Biomedicine & Pharmacotherapy 94, pages 930-936.
Crossref
Theodosios D. Filippatos & Moses S. Elisaf. (2015) Statin–Ezetimibe Combination Therapy In Diabetic Individuals. Angiology 67:6, pages 507-509.
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Antonio Hernandez-Mijares, Celia Bañuls, Susana Rovira-Llopis, Noelia Diaz-Morales, Irene Escribano-Lopez, Carmen de Pablo, Angeles Alvarez, Silvia Veses, Milagros Rocha & Victor M. Victor. (2016) Effects of simvastatin, ezetimibe and simvastatin/ezetimibe on mitochondrial function and leukocyte/endothelial cell interactions in patients with hypercholesterolemia. Atherosclerosis 247, pages 40-47.
Crossref
Theodosios D. Filippatos & Moses S. Elisaf. (2016) Effects of ezetimibe/simvastatin combination on metabolic parameters. International Journal of Cardiology 202, pages 273-274.
Crossref
Jun Masuda, Takashi Tanigawa, Tomomi Yamada, Yuki Nishimura, Takashi Sasou, Tomoyuki Nakata, Toshiki Sawai, Naoki Fujimoto, Kaoru Dohi, Masatoshi Miyahara, Masakatsu Nishikawa, Mashio Nakamura & Masaaki Ito. (2015) Effect of Combination Therapy of Ezetimibe and Rosuvastatin on Regression of Coronary Atherosclerosis in Patients With Coronary Artery Disease. International Heart Journal 56:3, pages 278-285.
Crossref
Ngoc‐Anh Le, Ran Jin, Joanne E. Tomassini, Andrew M. Tershakovec, David R. Neff & Peter W.F. Wilson. (2013) Changes in Lipoprotein Particle Number With Ezetimibe/Simvastatin Coadministered With Extended‐Release Niacin in Hyperlipidemic Patients. Journal of the American Heart Association 2:4.
Crossref
Elisavet Moutzouri, Constantinos C. Tellis, Kleopatra Rousouli, Evangelos N. Liberopoulos, Haralambos J. Milionis, Moses S. Elisaf & Alexandros D. Tselepis. (2012) Effect of simvastatin or its combination with ezetimibe on Toll-like receptor expression and lipopolysaccharide – Induced cytokine production in monocytes of hypercholesterolemic patients. Atherosclerosis 225:2, pages 381-387.
Crossref
Christopher Adlbrecht, Elmar Aigner, Juan M. Bellón, Izolde Bouloukaki, Alberto Bouzas‐Mosquera, Alexandre J. F. Carrilho, Kuo‐Chu Chang, Nipon Chattipakorn, Siriporn C. Chattipakorn, Yi‐Jen Chen, Yuan‐Chiang Chung, Roshan Colah, Christian Datz, Jens B. Frøkjær, Shunji Fujimori, Panagiota Georgiadou, Cintia M. Grion, Chih‐Ping Hsu, Martin Hülsmann, Ming‐Jui Hung, Ming‐Yow Hung, Efstathios K. Iliodromitis, Irene M. Lang, Ting‐ I. Lee, Winfried März, Sona B. Nair, Gemma Pascual, Jesús Peteiro, Choitsu Sakamoto, Atsushi Satomura, Sophia E. Schiza, Peter Stärkel, Tatjana Stojakovic, David L. Vesely, Darren L. Walters & Yusuf Yilmaz. (2012) Research update for articles published in EJCI in 2010. European Journal of Clinical Investigation 42:11, pages 1149-1164.
Crossref
Antonio Hernández-Mijares, Celia Bañuls, Lorena Bellod, Ana Jover, Eva Solá, Víctor M. Víctor & Milagros Rocha. (2012) Estudio de las subfracciones lipoproteicas tras el tratamiento de simvastatina y ezetimiba, en monoterapia o combinado, en pacientes hiperlipidémicos. Clínica e Investigación en Arteriosclerosis 24:5, pages 217-225.
Crossref
. (2012) Current World Literature. Current Opinion in Lipidology 23:2, pages 156-163.
Crossref
Katherine A. Lyseng-Williamson. (2012) Ezetimibe/Simvastatin: A Guide to its Clinical Use in Hypercholesterolemia. American Journal Cardiovascular Drugs 12:1, pages 49-56.
Crossref
Philipp A Gerber, Giatgen A Spinas & Kaspar Berneis. (2012) Small dense low-density lipoprotein particles: priority as a treatment target in Type 2 diabetes?. Diabetes Management 2:1, pages 65-74.
Crossref
Allen J. Taylor. (2011) Another clinical evidence straw on the $4 billion ezetimibe camel's back. Atherosclerosis 218:1, pages 23-25.
Crossref

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