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Review Article

A systematic review of the efficacy and safety outcomes of anti-VEGF agents used for treating neovascular age-related macular degeneration: comparison of ranibizumab and bevacizumab

Pages 1465-1475 | Accepted 29 Apr 2011, Published online: 31 May 2011

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Rajkumar Patil, Ching-Yu Cheng, Chui Ming Gemmy Cheung & Tien Yin Wong. 2017. Advances in Vision Research, Volume I. Advances in Vision Research, Volume I 497 507 .
Rajkumar Patil, Chee Wai Wong, Fabio Michelet, Kelvin Teo, Daniel Ting, Andrew Tsai, Chui Ming Gemmy Cheung & Tien Yin Wong. 2017. Biochemical Basis and Therapeutic Implications of Angiogenesis. Biochemical Basis and Therapeutic Implications of Angiogenesis 259 297 .
Emily D. Cole, Daniela Ferrara, Eduardo A. Novais, Ricardo N. Louzada & Nadia K. Waheed. (2016) CLINICAL TRIAL ENDPOINTS FOR OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION. Retina 36:Supplement 1, pages S83-S92.
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Crossref
H. Büning & U. T. Hacker. 2015. Protein Targeting Compounds. Protein Targeting Compounds 261 285 .
A. I. Markowska, Z. Cao & N. Panjwani. (2014) Glycobiology of ocular angiogenesis. Glycobiology 24:12, pages 1275-1282.
Crossref
Davin Johnson, Lisa Jagan, Ayaz Kurji, Klaudia Jumaa & Sanjay Sharma. (2014) Emergency department visits after intravitreal bevacizumab and ranibizumab injections in diabetic patients. Canadian Journal of Ophthalmology 49:6, pages e146-e148.
Crossref
Salman Sarwar, Jose R Maya, Mostafa Hanout, Yasir J Sepah, Diana V Do & Quan Dong Nguyen. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Wei Wang & Xiulan Zhang. (2014) Systemic Adverse Events after Intravitreal Bevacizumab versus Ranibizumab for Age-Related Macular Degeneration: A Meta-Analysis. PLoS ONE 9:10, pages e109744.
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Crossref
Szilárd Kiss, Ying Liu, Joseph Brown, Nancy M. Holekamp, Arghavan Almony, Joanna Campbell & Jonathan W. Kowalski. (2014) Clinical Monitoring of Patients With Age-Related Macular Degeneration Treated With Intravitreal Bevacizumab or Ranibizumab. Ophthalmic Surgery, Lasers and Imaging Retina 45:4, pages 285-291.
Crossref
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Crossref
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Crossref
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Crossref
Nicole H. Siegel & Manju L. Subramanian. 2014. Predictive ADMET. Predictive ADMET 569 581 .
Andrew Payne, Simon Kaja, Yuliya Naumchuk, Nancy Kunjukunju & Peter Koulen. (2014) Antioxidant Drug Therapy Approaches for Neuroprotection in Chronic Diseases of the Retina. International Journal of Molecular Sciences 15:2, pages 1865-1886.
Crossref
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Crossref
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Crossref
Usha Chakravarthy, Simon P Harding, Chris A Rogers, Susan M Downes, Andrew J Lotery, Lucy A Culliford & Barnaby C Reeves. (2013) Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial. The Lancet 382:9900, pages 1258-1267.
Crossref
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Crossref
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Crossref
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Crossref
Shaker A. Mousa. 2013. Angiogenesis Modulations in Health and Disease. Angiogenesis Modulations in Health and Disease 95 106 .
Michele Rinaldi, Flavia Chiosi, Roberto dell'Omo, Mario R. Romano, Francesco Parmeggiani, Francesco Semeraro, Rodolfo Mastropasqua & Ciro Costagliola. (2012) Intravitreal pegaptanib sodium (Macugen®) for treatment of diabetic macular oedema: a morphologic and functional study. British Journal of Clinical Pharmacology 74:6, pages 940-946.
Crossref
Bärbel RohrerBeth CoughlinMausumi Bandyopadhyay & V. Michael Holers. (2012) Systemic Human CR2-Targeted Complement Alternative Pathway Inhibitor Ameliorates Mouse Laser-Induced Choroidal Neovascularization. Journal of Ocular Pharmacology and Therapeutics 28:4, pages 402-409.
Crossref
Dalhia Abramovich, Griselda Irusta, Diana Bas, Natalia Isabel Cataldi, Fernanda Parborell & Marta Tesone. (2012) Angiopoietins/TIE2 System and VEGF Are Involved in Ovarian Function in a DHEA Rat Model of Polycystic Ovary Syndrome. Endocrinology 153:7, pages 3446-3456.
Crossref
James Harrison, Carole A. Bartlett, Gary Cowin, Philip K. Nicholls, Cameron W. Evans, Tristan D. Clemons, Bogdan Zdyrko, Igor A. Luzinov, Alan R. Harvey, K. Swaminathan Iyer, Sarah A. Dunlop & Melinda Fitzgerald. (2012) In vivo Imaging and Biodistribution of Multimodal Polymeric Nanoparticles Delivered to the Optic Nerve. Small 8:10, pages 1579-1589.
Crossref
Shusheng WangKyle M KosterYuguang HeQinbo Zhou. (2012) miRNAs as potential therapeutic targets for age-related macular degeneration. Future Medicinal Chemistry 4:3, pages 277-287.
Crossref
Courtney L. Kraus & Susan M. Culican. (2012) Use of Biologic Agents in Ocular Manifestations of Rheumatic Disease. International Journal of Rheumatology 2012, pages 1-6.
Crossref
Anna‐Lena Hård & Ann Hellström. (2011) On safety, pharmacokinetics and dosage of bevacizumab in ROP treatment – a review. Acta Paediatrica 100:12, pages 1523-1527.
Crossref
Focke Ziemssen & Bianka Sobolewska. (2011) Therapeutic Efficacy of Bevacizumab for Age-Related Macular Degeneration. Drugs & Aging 28:11, pages 853-865.
Crossref

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