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Original Article

Adherence and persistence to a regimen of basal insulin in a pre-filled pen compared to vial/syringe in insulin-naïve patients with type 2 diabetes

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Pages 1709-1717 | Accepted 16 Jun 2011, Published online: 11 Jul 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Mark L. Warren, Meryl Brod, Jonas Håkan-Bloch, Thomas Sparre & Louis B. Chaykin. (2019) Patient-reported outcomes from a randomized, crossover trial comparing a pen injector with insulin degludec versus a pen injector with insulin glargine U100 in patients with type 2 diabetes. Current Medical Research and Opinion 35:9, pages 1623-1629.
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Reema Mody, Michael Grabner, Maria Yu, Ralph Turner, Anita Y. M. Kwan, Whitney York & Laura Fernández Landó. (2018) Real-world effectiveness, adherence and persistence among patients with type 2 diabetes mellitus initiating dulaglutide treatment. Current Medical Research and Opinion 34:6, pages 995-1003.
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Xiaoning He, Liming Chen, Ke Wang, Haiya Wu & Jing Wu. (2017) Insulin adherence and persistence among Chinese patients with type 2 diabetes: a retrospective database analysis. Patient Preference and Adherence 11, pages 237-245.
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Usha Sambamoorthi, Rahul Garg, Arijita Deb, Tao Fan & Anders Boss. (2017) Persistence with rapid-acting insulin and its association with A1C level and severe hypoglycemia among elderly patients with type 2 diabetes. Current Medical Research and Opinion 33:7, pages 1309-1316.
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William H Polonsky & Robert R Henry. (2016) Poor medication adherence in type 2 diabetes: recognizing the scope of the problem and its key contributors. Patient Preference and Adherence 10, pages 1299-1307.
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Margaret Tiktin, Selda Celik & Lori Berard. (2016) Understanding adherence to medications in type 2 diabetes care and clinical trials to overcome barriers: a narrative review. Current Medical Research and Opinion 32:2, pages 277-287.
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Dilek Gogas Yavuz, Sevim Ozcan & Oguzhan Deyneli. (2015) Adherence to insulin treatment in insulin-naïve type 2 diabetic patients initiated on different insulin regimens. Patient Preference and Adherence 9, pages 1225-1231.
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Michael Grabner, James Chu, Swetha Raparla, Ralph Quimbo, Steve Zhou & Joseph Conoshenti. (2013) Clinical and Economic Outcomes Among Patients With Diabetes Mellitus Initiating Insulin Glargine Pen Versus Vial. Postgraduate Medicine 125:3, pages 204-213.
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Diana Witticke, Hanna Marita Seidling, Hans-Dieter Klimm & Walter Emil Haefeli. (2012) Do we prescribe what patients prefer? Pilot study to assess patient preferences for medication regimen characteristics. Patient Preference and Adherence 6, pages 679-684.
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Rosemarie Lajara, German Guerrero & Jerome Thurman. (2012) Healthcare professional and patient perceptions of a new prefilled insulin pen versus vial and syringe. Expert Opinion on Drug Delivery 9:10, pages 1181-1196.
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Articles from other publishers (28)

Jessica Schiro, Sylvia Pelayo, Louise Heyndels & Romaric Marcilly. 2024. Convergence: Breaking Down Barriers Between Disciplines. Convergence: Breaking Down Barriers Between Disciplines 275 285 .
Timothy T. Pham, Xiaoxue Chen, John Barron, Richard Hart, Jacob Abarca & Andrea DeVries. (2022) Effectiveness, safety and treatment adherence of biosimilar follow‐on insulin in diabetes management. Diabetes, Obesity and Metabolism 24:10, pages 1989-1997.
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Małgorzata Masierek, Katarzyna Nabrdalik, Oliwia Janota, Hanna Kwiendacz, Maksymilian Macherski & Janusz Gumprecht. (2022) The Review of Insulin Pens—Past, Present, and Look to the Future. Frontiers in Endocrinology 13.
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Hanxi ZhangJamie C BarnerLeticia R MoczygembaKaren L Rascati. (2020) Assessment of basal insulin adherence using 2 methodologies among Texas Medicaid enrollees with type 2 diabetes. Journal of Managed Care & Specialty Pharmacy 26:11, pages 1434-1444.
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Arvind GuptaSanjeev PhatakY. Sadashiv RaoJayanthy Ramesh & Debmalya Sanyal. (2020) Consensus on Choice of Insulin Pen Devices in Routine Clinical Practice in India. Diabetes Technology & Therapeutics 22:10, pages 777-786.
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Elizabeth L. EbySanjay BajpaiDouglas E. FariesVirginia S. HaynesMaureen J. Lage. (2020) The Association Between Adherence to Insulin Therapy and Health Care Costs for Adults with Type 2 Diabetes: Evidence from a U.S. Retrospective Claims Database. Journal of Managed Care & Specialty Pharmacy 26:9, pages 1081-1089.
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Jieling Chen, Christi Y. Kao, Xuanyao He, Ludi Fan, Jeffrey A. Jackson & Rattan Juneja. (2020) Treatment Patterns, Adherence, and Persistence Associated With Human Regular U-500 Insulin: A Real-World Evidence Study. Diabetes Spectrum 33:3, pages 264-272.
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Jieling ChenRadhika NairMir SiadatyKatelyn BrownYunus MeahApril Dawn TaylorXuanyao HeLudi Fan. (2020) Treatment Patterns and Characteristics of Individuals Initiating High-Dose Insulin for Type 2 Diabetes Mellitus. Journal of Managed Care & Specialty Pharmacy 26:7, pages 839-847.
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Thomas Weinhold, Marzia Del Zotto, Jessica Rochat, Jessica Schiro, Sylvia Pelayo & Romaric Marcilly. (2018) Improving the safety of disposable auto-injection devices: a systematic review of use errors. AAPS Open 4:1.
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Magaly Perez-Nieves, Kristina S. Boye, Jacek Kiljanski, Dachung Cao & Maureen J. Lage. (2018) Adherence to Basal Insulin Therapy Among People with Type 2 Diabetes: A Retrospective Cohort Study of Costs and Patient Outcomes. Diabetes Therapy 9:3, pages 1099-1111.
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Roman Mathaes & Alexander Streubel. 2018. Challenges in Protein Product Development. Challenges in Protein Product Development 191 202 .
Patrick N. Racsa, Yunus Meah, Jeffrey J. Ellis & Kimberly R. Saverno. (2017) Comparative Effectiveness of Rapid-Acting Insulins in Adults with Diabetes. Journal of Managed Care & Specialty Pharmacy 23:3, pages 291-298.
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Wenhui Wei, Jenny Jiang, Youbei Lou, Sohini Ganguli & Mark S. Matusik. (2017) Benchmarking Insulin Treatment Persistence Among Patients with Type 2 Diabetes Across Different U.S. Payer Segments. Journal of Managed Care & Specialty Pharmacy 23:3, pages 278-290.
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Samuel StolpeMichel A. KroesNeil WebbTami Wisniewski. (2016) A Systematic Review of Insulin Adherence Measures in Patients with Diabetes. Journal of Managed Care & Specialty Pharmacy 22:11, pages 1224-1246.
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Pieralessandro Lasalvia, Julián Esteban Barahona-Correa, Diana Marcela Romero-Alvernia, Sebastián Gil-Tamayo, Camilo Castañeda-Cardona, Juan Gabriel Bayona, Juan José Triana, Andrés Felipe Laserna, Miguel Mejía-Torres, Paula Restrepo-Jimenez, Juliana Jimenez-Zapata & Diego Rosselli. (2016) Pen Devices for Insulin Self-Administration Compared With Needle and Vial. Journal of Diabetes Science and Technology 10:4, pages 959-966.
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Ken Fujioka, Thomas Sparre, Lily Yong-Hui Sun, Susanne Krogsgaard & Robert F. Kushner. (2015) Usability of the Novel Liraglutide 3.0 mg Pen Injector Among Overweight or Obese Adult Patients With or Without Prior Injection Experience. Journal of Diabetes Science and Technology 10:1, pages 164-174.
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Eleonora Tan, Wenya Yang, Bo Pang, Mingliang Dai, F. Ellen Loh & Paul Hogan. (2015) Geographic Variation in Antidiabetic Agent Adherence and Glycemic Control Among Patients with Type 2 Diabetes. Journal of Managed Care & Specialty Pharmacy 21:12, pages 1195-1202.
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S. Lane Slabaugh, Jonathan R. Bouchard, Yong Li, Jean C. Baltz, Yunus A. Meah & D. Chad Moretz. (2015) Characteristics Relating to Adherence and Persistence to Basal Insulin Regimens Among Elderly Insulin-Naïve Patients with Type 2 Diabetes: Pre-Filled Pens versus Vials/Syringes. Advances in Therapy 32:12, pages 1206-1221.
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Simon Zhornitsky, Jamie Greenfield, Marcus W. Koch, Scott B. Patten, Colleen Harris, Winona Wall, Katayoun Alikhani, Jodie Burton, Kevin Busche, Fiona Costello, Jeptha W. Davenport, Scott E. Jarvis, Dina Lavarato, Helene Parpal, David G. Patry, Michael Yeung & Luanne M. Metz. (2015) Long-Term Persistence with Injectable Therapy in Relapsing-Remitting Multiple Sclerosis: An 18-Year Observational Cohort Study. PLOS ONE 10:4, pages e0123824.
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Lin XieSteve ZhouBrett W. PinskyErin K. BuysmanOnur Baser. (2014) Impact of Initiating Insulin Glargine Disposable Pen Versus Vial/Syringe on Real-World Glycemic Outcomes and Persistence Among Patients with Type 2 Diabetes Mellitus in a Large Managed Care Plan: A Claims Database Analysis. Diabetes Technology & Therapeutics 16:9, pages 567-575.
Crossref
Hua Heng McVin Cheen, Seng Han Lim, Ming Chien Huang, Yong Mong Bee & Hwee Lin Wee. (2014) Adherence to Premixed Insulin in a Prefilled Pen Compared With a Vial/Syringe in People With Diabetes in Singapore. Clinical Therapeutics 36:7, pages 1043-1053.
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Andrew AhmannSheryl L. SzeinbachJasvinder GillLouise TraylorSatish K. Garg. (2014) Comparing Patient Preferences and Healthcare Provider Recommendations with the Pen Versus Vial-and-Syringe Insulin Delivery in Patients with Type 2 Diabetes. Diabetes Technology & Therapeutics 16:2, pages 76-83.
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Wenhui Wei, Chunshen Pan, Lin Xie & Onur Baser. (2014) Real-World Insulin Treatment Persistence among Patients with Type 2 Diabetes. Endocrine Practice 20:1, pages 52-61.
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Raymond Miao, Wenhui Wei, Jay Lin, Lin Xie & Onur Baser. (2014) Does Device Make Any Difference? A Real-world Retrospective Study of Insulin Treatment Among Elderly Patients With Type 2 Diabetes. Journal of Diabetes Science and Technology 8:1, pages 150-158.
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Hanna M. Seidling, Anette Lampert, Kristina Lohmann, Julia T. Schiele, Alexander J. F. Send, Diana Witticke & Walter E. Haefeli. (2013) Safeguarding the process of drug administration with an emphasis on electronic support tools. British Journal of Clinical Pharmacology 76, pages 25-36.
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M. J. Davies, J. J. Gagliardino, L. J. Gray, K. Khunti, V. Mohan & R. Hughes. (2013) Real-world factors affecting adherence to insulin therapy in patients with Type 1 or Type 2 diabetes mellitus: a systematic review. Diabetic Medicine 30:5, pages 512-524.
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Lin XieSteve ZhouWenhui WeiJasvinder GillChunshen PanOnur Baser. (2013) Does Pen Help? A Real-World Outcomes Study of Switching from Vial to Disposable Pen Among Insulin Glargine-Treated Patients with Type 2 Diabetes Mellitus. Diabetes Technology & Therapeutics 15:3, pages 230-236.
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Andreas Pfützner, Christina Schipper, Marcus Niemeyer, Marianne Qvist, Andrea Löffler, Thomas Forst & Petra B. Musholt. (2012) Comparison of Patient Preference for Two Insulin Injection Pen Devices in Relation to Patient Dexterity Skills. Journal of Diabetes Science and Technology 6:4, pages 910-916.
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