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Neurology: Original Article

Minimally important clinical difference of the Timed 25-Foot Walk Test: results from a randomized controlled trial in patients with multiple sclerosis

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Pages 49-56 | Accepted 08 Nov 2011, Published online: 23 Nov 2011

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Maede Khalifeloo, Soofia Naghdi, Noureddin Nakhostin Ansari, Jan Dommerholt & Mohammad Ali Sahraian. (2022) Dry needling for the treatment of muscle spasticity in a patient with multiple sclerosis: a case report. Physiotherapy Theory and Practice 38:13, pages 3248-3254.
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L. Ramió-Torrentà, J.C. Álvarez-Cermeño, R. Arroyo, B. Casanova-Estruch, O. Fernández, J.A. García-Merino, M.A. Hernández, G. Izquierdo, S. Martínez-Yélamos, J. Meca, E. Moral, J. Olascoaga, J.M. Prieto & A. Saiz. (2018) A guide to treating gait impairment with prolonged-release fampridine (Fampyra ® ) in patients with multiple sclerosis. Neurología (English Edition) 33:5, pages 327-337.
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L. Ramió-Torrentà, J.C. Álvarez-Cermeño, R. Arroyo, B. Casanova-Estruch, O. Fernández, J.A. García-Merino, M.A. Hernández, G. Izquierdo, S. Martínez-Yélamos, J. Meca, E. Moral, J. Olascoaga, J.M. Prieto & A. Saiz. (2018) Guía de tratamiento del deterioro de la marcha con fampridina de liberación prolongada (Fampyra ® ) en pacientes con esclerosis múltiple. Neurología 33:5, pages 327-337.
Crossref
Laura Barin, Claude Vaney, Milo Alan Puhan & Viktor von Wyl. (2018) Recommended outcome measures for inpatient rehabilitation of multiple sclerosis are not appropriate for the patients with substantially impaired mobility. Multiple Sclerosis and Related Disorders 22, pages 108-114.
Crossref
Georgia Andreopoulou, Thomas H. Mercer & Marietta L. van der Linden. (2018) Walking measures to evaluate assistive technology for foot drop in multiple sclerosis: A systematic review of psychometric properties. Gait & Posture 61, pages 55-66.
Crossref
Núria Sola-Valls, Yolanda Blanco, María Sepúlveda, Sara Llufriu, Elena H. Martínez-Lapiscina, Irati Zubizarreta, Irene Pulido-Valdeolivas, Carmen Montejo, Pablo Villoslada & Albert Saiz. (2018) Combined walking outcome measures identify clinically meaningful response to prolonged-release fampridine. Therapeutic Advances in Neurological Disorders 11, pages 175628641878000.
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Crossref
Esther S. Kim. (2017) Fampridine Prolonged Release: A Review in Multiple Sclerosis Patients with Walking Disability. Drugs 77:14, pages 1593-1602.
Crossref
Robert W Motl, Jeffrey A Cohen, Ralph Benedict, Glenn Phillips, Nicholas LaRocca, Lynn D Hudson & Richard Rudick. (2017) Validity of the timed 25-foot walk as an ambulatory performance outcome measure for multiple sclerosis. Multiple Sclerosis Journal 23:5, pages 704-710.
Crossref
Magaly Lecat, Pierre Decavel, Eloi Magnin, Brigitte Lucas, Vincent  Gremeaux & Yoshimasa Sagawa. (2017) Multiple Sclerosis and Clinical Gait Analysis before and after Fampridine: A Systematic Review. European Neurology 78:5-6, pages 272-286.
Crossref
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Crossref
Sarah Morrow. 2017. Case Studies in Multiple Sclerosis. Case Studies in Multiple Sclerosis 77 83 .
Yoshimasa SagawaJr.Jr., Eloi Magnin, Laura Paillot, Thierry Moulin & Pierre Decavel. (2016) Fampridine and quality of life in individuals with multiple sclerosis. SpringerPlus 5:1.
Crossref
Katrina L. Williams, Nancy L. Low Choy & Sandra G. Brauer. (2016) Are Changes in Gait and Balance Across the Disease Step Rating Scale in Multiple Sclerosis Statistically Significant and Clinically Meaningful?. Archives of Physical Medicine and Rehabilitation 97:9, pages 1502-1508.
Crossref
H.B. Jensen, Sepehr Mamoei, M. Ravnborg, U. Dalgas & E. Stenager. (2016) Distribution-based estimates of minimum clinically important difference in cognition, arm function and lower body function after slow release-fampridine treatment of patients with multiple sclerosis. Multiple Sclerosis and Related Disorders 7, pages 58-60.
Crossref
Evan Campbell, Elaine H. Coulter, Paul G. Mattison, Linda Miller, Angus McFadyen & Lorna Paul. (2016) Physiotherapy Rehabilitation for People With Progressive Multiple Sclerosis: A Systematic Review. Archives of Physical Medicine and Rehabilitation 97:1, pages 141-151.e3.
Crossref
Etienne Allart, Anne Benoit, Anne Blanchard-Dauphin, Vincent Tiffreau, André Thevenon, Hélène Zephir, Olivier Outteryck, Arnaud Lacour & Patrick Vermersch. (2015) Sustained-released fampridine in multiple sclerosis: effects on gait parameters, arm function, fatigue, and quality of life. Journal of Neurology 262:8, pages 1936-1945.
Crossref
Robert W. Motl, Norman Putzki, Lara A. Pilutti & Diego Cadavid. (2015) Longitudinal Changes in Self-Reported Walking Ability in Multiple Sclerosis. PLOS ONE 10:5, pages e0125002.
Crossref
J. P. Stellmann, A. Neuhaus, N. Götze, S. Briken, C. Lederer, M. Schimpl, C. Heesen & M. Daumer. (2015) Ecological Validity of Walking Capacity Tests in Multiple Sclerosis. PLOS ONE 10:4, pages e0123822.
Crossref
Deborah M Miller, Nicolas R Thompson, Jeffrey A Cohen, Robert J Fox, Jen Hartman, Kathleen Schwetz, Devon S Conway & Richard A Rudick. (2014) Factors associated with clinically significant increased walking time in multiple sclerosis: Results of a survival analysis of short-term follow-up data from a clinical database. Multiple Sclerosis Journal 21:4, pages 457-465.
Crossref
Lori Mayer, Tina Warring, Stephanie Agrella, Helen L. Rogers & Edward J. Fox. (2015) Effects of Functional Electrical Stimulation on Gait Function and Quality of Life for People with Multiple Sclerosis Taking Dalfampridine. International Journal of MS Care 17:1, pages 35-41.
Crossref
Eloi Magnin, Yoshimasa Sagawa Jr, Ludivine Chamard, Eric Berger, Thierry Moulin & Pierre Decavel. (2015) Verbal Fluencies and Fampridine Treatment in Multiple Sclerosis. European Neurology 74:5-6, pages 243-250.
Crossref
HB Jensen, M Ravnborg, S Mamoei, U Dalgas & E Stenager. (2014) Changes in cognition, arm function and lower body function after Slow-Release Fampridine treatment. Multiple Sclerosis Journal 20:14, pages 1872-1880.
Crossref
J.P. Stellmann, E. Vettorazzi, J. Poettgen & C. Heesen. (2014) A 3meter Timed Tandem Walk is an early marker of motor and cerebellar impairment in fully ambulatory MS patients. Journal of the Neurological Sciences 346:1-2, pages 99-106.
Crossref
Abbey Downing, David Van Ryn, Anne Fecko, Christopher Aiken, Sean McGowan, Sarah Sawers, Thomas McInerny, Katie Moore, Louis Passariello & Helen Rogers. (2014) Effect of a 2-Week Trial of Functional Electrical Stimulation on Gait Function and Quality of Life in People with Multiple Sclerosis. International Journal of MS Care 16:3, pages 146-152.
Crossref
Andrew D. Goodman, Theodore R. Brown, Randall T. Schapiro, Michael Klingler, Ron Cohen & Andrew R. Blight. (2014) A Pooled Analysis of Two Phase 3 Clinical Trials of Dalfampridine in Patients with Multiple Sclerosis. International Journal of MS Care 16:3, pages 153-160.
Crossref
Ilse Baert, Jennifer Freeman, Tori Smedal, Ulrik Dalgas, Anders Romberg, Alon Kalron, Helen Conyers, Iratxe Elorriaga, Benoit Gebara, Johanna Gumse, Adnan Heric, Ellen Jensen, Kari Jones, Kathy Knuts, Benoît Maertens de Noordhout, Andrej Martic, Britt Normann, Bert O Eijnde, Kamila Rasova, Carmen Santoyo Medina, Veronik Truyens, Inez Wens & Peter Feys. (2014) Responsiveness and Clinically Meaningful Improvement, According to Disability Level, of Five Walking Measures After Rehabilitation in Multiple Sclerosis. Neurorehabilitation and Neural Repair 28:7, pages 621-631.
Crossref
Richard W. Bohannon & Susan S. Glenney. (2014) Minimal clinically important difference for change in comfortable gait speed of adults with pathology: a systematic review. Journal of Evaluation in Clinical Practice 20:4, pages 295-300.
Crossref
Alar Kuusik, Katrin Gross-Paju, Heigo Maamagi & Enar Reilent. (2014) Comparative Study of Four Instrumented Mobility Analysis Tests on Neurological Disease Patients. Comparative Study of Four Instrumented Mobility Analysis Tests on Neurological Disease Patients.
Henrik Boye Jensen, Mads Ravnborg, Ulrik Dalgas & Egon Stenager. (2013) 4-Aminopyridine for symptomatic treatment of multiple sclerosis: a systematic review. Therapeutic Advances in Neurological Disorders 7:2, pages 97-113.
Crossref
Peter Feys, Bo Bibby, Anders Romberg, Carme Santoyo, Benoit Gebara, Benoit Maertens de Noordhout, Kathy Knuts, Francois Bethoux, Anders Skjerbæk, Ellen Jensen, Ilse Baert, Claude Vaney, Vincent de Groot & Ulrik Dalgas. (2014) Within-day variability on short and long walking tests in persons with multiple sclerosis. Journal of the Neurological Sciences 338:1-2, pages 183-187.
Crossref
Brendan L Limone, Matthew F Sidovar & Craig I Coleman. (2013) Estimation of the effect of dalfampridine-ER on health utility by mapping the MSWS-12 to the EQ-5D in multiple sclerosis patients. Health and Quality of Life Outcomes 11:1.
Crossref
Myla D. GoldmanRobert W. MotlJohn ScagnelliJohn H. PulaJacob J. SosnoffDiego Cadavid. (2013) Clinically meaningful performance benchmarks in MS. Neurology 81:21, pages 1856-1863.
Crossref
Meheroz H. Rabadi, Kimberly Kreymborg & Andrea S. Vincent. (2013) Sustained-Release Fampridine (4-Aminopyridine) in Multiple Sclerosis: Efficacy and Impact on Motor Function. Drugs in R&D 13:3, pages 175-181.
Crossref
Jana Lizrova Preiningerova, Ulf Baumhackl, Tunde Csepany, Adam Czaplinski, Florian Deisenhammer, Tobias Derfuss, Tanja H. Fabjan, Franz Fazekas, Siegrid Fuchs, Eva Havrdova, Alenka Horvath Ledinek, Zsolt Illes, Sasa Sega Jazbec, Eleonora Klimova, Samuel Komoly, Egon Kurca, Michael Linnebank, Lubomir Lisy, Jan Mares, Lubica Prochazkova, Rozsa Csilla, Jarmila Szilasiova, Pavel Stourac, Radomir Talab, Peter Turcani, Marta Vachova, Laszlo Vecsei, David Vodusek, Olga Zapletalova & Thomas Berger. (2013) Recommendations for the Use of Prolonged‐Release Fampridine in Patients with Multiple Sclerosis ( MS ) . CNS Neuroscience & Therapeutics 19:5, pages 302-306.
Crossref
Andrew D. Goodman & Robert Thompson Stone. (2012) Enhancing Neural Transmission in Multiple Sclerosis (4-Aminopyridine Therapy). Neurotherapeutics 10:1, pages 106-110.
Crossref
C. Vaney, A. Bienz, R. Zwicky, M. Gerber & M. Traber. (2012) P7. Importance of mobility for quality of life in patients with multiple sclerosis. Clinical Neurophysiology 123:10, pages e104-e105.
Crossref
Carrie Hersh & Alex Rae-Grant. (2012) Extended-release dalfampridine in the management of multiple-sclerosis-related walking impairment. Therapeutic Advances in Neurological Disorders 5:4, pages 199-204.
Crossref
Bernd C. KieseierCarlo Pozzilli. (2012) Assessing walking disability in multiple sclerosis. Multiple Sclerosis Journal 18:7, pages 914-924.
Crossref

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