831
Views
36
CrossRef citations to date
0
Altmetric
Rheumatology: Original Article

Efficacy and safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and design of randomised, double-blind, placebo-controlled trial

, , , , , , , , , , & show all
Pages 231-239 | Accepted 07 Dec 2011, Published online: 17 Jan 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Weiyu Han, Shicai Fan, Xiaochun Bai & Changhai Ding. (2017) Strontium ranelate, a promising disease modifying osteoarthritis drug. Expert Opinion on Investigational Drugs 26:3, pages 375-380.
Read now
Kang Wang, Jianhua Xu, David J Hunter & Changhai Ding. (2015) Investigational drugs for the treatment of osteoarthritis. Expert Opinion on Investigational Drugs 24:12, pages 1539-1556.
Read now
Sara Tenti, Sara Cheleschi, Giacomo Maria Guidelli, Mauro Galeazzi & Antonella Fioravanti. (2014) What about strontium ranelate in osteoarthritis? Doubts and securities. Modern Rheumatology 24:6, pages 881-884.
Read now

Articles from other publishers (32)

Shengfa Li, Peihua Cao, Tianyu Chen & Changhai Ding. (2023) Latest insights in disease-modifying osteoarthritis drugs development. Therapeutic Advances in Musculoskeletal Disease 15, pages 1759720X2311698.
Crossref
Xin Wan, Xuefei Wang, Ran Pang, Chunlei Xu, Wei Shi, Huafeng Zhang, Hui Li & Zhijun Li. (2022) Mapping knowledge landscapes and emerging trends of the links between osteoarthritis and osteoporosis: A bibliometric analysis. Frontiers in Public Health 10.
Crossref
C.M. Parsons, A. Judge, R. Meyer, O. Bruyère, F. Petit-Dop, R. Chapurlat, J.-Y. Reginster, C. Cooper & H. Inskip. (2021) Determining individual trajectories of joint space loss: improved statistical methods for monitoring knee osteoarthritis disease progression. Osteoarthritis and Cartilage 29:1, pages 59-67.
Crossref
Frederike Sannmann, Jean-Denis Laredo, Christine Chappard & Klaus Engelke. (2020) Impact of meniscal coverage on subchondral bone mineral density of the proximal tibia in female subjects – A cross-sectional in vivo study using QCT. Bone 134, pages 115292.
Crossref
Peilin Hu, Jie Du, Shuai Zhang, Ting Wang, Jun Li, Gang Chen & Guangqian Zhou. (2019) Oral Administration of Strontium Gluconate Effectively Reduces Articular Cartilage Degeneration Through Enhanced Anabolic Activity of Chondrocytes and Chondrogenetic Differentiation of Mesenchymal Stromal Cells. Biological Trace Element Research 193:2, pages 422-433.
Crossref
Camille M. Parsons, Andrew Judge, Kirsten Leyland, Olivier Bruyère, Florence Petit Dop, Roland Chapurlat, Jean‐Yves Reginster, Mark H. Edwards, Elaine M. Dennison, Cyrus Cooper, Hazel Inskip, C. Christiansen, P. Delmas, H. Genant, J. Zacher, N. Bellamy, C. Speirs, G. Bréart, O. Meyer, D. Gensburger, M. Arlot, J.‐P. Roux, R. Deroisy, P. Sambrook, B. Leeb, A. Verbruggen, W. Bensen, T. Hala, M. Holm‐Bentzen, I. Valter, X. Chevalier, B. Swoboda, S. Adami, M. Kloppenburg, E. Grazuleviciute, J. Badurski, J. Branco, E. Nasonov, F. Navarro, T. Spector, L. Barnsley, S. Hall, G. Jones, A. Klestov, L. March, P. Nash, E. Romas, R. Will, L. Erlacher, F. B. Leeb, H. Resch, F. Rainer, O. Zamani, T. Appelboom, J. P. Devogelaer, A. Kvasz, F. Raeman, A. Verbruggen, A. D. Beaulieu, W. G. Bensen, J. Brown, A. A. Cividino, F. Morin, W. P. Olszynski, J. P. Raynauld, J. C. Thorne, T. Hala, K. Pavelka, P. Alexandersen, H. C. Hoeck, M. Holm‐Bentzen, P. Lundqvist, I. Valter, L. Aim, P. Audouy, P. Beaunier, C. L. Benhamou, F. Berenbaum, E. Chabaud, D. Chalet, X. Chevalier, M. Cohen‐Solal, D. Delbecq, L. Euller‐Ziegler, P. Fardellone, P. Hilliquin, E. Jacquety, N. Jude, D. Lechevalier, J. C. Mouchet, P. Richette, E. Sainte Lorette, T. Schaeverbeke, A. Sebbah, E. Vignot, T. Brabant, G. R. Burmester, J. Grifka, P. E. M. Müller, B. Swoboda, J. Zacher, S. Adami, G. Bianchi, W. Grassi, L. Di Matteo, V. Modena, O. Di Munno, S. Ortolani, L. Punzi, M. Zangari, E. Grazuleviciute, M. Kloppenburg, L. D. Roorda, P. L. C. M. Van Riel, J. Badurski, E. Czerwinski, A. Gorecki, W. Tlustochowicz, J. Branco, J. Canas Da Silva, J. A. Melo Gomes, L. M. Miranda, F. Radulescu, L. I. Alexeeva, A. V. Orlov‐Morozov, E. G. Pikhlak, V. G. Pilyaev, N. A. Shostak, E. I. Shmidt, N. V. Zagorodniy, L. Arboleya Rodríguez, P. Benito Ruiz, E. Chamizo Carmona, E. Collantes Estévez, G. Herrero‐Beaumont, E. Martín Mola, A. Moreno, A. Naranjo Hernández, F. Navarro Sarabia, J. M. Padrino, C. Palacios, A. Rodríguez De La Serna, J. A. Román Ivorra, A. Torrijos, E. Abdulhakim, N. Arden, F. Birrell, H. Donnachie, W. Fraser, R. Keen, R. Sarmiento & M. D. Stone. (2019) Novel Approach to Estimate Osteoarthritis Progression: Use of the Reliable Change Index in the Evaluation of Joint Space Loss. Arthritis Care & Research 71:2, pages 300-307.
Crossref
Florent Eymard, Camille Parsons, Mark H. Edwards, Florence Petit-Dop, Jean-Yves Reginster, Olivier Bruyère, Xavier Chevalier, Cyrus Cooper & Pascal Richette. (2019) Impact du traitement par statines dans la progression radiologique de la gonarthrose : résultats issus de l’analyse post-hoc de l’essai SEKOIA. Revue du Rhumatisme 86:1, pages 81-86.
Crossref
Florent Eymard, Camille Parsons, Mark H. Edwards, Florence Petit-Dop, Jean-Yves Reginster, Olivier Bruyère, Xavier Chevalier, Cyrus Cooper & Pascal Richette. (2018) Statin use and knee osteoarthritis progression: Results from a post-hoc analysis of the SEKOIA trial. Joint Bone Spine 85:5, pages 609-614.
Crossref
J. Geronimi & G. Saporta. (2017) Variable selection for multiply-imputed data with penalized generalized estimating equations. Computational Statistics & Data Analysis 110, pages 103-114.
Crossref
Alice Courties, Jérémie Sellam, Emmanuel Maheu, Christian Cadet, Yoann Barthe, Fabrice Carrat & Francis Berenbaum. (2017) Coronary heart disease is associated with a worse clinical outcome of hand osteoarthritis: a cross-sectional and longitudinal study. RMD Open 3:1, pages e000344.
Crossref
Marco Atteritano, Antonino Catalano, Domenico Santoro, Antonino Lasco & Salvatore Benvenga. (2015) Effects of strontium ranelate on markers of cardiovascular risk in postmenopausal osteoporotic women. Endocrine 53:1, pages 305-312.
Crossref
Mark H. Edwards, Camille Parsons, Olivier Bruyère, Forence Petit Dop, Roland Chapurlat, Frank W. Roemer, Ali Guermazi, Souhil Zaim, Harry Genant, Jean-Yves Reginster, Elaine M. Dennison & Cyrus Cooper. (2016) High Kellgren-Lawrence Grade and Bone Marrow Lesions Predict Worsening Rates of Radiographic Joint Space Narrowing; The SEKOIA Study. The Journal of Rheumatology 43:3, pages 657-665.
Crossref
W.E. Van Spil, P.M.J. Welsing, S.M.A. Bierma-Zeinstra, J.W.J. Bijlsma, L.D. Roorda, H.A. Cats & F.P.J.G. Lafeber. (2015) The ability of systemic biochemical markers to reflect presence, incidence, and progression of early-stage radiographic knee and hip osteoarthritis: data from CHECK. Osteoarthritis and Cartilage 23:8, pages 1388-1397.
Crossref
F. Eymard, C. Parsons, M.H. Edwards, F. Petit-Dop, J.-Y. Reginster, O. Bruyère, P. Richette, C. Cooper & X. Chevalier. (2015) Diabetes is a risk factor for knee osteoarthritis progression. Osteoarthritis and Cartilage 23:6, pages 851-859.
Crossref
Jean-Pierre Pelletier, Camille Roubille, Jean-Pierre Raynauld, François Abram, Marc Dorais, Philippe Delorme & Johanne Martel-Pelletier. (2015) Disease-modifying effect of strontium ranelate in a subset of patients from the Phase III knee osteoarthritis study SEKOIA using quantitative MRI: reduction in bone marrow lesions protects against cartilage loss. Annals of the Rheumatic Diseases 74:2, pages 422-429.
Crossref
G.E.R. Thomas, A.J.R. Palmer, R.N. Batra, A. Kiran, D. Hart, T. Spector, M.K. Javaid, A. Judge, D.W. Murray, A.J. Carr, N.K. Arden & S. Glyn-Jones. (2014) Subclinical deformities of the hip are significant predictors of radiographic osteoarthritis and joint replacement in women. A 20 year longitudinal cohort study. Osteoarthritis and Cartilage 22:10, pages 1504-1510.
Crossref
O. Bruyere, J.-Y. Reginster, N. Bellamy, R. Chapurlat, P. Richette & C. Cooper. (2014) Clinically meaningful effect of strontium ranelate on symptoms in knee osteoarthritis: a responder analysis. Rheumatology 53:8, pages 1457-1464.
Crossref
C. Cooper, K. M. Fox & J. S. Borer. (2013) Ischaemic cardiac events and use of strontium ranelate in postmenopausal osteoporosis: a nested case–control study in the CPRD. Osteoporosis International 25:2, pages 737-745.
Crossref
Ali Guermazi, Frank W. Roemer, David T. Felson & Kenneth D. Brandt. (2013) Unresolved Questions in Rheumatology: Motion for Debate: Osteoarthritis Clinical Trials Have Not Identified Efficacious Therapies Because Traditional Imaging Outcome Measures Are Inadequate. Arthritis & Rheumatism 65:11, pages 2748-2758.
Crossref
Jean-Yves Reginster, Charlotte Beaudart, Audrey Neuprez & Olivier Bruyère. (2013) Strontium ranelate in the treatment of knee osteoarthritis: new insights and emerging clinical evidence. Therapeutic Advances in Musculoskeletal Disease 5:5, pages 268-276.
Crossref
Christopher B. Little & David J. Hunter. (2013) Post-traumatic osteoarthritis: from mouse models to clinical trials. Nature Reviews Rheumatology 9:8, pages 485-497.
Crossref
Xavier Chevalier, Florent Eymard & Pascal Richette. (2013) Biologic agents in osteoarthritis: hopes and disappointments. Nature Reviews Rheumatology 9:7, pages 400-410.
Crossref
T. Lowitz, O. Museyko, V. Bousson, L. Laouisset, W.A. Kalender, J.-D. Laredo & K. Engelke. (2013) Bone marrow lesions identified by MRI in knee osteoarthritis are associated with locally increased bone mineral density measured by QCT. Osteoarthritis and Cartilage 21:7, pages 957-964.
Crossref
Simon C. Mastbergen, Daniël B. F. Saris & Floris P. J. G. Lafeber. (2013) Functional articular cartilage repair: here, near, or is the best approach not yet clear?. Nature Reviews Rheumatology 9:5, pages 277-290.
Crossref
Lukas Martin Wildi, Johanne Martel‐Pelletier, François Abram, Thomas Moser, Jean‐Pierre Raynauld & Jean‐Pierre Pelletier. (2013) Assessment of Cartilage Changes Over Time in Knee Osteoarthritis Disease‐Modifying Osteoarthritis Drug Trials Using Semiquantitative and Quantitative Methods: Pros and Cons. Arthritis Care & Research 65:5, pages 686-694.
Crossref
Songsong Zhu, Kan Chen, Yu Lan, Nan Zhang, Rulang Jiang & Jing Hu. (2013) Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats. Bone 53:2, pages 340-349.
Crossref
Johanne Martel-Pelletier & Jean-Pierre PelletierSimon C MastbergenWillemijn Noort-van der LaanFloris PJG Lafeber. 2013. Addressing Unmet Needs in Osteoarthritis. Addressing Unmet Needs in Osteoarthritis 70 85 .
Jean-Yves Reginster, Franz Pelousse & Olivier Bruyère. (2013) Is there potential for strontium ranelate in the management of osteoarthritis?. Clinical Practice 10:2, pages 201-207.
Crossref
Zuzana Saidak & Pierre J. Marie. (2012) Strontium signaling: Molecular mechanisms and therapeutic implications in osteoporosis. Pharmacology & Therapeutics 136:2, pages 216-226.
Crossref
Rik J U Lories & Frank P Luyten. (2012) Osteoarthritis, a disease bridging development and regeneration. BoneKEy Reports 1:8.
Crossref
Emma L WilliamsChristopher J Edwards, Cyrus Cooper & Richard OC Oreffo. (2012) Impact of inflammation on the osteoarthritic niche: implications for regenerative medicine. Regenerative Medicine 7:4, pages 551-570.
Crossref
Aoife G. Cotter & Patrick W. G. Mallon. (2012) Therapeutic Options for Low Bone Mineral Density in HIV-Infected Subjects. Current HIV/AIDS Reports 9:2, pages 148-159.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.