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Pain: Original Article

Extended-release tramadol/paracetamol in moderate-to-severe pain: a randomized, placebo-controlled study in patients with acute low back pain

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Pages 847-857 | Accepted 21 Mar 2012, Published online: 25 Apr 2012

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Joseph V. Pergolizzi$suffix/text()$suffix/text(), Jo Ann LeQuang, Robert Taylor$suffix/text()$suffix/text(), Michael H. Ossipov, Daniel Colucci & Robert B. Raffa. (2018) Designing safer analgesics: a focus on μ-opioid receptor pathways. Expert Opinion on Drug Discovery 13:10, pages 965-972.
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Articles from other publishers (15)

W. Watson Buchanan, K. D. Rainsford, Colin A. Kean & Walter F. Kean. (2023) Narcotic analgesics. Inflammopharmacology.
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Caitlin M P Jones, Richard O Day, Bart W Koes, Jane Latimer, Chris G Maher, Andrew J McLachlan, Laurent Billot, Sana Shan, Chung-Wei Christine Lin, Hanan McLachlan, Melissa Webb, Melanie Hamilton, Harbeer Ahedi, Angie Barber, Wendy Mak, Stephanie Mathieson, Veronika Petrova, Severine Bompoint, Sana Shan, Bridin Murnion, Nicholas Buckley, Apo Demirkol, Paul Wrigley, Christopher Needs, Louise Brooks, Samuel Cantori, Paul Preisz, James Aitken, Sujata Allan, Michael Burke, Greg Cameron, Francisco Javier Valencia Cepeda, Christopher Davis, Jayasree Dullur, Joseph Emmanuel, Catherine Errey, Sabine Fieuw-Makaroff, Adam Gaudry, L Genua, Ian Longhurst, Kenneth McCroary, Diana Merhi, Tanya Nguyen, Zahra Rassoly Obayd, Michelle Penm, Sharan Pobbathi, William S Poh, Paul Schnitzler, Sabiha Shahnaz, Ven Tan, Danny Tang, Brian Tan, Win Kyaw Thu, Thrasivolous Triantopolous, Ramana Venkatesan, Wicky Chun Fai Wong & Shu Ching Yang. (2023) Opioid analgesia for acute low back pain and neck pain (the OPAL trial): a randomised placebo-controlled trial. The Lancet 402:10398, pages 304-312.
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Magdi Hanna, Serge Perrot & Giustino Varrassi. (2023) Critical Appraisal of Current Acute LBP Management and the Role of a Multimodal Analgesia: A Narrative Review. Pain and Therapy 12:2, pages 377-398.
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Jae-Young Hong, Kwang-Sup Song, Jae Hwan Cho, Jae Hyup Lee & Nack Hwan Kim. (2022) An Updated Overview of Low Back Pain Management. Asian Spine Journal 16:6, pages 968-982.
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Michael A. Wewege, Matthew D. Jones, Sam A. Williams, Steven J. Kamper & James H. McAuley. (2022) Rescaling pain intensity measures for meta-analyses of analgesic medicines for low back pain appears justified: an empirical examination from randomised trials. BMC Medical Research Methodology 22:1.
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Giustino Varrassi, Magdi Hanna, Stefano Coaccioli, Meto Suada & Serge Perrot. (2022) DANTE Study: The First Randomized, Double-Blind, Placebo and Active-Controlled, Parallel Arm Group Study Evaluating the Analgesic Efficacy and Safety of Dexketoprofen TrometAmol aNd Tramadol Hydrochloride Oral FixEd Dose Combination on Moderate to Severe Acute Pain in Patients with Acute Low Back Pain—Rationale and Design. Pain and Therapy 11:3, pages 1055-1070.
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Jonathan L. Fu & Michael D. Perloff. (2022) Pharmacotherapy for Spine-Related Pain in Older Adults. Drugs & Aging 39:7, pages 523-550.
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Shinichi Kawai, Satoshi Sobajima, Masashi Jinnouchi, Hideshi Nakano, Hideaki Ohtani, Mineo Sakata & Takeshi Adachi. (2022) Efficacy and Safety of Tramadol Hydrochloride Twice-Daily Sustained-Release Bilayer Tablets with an Immediate-Release Component for Chronic Pain Associated with Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled, Treatment-Withdrawal Study. Clinical Drug Investigation 42:5, pages 403-416.
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Osamu Shirado, Yoshiyasu Arai, Tetsuhiro Iguchi, Shiro Imagama, Mamoru Kawakami, Takuya Nikaido, Tadanori Ogata, Sumihisa Orita, Daisuke Sakai, Kimiaki Sato, Masahiko Takahata, Katsushi Takeshita, Takashi Tsuji, Kei Ando, Yoshiyasu Arai, Teruaki Endo, Hironari Fukuda, Masafumi Goto, Hiroshi Hashidume, Masayuki Hino, Yohei Ide, Tetsuhiro Iguchi, Shiro Imagama, Hirokazu Inoue, Taro Inoue, Yuyu Ishimoto, Kenyu Ito, Sadayuki Ito, Masumi Iwabuchi, Shoji Iwahashi, Hiroshi Iwasaki, Ryohei Kagotani, Shunsuke Kanbara, Kinshi Kato, Mamoru Kawakami, Atsushi Kimura, Tomoko Kitagawa, Hiroshi Kobayashi, Kazuyoshi Kobayashi, Jun Komatsu, Hiroyuki Koshimizu, Masaaki Machino, Tsunemasa Matsubara, Yu Matsukura, Akihito Minamide, Masakazu Minetama, Kenji Mizokami, Tadao Morino, Masayoshi Morozumi, Keiji Nagata, Ichiro Nakae, Masafumi Nakagawa, Yukihiro Nakagawa, Takuya Nikaido, Tadanori Ogata, Sumihisa Orita, Kyotaro Ota, Daisuke Sakai, Kenichiro Sakai, Rikiya Saruwatari, Shinichi Sasaki, Kimiaki Sato, Takahiro Shimazaki, Osamu Shirado, Yasuyuki Shiraishi, Masahiko Takahata, Masanari Takami, Katsushi Takeshita, Satoshi Tanaka, Masatoshi Teraguchi, Ryoji Tominaga, Masaki Tomori, Ichiro Torigoe, Takashi Tsuji, Mikito Tsushima, Shunji Tsutsui, Kazuyuki Watanabe, Hiroshi Yamada, Kei Yamada, Hidetoshi Yamaguchi, Kimiaki Yokosuka, Takanori Yoshida, Tatsuhiro Yoshida, Masato Yuasa & Yasutsugu Yugawa. (2022) Formulation of Japanese Orthopaedic Association (JOA) clinical practice guideline for the management of low back pain- the revised 2019 edition. Journal of Orthopaedic Science 27:1, pages 3-30.
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D. Scott Kreiner, Paul Matz, Christopher M. Bono, Charles H. Cho, John E. Easa, Gary Ghiselli, Zoher Ghogawala, Charles A. Reitman, Daniel K. Resnick, William C. WattersIIIIII, Thiru M. Annaswamy, Jamie Baisden, Walter S. Bartynski, Shay Bess, Randall P. Brewer, R. Carter Cassidy, David S. Cheng, Sean D. Christie, Norman B. Chutkan, Bernard Allan Cohen, Simon Dagenais, Dennis E. Enix, Paul Dougherty, S. Raymond Golish, Padma Gulur, Steven W. Hwang, Cumhur Kilincer, Jeffrey A. King, Adam C. Lipson, Anthony J. Lisi, Richard J. Meagher, John E. O'Toole, Paul Park, Murat Pekmezci, Daniel R. Perry, Ravi Prasad, David A. Provenzano, Kris E. Radcliff, Gazanfar Rahmathulla, Tom E. Reinsel, Robert L. RichJr.Jr., Daniel S. Robbins, Karie A. Rosolowski, Jonathan N. Sembrano, Anil K. Sharma, Alison A. Stout, Christopher K. Taleghani, Ryan A. Tauzell, Terry Trammell, Yakov Vorobeychik & Amy M. Yahiro. (2020) Guideline summary review: an evidence-based clinical guideline for the diagnosis and treatment of low back pain. The Spine Journal 20:7, pages 998-1024.
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D. Samper Bernal, A. Alvarado Bonilla, L. Cánovas, A. Carregal, S.P. Fernández Sánchez, J.M. González Mesa, C. Guillén Astete, A. Loscos López, A.J. Lozano Martínez, J.M. Pérez-Castejón, G. Romero-Cullerés & E. Salido de Andrés. (2019) Documento de consenso sobre el uso de la combinación paracetamol/tramadol en pacientes con dolor moderado-intenso. Medicina de Familia. SEMERGEN 45:1, pages 52-62.
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Stephanie Mathieson, Richard Kasch, Christopher G. Maher, Rafael Zambelli Pinto, Andrew J. McLachlan, Bart W. Koes & Chung-Wei Christine Lin. (2019) Combination Drug Therapy for the Management of Low Back Pain and Sciatica: Systematic Review and Meta-Analysis. The Journal of Pain 20:1, pages 1-15.
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Jean-François Chenot, Bernhard Greitemann, Bernd Kladny, Frank Petzke, Michael Pfingsten & Susanne Gabriele Schorr. (2017) Non-Specific Low Back Pain. Deutsches Ärzteblatt international.
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Jae-Young Hong, Kwang-Sup Song, Jae Hwan Cho & Jae Hyup Lee. (2017) An Updated Overview of Low Back Pain Management in Primary Care. Asian Spine Journal 11:4, pages 653-660.
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W. Michael Hooten & Steven P. Cohen. (2015) Evaluation and Treatment of Low Back Pain. Mayo Clinic Proceedings 90:12, pages 1699-1718.
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