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Pain: Original Article

Efficacy and safety of fentanyl sublingual spray for the treatment of breakthrough cancer pain: a randomized, double-blind, placebo-controlled study

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Pages 859-870 | Accepted 02 Apr 2012, Published online: 02 May 2012

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Read on this site (7)

Richard Rauck, D. Alexander Oh, Neha Parikh, Christian Koch, Neil Singla, Jin Yu, Srinivas Nalamachu & Santosh Vetticaden. (2017) Pharmacokinetics and safety of fentanyl sublingual spray and fentanyl citrate intravenous: a single ascending dose study in opioid-naïve healthy volunteers. Current Medical Research and Opinion 33:11, pages 1915-1920.
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Andrew Chang, Eric J. Roeland, Rabia S. Atayee, Carolyn Revta & Joseph D. Ma. (2015) Transmucosal Immediate-Release Fentanyl for Breakthrough Cancer Pain: Opportunities and Challenges for Use in Palliative Care. Journal of Pain & Palliative Care Pharmacotherapy 29:3, pages 247-260.
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Sebastiano Mercadante & Antonino Giarratano. (2014) Assessing age and gender in studies of breakthrough pain medications. Current Medical Research and Opinion 30:7, pages 1353-1356.
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Susan M. Moeschler, Casandra Rosenberg, Drew Trainor, Richard H. Rho & W. David Mauck. (2014) Interventional Modalities to Treat Cancer-Related Pain. Hospital Practice 42:5, pages 14-23.
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Howard S Smith. (2013) Considerations in selecting rapid-onset opioids for the management of breakthrough pain. Journal of Pain Research 6, pages 189-200.
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Donald R Taylor. (2013) Single-dose fentanyl sublingual spray for breakthrough cancer pain. Clinical Pharmacology: Advances and Applications 5, pages 131-141.
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Nicholas Moore, Mona Darwish, Xavier Amores & Hélène Schneid. (2012) A review of the pharmacokinetic profile of transmucosal fentanyl formulations. Current Medical Research and Opinion 28:11, pages 1781-1790.
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Articles from other publishers (31)

Judith A. Paice, Kari Bohlke, Debra Barton, David S. Craig, Areej El-Jawahri, Dawn L. Hershman, Lynn R. Kong, Geana P. Kurita, Thomas W. LeBlanc, Sebastiano Mercadante, Kristina L. M. Novick, Ramy Sedhom, Carole Seigel, Joanna Stimmel & Eduardo Bruera. (2023) Use of Opioids for Adults With Pain From Cancer or Cancer Treatment: ASCO Guideline. Journal of Clinical Oncology 41:4, pages 914-930.
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Hironori MawatariTakuya ShinjoTatsuya MoritaHiroyuki KoharaKinomi Yomiya. (2022) Revision of Pharmacological Treatment Recommendations for Cancer Pain: Clinical Guidelines from the Japanese Society of Palliative Medicine. Journal of Palliative Medicine 25:7, pages 1095-1114.
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Senthil Marappan, Vigneshwaran Subramanian, Brindha Rathinasabapathy, Elvis Senthil & Shiladitya Bose. (2022) Comparative study between 2-chloroprocaine and combination of 2-chloroprocaine with fentanyl for spinal anaesthesia. Serbian Journal of Anesthesia and Intensive Therapy 44:5-6, pages 139-145.
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Ethan Williamson, Kelley L. Sharp & Steven D. Waldman. 2021. Pain Control in Ambulatory Surgery Centers. Pain Control in Ambulatory Surgery Centers 133 152 .
Mari Fihlman, E. Karru, P. Varpe, H. Huhtinen, N. Hagelberg, T. I. Saari & K. T. Olkkola. (2020) Feasibility of a transmucosal sublingual fentanyl tablet as a procedural pain treatment in colonoscopy patients: a prospective placebo-controlled randomized study. Scientific Reports 10:1.
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Sebastiano Mercadante, Vincenzo Restivo & Alessandra Casuccio. (2019) Effects of age and gender in patients receiving doses of opioids for breakthrough pain proportional to background opioid doses. Supportive Care in Cancer 28:8, pages 3813-3818.
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Francesca Ricchini, Augusto Caraceni, Ernesto Zecca, Alessandra Pigni, Fabio Centurioni, Andrea Manzoni, Stein Kaasa & Cinzia Brunelli. (2019) Effect of Opioid Exposure on Efficacy and Tolerability of Sublingual Fentanyl and Subcutaneous Morphine for Severe Cancer Pain Episodes. Secondary Analysis From a Double-Blind Double-Dummy, Randomized Trial. Journal of Pain and Symptom Management 58:4, pages 587-595.
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Jennifer S. Gewandter, Michael P. McDermott, Hua He, Shan Gao, Xueya Cai, John T. Farrar, Nathaniel P. Katz, John D. Markman, Stephen Senn, Dennis C. Turk & Robert H. Dworkin. (2019) Demonstrating Heterogeneity of Treatment Effects Among Patients: An Overlooked but Important Step Toward Precision Medicine. Clinical Pharmacology & Therapeutics 106:1, pages 204-210.
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M. Fallon, R. Giusti, F. Aielli, P. Hoskin, R. Rolke, M. Sharma & C.I. Ripamonti. (2018) Management of cancer pain in adult patients: ESMO Clinical Practice Guidelines. Annals of Oncology 29, pages iv166-iv191.
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Q. Liu, L.-L. Gao, Y.-L. Dai, Y.-X. Li, Y. Wang, C.-F. Bai, G.-X. Mu, X.-M. Chai, W.-J. Han, L.-J. Zhou, Y.-J. Zhang, L. Tang, J. Liu & J.-Q. Yu. (2018) Nitrous oxide/oxygen mixture for analgesia in adult cancer patients with breakthrough pain: A randomized, double-blind controlled trial. European Journal of Pain 22:3, pages 492-500.
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Jeannine Brant, Barbara Rodgers, Eva Gallagher & Thiruppavai Sundaramurthi. (2017) Breakthrough Cancer Pain: A Systematic Review of Pharmacologic Management
. Clinical Journal of Oncology Nursing 21:3, pages 71-80.
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Stephan A. Schug & Sonya Ting. (2017) Fentanyl Formulations in the Management of Pain: An Update. Drugs 77:7, pages 747-763.
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Richard RauckJanet BullNeha ParikhLarry DillahaLisa Stearns. (2016) Effective Dose Titration of Fentanyl Sublingual Spray in Patients With Breakthrough Cancer Pain. Pain Practice 16:8, pages 1012-1018.
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David S Alberts, Christina Cognata Smith, Neha Parikh & Richard L Rauck. (2016) Fentanyl sublingual spray for breakthrough cancer pain in patients receiving transdermal fentanyl. Pain Management 6:5, pages 427-434.
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Harold Minkowitz, Janet Bull, R. Charles Brownlow, Neha Parikh & Richard Rauck. (2016) Long-term safety of fentanyl sublingual spray in opioid-tolerant patients with breakthrough cancer pain. Supportive Care in Cancer 24:6, pages 2669-2675.
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Thomas W. LeBlanc, Lynn J. Howie & Amy P. Abernethy. 2016. Supportive Cancer Care. Supportive Cancer Care 127 137 .
Giovambattista Zeppetella & Andrew N Davies. (2015) Opioids for the management of breakthrough pain in cancer patients. Cochrane Database of Systematic Reviews.
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Richard RauckNeha ParikhLarry DillahaJerry BarkerLisa Stearns. (2015) Patient Satisfaction with Fentanyl Sublingual Spray in Opioid-Tolerant Patients with Breakthrough Cancer Pain. Pain Practice 15:6, pages 554-563.
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Morten Thronæs, Lars Popper, Martin Eeg, Ellen Jaatun, Magnar Kvitberg & Stein Kaasa. (2015) Efficacy and Tolerability of Intranasal Fentanyl Spray in Cancer Patients With Breakthrough Pain. Clinical Therapeutics 37:3, pages 585-596.
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Theodore H. Stanley. (2014) The Fentanyl Story. The Journal of Pain 15:12, pages 1215-1226.
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Furio Zucco, Cesare Bonezzi & Diego Fornasari. (2014) Breakthrough Cancer Pain (BTcP): a Synthesis of Taxonomy, Pathogenesis, Therapy, and Good Clinical Practice in Adult Patients in Italy. Advances in Therapy 31:7, pages 657-682.
Crossref
Sebastiano MercadanteGiampiero PorzioVittorio Gebbia. (2014) New Opioids. Journal of Clinical Oncology 32:16, pages 1671-1676.
Crossref
Andrew N. Davies. (2014) Breakthrough Cancer Pain. Current Pain and Headache Reports 18:6.
Crossref
Roberta Granata, Paolo Bossi, Rossella Bertulli & Luigi Saita. (2014) Rapid-Onset Opioids for the Treatment of Breakthrough Cancer Pain: Two Cases of Drug Abuse: Table 1. Pain Medicine 15:5, pages 758-761.
Crossref
Giovambattista Zeppetella & Andrew N Davies. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Gillian Bedard, Philippa Hawley, Liying Zhang, Marissa Slaven, Pierre Gagnon, Stuart Bisland, Margaret Bennett, Francois Tardif & Edward Chow. (2013) A survey of Canadian cancer patients’ perspectives on the characteristics and treatment of breakthrough pain. Supportive Care in Cancer 21:9, pages 2557-2563.
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Neha Parikh, Venkat Goskonda, Ashok Chavan & Larry Dillaha. (2013) Pharmacokinetics and Dose Proportionality of Fentanyl Sublingual Spray: a Single-Dose 5-Way Crossover Study. Clinical Drug Investigation 33:6, pages 391-400.
Crossref
Giovambattista Zeppetella. (2013) Fentanyl Sublingual Spray for Breakthrough Pain in Cancer Patients. Pain and Therapy 2:1, pages 1-9.
Crossref
Neha Parikh, Venkat Goskonda, Ashok Chavan & Larry Dillaha. (2013) Single-Dose Pharmacokinetics of Fentanyl Sublingual Spray and Oral Transmucosal Fentanyl Citrate in Healthy Volunteers: A Randomized Crossover Study. Clinical Therapeutics 35:3, pages 236-243.
Crossref
Jörn Lötsch, Carmen Walter, Michael J. Parnham, Bruno G. Oertel & Gerd Geisslinger. (2012) Pharmacokinetics of Non-Intravenous Formulations of Fentanyl. Clinical Pharmacokinetics 52:1, pages 23-36.
Crossref
Donald R TaylorDonald Taylor. 2013. Managing Cancer Breakthrough Pain. Managing Cancer Breakthrough Pain 29 66 .

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