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Pain: Original Article

Dosing fentanyl buccal tablet for breakthrough cancer pain: dose titration versus proportional doses

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Pages 963-968 | Accepted 03 Apr 2012, Published online: 22 May 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Sebastiano Mercadante. (2018) Treating breakthrough pain in oncology. Expert Review of Anticancer Therapy 18:5, pages 445-449.
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Sebastiano Mercadante. (2017) New drugs for pain management in advanced cancer patients. Expert Opinion on Pharmacotherapy 18:5, pages 497-502.
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Sebastiano Mercadante. (2017) Fentanyl products in the management of episodic pain in the cancer patient. Expert Review of Quality of Life in Cancer Care 2:1, pages 41-45.
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Sebastiano Mercadante, Giovanna Prestia & Alessandra Casuccio. (2016) Nurse-based monitoring and management of breakthrough pain in an acute pain relief and palliative care unit. Hospital Practice 44:4, pages 203-206.
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Sebastiano Mercadante. (2015) Fentanyl buccal tablet for the treatment of cancer-related breakthrough pain. Expert Review of Clinical Pharmacology 8:1, pages 9-13.
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Cesar Margarit, Joaquim Juliá, Rafael López, Antonio Anton, Yolanda Escobar, Ana Casas, Juan Jesús Cruz, Rafael Galvez, Ana Mañas & Francisco Zaragozá. (2012) Breakthrough cancer pain – still a challenge. Journal of Pain Research 5, pages 559-566.
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Articles from other publishers (39)

Sebastiano Mercadante. (2023) Once again... breakthrough cancer pain: an updated overview. Journal of Anesthesia, Analgesia and Critical Care 3:1.
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Judith A. Paice, Kari Bohlke, Debra Barton, David S. Craig, Areej El-Jawahri, Dawn L. Hershman, Lynn R. Kong, Geana P. Kurita, Thomas W. LeBlanc, Sebastiano Mercadante, Kristina L. M. Novick, Ramy Sedhom, Carole Seigel, Joanna Stimmel & Eduardo Bruera. (2023) Use of Opioids for Adults With Pain From Cancer or Cancer Treatment: ASCO Guideline. Journal of Clinical Oncology 41:4, pages 914-930.
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Mi-Young Kwon, Mi-Yeon Lee, Yun Jae Han, Sung Hyun Lee, Eo Jin Kim, Songyi Park, Yun‑Gyoo Lee & Dong-Hoe Koo. (2023) Predicting tolerability of high-dose fentanyl buccal tablets in cancer patients. PLOS ONE 18:1, pages e0280212.
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Benjamín Folgueira Hernández Folgueira Hernández, Elena María Brozos Vázquez, Juan Carlos Cámara Vicario, Luis Olay Gayoso, María Belén González Gragera, Oliver Higuera Gómez, Patrícia Ramirez Daffos, Hugo Arasanz Arasanz Esteban & Enrique García Gen. (2023) Estudio observacional, prospectivo y multicéntrico sobre el uso de citrato de fentanilo transmucosa en la práctica clínica habitual para el control de las crisis de dolor irruptivo en pacientes oncológicos. Revista de la Sociedad Española del Dolor.
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Sebastiano Mercadante. (2022) Cancer Pain Treatment Strategies in Patients with Cancer. Drugs 82:13, pages 1357-1366.
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Hironori MawatariTakuya ShinjoTatsuya MoritaHiroyuki KoharaKinomi Yomiya. (2022) Revision of Pharmacological Treatment Recommendations for Cancer Pain: Clinical Guidelines from the Japanese Society of Palliative Medicine. Journal of Palliative Medicine 25:7, pages 1095-1114.
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Paolo Bossi, Yolanda Escobar & Federico Pea. (2022) Rapid-Onset Opioids for Management of Breakthrough Cancer Pain: Considerations for Daily Practice. Frontiers in Pain Research 3.
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Sebastiano Mercadante & Russell K. Portenoy. (2021) Understanding the Chameleonic Breakthrough Cancer Pain. Drugs 81:4, pages 411-418.
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Sebastiano Mercadante, Vincenzo Restivo & Alessandra Casuccio. (2019) Effects of age and gender in patients receiving doses of opioids for breakthrough pain proportional to background opioid doses. Supportive Care in Cancer 28:8, pages 3813-3818.
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Francesca Ricchini, Augusto Caraceni, Ernesto Zecca, Alessandra Pigni, Fabio Centurioni, Andrea Manzoni, Stein Kaasa & Cinzia Brunelli. (2019) Effect of Opioid Exposure on Efficacy and Tolerability of Sublingual Fentanyl and Subcutaneous Morphine for Severe Cancer Pain Episodes. Secondary Analysis From a Double-Blind Double-Dummy, Randomized Trial. Journal of Pain and Symptom Management 58:4, pages 587-595.
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Mª. Dolores López Alarcón, Francisco Villegas Estévez, Luis Cabezón-Gutiérrez, Manuel Castillo Padrós, José Manuel Trinidad Martín-Arroyo, Maite Antonio Rebollo, Antonio Javier Jiménez-López & Almudena Sanz-Yagüe. (2019) Expert consensus on the management of breakthrough cancer pain in older patients. A Delphi study. Journal of Geriatric Oncology 10:4, pages 643-652.
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Sebastiano Mercadante, Claudio Adile, Francesco Masedu, Paolo Marchetti, Andrea Costanzi & Federica Aielli. (2018) Factors influencing the use of opioids for breakthrough cancer pain: A secondary analysis of the IOPS‐MS study. European Journal of Pain 23:4, pages 719-726.
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Caterina Magnani, Diana Giannarelli, Alice Calvieri, Ana Dardeli, Giovanni Eusepi, Maria Rosa Restuccia, Chiara Mastroianni & Giuseppe Casale. (2018) Breakthrough cancer pain tailored treatment: which factors influence the medication choice? An observational, prospective and cross-sectional study in patients with terminal cancer. Postgraduate Medical Journal 94:1116, pages 566-570.
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Tsung-Yu Yen, Jeng-Fong Chiou, Wei-Yong Chiang, Wen-Hao Su, Ming-Yuan Huang, Ming-Hung Hu, Shen-Chi Wu & Yuen-Liang Lai. (2018) Proportional dose of rapid-onset opioid in breakthrough cancer pain management. Medicine 97:30, pages e11593.
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Mi-Young Kwon, Ha-Na Cho, Dong-Hoe Koo, Yun-Gyoo Lee, Sukjoong Oh & Seung-Sei Lee. (2018) Initial titration with 200 μg fentanyl buccal tablets: a retrospective safety analysis in Korean cancer patients. The Korean Journal of Internal Medicine 33:3, pages 577-584.
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Robert Janknegt, Marieke van den Beuken, Sjouke Schiere, Michael Überall, Roger Knaggs, Jaquie Hanley & Morten Thronaes. (2018) Rapid acting fentanyl formulations in breakthrough pain in cancer. Drug selection by means of the System of Objectified Judgement Analysis. European Journal of Hospital Pharmacy 25:3, pages e2-e2.
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Sebastiano Mercadante. (2018) Episodic Breathlessness in Patients with Advanced Cancer: Characteristics and Management. Drugs 78:5, pages 543-547.
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David Hui, Kelly Kilgore, Susan Frisbee-Hume, Minjeong Park, Diane Liu, Diwakar D. Balachandran & Eduardo Bruera. (2017) Effect of Prophylactic Fentanyl Buccal Tablet on Episodic Exertional Dyspnea: A Pilot Double-Blind Randomized Controlled Trial. Journal of Pain and Symptom Management 54:6, pages 798-805.
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Stephan A. Schug & Sonya Ting. (2017) Fentanyl Formulations in the Management of Pain: An Update. Drugs 77:7, pages 747-763.
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Sebastiano Mercadante, Claudio Adile, Arturo Cuomo, Federica Aielli, Franco Marinangeli & Alessandra Casuccio. (2016) The use of low doses of a sublingual fentanyl formulation for breakthrough pain in patients receiving low doses of opioids. Supportive Care in Cancer 25:2, pages 645-649.
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Sebastiano Mercadante, Paolo Marchetti, Arturo Cuomo, Augusto Caraceni, Rocco Domenico Mediati, Massimo Mammucari, Silvia Natoli, Marzia Lazzari, Mario Dauri, Mario Airoldi, Giuseppe Azzarello, Mauro Bandera, Livio Blasi, Giacomo Cartenì, Bruno Chiurazzi, Benedetta Veruska Pierpaola Costanzo, Daniela Degiovanni, Flavio Fusco, Vittorio Guardamagna, Vincenzo Iaffaioli, Simeone Liguori, Vito Lorusso, Sergio Mameli, Rodolfo Mattioli, Teresita Mazzei, Rita Maria Melotti, Valentino Menardo, Danilo Miotti, Stefano Moroso, Stefano De Santis, Remo Orsetti, Alfonso Papa, Sergio Ricci, Alessandro Fabrizio Sabato, Elvira Scelzi, Michele Sofia, Giuseppe Tonini, Federica Aielli & Alessandro Valle. (2016) Breakthrough Cancer Pain: Preliminary Data of The Italian Oncologic Pain Multisetting Multicentric Survey (IOPS-MS). Advances in Therapy 34:1, pages 120-135.
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Sebastiano Mercadante & Russell K. Portenoy. (2016) Breakthrough cancer pain: twenty-five years of study. Pain 157:12, pages 2657-2663.
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David Hui, Kelly Kilgore, Minjeong Park, Janet Williams, Diane Liu & Eduardo Bruera. (2016) Impact of Prophylactic Fentanyl Pectin Nasal Spray on Exercise-Induced Episodic Dyspnea in Cancer Patients: A Double-Blind, Randomized Controlled Trial. Journal of Pain and Symptom Management 52:4, pages 459-468.e1.
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Sebastiano Mercadante & Arturo Cuomo. (2016) Breakthrough Cancer Pain: Ten Commandments. Value in Health 19:5, pages 531-536.
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Sebastiano Mercadante, Federica Aielli, Claudio Adile, Andrea Costanzi & Alessandra Casuccio. (2016) Fentanyl Pectin Nasal Spray Versus Oral Morphine in Doses Proportional to the Basal Opioid Regimen for the Management of Breakthrough Cancer Pain: A Comparative Study. Journal of Pain and Symptom Management 52:1, pages 27-34.
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Sebastiano Mercadante, Paolo Marchetti, Arturo Cuomo, Massimo Mammucari & Augusto Caraceni. (2015) Breakthrough pain and its treatment: critical review and recommendations of IOPS (Italian Oncologic Pain Survey) expert group. Supportive Care in Cancer 24:2, pages 961-968.
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Marco Cascella, Arturo Cuomo & Daniela ViscardiMarco Cascella, Arturo Cuomo & Daniela Viscardi. 2016. Features and Management of the Pelvic Cancer Pain. Features and Management of the Pelvic Cancer Pain 73 93 .
Sebastiano Mercadante, Claudio Adile, Arturo Cuomo, Federica Aielli, Andrea Cortegiani, Alessandra Casuccio & Giampiero Porzio. (2015) Fentanyl Buccal Tablet vs. Oral Morphine in Doses Proportional to the Basal Opioid Regimen for the Management of Breakthrough Cancer Pain: A Randomized, Crossover, Comparison Study. Journal of Pain and Symptom Management 50:5, pages 579-586.
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Sebastiano Mercadante. (2015) Breakthrough pain in cancer patients. Current Opinion in Anaesthesiology 28:5, pages 559-564.
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N. Shimoyama, I. Gomyo, O. Teramoto, K. Kojima, H. Higuchi, N. Yukitoshi, E. Ohta & M. Shimoyama. (2014) Efficacy and safety of sublingual fentanyl orally disintegrating tablet at doses determined from oral morphine rescue doses in the treatment of breakthrough cancer pain. Japanese Journal of Clinical Oncology 45:2, pages 189-196.
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Rajesh Munglani & Arun Bhaskar. (2015) Pain and Suffering in Cancer Patients. Modern Believing 56:2, pages 145-162.
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Richard J. Bodnar. (2014) Endogenous opiates and behavior: 2013. Peptides 62, pages 67-136.
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Sebastiano MercadanteGiampiero PorzioVittorio Gebbia. (2014) New Opioids. Journal of Clinical Oncology 32:16, pages 1671-1676.
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Sebastiano Mercadante, Giovanna Prestia, Claudio Adile & Alessandra Casuccio. (2014) Intranasal Fentanyl Versus Fentanyl Pectin Nasal Spray for the Management of Breakthrough Cancer Pain in Doses Proportional to Basal Opioid Regimen. The Journal of Pain 15:6, pages 602-607.
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Ignacio Velázquez Rivera, José Carlos Muñoz Garrido, Pilar García Velasco, Inmaculada España Ximénez de Enciso & Lourdes Velázquez Clavarana. (2014) Efficacy of Sublingual Fentanyl vs. Oral Morphine for Cancer-Related Breakthrough Pain. Advances in Therapy 31:1, pages 107-117.
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Sebastiano Mercadante. 2014. Bone Metastases. Bone Metastases 157 173 .
Sebastiano Mercadante, Giampiero Porzio, Federica Aielli, Lucilla Averna, Corrado Ficorella & Alessandra Casuccio. (2013) The use of fentanyl buccal tablets for breakthrough pain by using doses proportional to opioid basal regimen in a home care setting. Supportive Care in Cancer 21:8, pages 2335-2339.
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Sebastiano Mercadante. (2013) Cancer pain. Current Opinion in Supportive & Palliative Care 7:2, pages 139-143.
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Antonio Gatti, Rocco D. Mediati, Carlo Reale, Arturo Cuomo, Renato Vellucci, Gennaro Russo, Amedeo Costantini, Alessandro Canneti, Marta Luzi, Massimo Mammucari & Alessandro Fabrizio Sabato. (2012) Breakthrough Pain in Patients Referred to Pain Clinics: The Italian Pain Network Retrospective Study. Advances in Therapy 29:5, pages 464-472.
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