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Current Medical Research and Opinion Volume 28, 2012 - Issue 10
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Diabetes: Original Articles

Effects of saxagliptin added to sub-maximal doses of metformin compared with uptitration of metformin in type 2 diabetes: the PROMPT study

Michel P. HermansEndocrinologie et Nutrition, Cliniques universitaires Saint-Luc BrusselsBelgiumCorrespondence[email protected]
,
Tuncay DelibasiAnkara Diskapi Training and Research Hospital AnkaraTurkey
,
Ian FarmerThe Surgery Stanwell Road, AshfordUK
,
Leif LohmAstraZeneca SödertäljeSweden
,
Pierre MaheuxAstraZeneca BrusselsBelgium
,
PierMarco PiattiSan Raffaele Scientific Institute MilanItaly
,
Elmas MalvoltiBristol-Myers Squibb ParisFrance
,
Silke JörgensAptiv Solutions KölnGermany
&
Bernard CharbonnelClinique d’Endocrinologie, University of NantesFrance
 show all
Pages 1635-1645 | Accepted 21 Sep 2012, Published online: 12 Oct 2012

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Huan Yu & Vincent C Woo. (2017) Emerging use of combination therapies for the management of type 2 diabetes – focus on saxagliptin and dapagliflozin. Diabetes, Metabolic Syndrome and Obesity 10, pages 317-332.
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Peter P Toth. (2015) Overview of saxagliptin efficacy and safety in patients with type 2 diabetes and cardiovascular disease or risk factors for cardiovascular disease. Vascular Health and Risk Management 11, pages 9-23.
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Keith C. Ferdinand & Samar A. Nasser. (2015) Racial/ethnic disparities in prevalence and care of patients with type 2 diabetes mellitus. Current Medical Research and Opinion 31:5, pages 913-923.
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George S Panagoulias & John Doupis. (2014) Clinical utility in the treatment of type 2 diabetes with the saxagliptin/metformin fixed combination. Patient Preference and Adherence 8, pages 227-236.
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Articles from other publishers (22)

Liyun He, Jialu Wang, Fan Ping, Na Yang, Jingyue Huang, Wei Li, Lingling Xu, Huabing Zhang & Yuxiu Li. (2022) Dipeptidyl peptidase-4 inhibitors and gallbladder or biliary disease in type 2 diabetes: systematic review and pairwise and network meta-analysis of randomised controlled trials. BMJ, pages e068882.
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A.J. Scheen. (2020) Reduction in HbA1c with SGLT2 inhibitors vs. DPP-4 inhibitors as add-ons to metformin monotherapy according to baseline HbA1c: A systematic review of randomized controlled trials. Diabetes & Metabolism 46:3, pages 186-196.
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Rohan MahabaleshwarkarTsai-Ling LiuHolly Mulder. (2019) Comparative Effectiveness of Metformin Dosage Uptitration Versus Adding Another Antihyperglycemic Medication on Glycemic Control in Type 2 Diabetes Patients Failing Initial Metformin Monotherapy: A Retrospective Cohort Study. Population Health Management 22:5, pages 457-463.
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Peng Men, Xiao-tong Li, Hui-lin Tang & Suo-di Zhai. (2018) Efficacy and safety of saxagliptin in patients with type 2 diabetes: A systematic review and meta-analysis. PLOS ONE 13:5, pages e0197321.
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Eugenio Cersosimo, Eric L. Johnson, Christina Chovanes & Neil Skolnik. (2018) Initiating therapy in patients newly diagnosed with type 2 diabetes: Combination therapy vs a stepwise approach. Diabetes, Obesity and Metabolism 20:3, pages 497-507.
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Fabrice Bonnet & André Scheen. (2017) Understanding and overcoming metformin gastrointestinal intolerance. Diabetes, Obesity and Metabolism 19:4, pages 473-481.
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Linda Zaharenko, Ineta Kalnina, Kristine Geldnere, Ilze Konrade, Solveiga Grinberga, Jozef Židzik, Martin Javorský, Aivars Lejnieks, Liene Nikitina-Zake, Davids Fridmanis, Raitis Peculis, Ilze Radovica-Spalvina, Dace Hartmane, Osvalds Pugovics, Ivan Tkáč, Lucia Klimčáková, Valdis Pīrāgs & Janis Klovins. (2016) Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients. European Journal of Endocrinology 175:6, pages 531-540.
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Feng-fei Li, Lan-lan Jiang, Reng-na Yan, Hong-hong Zhu, Pei-hua Zhou, Dan-feng Zhang, Xiao-fei Su, Jin-dan Wu, Lei Ye & Jian-hua Ma. (2016) Effects of saxagliptin add-on therapy to insulin on blood glycemic fluctuations in patients with type 2 diabetes. Medicine 95:43, pages e5229.
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W. Gao, Q. Wang & S. Yu. (2016) Efficacy, safety and impact on β-cell function of dipeptidyl peptidase-4 inhibitors plus metformin combination therapy in patients with type 2 diabetes and the difference between Asians and Caucasians: a meta-analysis. Journal of Endocrinological Investigation 39:9, pages 1061-1074.
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Wenjia Yang, Xiaoling Cai, Xueyao Han & Linong Ji. (2016) DPP-4 inhibitors and risk of infections: a meta-analysis of randomized controlled trials. Diabetes/Metabolism Research and Reviews 32:4, pages 391-404.
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Hui WangXiufei LiuMin LongYi HuangLinlin ZhangRui ZhangYi ZhengXiaoyu LiaoYuren WangQian LiaoWenjie LiZili TangQiang TongXiaocui WangFang FangMontserrat Rojo de la VegaQin OuyangDonna D. ZhangShicang YuHongting Zheng. (2016) NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis. Science Translational Medicine 8:334.
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Abdulrahman S. Alanazi. (2015) Systematic review and meta-analysis of efficacy and safety of combinational therapy with metformin and dipeptidyl peptidase-4 inhibitors. Saudi Pharmaceutical Journal 23:6, pages 603-613.
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Rajeev Jain. (2015) Utility of Saxagliptin in the Treatment of Type 2 Diabetes: Review of Efficacy and Safety. Advances in Therapy 32:11, pages 1065-1084.
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Sohita Dhillon. (2015) Saxagliptin: A Review in Type 2 Diabetes. Drugs 75:15, pages 1783-1796.
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Judith L White, Patricia Buchanan, Jia Li & Robert Frederich. (2014) A randomized controlled trial of the efficacy and safety of twice-daily saxagliptin plus metformin combination therapy in patients with type 2 diabetes and inadequate glycemic control on metformin monotherapy. BMC Endocrine Disorders 14:1.
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Brian Bryzinski, Elsie Allen, William Cook & Boaz Hirshberg. (2014) Saxagliptin efficacy and safety in patients with type 2 diabetes receiving concomitant statin therapy. Journal of Diabetes and its Complications 28:6, pages 887-893.
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Boaz Hirshberg, Artist Parker, Helen Edelberg, Mark Donovan & Nayyar Iqbal. (2014) Safety of saxagliptin: events of special interest in 9156 patients with type 2 diabetes mellitus. Diabetes/Metabolism Research and Reviews 30:7, pages 556-569.
Crossref
Shiying Wu, Ingrid Hopper, Marina Skiba & Henry Krum. (2014) Dipeptidyl Peptidase-4 Inhibitors and Cardiovascular Outcomes: Meta-Analysis of Randomized Clinical Trials with 55,141 Participants. Cardiovascular Therapeutics 32:4, pages 147-158.
Crossref
Shikhar Agarwal, Akhil Parashar & Venu Menon. (2014) Meta-Analysis of the Cardiovascular Outcomes with Dipeptidyl Peptidase 4 Inhibitors: Validation of the Current FDA Mandate. American Journal of Cardiovascular Drugs 14:3, pages 191-207.
Crossref
Katherine A. Lyseng-Williamson & Lily P. H. Yang. (2014) Saxagliptin: a guide to its use in type 2 diabetes mellitus. Drugs & Therapy Perspectives 30:3, pages 92-99.
Crossref
Nayyar Iqbal, Artist Parker, Robert Frederich, Mark Donovan & Boaz Hirshberg. (2014) Assessment of the cardiovascular safety of saxagliptin in patients with type 2 diabetes mellitus: pooled analysis of 20 clinical trials. Cardiovascular Diabetology 13:1, pages 33.
Crossref
M.P. Hermans, S.A. Ahn & M.F. Rousseau. (2013) What is the phenotype of patients with gastrointestinal intolerance to metformin?. Diabetes & Metabolism 39:4, pages 322-329.
Crossref

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