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Neurology: Original articles

Gabapentin enacarbil in Japanese patients with restless legs syndrome: a 12-week, randomized, double-blind, placebo-controlled, parallel-group study

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Pages 13-21 | Accepted 31 Oct 2012, Published online: 30 Nov 2012

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Read on this site (3)

Marco Zucconi, Andrea Galbiati, Fabrizio Rinaldi, Francesca Casoni & Luigi Ferini-Strambi. (2018) An update on the treatment of Restless Legs Syndrome/Willis-Ekbom Disease: prospects and challenges. Expert Review of Neurotherapeutics 18:9, pages 705-713.
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Diego Garcia-Borreguero, Arturo Benitez, Ralf Kohnen & Richard Allen. (2015) Augmentation of restless leg syndrome (Willis-Ekbom disease) during long-term dopaminergic treatment. Postgraduate Medicine 127:7, pages 716-725.
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Articles from other publishers (24)

Sandra Iskandar, Marina Souto Martins, Andrew Hudson, Jason G. Hirsch & Jonathan S. Jahr. (2022) Does Dexmedetomidine Improve or Worsen Restless Leg Syndrome under Sedation: A Case Report and Extensive Review. Case Reports in Critical Care 2022, pages 1-5.
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Yuichi Inoue, Koichi Hirata, Yuya Hoshino & Yusuke Yamaguchi. (2021) Difference in background factors between responders to gabapentin enacarbil treatment and responders to placebo: pooled analyses of two randomized, double-blind, placebo-controlled studies in Japanese patients with restless legs syndrome. Sleep Medicine 85, pages 138-146.
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Qing Lv, Xinlin Wang, Tetsuya Asakawa & Xiao Ping Wang. (2021) Pharmacologic Treatment of Restless Legs Syndrome. Current Neuropharmacology 19:3, pages 372-382.
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E.A. Katunina, N.V. Titova, D.A. Katunin, S.D. Bagmanyan & A.R. Pogorova. (2021) Restless legs syndrome. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 121:2, pages 106.
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Valérie Cochen De Cock. (2019) Therapies for Restless Legs in Parkinson’s Disease. Current Treatment Options in Neurology 21:11.
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N. Limousin, M. Flamand, C. Schröder & C. Charley Monaca. (2019) Traitement du syndrome des jambes sans repos nouvellement diagnostiqué. Médecine du Sommeil 16:2, pages 106-113.
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Ningyuan Zhang, Yunfei Li, Yinghua Lv, Ling Xu, Junchao Chen, Hongxia Liu, Lujin Li & Qingshan Zheng. (2019) Quantitative Comparison of the Efficacies of 5 First‐Line Drugs for Primary Restless Leg Syndrome. The Journal of Clinical Pharmacology.
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Imad Ghorayeb. 2019. Pharmacology of Restless Legs Syndrome (RLS). Pharmacology of Restless Legs Syndrome (RLS) 207 235 .
Aaro V. Salminen & Juliane Winkelmann. (2018) Restless Legs Syndrome and Other Movement Disorders of Sleep—Treatment Update. Current Treatment Options in Neurology 20:12.
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N. Limousin, M. Flamand, C. Schröder & C. Charley Monaca. (2018) French consensus: Treatment of newly diagnosed restless legs syndrome. Revue Neurologique 174:7-8, pages 515-521.
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Juliane Winkelmann, Richard P. Allen, Birgit Högl, Yuichi Inoue, Wolfgang Oertel, Aaro V. Salminen, John W. Winkelman, Claudia Trenkwalder & Cristina Sampaio. (2018) Treatment of restless legs syndrome: Evidence-based review and implications for clinical practice (Revised 2017) § . Movement Disorders 33:7, pages 1077-1091.
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I. H. Iftikhar, L. Alghothani & L. M. Trotti. (2017) Gabapentin enacarbil, pregabalin and rotigotine are equally effective in restless legs syndrome: a comparative meta-analysis. European Journal of Neurology 24:12, pages 1446-1456.
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Daniel L. Picchietti, Stephen K. Van Den Eeden, Yuichi Inoue & Klaus Berger. (2017) Achievements, challenges, and future perspectives of epidemiologic research in restless legs syndrome (RLS). Sleep Medicine 31, pages 3-9.
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Esther S. Kim & Emma D. Deeks. (2016) Gabapentin Enacarbil: A Review in Restless Legs Syndrome. Drugs 76:8, pages 879-887.
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Neal Hermanowicz, Aaron Ellenbogen, Gordon Irving, Mark Buchfuhrer, Mark J. Jaros, Gwendoline Shang & Richard Kim. (2016) The Effect of Gabapentin Enacarbil on Pain Associated with Moderate-to-Severe Primary Restless Legs Syndrome in Adults: Pooled Analyses from Three Randomized Controlled Trials. CNS Drugs 30:5, pages 443-454.
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Alon Y. Avidan, Daniel Lee, Margaret Park, Mark J. Jaros, Gwendoline Shang & Richard Kim. (2016) The Effect of Gabapentin Enacarbil on Quality of Life and Mood Outcomes in a Pooled Population of Adult Patients with Moderate-to-Severe Primary Restless Legs Syndrome. CNS Drugs 30:4, pages 305-316.
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Daniel O. Lee, Mark J. Buchfuhrer, Diego Garcia-Borreguero, Alon Y. Avidan, Mansoor Ahmed, Ryan Hays, William G. Ondo, Mark J. Jaros, Richard Kim & Gwendoline Shang. (2016) Efficacy of gabapentin enacarbil in adult patients with severe primary restless legs syndrome. Sleep Medicine 19, pages 50-56.
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Guang Jian Liu, Lang Wu, Song Lin Wang, Li Ding, Li Li Xu, Yun Fu Wang & Li Ying Chang. (2016) Incidence of Augmentation in Primary Restless Legs Syndrome Patients May Not Be That High. Medicine 95:2, pages e2504.
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Birgit Högl & Cynthia Comella. (2015) Therapeutic advances in restless legs syndrome (RLS). Movement Disorders 30:11, pages 1574-1579.
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Claudia Trenkwalder, Juliane Winkelmann, Yuichi Inoue & Walter Paulus. (2015) Restless legs syndrome—current therapies and management of augmentation. Nature Reviews Neurology 11:8, pages 434-445.
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William G. Ondo. (2014) Restless Legs Syndrome: Pathophysiology and Treatment. Current Treatment Options in Neurology 16:11.
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Prachaya Srivanitchapoom, Sanjay Pandey & Mark Hallett. (2014) Restless legs syndrome and pregnancy: A review. Parkinsonism & Related Disorders 20:7, pages 716-722.
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Jin Seo YangYong Jun ChoSuk Hyung KangHyuk Jai Choi. (2014) Demographic and Clinical Characteristics of Patients with Restless Legs Syndrome in Spine Clinic. Journal of Korean Neurosurgical Society 55:2, pages 83.
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Maria Davy, James Upward, Thangam Arumugham, Colleen Twomey, Chao Chen & Brendt Stier. (2013) Cardiac Repolarization With Gabapentin Enacarbil in a Randomized, Double-Blind, Placebo- and Active-Controlled, Crossover Thorough QT/QTc Study in Healthy Adults. Clinical Therapeutics 35:12, pages 1964-1974.
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