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Research Article

Efficacy and safety profile of fluticasone/formoterol combination therapy compared to its individual components administered concurrently in asthma: a randomised controlled trial

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Pages 579-588 | Accepted 30 Jan 2013, Published online: 20 Feb 2013

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Read on this site (6)

Satish Chandra Kilaru, Avya Gopal Bansal, Vaishali Sandeep Naik, Meena Lopez & Jaideep Ashok Gogtay. (2022) A review of the efficacy and safety of fluticasone propionate/formoterol fixed-dose combination. Expert Review of Respiratory Medicine 16:5, pages 529-540.
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Shiyuan Zhang, Denise King, Virginia M Rosen & Afisi S Ismaila. (2020) Impact of Single Combination Inhaler versus Multiple Inhalers to Deliver the Same Medications for Patients with Asthma or COPD: A Systematic Literature Review. International Journal of Chronic Obstructive Pulmonary Disease 15, pages 417-438.
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A Papi, D Dokic, W Tzimas, I Mészáros, A Olech-Cudzik, Z Koroknai, K McAulay, S Mersmann, PS Dalvi & T Overend. (2017) Fluticasone propionate/formoterol for COPD management: a randomized controlled trial. International Journal of Chronic Obstructive Pulmonary Disease 12, pages 1961-1971.
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Theresa R Prosser & Suzanne G Bollmeier. (2015) Fluticasone-formoterol: a systematic review of its potential role in the treatment of asthma. Therapeutics and Clinical Risk Management 11, pages 889-899.
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Ricardo Antonio Tan & Jonathan Corren. (2014) Clinical utility and development of the fluticasone/formoterol combination formulation (Flutiform®) for the treatment of asthma. Drug Design, Development and Therapy 8, pages 1555-1561.
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David Price & Elizabeth V Hillyer. (2014) Fluticasone propionate/formoterol fumarate in fixed-dose combination for the treatment of asthma. Expert Review of Respiratory Medicine 8:3, pages 275-291.
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Articles from other publishers (24)

Yuji Oba, Sumayya Anwer, Tarang Patel, Tinashe Maduke & Sofia Dias. (2023) Addition of long-acting beta2 agonists or long-acting muscarinic antagonists versus doubling the dose of inhaled corticosteroids (ICS) in adolescents and adults with uncontrolled asthma with medium dose ICS: a systematic review and network meta-analysis. Cochrane Database of Systematic Reviews 2023:8.
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Sanjeeva Dissanayake, Gill MundinJo WoodwardMark LomaxPrashant Dalvi. (2023) Pharmacokinetic and Pharmacodynamic Comparison of Fluticasone Propionate/Formoterol Fumarate Administered via a Pressurized Metered-Dose Inhaler and a Novel Breath-Actuated Inhaler in Healthy Volunteers. Journal of Aerosol Medicine and Pulmonary Drug Delivery 36:2, pages 65-75.
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Iain Crossingham, Sally Turner, Sanjay Ramakrishnan, Anastasia Fries, Matthew Gowell, Farhat Yasmin, Rebekah Richardson, Philip Webb, Emily O'Boyle & Timothy SC Hinks. (2021) Combination fixed-dose beta agonist and steroid inhaler as required for adults or children with mild asthma. Cochrane Database of Systematic Reviews 2021:5.
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David B. Price, Victoria Carter, Jessica Martin, Elizabeth A. Gardener, Derek Skinner, Sen Yang, Matthias Hoffman, Jenna C. Willis & Andrew J. Cooper. (2019) Comparative Safety Profile of the Fixed-Dose Combination Corticosteroid and Long-acting β2-Agonist Fluticasone Propionate/Formoterol Fumarate: A 36-Month Longitudinal Cohort Study in UK Primary Care. Drugs 80:1, pages 47-60.
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Chengzhi Zhang & Guiying Yan. (2019) Synergistic drug combinations prediction by integrating pharmacological data. Synthetic and Systems Biotechnology 4:1, pages 67-72.
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Murugesh Shivashankar & Mani Dhandayuthapani. (2019) A study of Inhalation Drugs in the Management of Asthma in Northern Parts of Tamilnadu. Materials Today: Proceedings 15, pages 268-272.
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Dominik Kappeler, Knut Sommerer, Claudius Kietzig, Bärbel Huber, Jo Woodward, Mark Lomax & Prashant Dalvi. (2018) Pulmonary deposition of fluticasone propionate/formoterol in healthy volunteers, asthmatics and COPD patients with a novel breath-triggered inhaler. Respiratory Medicine 138, pages 107-114.
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Vibeke Backer, Adam Ellery, Sylvia Borzova, Stephen Lane, Magda Kleiberova, Peter Bengtsson, Tadeusz Tomala, Dominique Basset-Stheme, Carla Bennett, Dirk Lindner, Arthur Meiners & Tim Overend. (2018) Non-interventional study of the safety and effectiveness of fluticasone propionate/formoterol fumarate in real-world asthma management. Therapeutic Advances in Respiratory Disease 12, pages 175346661879698.
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Anna Płoszczuk, Miroslava Bosheva, Kay Spooner, Tammy McIver & Sanjeeva Dissanayake. (2018) Efficacy and safety of fluticasone propionate/formoterol fumarate in pediatric asthma patients: a randomized controlled trial. Therapeutic Advances in Respiratory Disease 12, pages 175346661877792.
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David BellLucielle MansfieldMark Lomax. (2017) A Randomized, Crossover Trial Evaluating Patient Handling, Preference, and Ease of Use of the Fluticasone Propionate/Formoterol Breath-Triggered Inhaler. Journal of Aerosol Medicine and Pulmonary Drug Delivery 30:6, pages 425-434.
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Simon Wan Yau Ming, John Haughney, Iain Small, Stephanie Wolfe, John Hamill, Kevin Gruffydd-Jones, Cathal Daly, Joan B. Soriano, Elizabeth Gardener, Derek Skinner, Martina Stagno d'Alcontres & David B. Price. (2017) Initiating or changing to a fixed-dose combination of Fluticasone propionate/Formoterol over Fluticasone propionate/Salmeterol: A real-life effectiveness and cost impact evaluation. Respiratory Medicine 129, pages 199-206.
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Fabio Arpinelli, Mauro Carone, Gioacchino Riccardo & Giorgio Bertolotti. (2016) Health-related quality of life measurement in asthma and chronic obstructive pulmonary disease: review of the 2009-2014 literature. Multidisciplinary Respiratory Medicine 11:1.
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Alberto PapiAdel H. MansurTetyana PertsevaKirsten KaiserTammy McIverBirgit GrotheSanjeeva Dissanayake. (2016) Long-Term Fluticasone Propionate/Formoterol Fumarate Combination Therapy Is Associated with a Low Incidence of Severe Asthma Exacerbations. Journal of Aerosol Medicine and Pulmonary Drug Delivery 29:4, pages 346-361.
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René Aalbers, Claus Vogelmeier & Piotr Kuna. (2016) Achieving asthma control with ICS/LABA: A review of strategies for asthma management and prevention. Respiratory Medicine 111, pages 1-7.
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J.A. Quintano Jiménez, L. Ginel Mendoza, L.M. Entrenas Costa & J. Polo García. (2016) Combinación a dosis fija de fluticasona propionato/formoterol fumarato para el tratamiento del asma: una revisión de la farmacología, eficacia y tolerabilidad. SEMERGEN - Medicina de Familia 42, pages 2-9.
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Alberto Papi & Mario Cazzola. (2015) Combination treatment in asthma: Reviewing old and new options. Pulmonary Pharmacology & Therapeutics 34, pages 72-74.
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M. Latorre, P. Paggiaro, W. Canonica, M.P. Foschino & A. Papi. (2015) A valid option for asthma control: Clinical evidence on efficacy and safety of fluticasone propionate/formoterol combination in a single inhaler. Pulmonary Pharmacology & Therapeutics 34, pages 31-36.
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Nicola Scichilone, Andrea Rossi & Andrea Melani. (2015) Revising old principles of inhaled treatment in new fixed combinations for asthma. Pulmonary Pharmacology & Therapeutics 33, pages 32-38.
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Haley M. Hoy & Louise C. O'Keefe. (2015) Practical guidance on the recognition of uncontrolled asthma and its management. Journal of the American Association of Nurse Practitioners 27:8, pages 466-475.
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Alberto Papi, David Price, Joaquin Sastre, Kirsten Kaiser, Mark Lomax, Tammy McIver & Sanjeeva Dissanayake. (2015) Efficacy of fluticasone propionate/formoterol fumarate in the treatment of asthma: A pooled analysis. Respiratory Medicine 109:2, pages 208-217.
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P. Devillier, H. Salvator, S. Grassin-Delyle, E. Naline, C. Advenier & N. Roche. (2014) Une nouvelle association fixe de fluticasone/formotérol dans un aérosol-doseur pressurisé pour le traitement de l’asthme. Revue des Maladies Respiratoires 31:8, pages 700-713.
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A. Papi, F. Blasi, G.W. Canonica, M. Cazzola, S. Centanni, M.P. Foschino Barbaro, A.S. Melani, P. Paggiaro, F. Ricciardolo, A. Rossi & N. Scichilone. (2014) Fluticasone propionate/formoterol: A fixed-combination therapy with flexible dosage. European Journal of Internal Medicine 25:8, pages 695-700.
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Gillian M. Keating & Kate McKeage. (2013) Fluticasone propionate/formoterol fumarate: a guide to its use in persistent asthma. Drugs & Therapy Perspectives 29:11, pages 342-347.
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A. Cukier, C.M.A. Jacob, N.A. Rosario Filho, J. Fiterman, E.O. Vianna, J.L. Hetzel, M.A. Neis, E. Fiss, F.F.M. Castro, A.L.G. Fernandes, R. Stirbulov & E. Pizzichini. (2013) Fluticasone/formoterol dry powder versus budesonide/formoterol in adults and adolescents with uncontrolled or partly controlled asthma. Respiratory Medicine 107:9, pages 1330-1338.
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