Citations (62)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (1)
Kim Nguyen, Judith S. Kempfle, David H. Jung & Charles E. McKenna. (2017) Recent advances in therapeutics and drug delivery for the treatment of inner ear diseases: a patent review (2011-2015). Expert Opinion on Therapeutic Patents 27:2, pages 191-202.
Read now
Read now
Articles from other publishers (61)
Joanna Żukowska, Stephen J. Moss, Vasanta Subramanian & K. Ravi Acharya. (2023) Molecular basis of selective amyloid‐β degrading enzymes in Alzheimer's disease. The FEBS Journal.
Crossref
Crossref
Snehal Raut, Aditya Bhalerao, Michael Powers, Minelly Gonzalez, Salvatore Mancuso & Luca Cucullo. (2023) Hypometabolism, Alzheimer’s Disease, and Possible Therapeutic Targets: An Overview. Cells 12:16, pages 2019.
Crossref
Crossref
Yong Peng, Hong Jin, Ya-hui Xue, Quan Chen, Shun-yu Yao, Miao-qiao Du & Shu Liu. (2023) Current and future therapeutic strategies for Alzheimer’s disease: an overview of drug development bottlenecks. Frontiers in Aging Neuroscience 15.
Crossref
Crossref
Annelise Colvin & Lynn Petukhova. (2023) Inborn Errors of Immunity in Hidradenitis Suppurativa Pathogenesis and Disease Burden. Journal of Clinical Immunology 43:6, pages 1040-1051.
Crossref
Crossref
Vladimir Volloch & Sophia Rits-Volloch. (2023) The Amyloid Cascade Hypothesis 2.0 for Alzheimer’s Disease and Aging-Associated Cognitive Decline: From Molecular Basis to Effective Therapy. International Journal of Molecular Sciences 24:15, pages 12246.
Crossref
Crossref
Korrakod Petsri, Masashi Yokoya, Satapat Racha, Sunisa Thongsom, Chorpaka Thepthanee, Bhurichaya Innets, Zin Zin Ei, Daiki Hotta, Hongbin Zou & Pithi Chanvorachote. (2023) Novel Synthetic Derivative of Renieramycin T Right-Half Analog Induces Apoptosis and Inhibits Cancer Stem Cells via Targeting the Akt Signal in Lung Cancer Cells. International Journal of Molecular Sciences 24:6, pages 5345.
Crossref
Crossref
Mrinal GounderRavin RatanThierry AlcindorPatrick SchöffskiWinette T. van der GraafBreelyn A. WilkyRichard F. RiedelAllison LimL. Mary SmithStephanie MoodySteven AttiaSant ChawlaGina D’AmatoNoah FedermanPriscilla MerriamBrian A. Van TineBruno VincenziCharlotte BensonNam Quoc BuiRashmi ChughGabriel TinocoJohn CharlsonPalma DileoLee HartnerLore LapeireFilomena MazzeoEmanuela Palmerini, Peter ReichardtSilvia StacchiottiHoward H. BaileyMelissa A. BurgessGregory M. CoteLara E. DavisHari DeshpandeHans GelderblomGiovanni GrignaniElizabeth LoggersTony PhilipJoseph G. Pressey, Shivaani KummarBernd Kasper. (2023) Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors. New England Journal of Medicine 388:10, pages 898-912.
Crossref
Crossref
Stephan A. Müller, Merav D. Shmueli, Xiao Feng, Johanna Tüshaus, Neele Schumacher, Ryan Clark, Brad E. Smith, An Chi, Stefan Rose-John, Matthew E. Kennedy & Stefan F. Lichtenthaler. (2023) The Alzheimer’s disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130. Molecular Neurodegeneration 18:1.
Crossref
Crossref
Samantha L. Hodges, Alexandra A. Bouza & Lori L. Isom. (2022) Therapeutic Potential of Targeting Regulated Intramembrane Proteolysis Mechanisms of Voltage-Gated Ion Channel Subunits and Cell Adhesion Molecules. Pharmacological Reviews 74:4, pages 1030-1050.
Crossref
Crossref
Vladimir Volloch & Sophia Rits-Volloch. (2022) The Amyloid Cascade Hypothesis 2.0: On the Possibility of Once-in-a-Lifetime-Only Treatment for Prevention of Alzheimer’s Disease and for Its Potential Cure at Symptomatic Stages. Journal of Alzheimer's Disease Reports 6:1, pages 369-399.
Crossref
Crossref
Naveen Kumar, Vijay Kumar, Piyush Anand, Vinay Kumar, Ashish Ranjan Dwivedi & Vinod Kumar. (2022) Advancements in the development of multi-target directed ligands for the treatment of Alzheimer’s disease. Bioorganic & Medicinal Chemistry 61, pages 116742.
Crossref
Crossref
Riyad N. H. Seervai, Woo Cheal Cho, Emily Y. Chu, Mario L. Marques‐Piubelli, Debora A. Ledesma, Kristen Richards, Meghan M. Heberton, Kelly C. Nelson, Priyadharsini Nagarajan, Carlos A. Torres‐Cabala, Victor G. Prieto & Jonathan L. Curry. (2021) Diverse landscape of dermatologic toxicities from small‐molecule inhibitor cancer therapy. Journal of Cutaneous Pathology 49:1, pages 61-81.
Crossref
Crossref
Matthew G. Bursavich, Bryce A. Harrison, Raksha Acharya, Donald E. Costa, Emily A. Freeman, Lori A. Hrdlicka, Hong Jin, Sudarshan Kapadnis, Jeffrey S. Moffit, Deirdre Murphy, Scott J. Nolan, Holger Patzke, Cuyue Tang, Hilliary E. Van Voorhies, Melody Wen, Gerhard Koenig, Jean-François Blain & Duane A. Burnett. (2021) Discovery of the Oxadiazine FRM-024: A Potent CNS-Penetrant Gamma Secretase Modulator. Journal of Medicinal Chemistry 64:19, pages 14426-14447.
Crossref
Crossref
Anuradha Yadav, Brashket Seth & Rajnish Kumar Chaturvedi. (2020) Brain Organoids: Tiny Mirrors of Human Neurodevelopment and Neurological Disorders. The Neuroscientist 27:4, pages 388-426.
Crossref
Crossref
Gautham Vellaichamy, Peter Dimitrion, Li Zhou, David Ozog, Henry W. Lim, Wilson Liao, Iltefat H. Hamzavi & Qing-Sheng Mi. (2021) Insights from γ-Secretase: Functional Genetics of Hidradenitis Suppurativa. Journal of Investigative Dermatology 141:8, pages 1888-1896.
Crossref
Crossref
Yi-An Chen, Cheng-Hsiu Lu, Chien-Chih Ke, Sain-Jhih Chiu, Fong-Shya Jeng, Chi-Wei Chang, Bang-Hung Yang & Ren-Shyan Liu. (2021) Mesenchymal Stem Cell-Derived Exosomes Ameliorate Alzheimer’s Disease Pathology and Improve Cognitive Deficits. Biomedicines 9:6, pages 594.
Crossref
Crossref
Stefan Saretz, Gabriele Basset, Liridona Useini, Markus Laube, Jens Pietzsch, Dijana Drača, Danijela Maksimović-Ivanić, Johannes Trambauer, Harald Steiner & Evamarie Hey-Hawkins. (2021) Modulation of γ-Secretase Activity by a Carborane-Based Flurbiprofen Analogue. Molecules 26:10, pages 2843.
Crossref
Crossref
Reisa Sperling, David Henley, Paul S. Aisen, Rema Raman, Michael C. Donohue, Karin Ernstrom, Michael S. Rafii, Johannes Streffer, Yingqi Shi, Keith Karcher, Nandini Raghavan, Yevgen Tymofyeyev, Jennifer Bogert, H. Robert Brashear, Gerald Novak, John Thipphawong, Ziad S. Saad, Hartmuth Kolb, Hany Rofael, Panna Sanga & Gary Romano. (2021) Findings of Efficacy, Safety, and Biomarker Outcomes of Atabecestat in Preclinical Alzheimer Disease. JAMA Neurology 78:3, pages 293.
Crossref
Crossref
Allison B. Reiss, Natalie Montufar, Joshua DeLeon, Aaron Pinkhasov, Irving H. Gomolin, Amy D. Glass, Hirra A. Arain & Mark M. Stecker. (2021) Alzheimer Disease Clinical Trials Targeting Amyloid. The Neurologist 26:2, pages 52-61.
Crossref
Crossref
Luisa Quinti, Joseph Park, Emma Brand, Rudolph E. Tanzi & Doo Yeon Kim. 2021. Neurotherapeutics in the Era of Translational Medicine. Neurotherapeutics in the Era of Translational Medicine
311
331
.
Alison C. Todd & Giles E. Hardingham. (2020) The Regulation of Astrocytic Glutamate Transporters in Health and Neurodegenerative Diseases. International Journal of Molecular Sciences 21:24, pages 9607.
Crossref
Crossref
Samuel King & Cenk Suphioglu. 2020. Neuroprotection - New Approaches and Prospects. Neuroprotection - New Approaches and Prospects.
Luca Pagliaro, Claudia Sorrentino & Giovanni Roti. (2020) Targeting Notch Trafficking and Processing in Cancers. Cells 9:10, pages 2212.
Crossref
Crossref
Rakesh K. Singh. (2020) Recent Trends in the Management of Alzheimer’s Disease: Current Therapeutic Options and Drug Repurposing Approaches. Current Neuropharmacology 18:9, pages 868-882.
Crossref
Crossref
Gökhan Güner & Stefan F. Lichtenthaler. (2020) The substrate repertoire of γ-secretase/presenilin. Seminars in Cell & Developmental Biology 105, pages 27-42.
Crossref
Crossref
Rakesh Kumar Singh. (2020) Antagonism of cysteinyl leukotrienes and their receptors as a neuroinflammatory target in Alzheimer’s disease. Neurological Sciences 41:8, pages 2081-2093.
Crossref
Crossref
Anna Slanzi, Giulia Iannoto, Barbara Rossi, Elena Zenaro & Gabriela Constantin. (2020) In vitro Models of Neurodegenerative Diseases. Frontiers in Cell and Developmental Biology 8.
Crossref
Crossref
Nurul Husna Ibrahim, Mohamad Fairuz Yahaya, Wael Mohamed, Seong Lin Teoh, Chua Kien Hui & Jaya Kumar. (2020) Pharmacotherapy of Alzheimer’s Disease: Seeking Clarity in a Time of Uncertainty. Frontiers in Pharmacology 11.
Crossref
Crossref
Diana M. Ho, Spyros Artavanis‐Tsakonas & Angeliki Louvi. (2019) The Notch pathway in CNS homeostasis and neurodegeneration. WIREs Developmental Biology 9:1.
Crossref
Crossref
A. V. Voronkov, D. I. Pozdnyakov, S. L. Adzhiakhmetova, N. M. Chervonnaya, K. A. Miroshnichenko, A. V. Sosnovskaya & E. I. Chereshkova. (2019) EFFECT OF PUMPKIN (CUCURBITA PEPO L.) AND MARIGOLD (TAGETES PATULA L.) EXTRACTS ON HIPPOCAMPAL MITOCHONDRIA FUNCTIONAL ACTIVITY WITHIN CONDITIONS OF EXPERIMENTAL ACUTE BRAIN HYPOMETABOLISM. Pharmacy & Pharmacology 7:4, pages 198-207.
Crossref
Crossref
Zhen Wang, Jianhui Wu, Xiuyun Tian & Chunyi Hao. (2019) Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects. Frontiers of Medicine 13:4, pages 427-437.
Crossref
Crossref
Lídia Pinheiro & Célia Faustino. (2019) Therapeutic Strategies Targeting Amyloid-β in Alzheimer’s Disease. Current Alzheimer Research 16:5, pages 418-452.
Crossref
Crossref
Tessandra Stewart, Min Shi, Aanchal Mehrotra, Patrick Aro, David Soltys, Kathleen F. Kerr, Cyrus P. Zabetian, Elaine R. Peskind, Peggy Taylor, Leslie M. Shaw, John Q. Trojanowski & Jing Zhang. (2019) Impact of Pre-Analytical Differences on Biomarkers in the ADNI and PPMI Studies: Implications in the Era of Classifying Disease Based on Biomarkers. Journal of Alzheimer's Disease 69:1, pages 263-276.
Crossref
Crossref
Weilin Sun, William J. Netzer, Anjana Sinha, Katherina Gindinova, Emily Chang & Subhash C. Sinha. (2019) Development of Gleevec Analogues for Reducing Production of β-Amyloid Peptides through Shifting β-Cleavage of Amyloid Precursor Proteins. Journal of Medicinal Chemistry 62:6, pages 3122-3134.
Crossref
Crossref
Florent Alix, Vincent Gembus, Laurent Coquet, Marie Hubert-Roux, Philippe Chan, Lina Truong, Muriel Sebban, Gaël Coadou, Hassan Oulyadi, Cyril Papamicaël & Vincent Levacher. (2018) Dihydroquinoline Carbamate DQS1-02 as a Prodrug of a Potent Acetylcholinesterase Inhibitor for Alzheimer’s Disease Therapy: Multigram-Scale Synthesis, Mechanism Investigations, in Vitro Safety Pharmacology, and Preliminary in Vivo Toxicology Profile. ACS Omega 3:12, pages 18387-18397.
Crossref
Crossref
Geraldine O’Sullivan Coyne, Therese S. Woodring, Chyi-Chia R. Lee, Alice P. Chen & Heidi H. Kong. (2018) Hidradenitis Suppurativa-Like Lesions Associated with Pharmacologic Inhibition of Gamma-Secretase. Journal of Investigative Dermatology 138:4, pages 979-981.
Crossref
Crossref
Maya L. Gosztyla, Holly M. Brothers & Stephen R. Robinson. (2018) Alzheimer’s Amyloid-β is an Antimicrobial Peptide: A Review of the Evidence. Journal of Alzheimer's Disease 62:4, pages 1495-1506.
Crossref
Crossref
Lotta Agholme, Marcus Clarin, Eleni Gkanatsiou, Petronella Kettunen, Jasmine Chebli, Gunnar Brinkmalm, Kaj Blennow, Petra Bergström, Erik Portelius & Henrik Zetterberg. (2017) Low-dose γ-secretase inhibition increases secretion of Aβ peptides and intracellular oligomeric Aβ. Molecular and Cellular Neuroscience 85, pages 211-219.
Crossref
Crossref
Alessandro Medoro, Silvia Bartollino, Donatella Mignogna, Daniela Passarella, Carola Porcile, Aldo Pagano, Tullio Florio, Mario Nizzari, Germano Guerra, Roberto Di Marco, Mariano Intrieri, Gennaro Raimo & Claudio Russo. (2017) Complexity and Selectivity of γ-Secretase Cleavage on Multiple Substrates: Consequences in Alzheimer’s Disease and Cancer. Journal of Alzheimer's Disease 61:1, pages 1-15.
Crossref
Crossref
Shivaani KummarGeraldine O'Sullivan CoyneKhanh T. DoBaris TurkbeyPaul S. MeltzerEric PolleyPeter L. ChoykeRobert MeehanRasa VilimasYvonne HornefferLamin JuwaraAnn LihAmul ChoudharySandra A. MitchellLee J. HelmanJames H. DoroshowAlice P. Chen. (2017) Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis). Journal of Clinical Oncology 35:14, pages 1561-1569.
Crossref
Crossref
M.M. Alshehri, S.M. Robbins & D.L. Senger. 2017. Neurotrophins. Neurotrophins
367
404
.
Howard Friel & Sally Frautschy. 2017. A Paradigm Shift to Prevent and Treat Alzheimer's Disease. A Paradigm Shift to Prevent and Treat Alzheimer's Disease
151
224
.
Caroline Coleman-Vaughan, Arijit Mal, Abhijit De & Justin V. McCarthy. 2017. Pathophysiological Aspects of Proteases. Pathophysiological Aspects of Proteases
47
87
.
Douglas S. Johnson & Martin Pettersson. 2017. Alzheimer’s Disease II. Alzheimer’s Disease II
87
118
.
Kyaw L. Aung & Lillian L. Siu. (2016) Genomically personalized therapy in head and neck cancer. Cancers of the Head & Neck 1:1.
Crossref
Crossref
Jeffrey Cummings, Paul S. Aisen, Bruno DuBois, Lutz Frölich, Clifford R. JackJrJr, Roy W. Jones, John C. Morris, Joel Raskin, Sherie A. Dowsett & Philip Scheltens. (2016) Drug development in Alzheimer’s disease: the path to 2025. Alzheimer's Research & Therapy 8:1.
Crossref
Crossref
Jean-François Blain, Matthew G. Bursavich, Emily A. Freeman, Lori A. Hrdlicka, Hilliary E. Hodgdon, Ting Chen, Don E. Costa, Bryce A. Harrison, Sudarshan Kapadnis, Deirdre A. Murphy, Scott Nolan, Zhiming Tu, Cuyue Tang, Duane A. Burnett, Holger Patzke & Gerhard Koenig. (2016) Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer’s disease. Alzheimer's Research & Therapy 8:1.
Crossref
Crossref
Se Hoon Choi, Young Hye Kim, Luisa Quinti, Rudolph E. Tanzi & Doo Yeon Kim. (2016) 3D culture models of Alzheimer’s disease: a road map to a “cure-in-a-dish”. Molecular Neurodegeneration 11:1.
Crossref
Crossref
Courtney M. Carroll & Yue-Ming Li. (2016) Physiological and pathological roles of the γ-secretase complex. Brain Research Bulletin 126, pages 199-206.
Crossref
Crossref
Matthew G. Bursavich, Bryce A. Harrison & Jean-François Blain. (2016) Gamma Secretase Modulators: New Alzheimer’s Drugs on the Horizon?. Journal of Medicinal Chemistry 59:16, pages 7389-7409.
Crossref
Crossref
Paul B. Rosenberg, Krista L. Lanctôt, Nathan Herrmann, Jacobo E. Mintzer, Anton P. Porsteinsson, Xiaoying Sun & Rema Raman. (2016) Changes in Neuropsychiatric Inventory Associated with Semagacestat Treatment of Alzheimer’s Disease. Journal of Alzheimer's Disease 54:1, pages 373-381.
Crossref
Crossref
Ross Penninkilampi, Holly M. Brothers & Guy D. Eslick. (2016) Pharmacological Agents Targeting γ-Secretase Increase Risk of Cancer and Cognitive Decline in Alzheimer’s Disease Patients: A Systematic Review and Meta-Analysis. Journal of Alzheimer's Disease 53:4, pages 1395-1404.
Crossref
Crossref
Roxane Khoogar, Byung-Chang Kim, Jay Morris & Michael J. Wargovich. (2016) Chemoprevention in gastrointestinal physiology and disease. Targeting the progression of cancer with natural products: a focus on gastrointestinal cancer. American Journal of Physiology-Gastrointestinal and Liver Physiology 310:9, pages G629-G644.
Crossref
Crossref
Tara P. Hurst, Caroline Coleman-Vaughan, Indu Patwal & Justin V. McCarthy. (2016) Regulated intramembrane proteolysis, innate immunity and therapeutic targets in Alzheimer’s disease. AIMS Molecular Science 3:2, pages 138-157.
Crossref
Crossref
Nicole J. Brandt & Daniel Z. Mansour. 2016. Dementia Care. Dementia Care
73
95
.
David B Henley, Sherie A Dowsett, Yun-Fei Chen, Hong Liu-Seifert, Joshua D Grill, Rachelle S Doody, Paul Aisen, Rema Raman, David S Miller, Ann M Hake & Jeffrey Cummings. (2015) Alzheimer’s disease progression by geographical region in a clinical trial setting. Alzheimer's Research & Therapy 7:1.
Crossref
Crossref
Carla D'Avanzo, Jenna Aronson, Young Hye Kim, Se Hoon Choi, Rudolph E. Tanzi & Doo Yeon Kim. (2015) Alzheimer's in 3D culture: Challenges and perspectives. BioEssays 37:10, pages 1139-1148.
Crossref
Crossref
Carla D’Avanzo, Christopher Sliwinski, Steven L. Wagner, Rudolph E. Tanzi, Doo Yeon Kim & Dora M. Kovacs. (2015)
γ-Secretase modulators reduce endogenous amyloid β
42
levels in human neural progenitor cells without altering neuronal differentiation
. The FASEB Journal 29:8, pages 3335-3341.
Crossref
Crossref
Polina Egorova, Elena Popugaeva & Ilya Bezprozvanny. (2015) Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease. Seminars in Cell & Developmental Biology 40, pages 127-133.
Crossref
Crossref
Kia Strömberg, Susanna Eketjäll, Biljana Georgievska, Karin Tunblad, Kristina Eliason, Fredrik Olsson, Ann-Cathrin Radesäter, Rebecka Klintenberg, Per I. Arvidsson, Stefan von Berg, Johanna Fälting, Richard F. Cowburn & Michael Dabrowski. (2015) Combining an amyloid-beta (Aβ) cleaving enzyme inhibitor with a γ-secretase modulator results in an additive reduction of Aβ production. FEBS Journal 282:1, pages 65-73.
Crossref
Crossref
Bart De Strooper. (2014) Lessons from a Failed γ-Secretase Alzheimer Trial. Cell 159:4, pages 721-726.
Crossref
Crossref